34 Works

Additional file 3 of Detection of Salmonella Typhi nucleic acid by RT-PCR and anti-HlyE, -CdtB, -PilL, and -Vi IgM by ELISA at sites in Ghana, Madagascar and Ethiopia

Ursula Panzner, Ondari Daniel Mogeni, Yaw Adu-Sarkodie, Trevor Toy, Hyon Jin Jeon, Gi Deok Pak, Se Eun Park, Yeetey Enuameh, Ellis Owusu-Dabo, Trinh Van Tan, Abraham Aseffa, Mekonnen Teferi, Biruk Yeshitela, Stephen Baker, Raphael Rakotozandrindrainy & Florian Marks
Additional file 3. Mean ELISA ODs by antigen. Notes: OD=optical density; red dot=mean of original data; blue dot=mean of each 1,000 bootstrap random samples; light red dashed line=upper and lower 95% confidence interval (CI) of original data; dark red dashed line=upper and lower 99% confidence interval (CI) of original data

Additional file 3 of Detection of Salmonella Typhi nucleic acid by RT-PCR and anti-HlyE, -CdtB, -PilL, and -Vi IgM by ELISA at sites in Ghana, Madagascar and Ethiopia

Ursula Panzner, Ondari Daniel Mogeni, Yaw Adu-Sarkodie, Trevor Toy, Hyon Jin Jeon, Gi Deok Pak, Se Eun Park, Yeetey Enuameh, Ellis Owusu-Dabo, Trinh Van Tan, Abraham Aseffa, Mekonnen Teferi, Biruk Yeshitela, Stephen Baker, Raphael Rakotozandrindrainy & Florian Marks
Additional file 3. Mean ELISA ODs by antigen. Notes: OD=optical density; red dot=mean of original data; blue dot=mean of each 1,000 bootstrap random samples; light red dashed line=upper and lower 95% confidence interval (CI) of original data; dark red dashed line=upper and lower 99% confidence interval (CI) of original data

Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Abstract Background Malaria remains a leading cause of morbidity and mortality worldwide, with progress in malaria control stalling in recent years. Proactive community case management (pro-CCM) has been shown to increase access to diagnosis and treatment and reduce malaria burden. However, lack of experimental evidence may hinder the wider adoption of this intervention. We conducted a cluster randomized community intervention trial to assess the efficacy of pro-CCM at decreasing malaria prevalence in rural endemic areas...

Comparative effect of artemether-lumefantrine and artesunate-amodiaquine on gametocyte clearance in children with uncomplicated Plasmodium falciparum malaria in Madagascar

Malalanandrianina A. Rakotoarisoa, Jocia Fenomanana, Bronislaw Tchesterico Dodoson, Voahangy Hanitriniaina I. Andrianaranjaka & Arsène Ratsimbasoa
Abstract Background Gametocytes are the sexual stages ensuring continuity of the development cycle of the parasite, as well as its transmission to humans. The efficacy of artemisinin-based anti-malarials against asexual stages of Plasmodium has been reported in Madagascar, but their effects on gametocytes are not well documented. The present study aims to determine the emergence of gametocyte and gametocyte clearance after artesunate-amodiaquine (ASAQ) or artemether-lumefantrine (AL) treatment in children with uncomplicated Plasmodium falciparum malaria in...

Comparative effect of artemether-lumefantrine and artesunate-amodiaquine on gametocyte clearance in children with uncomplicated Plasmodium falciparum malaria in Madagascar

Malalanandrianina A. Rakotoarisoa, Jocia Fenomanana, Bronislaw Tchesterico Dodoson, Voahangy Hanitriniaina I. Andrianaranjaka & Arsène Ratsimbasoa
Abstract Background Gametocytes are the sexual stages ensuring continuity of the development cycle of the parasite, as well as its transmission to humans. The efficacy of artemisinin-based anti-malarials against asexual stages of Plasmodium has been reported in Madagascar, but their effects on gametocytes are not well documented. The present study aims to determine the emergence of gametocyte and gametocyte clearance after artesunate-amodiaquine (ASAQ) or artemether-lumefantrine (AL) treatment in children with uncomplicated Plasmodium falciparum malaria in...

Additional file 1 of Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
Additional file 1. Modified MARAIS Score (modified from Marais et al. [27]).

Additional file 2 of Detection of Salmonella Typhi nucleic acid by RT-PCR and anti-HlyE, -CdtB, -PilL, and -Vi IgM by ELISA at sites in Ghana, Madagascar and Ethiopia

Ursula Panzner, Ondari Daniel Mogeni, Yaw Adu-Sarkodie, Trevor Toy, Hyon Jin Jeon, Gi Deok Pak, Se Eun Park, Yeetey Enuameh, Ellis Owusu-Dabo, Trinh Van Tan, Abraham Aseffa, Mekonnen Teferi, Biruk Yeshitela, Stephen Baker, Raphael Rakotozandrindrainy & Florian Marks
Additional file 2. Distribution of ELISA OD values by antigen.

Additional file 1 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 1: Figure S1. Flowchart of the households and individuals included on the survey from the baseline. Figure S2. Comparison of malaria incidence and positivity in the intervention area during March-October 2017 with average values for Mananjary District. Figure S3. Comparison of malaria community case management in the intervention and control arms during pro-CCM implementation and during the two years prior. Figure S4. Map of Mananjary district and the fokontany included in the intervention...

Additional file 2 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 2. Table S1. Distribution of positive RDT results in the 22 fokontany. Table S2. Impact of Pro-CCM and IRS on malaria prevalence, per-protocol analyses. Table S3. Comparison of observed proportion of parasite prevalence by RDT by age group between intervention and control arms. Table S4. Comparison of reported bed net use (LLIN) by age group between baseline and endline surveys.

Additional file 3 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 3. Analyses and findings on anemia and PRO-CCM. Table S5. Prevalence of anemia among all women of reproductive age at baseline and endline, by study arm. Table S6. Unadjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models. Table S7. Adjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models.

Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Abstract Background Malaria remains a leading cause of morbidity and mortality worldwide, with progress in malaria control stalling in recent years. Proactive community case management (pro-CCM) has been shown to increase access to diagnosis and treatment and reduce malaria burden. However, lack of experimental evidence may hinder the wider adoption of this intervention. We conducted a cluster randomized community intervention trial to assess the efficacy of pro-CCM at decreasing malaria prevalence in rural endemic areas...

Additional file 1 of Comparative effect of artemether-lumefantrine and artesunate-amodiaquine on gametocyte clearance in children with uncomplicated Plasmodium falciparum malaria in Madagascar

Malalanandrianina A. Rakotoarisoa, Jocia Fenomanana, Bronislaw Tchesterico Dodoson, Voahangy Hanitriniaina I. Andrianaranjaka & Arsène Ratsimbasoa
Additional file 1: ASAQ dosage.

Supporting code, tables and data for: Megafrugivores as fading shadows of the past: Extant frugivores and the abiotic environment as the most important determinants of the distribution of palms in Madagascar

Laura Méndez, Duarte S. Viana, Adriana Alzate, Wolf L. Eiserhardt, Roberto Rozzi, W. Daniel Kissling, Mijoro Rakotoarinivo & Renske E. Onstein
The extinction of all Madagascar’s megafrugivores ca. 1000 years ago, may have left its signature on the current distribution of vertebrate-dispersed plants across the island, due to the loss of effective seed dispersal. In this study, we dissect the roles of extinct and extant frugivore distributions, abiotic variables, human impact and spatial predictors on the compositional turnover, or beta-diversity, of palm (Arecaceae) species and their fruit sizes across 40 assemblages on Madagascar. Variation partitioning showed...

Data from: Phylogenomics and generic limits of Dypsidinae (Arecaceae), the largest palm radiation in Madagascar

Wolf Eiserhardt, Sidonie Bellot, Robyn Cowan, John Dransfield, Lars Emil Hansen, Karolina Heyduk, Romer Rabarijaona, Mijoro Rakotoarinivo & William Baker
With 178 species, the palm subtribe Dypsidinae is one of the largest plant radiations on Madagascar. A well-resolved species-level phylogeny is required not only to unpick the drivers of this spectacular radiation but also to define natural and useful generic limits in this taxonomically difficult group. The only recent taxonomic revision of Dypsidinae recognized just four genera, including the large genus Dypsis (currently with 172 species), which was considered impossible to divide further based on...

Additional file 1 of Detection of Salmonella Typhi nucleic acid by RT-PCR and anti-HlyE, -CdtB, -PilL, and -Vi IgM by ELISA at sites in Ghana, Madagascar and Ethiopia

Ursula Panzner, Ondari Daniel Mogeni, Yaw Adu-Sarkodie, Trevor Toy, Hyon Jin Jeon, Gi Deok Pak, Se Eun Park, Yeetey Enuameh, Ellis Owusu-Dabo, Trinh Van Tan, Abraham Aseffa, Mekonnen Teferi, Biruk Yeshitela, Stephen Baker, Raphael Rakotozandrindrainy & Florian Marks
Additional file 1. Location of sites in Ethiopia [1A], Ghana [1B] and Madagascar [1C]. Notes: The location of each site is indicated as a black dot and the site’s name in red font; Ethiopia (Figure 1A): nine regional states (black italic, capital letters) and two chartered cities (black italic, lower letters) are shown;SNNPR=Southern Nations, Nationalities and People’s Region; Ghana (Figure 1B): ten regions (black italic, capital letters) are shown; Madagascar (Figure 1C): six provinces (black...

Additional file 3 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 3. Analyses and findings on anemia and PRO-CCM. Table S5. Prevalence of anemia among all women of reproductive age at baseline and endline, by study arm. Table S6. Unadjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models. Table S7. Adjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models.

Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
Abstract Background Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and...

Additional file 2 of Comparative effect of artemether-lumefantrine and artesunate-amodiaquine on gametocyte clearance in children with uncomplicated Plasmodium falciparum malaria in Madagascar

Malalanandrianina A. Rakotoarisoa, Jocia Fenomanana, Bronislaw Tchesterico Dodoson, Voahangy Hanitriniaina I. Andrianaranjaka & Arsène Ratsimbasoa
Additional file 2: AL dosage.

Additional file 1 of Detection of Salmonella Typhi nucleic acid by RT-PCR and anti-HlyE, -CdtB, -PilL, and -Vi IgM by ELISA at sites in Ghana, Madagascar and Ethiopia

Ursula Panzner, Ondari Daniel Mogeni, Yaw Adu-Sarkodie, Trevor Toy, Hyon Jin Jeon, Gi Deok Pak, Se Eun Park, Yeetey Enuameh, Ellis Owusu-Dabo, Trinh Van Tan, Abraham Aseffa, Mekonnen Teferi, Biruk Yeshitela, Stephen Baker, Raphael Rakotozandrindrainy & Florian Marks
Additional file 1. Location of sites in Ethiopia [1A], Ghana [1B] and Madagascar [1C]. Notes: The location of each site is indicated as a black dot and the site’s name in red font; Ethiopia (Figure 1A): nine regional states (black italic, capital letters) and two chartered cities (black italic, lower letters) are shown;SNNPR=Southern Nations, Nationalities and People’s Region; Ghana (Figure 1B): ten regions (black italic, capital letters) are shown; Madagascar (Figure 1C): six provinces (black...

Additional file 2 of Detection of Salmonella Typhi nucleic acid by RT-PCR and anti-HlyE, -CdtB, -PilL, and -Vi IgM by ELISA at sites in Ghana, Madagascar and Ethiopia

Ursula Panzner, Ondari Daniel Mogeni, Yaw Adu-Sarkodie, Trevor Toy, Hyon Jin Jeon, Gi Deok Pak, Se Eun Park, Yeetey Enuameh, Ellis Owusu-Dabo, Trinh Van Tan, Abraham Aseffa, Mekonnen Teferi, Biruk Yeshitela, Stephen Baker, Raphael Rakotozandrindrainy & Florian Marks
Additional file 2. Distribution of ELISA OD values by antigen.

Discovery and genetic characterization of single cohort adult colonies with male aggregations, and preliminary evidence for lekking in a Malagasy kite spider (Isoxya, Gasteracanthinae)

Ingi Agnarsson, James Starrett, Zachary Babbitz, Jason Bond, Matjaž Gregorič, Onja Raberahona, Steven Williams & Matjaž Kuntner
Spiders are notoriously solitary and cannibalistic, with instances of colonial or social lifestyles in only about 50-60, or ~0.1% of 50,000 described species. Population analyses indicate that most colonies consist of multiple cohorts formed by close relatives. Territorial social spiders facultatively form colonies by interlinking individual webs, but further cooperation is infrequent, and only among juveniles or (rarely) females. In spiders, therefore, aggregations of males outside of the male-male competition context have been unknown. Here,...

Additional file 2 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 2. Table S1. Distribution of positive RDT results in the 22 fokontany. Table S2. Impact of Pro-CCM and IRS on malaria prevalence, per-protocol analyses. Table S3. Comparison of observed proportion of parasite prevalence by RDT by age group between intervention and control arms. Table S4. Comparison of reported bed net use (LLIN) by age group between baseline and endline surveys.

Additional file 1 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 1: Figure S1. Flowchart of the households and individuals included on the survey from the baseline. Figure S2. Comparison of malaria incidence and positivity in the intervention area during March-October 2017 with average values for Mananjary District. Figure S3. Comparison of malaria community case management in the intervention and control arms during pro-CCM implementation and during the two years prior. Figure S4. Map of Mananjary district and the fokontany included in the intervention...

Speciation rates are unrelated to the formation of population structure in Malagasy Gemsnakes

Frank Burbrink, Sara Ruane, Nirhy Rabibisoa, Achille Raselimanana, Christopher Raxworthy & Arianna Kuhn
Speciation rates vary substantially over the tree of life. These rates should be linked to the rate at which population structure forms if a continuum between micro and macroevolutionary processes exists. Previous studies examining the link between speciation rates and the degree of population formation in clades have shown both correlation and no correlation. No study has examined the relationship between speciation rates and population structure in a young group endemic to an island. We...

Additional file 1 of Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
Additional file 1. Modified MARAIS Score (modified from Marais et al. [27]).

Registration Year

  • 2022
    34

Resource Types

  • Text
    20
  • Collection
    8
  • Dataset
    6

Affiliations

  • University of Antananarivo
    34
  • Institut Pasteur de Madagascar
    14
  • Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
    8
  • Kwame Nkrumah University of Science and Technology
    8
  • Kangbuk Samsung Hospital
    8
  • University of Cambridge
    8
  • Federal Ministry of Health
    8
  • World Health Organization
    8
  • Center for Global Health
    8
  • University of Basel
    8