439 Works

Mechanical thrombectomy for large vessel occlusion between 6 and 24 h: outcome comparison of DEFUSE-3/DAWN eligible versus non-eligible patients

Tolga D Dittrich, Peter B Sporns, Lilian F Kriemler, Salome Rudin, Anh Nguyen, Annaelle Zietz, Alexandros A Polymeris, Christopher Tränka, Sebastian Thilemann, Benjamin Wagner, Valerian L Altersberger, Ines Piot, Filip Barinka, Martin Hänsel, Henrik Gensicke, Stefan T Engelter, Philippe A Lyrer, Raoul Sutter, Christian H Nickel, Mira Katan, Nils Peters, Lars Michels, Zsolt Kulcsár, Grzegorz M Karwacki, Marco Pileggi … & Gian Marco De Marchis
Background:The DEFUSE-3 and DAWN trials showed that mechanical thrombectomy (MT) improves the outcome of selected patients with anterior circulation large vessel occlusions (LVO) up to 24 h after stroke onset. However, it is unknown whether only those patients fulfilling the trial inclusion criteria benefit, or whether benefit is seen in a broader range of patients presenting between 6 and 24 h.Aims:We determined whether fulfilling the DEFUSE-3 and DAWN selection criteria affects outcomes in MT patients...

What the policy and stewardship landscape of a national health research system looks like in a developing country like Iran: a qualitative study

Atousa Poursheikhali, Mohammed Alkhaldi, Reza Dehnavieh, AliAkbar Haghdoost, Ali Masoud, Somayeh Noorihekmat, Mohammad Reza Cheshmyazdan & Mousa Bamir
Abstract Background The health research system (HRS) is an important national priority that requires a systematic and functional approach. Evaluating the HRS of Iran as a developing country and identifying its challenges reveals the stewardship-related role in how the whole system is operating well. This study aims to assess the HRS in terms of stewardship functions and highlight the enhancement points. Methods This study was carried out between March 2020 and April 2021 using a...

Additional file 1 of Evidence for publicly reported quality indicators in residential long-term care: a systematic review

Magdalena Osińska, Lauriane Favez & Franziska Zúñiga
Additional file 1. Search strings used in the databases.

Additional file 2 of Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD

Maria Schroeder-Castagno, Alba Del Rio-Serrato, Andreas Wilhelm, Silvina Romero-Suárez, Patrick Schindler, Cesar Alvarez-González, Ankelien-Solveig Duchow, Judith Bellmann-Strobl, Klemens Ruprecht, Maria Hastermann, Gerald Grütz, Brigitte Wildemann, Sven Jarius, Tanja Schmitz-Hübsch, Friedemann Paul & Carmen Infante-Duarte
Additional file 2: Figure S2. Evaluation of spontaneous and PMA induced ROS production in AQP4 + NMOSD, MOGAD patients and HC granulocytes. Granulocytes from patients and matched HC were isolated and analyzed simultaneously and cultured without (black dots, none) and with PMA (red dots). Intracellular ROS were indirectly assessed by flow cytometry analysis of DHR 123. Depicted is the mean fluorescence intensity (MFI) of oxidized-DHR123. A) Data are represented with lines connecting the unstimulated and...

Additional file 2 of Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD

Maria Schroeder-Castagno, Alba Del Rio-Serrato, Andreas Wilhelm, Silvina Romero-Suárez, Patrick Schindler, Cesar Alvarez-González, Ankelien-Solveig Duchow, Judith Bellmann-Strobl, Klemens Ruprecht, Maria Hastermann, Gerald Grütz, Brigitte Wildemann, Sven Jarius, Tanja Schmitz-Hübsch, Friedemann Paul & Carmen Infante-Duarte
Additional file 2: Figure S2. Evaluation of spontaneous and PMA induced ROS production in AQP4 + NMOSD, MOGAD patients and HC granulocytes. Granulocytes from patients and matched HC were isolated and analyzed simultaneously and cultured without (black dots, none) and with PMA (red dots). Intracellular ROS were indirectly assessed by flow cytometry analysis of DHR 123. Depicted is the mean fluorescence intensity (MFI) of oxidized-DHR123. A) Data are represented with lines connecting the unstimulated and...

Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD

Maria Schroeder-Castagno, Alba Del Rio-Serrato, Andreas Wilhelm, Silvina Romero-Suárez, Patrick Schindler, Cesar Alvarez-González, Ankelien-Solveig Duchow, Judith Bellmann-Strobl, Klemens Ruprecht, Maria Hastermann, Gerald Grütz, Brigitte Wildemann, Sven Jarius, Tanja Schmitz-Hübsch, Friedemann Paul & Carmen Infante-Duarte
Abstract Background In neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neutrophils are found in CNS lesions. We previously demonstrated that NMOSD neutrophils show functional deficiencies. Thus, we hypothesized that neutrophil accumulation in the CNS may be facilitated by impairments affecting mechanisms of neutrophil death. Objective To evaluate cell death in blood neutrophils from aquaporin-4 (AQP4)-IgG-seropositive NMOSD and MOGAD patients as well as matched healthy controls (HC) using in vitro assays....

Additional file 2 of Unraveling implementation context: the Basel Approach for coNtextual ANAlysis (BANANA) in implementation science and its application in the SMILe project

Juliane Mielke, Lynn Leppla, Sabine Valenta, Leah L. Zullig, Franziska Zúñiga, Sandra Staudacher, Alexandra Teynor & Sabina De Geest
Additional file 2. Key resources for each component of the Basel Approach for coNtextual ANAlysis (BANANA).

Additional file 1 of Development and validation of a drill attachment for faster and safer deployments of fin-mounted geolocators in large-bodied sharks

Vital Heim, Daniel Lüscher, Jürgen Hottinger & Dieter Ebert
Additional file 1. Technical drawings.

Additional file 5 of Health care providers’ knowledge of clinical protocols for postpartum hemorrhage care in Kenya: a cross-sectional study

Junita Henry, Emma Clarke-Deelder, Dan Han, Nora Miller, Kennedy Opondo, Monica Oguttu, Thomas Burke, Jessica L. Cohen & Margaret McConnell
Additional file 5. Distribution of interviewed cadre across facilities.

Additional file 6 of Health care providers’ knowledge of clinical protocols for postpartum hemorrhage care in Kenya: a cross-sectional study

Junita Henry, Emma Clarke-Deelder, Dan Han, Nora Miller, Kennedy Opondo, Monica Oguttu, Thomas Burke, Jessica L. Cohen & Margaret McConnell
Additional file 6. Facility-level comparisons of scores for each domain.

Additional file 7 of Health care providers’ knowledge of clinical protocols for postpartum hemorrhage care in Kenya: a cross-sectional study

Junita Henry, Emma Clarke-Deelder, Dan Han, Nora Miller, Kennedy Opondo, Monica Oguttu, Thomas Burke, Jessica L. Cohen & Margaret McConnell
Additional file 7. Differences in scores by domain across desired improvements.

Additional file 1 of Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study

Olivia Yip, Suzanne Dhaini, Jan Esser, Flaka Siqeca, Maria Jose Mendieta, Evelyn Huber, Andreas Zeller, Sabina De Geest, Mieke Deschodt, Franziska Zúñiga, Leah L. Zullig & Heather A. King
Additional file 1. Survey questions extracted from the original INSPIRE Population Survey (translated from German) (Siqeca et al., 2021).

Additional file 2 of Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study

Olivia Yip, Suzanne Dhaini, Jan Esser, Flaka Siqeca, Maria Jose Mendieta, Evelyn Huber, Andreas Zeller, Sabina De Geest, Mieke Deschodt, Franziska Zúñiga, Leah L. Zullig & Heather A. King
Additional file 2. INSPIRE population survey respondents and dichotomized responses by content domain.

Additional file 3 of Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study

Olivia Yip, Suzanne Dhaini, Jan Esser, Flaka Siqeca, Maria Jose Mendieta, Evelyn Huber, Andreas Zeller, Sabina De Geest, Mieke Deschodt, Franziska Zúñiga, Leah L. Zullig & Heather A. King
Additional file 3. Example Questions from the Interview Guide used in the INSPIRE parent study (translated from German) (Esser et al., 2022).

Additional file 5 of Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study

Olivia Yip, Suzanne Dhaini, Jan Esser, Flaka Siqeca, Maria Jose Mendieta, Evelyn Huber, Andreas Zeller, Sabina De Geest, Mieke Deschodt, Franziska Zúñiga, Leah L. Zullig & Heather A. King
Additional file 5. Concepts related to care and support of frail older adults in 2018 and preferences for future, mapped to adapted domains of the SELFIE framework, including only respondents who indicated no current use for each question respectively, but responded for future preferences.

Additional file 5 of Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study

Olivia Yip, Suzanne Dhaini, Jan Esser, Flaka Siqeca, Maria Jose Mendieta, Evelyn Huber, Andreas Zeller, Sabina De Geest, Mieke Deschodt, Franziska Zúñiga, Leah L. Zullig & Heather A. King
Additional file 5. Concepts related to care and support of frail older adults in 2018 and preferences for future, mapped to adapted domains of the SELFIE framework, including only respondents who indicated no current use for each question respectively, but responded for future preferences.

Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study

Olivia Yip, Suzanne Dhaini, Jan Esser, Flaka Siqeca, Maria Jose Mendieta, Evelyn Huber, Andreas Zeller, Sabina De Geest, Mieke Deschodt, Franziska Zúñiga, Leah L. Zullig & Heather A. King
Abstract Background Home-dwelling frail older adults are often faced with multimorbidity and complex care needs, requiring health and social care systems that support frail older adults to age in place. The objective of this paper was to investigate the types of formal health and social care as well as informal care and social support used by home-dwelling frail older adults; whether they perceive their support as sufficient; and their experience with and preferences for care...

Additional file 4 of Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms

Manja Deforth, Caroline E. Gebhard, Susan Bengs, Philipp K. Buehler, Reto A. Schuepbach, Annelies S. Zinkernagel, Silvio D. Brugger, Claudio T. Acevedo, Dimitri Patriki, Benedikt Wiggli, Raphael Twerenbold, Gabriela M. Kuster, Hans Pargger, Joerg C. Schefold, Thibaud Spinetti, Pedro D. Wendel-Garcia, Daniel A. Hofmaenner, Bianca Gysi, Martin Siegemund, Georg Heinze, Vera Regitz-Zagrosek, Catherine Gebhard & Ulrike Held
Additional file 4. Logistic regression model based on the ABE and ABESS variable selection, calculated on the total cohort.

Additional file 1 of What the policy and stewardship landscape of a national health research system looks like in a developing country like Iran: a qualitative study

Atousa Poursheikhali, Mohammed Alkhaldi, Reza Dehnavieh, AliAkbar Haghdoost, Ali Masoud, Somayeh Noorihekmat, Mohammad Reza Cheshmyazdan & Mousa Bamir
Additional file 1: Standards for Reporting Qualitative Research (SRQR)a.

Mobilisation of critically ill patients receiving norepinephrine: a retrospective cohort study

Maximilian Lindholz, Clara M. Schellenberg, Julius J. Grunow, Simone Kagerbauer, Annette Milnik, Daniel Zickler, Stefan Angermair, Anett Reißhauer, Martin Witzenrath, Mario Menk, Sebastian Boie, Felix Balzer & Stefan J. Schaller
Abstract Background Mobilisation and exercise intervention in general are safe and feasible in critically ill patients. For patients requiring catecholamines, however, doses of norepinephrine safe for mobilisation in the intensive care unit (ICU) are not defined. This study aimed to describe mobilisation practice in our hospital and identify doses of norepinephrine that allowed a safe mobilisation. Methods We conducted a retrospective single-centre cohort study of 16 ICUs at a university hospital in Germany with patients...

Additional file 1 of The use of routine health facility data for micro-stratification of malaria risk in mainland Tanzania

Sumaiyya G. Thawer, Monica Golumbeanu, Khalifa Munisi, Sijenunu Aaron, Frank Chacky, Samwel Lazaro, Ally Mohamed, Noela Kisoka, Christian Lengeler, Fabrizio Molteni, Amanda Ross, Robert W. Snow & Emilie Pothin
Additional file 1. Additional tables, text and figures.

Additional file 2 of The use of routine health facility data for micro-stratification of malaria risk in mainland Tanzania

Sumaiyya G. Thawer, Monica Golumbeanu, Khalifa Munisi, Sijenunu Aaron, Frank Chacky, Samwel Lazaro, Ally Mohamed, Noela Kisoka, Christian Lengeler, Fabrizio Molteni, Amanda Ross, Robert W. Snow & Emilie Pothin
Additional file 2: Table S3. Shows the proportion of heterogeneity per council.

sj-docx-1-eso-10.1177_23969873221143570 – Supplemental material for The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial

Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Marco Duering, Julie Staals, Martin Middeke, Elisabeth André, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N Doubal, Robert van Oostenbrugge, Geert Jan Biessels, Alastair JS Webb, Joanna M Wardlaw & Martin Dichgans
Supplemental material, sj-docx-1-eso-10.1177_23969873221143570 for The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial by Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Marco Duering, Julie Staals, Martin Middeke, Elisabeth André, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N...

The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial

Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Marco Duering, Julie Staals, Martin Middeke, Elisabeth André, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N Doubal, Robert van Oostenbrugge, Geert Jan Biessels, Alastair JS Webb, Joanna M Wardlaw & Martin Dichgans
Background:Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially affect microvascular function in SVDs.Aims:To test whether amlodipine has a beneficial effect on microvascular function when compared to either losartan or atenolol, and whether losartan has a beneficial effect when compared to atenolol in patients with symptomatic SVDs.Design:TREAT-SVDs is an investigator-led, prospective, open-label, randomised crossover trial with blinded endpoint assessment (PROBE design) conducted...

The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial

Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Marco Duering, Julie Staals, Martin Middeke, Elisabeth André, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N Doubal, Robert van Oostenbrugge, Geert Jan Biessels, Alastair JS Webb, Joanna M Wardlaw & Martin Dichgans
Background:Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially affect microvascular function in SVDs.Aims:To test whether amlodipine has a beneficial effect on microvascular function when compared to either losartan or atenolol, and whether losartan has a beneficial effect when compared to atenolol in patients with symptomatic SVDs.Design:TREAT-SVDs is an investigator-led, prospective, open-label, randomised crossover trial with blinded endpoint assessment (PROBE design) conducted...

Registration Year

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Affiliations

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    439
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