8 Works

Data from: Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency

Bradley W. Richmond, Robert M. Brucker, Wei Han, Rui-Hong Du, Yongqin Zhang, Dong-Sheng Cheng, Linda Gleaves, Rasul Abdolrasulnia, Dina Polosukhina, Peter E. Clark, Seth R. Bordenstein, Timothy S. Blackwell & Vasiliy V. Polosukhin
Mechanisms driving persistent airway inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) deficiency in small airways has been reported in COPD patients, we hypothesized that immunobarrier dysfunction resulting from reduced SIgA contributes to chronic airway inflammation and disease progression. Here we show that polymeric immunoglobulin receptor-deficient (pIgR−/−) mice, which lack SIgA, spontaneously develop COPD-like pathology as they age. Progressive airway wall remodelling and emphysema in pIgR−/− mice are...

Data from: Phylosymbiosis: relationships and functional effects of microbial communities across host evolutionary history

Andrew W. Brooks, Kevin D. Kohl, Robert M. Brucker, Edward J. Van Opstal & Seth R. Bordenstein
Phylosymbiosis was recently proposed to describe the eco-evolutionary pattern whereby the ecological relatedness of host-associated microbial communities parallels the phylogeny of related host species. Here, we analyze the prevalence of phylosymbiosis and its functional significance under highly controlled conditions by characterizing the microbiota of 24 animal species from four different groups (Peromyscus deer mice, Drosophila flies, mosquitoes, Nasonia wasps) and re-evaluate the phylosymbiotic relationships of seven species of wild hominids. We demonstrate three key findings....

Data from: Specificity in the symbiotic association between fungus-growing ants and protective Pseudonocardia bacteria

Matías J. Cafaro, Michael Poulsen, Ainslie E. F. Little, Shauna L. Price, Nicole M. Gerardo, Bess Wong, Alison E. Stuart, Bret Larget, Patrick Abbot & Cameron R. Currie
Fungus-growing ants (tribe Attini) engage in a mutualism with a fungus that serves as the ants' primary food source, but successful fungus cultivation is threatened by microfungal parasites (genus Escovopsis). Actinobacteria (genus Pseudonocardia) associate with most of the phylogenetic diversity of fungus-growing ants; are typically maintained on the cuticle of workers; and infection experiments, bioassay challenges and chemical analyses support a role of Pseudonocardia in defence against Escovopsis through antibiotic production. Here we generate a...

Data from: Assessing niche conservatism using a multiproxy approach: dietary ecology of extinct and extant spotted hyenas

Larisa R. G. DeSantis, Zhijie Jack Tseng, Jinyi Liu, Aaron Hurst, Blaine Schubert & Qigao Jiangzuo
A central premise of bioclimatic envelope modeling is the assumption of niche conservatism. Whereas such assumptions are testable in modern populations, it is unclear if niche conservatism holds over deeper time spans and over very large geographic ranges. Hyaenids occupied a diversity of ecological niches over time and space, and until the end-Pleistocene they occurred in Europe and most of Asia, with Asian populations of Crocuta suggested as being genetically distinct from their closest living...

Data from: Ediacaran distributions in space and time: testing assemblage concepts of earliest macroscopic body fossils

Thomas H. Boag, Simon A. F. Darroch & Marc Laflamme
The mid-late Ediacaran Period (~579–541 Ma) is characterized by globally distributed marine soft-bodied organisms of unclear phylogenetic affinities colloquially called the “Ediacara biota.” Despite an absence of systematic agreement, previous workers have tested for underlying factors that may control the occurrence of Ediacaran macrofossils in space and time. Three taxonomically distinct “assemblages,” termed the Avalon, White Sea, and Nama, were identified and informally incorporated into Ediacaran biostratigraphy. After ~15 years of new fossil discoveries and...

Data from: Three-dimensional simulation for fast forward flight of a calliope hummingbird

Jialei Song, Bret W. Tobalske, Donald R. Powers, Tyson L. Hedrick & Haoxiang Luo
We present a computational study of flapping-wing aerodynamics of a calliope hummingbird (Selasphorus calliope) during fast forward flight. Three-dimensional wing kinematics were incorporated into the model by extracting time-dependent wing position from high-speed videos of the bird flying in a wind tunnel at 8.3 m s−1. The advance ratio, i.e. the ratio between flight speed and average wingtip speed, is around one. An immersed-boundary method was used to simulate flow around the wings and bird...

Data from: Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis

Marcin J. Skwark, Nicholas J. Croucher, Santeri Puranen, Claire Chewapreecha, Maiju Pesonen, Ying Ying Xu, Paul Turner, Simon R. Harris, Stephen B. Beres, James M. Musser, Julian Parkhill, Stephen D. Bentley, Erik Aurell & Jukka Corander
Recent advances in the scale and diversity of population genomic datasets for bacteria now provide the potential for genome-wide patterns of co-evolution to be studied at the resolution of individual bases. Here we describe a new statistical method, genomeDCA, which uses recent advances in computational structural biology to identify the polymorphic loci under the strongest co-evolutionary pressures. We apply genomeDCA to two large population data sets representing the major human pathogens Streptococcus pneumoniae (pneumococcus) and...

Data from: Dietary responses of Sahul (Pleistocene Australia–New Guinea) megafauna to climate and environmental change

Larisa R.G. DeSantis, Judith H. Field, Stephen Wroe & John R. Dodson
Throughout the late Quaternary, the Sahul (Pleistocene Australia–New Guinea) vertebrate fauna was dominated by a diversity of large mammals, birds, and reptiles, commonly referred to as megafauna. Since ca. 450–400Ka, approximately 88 species disappeared in Sahul, including kangaroos exceeding 200kg in size, wombat-like animals the size of hippopotamuses, flightless birds, and giant monitor lizards that were likely venomous. Ongoing debates over the primary cause of these extinctions have typically favored climate change or human activities....

Registration Year

  • 2016

Resource Types

  • Dataset


  • Vanderbilt University
  • University of Toronto
  • University of Montana
  • George Fox University
  • University of North Carolina
  • University of Cambridge
  • State University of New York
  • University of Oslo
  • University of Wisconsin-Madison
  • Mahidol University