25 Works

Population and landscape genetic analysis of the Malayan sun bear Helarctos malayanus

Miriam Kunde, Renata Martins, Joe Premier, Jörns Fickel & Daniel Förster
Conservation genetics can provide data needed by conservation practitioners for their decisions regarding the management of vulnerable or endangered species, such as the sun bear Helarctos malayanus. Throughout its range, the sun bear is threatened by loss and fragmentation of its habitat and the illegal trade of both live bears and bear parts. Sharply declining population numbers and population sizes, and a lack of natural dispersal between populations all threaten the genetic diversity of the...

Chiral 4-O-acylterpineol as transdermal permeation enhancers: insights of the enhancement mechanisms of a transdermal enantioselective delivery system for flurbiprofen

Tianzhe Chu, Chunyan Wang, Jing Wang, Heping Wang, Dandan Geng, Chensi Wu, Linlin Zhao & Ligang Zhao
In order to devise more effective penetration enhancers, 4-O-acylterpineol derivatives which were expected to be hydrolyzed into nontoxic metabolites by esterase in the living epidermis, were synthesized from 4-terpineol (4-TER) enantiomers and straight chain fatty acids. Their promoting activities on the SR-flurbiprofen and its enantiomers were tested across full-thickness rabbit skin, as well as to correlate under in vitro and in vivo conditions. The permeation studies indicated that both d-4-O-acylterpineol and l-4-O-acylterpineol had significant enhancing...

Surgical applications of intracorporal tissue adhesive agents: current evidence and future development

Nicholas Gillman, David Lloyd, Randy Bindra, Rui Ruan & Minghao Zheng
Introduction: Traditional mechanical closure techniques pose many challenges including the risk of infection, tissue reaction, and injury to both patients and clinicians. There is an urgent need to develop tissue adhesive agents to reform closure technique. This review examined a variety of tissue adhesive agents available in the market in an attempt to gain a better understanding of intracorporal tissue adhesive agents as medical devices. Areas covered: Fundamental principles and clinical determinants of the tissue...

Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cells

Reeja S. Maskey, Fang Wang, Elyssa Lehman, Yiqun Wang, Natasha Emmanuel, Wenyan Zhong, Guixian Jin, Robert T. Abraham, Kim T. Arndt, Jeremy S. Myers & Anthony Mazurek
Palbociclib, a selective CDK4/6 kinase inhibitor, is approved in combination with endocrine therapies for the treatment of advanced estrogen receptor positive (ER+) breast cancer. In pre-clinical cancer models, CDK4/6 inhibitors act primarily as cytostatic agents. In two commonly studied ER+ breast cancer cell lines (MCF7 and T47D), CDK4/6 inhibition drives G1-phase arrest and the acquisition of a senescent-like phenotype, both of which are reversible upon palbociclib withdrawal (incomplete senescence). Here we identify an ER+ breast...

Oligocene divergence of frogmouth birds (Podargidae) across Wallace’s line

Paul Oliver, Holly Heiniger, Andrew Hugall, Leo Joseph & Kieren Mitchell
Wallace’s Line demarcates the transition between the differentiated regional faunas of Asia and Australia. However, while patterns of biotic differentiation across these two continental landmasses and the intervening island groups (“Wallacea”) have been extensively studied, patterns of long-term dispersal and diversification across this region are less well understood. Frogmouths (Aves: Podargidae) are a relictual family of large nocturnal birds represented by three extant genera occurring respectively in Asia, “Sahul” (Australia and New Guinea), and the...

Density estimates of African lions in Queen Elizabeth National Park

Aleksander Braczkowski
African lions are declining across much of their range, yet robust measures of population densities remain rare. The Queen Elizabeth Conservation Area (QECA; 2400 km2) in East Africa’s Albertine Rift has potential to support a significant lion population. However, QECA lions are threatened, and information on the status of lions in the region is lacking. Here, we use a spatially explicit search encounter approach to estimate key population parameters of lions in the QECA. We...

Soil fungi and fine root biomass mediate drought-induced reductions in soil respiration

Guiyao Zhou, Xuhui Zhou, Ruiqiang Liu, Zhenggang Du, Lingyan Zhou, Songsong Li, Huiying Liu, Junjiong Shao, Jiawei Wang, Yuanyuan Nie, Jie Gao, Minhuang Wang, Mingyue Zhang, Xihua Wang & Shahla Hosseini Bai
Climate change has increased the frequency and intensity of droughts, with potential impacts on carbon (C) release from soil (i.e., soil respiration, Rs). Although numerous studies have investigated drought-induced changes in Rs, how roots and the soil microbial community regulate responses of Rs to drought remains unclear. We conducted a 4-year field experiment (2014 - 2017) with three treatments (i.e., 70% rainfall reduction, control and ambient) in a subtropical forest to examine effects of drought...

Thioridazine hydrochloride: an antipsychotic agent that inhibits tumor growth and lung metastasis in triple-negative breast cancer via inducing G0/G1 arrest and apoptosis

Yanlin Song, Lu Li, Jiao Chen, Hongli Chen, Bomiao Cui, Yun Feng, Ping Zhang, Qiangsheng Zhang, Yong Xia & Min Luo
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer and still lacks available targeted therapy options. Thioridazine hydrochloride (Thi-hyd), a common phenothiazine antipsychotic drug, has shown great tumor-suppressive potential in several types of cancer cells. In this study, we explored the anti-tumor effects of Thi-hyd on TNBC. Thi-hyd significantly inhibited the viability and migration of TNBC cells in vitro. PI3K/AKT signaling pathway was verified to be related to Thi-hyd-induced tumor inhibition. G0/G1...

Global Diversification Dynamics Since the Jurassic: Low Dispersal and Habitat-Dependent Evolution Explain Hotspots of Diversity and Shell Disparity in River Snails (Viviparidae)

Björn Stelbrink, Romy Richter, Frank Köhler, Frank Riedel, Ellen Strong, Bert Van Bocxlaer, Christian Albrecht, Torsten Hauffe, Timothy Page, David Aldridge, Arthur Bogan, Li-Na Du, Marivene Manuel-Santos, Ristiyanti Marwoto, Alena Shirokaya & Thomas Von Rintelen
The Viviparidae, commonly known as River Snails, is a dominant group of freshwater snails with a nearly worldwide distribution that reaches its highest taxonomic and morphological diversity in Southeast Asia. The rich fossil record is indicative of a probable Middle Jurassic origin on the Laurasian supercontinent where the group started to diversify during the Cretaceous. However, it remains uncertain when and how the biodiversity hotspot in Southeast Asia was formed. Here, we used a comprehensive...

Developing a strategy to improve data sharing in health research: A mixed-methods study to identify barriers and facilitators

Michelle A Krahe, Malcolm Wolski, Sharon Mickan, Julie Toohey, Paul Scuffham & Sheena Reilly
Background:Data sharing presents new opportunities across the spectrum of research and is vital for science that is open, where data are easily discoverable, accessible, intelligible, reproducible, replicable and verifiable. Despite this, it is yet to become common practice. Global efforts to develop practical guidance for data sharing and open access initiatives are underway, however evidence-based studies to inform the development and implementation of effective strategies are lacking.Objective:This study sought to determine the barriers and facilitators...

Chiral 4-O-acylterpineol as transdermal permeation enhancers: insights of the enhancement mechanisms of a transdermal enantioselective delivery system for flurbiprofen

Tianzhe Chu, Chunyan Wang, Jing Wang, Heping Wang, Dandan Geng, Chensi Wu, Linlin Zhao & Ligang Zhao
In order to devise more effective penetration enhancers, 4-O-acylterpineol derivatives which were expected to be hydrolyzed into nontoxic metabolites by esterase in the living epidermis, were synthesized from 4-terpineol (4-TER) enantiomers and straight chain fatty acids. Their promoting activities on the SR-flurbiprofen and its enantiomers were tested across full-thickness rabbit skin, as well as to correlate under in vitro and in vivo conditions. The permeation studies indicated that both d-4-O-acylterpineol and l-4-O-acylterpineol had significant enhancing...

Surgical applications of intracorporal tissue adhesive agents: current evidence and future development

Nicholas Gillman, David Lloyd, Randy Bindra, Rui Ruan & Minghao Zheng
Introduction: Traditional mechanical closure techniques pose many challenges including the risk of infection, tissue reaction, and injury to both patients and clinicians. There is an urgent need to develop tissue adhesive agents to reform closure technique. This review examined a variety of tissue adhesive agents available in the market in an attempt to gain a better understanding of intracorporal tissue adhesive agents as medical devices. Areas covered: Fundamental principles and clinical determinants of the tissue...

Effects of habitat transitions on rainforest bird communities across an anthropogenic landscape mosaic

Guohualing Huang & Carla Catterall
We compared bird community responses to the habitat transitions of: rainforest-to-pasture conversion, consequent habitat fragmentation, and post-agricultural regeneration, across a landscape mosaic of about 600 km2 in the eastern Australian subtropics. Birds were surveyed in seven habitats: continuous mature rainforest; two size-classes of mature rainforest fragment (4-21 ha, 1-3 ha); regrowth forest patches dominated by a non-native tree (2-20 ha, 30-50 years old); two types of isolated mature trees in pasture; and treeless pasture; with...

Environmental Chemistry

Darryl Hawker
Development and calibration of novel passive samplers for analytes of emerging interest.

Supplemental Material, sj-pdf-1-him-10.1177_1833358320917207 - Developing a strategy to improve data sharing in health research: A mixed-methods study to identify barriers and facilitators

Michelle A Krahe, Malcolm Wolski, Sharon Mickan, Julie Toohey, Paul Scuffham & Sheena Reilly
Supplemental Material, sj-pdf-1-him-10.1177_1833358320917207 for Developing a strategy to improve data sharing in health research: A mixed-methods study to identify barriers and facilitators by Michelle A Krahe, Malcolm Wolski, Sharon Mickan, Julie Toohey, Paul Scuffham and Sheena Reilly in Health Information Management Journal

Foliar water uptake by coastal wetland plants: a novel water acquisition mechanism in arid and humid subtropical mangroves

Matthew Hayes, Samantha Chapman, Amber Jesse, Elizabeth O'Brien, Adam Langley, Remi Bardou, John Devaney, John Parker & Kyle C. Cavanaugh
1. Climate change alters freshwater availability in many ecosystems leading to shifts in distributions for many plants. Despite living exclusively in intertidal, saline environments, mangroves rely on non-saline water to maintain plant productivity. However, several mangrove species persist in arid environments where non-saline water from rain and groundwater sources are limited. Under these conditions, foliar water uptake from fog and mist may be an important water acquisition strategy. 2. We conducted a field experiment in...

Data from: Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation

Michael Hildebrand, Victoria Jackson, Thomas Scerri, Olivia Van Reyk, Matthew Coleman, Ruth Braden, Samantha Turner, Kristin Rigbye, Amber Boys, Sarah Barton, Richard Webster, Michael Fahey, Kerryn Saunders, Bronwyn Parry-Fielder, Georgia Paxton, Michael Hayman, David Coman, Himanshu Goel, Anne Baxter, Alan Ma, Noni Davis, Sheena Reilly, Martin Delatycki, Frederique Liégeois, Alan Connelly … & Angela Morgan
Objective: Determining the genetic basis of speech disorders provides insight into the neurobiology of human communication. Despite intensive investigation over the past two decades, the etiology of most children with speech disorder remains unexplained. Here we searched for a genetic etiology in children with severe speech disorder, specifically childhood apraxia of speech (CAS). Methods: Precise phenotyping together with research genome or exome analysis were performed on children referred with a primary diagnosis of CAS, as...

Supplemental Material, HIMJ-19-0147_Krahe_et_al_Supplemental_Material - Developing a strategy to improve data sharing in health research: A mixed-methods study to identify barriers and facilitators

Michelle A Krahe, Malcolm Wolski, Sharon Mickan, Julie Toohey, Paul Scuffham & Sheena Reilly
Supplemental Material, HIMJ-19-0147_Krahe_et_al_Supplemental_Material for Developing a strategy to improve data sharing in health research: A mixed-methods study to identify barriers and facilitators by Michelle A Krahe, Malcolm Wolski, Sharon Mickan, Julie Toohey, Paul Scuffham and Sheena Reilly in Health Information Management Journal

High Resolution Ocean Modelling for South-east Queensland

Daijiro Kobashi
This data set contains research conducted by Dr. Daijirro Kobashi for the period of Jan 2011 to Jan 2014. The dataset contains a series of files containing modelling data pertaining to ocean readings from the South-East Queensland region. The format of the model outputs are netcdf. The files are archived for further analysis. The project implements high-resolution ocean models to investigate coastal processes for the South-East Queensland.

Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cells

Reeja S. Maskey, Fang Wang, Elyssa Lehman, Yiqun Wang, Natasha Emmanuel, Wenyan Zhong, Guixian Jin, Robert T. Abraham, Kim T. Arndt, Jeremy S. Myers & Anthony Mazurek
Palbociclib, a selective CDK4/6 kinase inhibitor, is approved in combination with endocrine therapies for the treatment of advanced estrogen receptor positive (ER+) breast cancer. In pre-clinical cancer models, CDK4/6 inhibitors act primarily as cytostatic agents. In two commonly studied ER+ breast cancer cell lines (MCF7 and T47D), CDK4/6 inhibition drives G1-phase arrest and the acquisition of a senescent-like phenotype, both of which are reversible upon palbociclib withdrawal (incomplete senescence). Here we identify an ER+ breast...

Thioridazine hydrochloride: an antipsychotic agent that inhibits tumor growth and lung metastasis in triple-negative breast cancer via inducing G0/G1 arrest and apoptosis

Yanlin Song, Lu Li, Jiao Chen, Hongli Chen, Bomiao Cui, Yun Feng, Ping Zhang, Qiangsheng Zhang, Yong Xia & Min Luo
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer and still lacks available targeted therapy options. Thioridazine hydrochloride (Thi-hyd), a common phenothiazine antipsychotic drug, has shown great tumor-suppressive potential in several types of cancer cells. In this study, we explored the anti-tumor effects of Thi-hyd on TNBC. Thi-hyd significantly inhibited the viability and migration of TNBC cells in vitro. PI3K/AKT signaling pathway was verified to be related to Thi-hyd-induced tumor inhibition. G0/G1...

Data from: Disease swamps molecular signatures of genetic-environmental associations to abiotic factors in Tasmanian devil (Sarcophilus harrisii) populations

Alexandra Kaye Fraik, Mark Margres, Brendan Epstein, Soraia Barbosa, Menna Jones, Sarah Hendricks, Barbara Schonfeld, Amanda R. Stahlke, Anne Veillet, Rodrigo Hamede, Hamish McCallum, Elisa Lopez-Contreras, Samantha J Kallinen, Paul A Hohenlohe, Joanna Kelley & Andrew Storfer
Landscape genomics studies focus on identifying candidate genes under selection via spatial variation in abiotic environmental variables, but rarely by biotic factors such as disease. The Tasmanian devil (Sarcophilus harrisii) is found only on the environmentally heterogeneous island of Tasmania and is threatened with extinction by a nearly 100% fatal, transmissible cancer, devil facial tumor disease (DFTD). Devils persist in regions of long-term infection despite epidemiological model predictions of species’ extinction, suggesting possible adaptation to...

Data from: The global diversity and distribution of lizard clutch sizes

Shai Meiri, Luciano Avila, Aaron Bauer, David Chapple, Indraneil Das, Tiffany Doan, Paul Doughty, Ryan Ellis, Lee Grismer, Fred Kraus, Mariana Morando, Paul Oliver, Daniel Pincheira-Donoso, Marco-Antonio Ribeiro-Junior, Glenn Shea, Omar Torres-Carvajal, Alex Slavenko & Uri Roll
Aim. Clutch size is a key life-history trait. In lizards, it ranges over two orders of magnitude. The global drivers of spatial and phylogenetic variation in clutch have been extensively studied in birds, but such tests in other organisms are lacking. To test the generality of latitudinal gradients in clutch size, and their putative drivers, we present the first global-scale analysis of clutch sizes across of lizard taxa. Location, Global Time period. Recent Major taxa...

Developing a strategy to improve data sharing in health research: A mixed-methods study to identify barriers and facilitators

Michelle A Krahe, Malcolm Wolski, Sharon Mickan, Julie Toohey, Paul Scuffham & Sheena Reilly
Background:Data sharing presents new opportunities across the spectrum of research and is vital for science that is open, where data are easily discoverable, accessible, intelligible, reproducible, replicable and verifiable. Despite this, it is yet to become common practice. Global efforts to develop practical guidance for data sharing and open access initiatives are underway, however evidence-based studies to inform the development and implementation of effective strategies are lacking.Objective:This study sought to determine the barriers and facilitators...

Data from: Hurricanes overcome migration lag and shape intraspecific genetic variation beyond a poleward mangrove range limit

John Paul Kennedy, Emily M. Dangremond, Matthew A. Hayes, Richard F. Preziosi, Jennifer K. Rowntree & Ilka C. Feller
Expansion of many tree species lags behind climate-change projections. Extreme storms can rapidly overcome this lag, especially for coastal species, but how will storm-driven expansion shape intraspecific genetic variation? Do storms provide recruits only from the nearest sources, or from more distant sources? Answers to these questions have ecological and evolutionary implications, but empirical evidence is absent from the literature. Hurricane Irma provided an opportunity to address this knowledge gap at the northern range limit...

Registration Year

  • 2020
    25

Resource Types

  • Dataset
    12
  • Text
    10
  • Collection
    2
  • Other
    1

Affiliations

  • Griffith University
    25
  • Zhejiang University
    6
  • Bond University
    4
  • West China Second University Hospital of Sichuan University
    4
  • Air Force Medical University
    4
  • Chengdu University of Traditional Chinese Medicine
    4
  • University of Queensland
    4
  • China Astronaut Research and Training Center
    2
  • Hainan Medical University
    2
  • Third Hospital of Hebei Medical University
    2