Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome

Philippe Cloutier, Christian Poitras, Denis Faubert, Annie Bouchard, Mathieu Blanchette, Marie-Soleil Gauthier & Benoit Coulombe
The PAQosome is an eleven-subunit chaperone involved in the biogenesis of several human protein complexes. We show that ASDURF, a recently discovered upstream open reading frame (uORF) in the 5’ UTR of ASNSD1 mRNA, encodes the twelfth subunit of the PAQosome. ASDURF, displays significant structural homology to beta-prefoldins and assembles with the five known subunits of the prefoldin-like module of the PAQosome to form a heterohexameric prefoldin-like complex. A model of the PAQosome prefoldin-like module...

Registration Year

  • 2019
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Resource Types

  • Dataset
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Affiliations

  • University of Montreal
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  • McGill University
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  • Université du Québec à Trois-Rivières
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