215 Works

The industrial solvent 1,4-Dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1

Xiaoyi Mo, Qiang Liu, Luna Gao, Chang Xie, Xin Wei, Peiyuan Pang, Quan Tian, Yue Gao, Youjing Zhang, Yuanyuan Wang, Tianchen Xiong, Bo Zhong, Dongdong Li & Jing Yao
Background: The synthetic chemical 1,4-dioxane is used as industrial solvent, food and care product additive. 1,4-Dioxane has been noted to influence the nervous system in long-term animal experiments and in humans, but the molecular mechanisms underlying its effects on animals were not previously known. Results: Here, we report that 1,4-dioxane potentiates the capsaicin-sensitive transient receptor potential (TRP) channel TRPV1, thereby causing hyperalgesia in mouse model. This effect was abolished by CRISPR/Cas9-mediated genetic deletion of TRPV1...

Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial

David Adams, Ivailo L. Tournev, Mark S. Taylor, Teresa Coelho, Violaine Planté-Bordeneuve, John L. Berk, Alejandra González-Duarte, Julian D. Gillmore, Soon-Chai Low, Yoshiki Sekijima, Laura Obici, Chongshu Chen, Prajakta Badri, Seth M. Arum, John Vest & Michael Polydefkis
The study objective was to assess the effect of vutrisiran, an RNA interference therapeutic that reduces transthyretin (TTR) production, in patients with hereditary transthyretin (ATTRv) amyloidosis with polyneuropathy. HELIOS-A was a phase 3, global, open-label study comparing the efficacy and safety of vutrisiran with an external placebo group (APOLLO study). Patients were randomized 3:1 to subcutaneous vutrisiran 25 mg every 3 months (Q3M) or intravenous patisiran 0.3 mg/kg every 3 weeks (Q3W) for 18 months....

Additional file 2 of Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Alice Blet, Joel B. McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti, Gad Cotter, Agnès Dauvergne, Beth Davison, Kévin Duarte, Jacques Duranteau, Marie-Céline Fournier, Etienne Gayat, Samir Jaber, Sigismond Lasocki, Thomas Merkling, Katell Peoc’h, Imke Mayer, Malha Sadoune, Pierre-François Laterre, Romain Sonneville, Lorraine Ware, Alexandre Mebazaa & Antoine Kimmoun
Additional file 2: Supplemental Text.

sj-docx-1-jiv-10.1177_08862605221124263 – Supplemental material for Child Sexual Abuse in the Roman Catholic Church in France: Prevalence and Comparison With Other Social Spheres

Nathalie Bajos, Julie Ancian, Josselin Tricou, Axelle Valendru, Jeanna-Eve Pousson & Caroline Moreau
Supplemental material, sj-docx-1-jiv-10.1177_08862605221124263 for Child Sexual Abuse in the Roman Catholic Church in France: Prevalence and Comparison With Other Social Spheres by Nathalie Bajos, Julie Ancian, Josselin Tricou, Axelle Valendru, Jeanna-Eve Pousson and Caroline Moreau in Journal of Interpersonal Violence

Additional file 6 of Atypical working hours are associated with tobacco, cannabis and alcohol use: longitudinal analyses from the CONSTANCES cohort

Nadine Hamieh, Guillaume Airagnes, Alexis Descatha, Marcel Goldberg, Frédéric Limosin, Yves Roquelaure, Cédric Lemogne, Marie Zins & Joane Matta
Additional file 6: Supplementary Table S6. Baseline characteristics of the employees by indicators of atypical working hours in women between 2012-2017.

Additional file 2 of Atypical working hours are associated with tobacco, cannabis and alcohol use: longitudinal analyses from the CONSTANCES cohort

Nadine Hamieh, Guillaume Airagnes, Alexis Descatha, Marcel Goldberg, Frédéric Limosin, Yves Roquelaure, Cédric Lemogne, Marie Zins & Joane Matta
Additional file 2: Supplementary Table S2. The principal component analysis of the qualitative food frequency questionnaire using the Varimax rotation.

Additional file 1 of Pharmacokinetics, efficacy and tolerance of cefoxitin in the treatment of cefoxitin-susceptible extended-spectrum beta-lactamase producing Enterobacterales infections in critically ill patients: a retrospective single-center study

Paul Chabert, Judith Provoost, Sabine Cohen, Céline Dupieux-Chabert, Laurent Bitker, Tristan Ferry, Sylvain Goutelle & Jean-Christophe Richard
Additional file 1: Table S1. Characteristics and outcome of patients presenting with cefoxitin-susceptible-ESBL-PE infections admitted in the ICU during the study period.

Additional file 5 of Pharmacokinetics, efficacy and tolerance of cefoxitin in the treatment of cefoxitin-susceptible extended-spectrum beta-lactamase producing Enterobacterales infections in critically ill patients: a retrospective single-center study

Paul Chabert, Judith Provoost, Sabine Cohen, Céline Dupieux-Chabert, Laurent Bitker, Tristan Ferry, Sylvain Goutelle & Jean-Christophe Richard
Additional file 5: Figure S3. Probability of target attainment for various cefoxitin doses in patients with CCRIBW = 100 ml/min.

Additional file 6 of Pharmacokinetics, efficacy and tolerance of cefoxitin in the treatment of cefoxitin-susceptible extended-spectrum beta-lactamase producing Enterobacterales infections in critically ill patients: a retrospective single-center study

Paul Chabert, Judith Provoost, Sabine Cohen, Céline Dupieux-Chabert, Laurent Bitker, Tristan Ferry, Sylvain Goutelle & Jean-Christophe Richard
Additional file 6: Figure S4. Probability of target attainment for different levels of renal function with a cefoxitin dose of 6g/day.

Additional file 1 of Growth pattern in children with X-linked hypophosphatemia treated with burosumab and growth hormone

Diana-Alexandra Ertl, Justin Le Lorier, Andreas Gleiss, Séverine Trabado, Candace Bensignor, Christelle Audrain, Volha Zhukouskaya, Régis Coutant, Jugurtha Berkenou, Anya Rothenbuhler, Gabriele Haeusler & Agnès Linglart
Additional file 1: Table S1. Demographic, clinical and biochemical characteristics for group 1 (burosumab only). Median, minimum and maximum for demographic and biochemical parameters.

Growth pattern in children with X-linked hypophosphatemia treated with burosumab and growth hormone

Diana-Alexandra Ertl, Justin Le Lorier, Andreas Gleiss, Séverine Trabado, Candace Bensignor, Christelle Audrain, Volha Zhukouskaya, Régis Coutant, Jugurtha Berkenou, Anya Rothenbuhler, Gabriele Haeusler & Agnès Linglart
Abstract Background X-linked hypophosphatemia (XLH) is characterized by increased serum concentrations of fibroblast growth factor 23 (FGF23), hypophosphatemia and insufficient endogenous synthesis of calcitriol. Beside rickets, odonto- and osteomalacia, disproportionate short stature is seen in most affected individuals. Vitamin D analogs and phosphate supplements, i.e., conventional therapy, can improve growth especially when started early in life. Recombinant human growth hormone (rhGH) therapy in XLH children with short stature has positive effects, although few reports are...

Additional file 1 of Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
Additional file 1. Modified MARAIS Score (modified from Marais et al. [27]).

Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
Abstract Background Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and...

Additional file 5 of Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Additional file 5: Additional Table 3. Association between AL incidence rate and crop densitya in municipalities of residence at birth with restriction to municipalities situated outside of the Paris urban unit, and municipalities in urban units with a population of less than 100,000, mainland France, RNCE, 1990–2015.

Additional file 6 of Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Additional file 6: Additional Table 4. Association between ALL and BCP-ALL incidence rates and crop densitiesa in the municipalities of residence at birth, stratified by age group (mainland France, RNCE, 1990–2015).

Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Abstract Background Domestic and parental occupational pesticide exposures are suspected of involvement in the occurrence of childhood acute leukaemia (AL), but the role of exposure to agricultural activities is little known. In a previous ecological study conducted in France, we observed an increase in acute lymphoblastic leukaemia (ALL) incidence rate with increasing viticulture density in the municipalities of residence at diagnosis. Objectives This study aimed to test the hypothesis that residential proximity to croplands at...

Additional file 1 of Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Additional file 1: Additional Figure 1. Annual standardized incidence ratio (SIR) of childhood AL, RNCE, 1990-2015, mainland France.

Additional file 1 of Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Alice Blet, Joel B. McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti, Gad Cotter, Agnès Dauvergne, Beth Davison, Kévin Duarte, Jacques Duranteau, Marie-Céline Fournier, Etienne Gayat, Samir Jaber, Sigismond Lasocki, Thomas Merkling, Katell Peoc’h, Imke Mayer, Malha Sadoune, Pierre-François Laterre, Romain Sonneville, Lorraine Ware, Alexandre Mebazaa & Antoine Kimmoun
Additional file 1: Figures and Tables.

Additional file 1 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 1 Supplementary Table 1. List of 335 differentially expressed mRNAs identified in Li responders (R) versus non-responders (NR) with |FC| ≥ 1.2 and p-value ≤0.05.

Additional file 3 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 3 Supplementary Table 3. List of 54 statistically significant pathways modulated by 335 differentially expressed genes identified using IPA. Ratio is calculated as the number of analysis-ready genes in a given pathway, divided by the total number of genes in the reference dataset that makes up that pathway. Z-score predicts the activation state of the canonical pathways, using the gene expression patterns of the genes within the pathway. A negative z value connotes...

Additional file 7 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 7 Supplementary Table 7. List of 5450 significant mature miRNA-mRNA interactions with p-value ≤0.05 and Pearson correlation index ρ ≤ − 0.38.

Additional file 8 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 8 Supplementary Table 8. List of 2027 significant mature miRNA-mRNA interactions with p-value ≤0.05 and Pearson correlation index ρ ≤ − 0.5.

A universal predictive and mechanistic urinary peptide signature in acute kidney injury

Alexis Piedrafita, Justyna Siwy, Julie Klein, Amal Akkari, Ana Amaya-garrido, Alexandre Mebazaa, Anna Belen Sanz, Benjamin Breuil, Laura Montero Herrero, Bertrand Marcheix, François Depret, Lucie Fernandez, Elsa Tardif, Vincent Minville, Melinda Alves, Jochen Metzger, Julia Grossac, Harald Mischak, Alberto Ortiz, Stéphane Gazut, Joost P. Schanstra, Stanislas Faguer, Nicolas Mayeur, Audrey Casemayou & François Labaste
Abstract Background The delayed diagnosis of acute kidney injury (AKI) episodes and the lack of specificity of current single AKI biomarkers hamper its management. Urinary peptidome analysis may help to identify early molecular changes in AKI and grasp its complexity to identify potential targetable molecular pathways. Methods In derivation and validation cohorts totalizing 1170 major cardiac bypass surgery patients and in an external cohort of 1569 intensive care unit (ICU) patients, a peptide-based score predictive...

Additional file 1 of Predictors of shorter- and longer-term mortality after COVID-19 presentation among dialysis patients: parallel use of machine learning models in Latin and North American countries

Adrián M. Guinsburg, Yue Jiao, María Inés Díaz Bessone, Caitlin K. Monaghan, Beatriz Magalhães, Michael A. Kraus, Peter Kotanko, Jeffrey L. Hymes, Robert J. Kossmann, Juan Carlos Berbessi, Franklin W. Maddux, Len A. Usvyat & John W. Larkin
Additional file 1: Supplementary Table 1. Initial, Tuning Range, and Final Hyperparameter Settings for Models. Supplementary Table 2. Mean SHAP values for all predictors of death any time after COVID-19 presentation, by region. Supplementary Table 3. Mean SHAP values for all predictors of death 0-14 days after COVID-19 presentation, by region. Supplementary Table 4. Mean SHAP values for all predictors of death 15-30 days after COVID-19 presentation, by region. Supplementary Table 5. Mean SHAP values...

Additional file 1 of Predictors of shorter- and longer-term mortality after COVID-19 presentation among dialysis patients: parallel use of machine learning models in Latin and North American countries

Adrián M. Guinsburg, Yue Jiao, María Inés Díaz Bessone, Caitlin K. Monaghan, Beatriz Magalhães, Michael A. Kraus, Peter Kotanko, Jeffrey L. Hymes, Robert J. Kossmann, Juan Carlos Berbessi, Franklin W. Maddux, Len A. Usvyat & John W. Larkin
Additional file 1: Supplementary Table 1. Initial, Tuning Range, and Final Hyperparameter Settings for Models. Supplementary Table 2. Mean SHAP values for all predictors of death any time after COVID-19 presentation, by region. Supplementary Table 3. Mean SHAP values for all predictors of death 0-14 days after COVID-19 presentation, by region. Supplementary Table 4. Mean SHAP values for all predictors of death 15-30 days after COVID-19 presentation, by region. Supplementary Table 5. Mean SHAP values...

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