2 Works

Data from: Positive epistasis drives the acquisition of multidrug resistance.

Sandra Trindade, Ana Sousa, Karina Bivar Xavier, Francisco Dionisio, Miguel Godinho Ferreira & Isabel Gordo
The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact—epistasis. Information on the level of epistasis between antibiotic resistance mutations is of key importance to understanding epistasis amongst deleterious alleles, a key theoretical question, and to improving public health measures. Here we show that in an antibiotic-free environment...

Data from: Geographic population structure of the African malaria vector Anopheles gambiae suggests a role for the forest-savannah biome transition as a barrier to gene flow

Joao Pinto, Alexander Egyir-Yawson, José L. Vicente, Bruno Gomes, Federica Santalomazza, Marta Moreno, Jacques D. Charlwood, Frederic Simard, Nohal Elissa, David Weetman, Martin J. Donnelly, Adalgisa Caccone, Alessandra Della Torre, Caccone A, Simard F, Pinto J, Vicente JL, Gomes B, Elissa N, Weetman D & Donnelly MJ
The primary Afrotropical malaria mosquito vector Anopheles gambiae sensu stricto has a complex population structure. In western Africa, this species is split into two molecular forms and displays local and regional variation in chromosomal arrangements and behaviours. To investigate patterns of macro-geographic population substructure, 25 An. gambiae samples from 12 African countries were genotyped at 13 microsatellite loci. This analysis detected the presence of additional population structuring, with the M-form being subdivided into distinct west,...

Registration Year

  • 2013
    2

Resource Types

  • Dataset
    2

Affiliations

  • Universidade Nova de Lisboa
    2
  • Institut de Recherche pour le Développement
    1
  • University of California, San Diego
    1
  • University of Lisbon
    1
  • Sapienza University of Rome
    1
  • French National Centre for Scientific Research
    1
  • Institut Pasteur de Madagascar
    1
  • Liverpool School of Tropical Medicine
    1
  • Yale University
    1
  • Instituto Gulbenkian de Ciência
    1