Single cell RNA sequencing (drop-seq) data of forebrain organoids carrying pathogenic MAPT R406W and V337M mutations. Organoids were generated from 5 heterozygous donor lines (two R406W lines and three V337M lines) and respective CRISPR-corrected isogenic controls. Organoids were also generated from one homozygous R406W donor line. Single-cell sequencing was performed at 1, 2, 3, 4, 6 and 8 months of organoid maturation.

In spin torque magnetic memories, electrically actuated spin currents are used to switch a magnetic bit. Typically, these require a multilayer geometry including both a free ferromagnetic layer and a second layer providing spin injection. For example, spin may be injected by a non-magnetic layer exhibiting a large spin Hall effect, a phenomenon known as spin-orbit torque. Here, we demonstrate a spin-orbit torque magnetic bit in a single two-dimensional system with intrinsic magnetism and strong...

The impact of polymer architecture on network dynamics and self-healing is presented using bottlebrushes containing side chains that are end-functionalized with 2-ureido-4[1H]-pyrimidinone (UPy). The synthesis of these materials is straightforward through a three-step process: (1) synthesizing rubbery poly(4-methylcaprolactone) macromonomers (pMCL−OH) with a norbornene-based initiator, (2) functionalizing the terminal hydroxyl group with UPy−isocyanate (pMCL−UPy), and (3) statistically copolymerizing pMCL−OH and pMCL−UPy via ring-opening metathesis polymerization (ROMP) to form hydrogen-bonding bottlebrushes having a fraction (p) of side...

Supplemental material, sj-docx-1-tar-10.1177_17534666231155747 for Adenosine deaminase-based measurement in the differential diagnosis of pleural effusion: a multicenter retrospective study by Lijuan Gao, Wujun Wang, Ying Zhang, Xueru Hu, Jing An, Yang Li, Mei Chen and Yongchun Shen in Therapeutic Advances in Respiratory Disease

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The City of Santa Barbara’s commitment to reaching 100% renewable energy by 2030 has led to an exploration of opportunities for clean generation with an emphasis on local projects for increased energy resilience. Floating solar (FPV) technology presents a unique and attractive solution to achieving this goal by increasing local renewable energy generation without occupying scarce available land in Santa Barbara. This report explores Lauro Reservoir as an appealing site for implementing this technology, technology...

Climate change is causing large declines in many Pacific salmon populations. In particular, warm rivers are associated with high levels of premature mortality in migrating adults. The Fraser River watershed in British Columbia, Canada, supports some of the largest Chinook salmon (Oncorhynchus tshawytscha) runs in the world. However, the Fraser River is warming at a rate that threatens these populations at critical freshwater life stages. A growing body of literature suggests salmonids are locally adapted...

The Silurian-age shift in fluvial stratigraphic architecture is associated with the predominance of shallow pancontinental braidplains in the vegetation-free, pre-Silurian period. Recognition of deep, single-threaded channels in pre-Silurian strata challenge this paradigm; however, it is unclear how these rivers sustained stable banks. Here, we combine measurements of fluvial cross-strata from the 1.2 Ga Stoer Group with quantitative paleohydraulic tools to reconstruct river geometry and planform. We show that the deposits are consistent with deep (4-7...

Within state water transfers by buyer and seller, price, and year.

Structured illumination microscopy (SIM) is a popular super-resolution imaging technique that can achieve resolution improvements of 2x and greater depending on the illumination patterns used. Traditionally, images are reconstructed using the linear SIM reconstruction algorithm. However, this algorithm has hand-tuned parameters which can often lead to artifacts and it cannot be used with more complex illumination patterns. Recently, deep neural networks (DNNs) have been used for SIM reconstruction, yet they require training sets which are...

Predators suppress prey populations and elicit defensive phenotypes in prey. The magnitude of predator effects depends upon several factors, including the density of predators, and their cue concentrations, in the environment. Predator density manipulations have often relied on laboratory studies that use unrealistic densities of predators and prey over unnatural temporal and spatial scales. Field studies can provide insights into predator-prey interactions under more realistic scenarios. However, field studies linking predator density and prey populations...

Spatial cognition depends on an accurate representation of orientation within an environment. Head direction cells in distributed brain regions receive a range of sensory inputs, but visual input is particularly important for aligning their responses to environmental landmarks. To investigate how population-level heading responses are aligned to visual input, we recorded from retrosplenial cortex (RSC) of head-fixed mice in a moving environment using two-photon calcium imaging. We show that RSC neurons are tuned to the...

Structured illumination microscopy (SIM) is a popular super-resolution imaging technique that can achieve resolution improvements of 2x and greater depending on the illumination patterns used. Traditionally, images are reconstructed using the linear SIM reconstruction algorithm. However, this algorithm has hand-tuned parameters which can often lead to artifacts and it cannot be used with more complex illumination patterns. Recently, deep neural networks (DNNs) have been used for SIM reconstruction, yet they require training sets which are...

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Structured illumination microscopy (SIM) is a popular super-resolution imaging technique that can achieve resolution improvements of 2x and greater depending on the illumination patterns used. Traditionally, images are reconstructed using the linear SIM reconstruction algorithm. However, this algorithm has hand-tuned parameters which can often lead to artifacts and it cannot be used with more complex illumination patterns. Recently, deep neural networks (DNNs) have been used for SIM reconstruction, yet they require training sets which are...

This perspective discusses new advances in the predictability of east African rains and highlights the potential for improved early warning systems (EWS), humanitarian relief efforts, and agricultural decision-making. Following an unprecedented sequence of five droughts, in 2022, 23 million east Africans faced starvation, requiring >$2 billion in aid. Here, we update climate attribution studies showing that these droughts resulted from an interaction of climate change and La Niña. Then we describe, for the first time,...

Seed size affects individual fitness in wild plant populations, but its ability to evolve may be limited by low narrow-sense heritability (h2). h2 is estimated as the proportion of total phenotypic variance (s2P) attributable to additive genetic variance (s2A), so low values of h2 may be due to low s2A (potentially eroded by natural selection) or to high values of the other factors that contribute to s2P, such as extranuclear maternal effects (m2) and environmental...

Introduction:The differential diagnosis of pleural effusion is difficult, and studies have reported on the potential role of adenosine deaminase (ADA) in the differential diagnosis of undiagnosed pleural effusion. This retrospective study aimed to investigate the diagnostic role of ADA in pleural effusion.Methods:266 patients with pleural effusion from three centers were enrolled. The concentrations of ADA and lactate dehydrogenase (LDH) were measured in pleural fluids and serum samples of the patients. The diagnostic performance of ADA-based...

Introduction:The differential diagnosis of pleural effusion is difficult, and studies have reported on the potential role of adenosine deaminase (ADA) in the differential diagnosis of undiagnosed pleural effusion. This retrospective study aimed to investigate the diagnostic role of ADA in pleural effusion.Methods:266 patients with pleural effusion from three centers were enrolled. The concentrations of ADA and lactate dehydrogenase (LDH) were measured in pleural fluids and serum samples of the patients. The diagnostic performance of ADA-based...

Supplemental material, sj-docx-1-tar-10.1177_17534666231155747 for Adenosine deaminase-based measurement in the differential diagnosis of pleural effusion: a multicenter retrospective study by Lijuan Gao, Wujun Wang, Ying Zhang, Xueru Hu, Jing An, Yang Li, Mei Chen and Yongchun Shen in Therapeutic Advances in Respiratory Disease

Global climate change is increasing thermal variability in coastal marine environments and the frequency, intensity, and duration of marine heatwaves. At the same time, food availability and quality are being altered by anthropogenic environmental changes. Marine ectotherms often cope with changes in temperature through physiological acclimation, which can take several weeks and is a nutritionally demanding process. Here, we tested the hypothesis that different ecologically relevant diets (omnivorous, herbivorous, carnivorous) impact thermal acclimation rate and...

Roughly three billion people worldwide live along large rivers and rely upon them for food, water, transport, and energy. To ensure the safety and sustainability of these riverside communities, it is important that we understand how rivers migrate over time. Satellite missions like NASA Landsat have captured millions of images of migrating rivers worldwide for more than thirty years—more images than can be feasibly mapped manually.These data and codes accompany the manuscript "Remote Sensing of...

Chinese onion is a common vegetable in daily diet, especially in Southwest China. We collected 184 samples from farm and market in Chongqing Municipality during 2020–2021 and established a multi-residue method for analysis of 79 pesticide residues on Chinese onion. Sixty-three of 184 samples were found pesticide resdues, accounting for 34.2%. A total of 31 pesticides were detected, and 6 pesticides in 11 samples have exceeded the Chinese MRLs, 5.98% of all samples. The chronic...

Chinese onion is a common vegetable in daily diet, especially in Southwest China. We collected 184 samples from farm and market in Chongqing Municipality during 2020–2021 and established a multi-residue method for analysis of 79 pesticide residues on Chinese onion. Sixty-three of 184 samples were found pesticide resdues, accounting for 34.2%. A total of 31 pesticides were detected, and 6 pesticides in 11 samples have exceeded the Chinese MRLs, 5.98% of all samples. The chronic...

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