155 Works

Data from: A new moth-preying alpine pitviper species from Qinghai-Tibetan plateau (Viperidae, Crotalinae)

Jingsong Shi, Gang Wang, Xi'er Chen, Li Ding, Song Huang, Mian Hou, Jun Liu, Pipeng Li, Xi’er Chen & Yihao Fang
The Sanjiangyuan region of Qinghai-Tibetan Plateau is recognized as a biodiversity hotspot of alpine mammals but a barren area in terms of amphibians and reptiles. Here, we describe a new pit viper species, Gloydius rubromaculatus sp. n. Shi, Li and Liu, 2017 that was discovered in this region, with a brief taxonomic revision of the genus Gloydius. The new species can be distinguished from the other congeneric species by the following characteristics: cardinal crossbands on...

Decomposing niche components reveals simultaneous effects of opposite deterministic processes structuring alpine small mammal assembly

Wenyu Song, Kenneth Otieno Onditi, Xueyou Li, Zhongzheng Chen, Shuiwang He, Quan Li & Xuelong Jiang
Our knowledge of community assembly dynamics under multiple stressors is limited because of opposite niche-based processes, i.e., limiting similarity and habitat filtering could simultaneously occur, masking the overall patterns. Alpine biomes provide the ideal systems to explore the influences of co-occurrence processes as these communities usually face multiple stresses such as resources limitation and habitat constraints. However, the assembly processes of mammals in alpine areas have hardly been exclusively studied. Here, we aimed to address...

Protective effects of psoralen polymer lipid nanoparticles on doxorubicin - induced myocardial toxicity

Fansu Meng, Yong Ouyang, Qianqian Ma, Manling Du, Hui Liu, Yong Zhuang, Mujuan Pang, Tiange Cai & Yu Cai
Abstract Doxorubicin (DOX) induced myocardial toxicity may limit its therapeutic use in clinic. Psoralen (PSO), a major active tricyclic furocoumarin extracted from Psoralea corylifolia, is widely used as an antineoplastic agent in treatment of leukemia and other cancers. This study is aim to find the protective effect of psoralen polymer lipid nanoparticles (PSO-PLN) on doxorubicin-induced myocardial toxicity in mice. The model of myocardial toxicity induced by DOX was established. The experiment was divided into 6...

Effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines against SARS-CoV-2 Omicron BA. 2 variant infection, severe illness, and death

Zhuoying Huang, Shuangfei Xu, Jiechen Liu, Linlin Wu, Jing Qiu, Nan Wang, Jia Ren, Zhi Li, Xiang Guo, Fangfang Tao, Jian Chen, Donglei Lu, Xiaodong Sun & Weibing Wang
Abstract Background Limited data are available on the effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines in real-world use—especially against Omicron variants in SARS-CoV-2 infection-naïve population. Methods A matched case-control study was conducted among people aged ≥ 3 years between 2 December 2021 and 13 May 2022. Cases were SARS-CoV-2-infected individuals, individuals with severe/critical COVID-19, or COVID-19-related deaths. Controls were selected from consecutively test-negative individuals at the same time as cases were diagnosed and were exact-matched...

Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid β and P-tau and improve cognitive ability in APP/PS1 transgenic mice

Longfei Xu, Mingzhe Li, Aili Wei, Miaomiao Yang, Chao Li, Ran Liu, Yuejun Zheng, Yuxin Chen, Zixi Wang, Kun Wang & Tianhui Wang
Abstract Background Moderate physical exercise is conducive to the brains of healthy humans and AD patients. Previous reports have suggested that treadmill exercise plays an anti-AD role and improves cognitive ability by promoting amyloid clearance, inhibiting neuronal apoptosis, reducing oxidative stress level, alleviating brain inflammation, and promoting autophagy–lysosome pathway in AD mice. However, few studies have explored the relationships between the ubiquitin–proteasome system and proper exercise in AD. The current study was intended to investigate...

Additional file 1 of In-hospital initiation of PCSK9 inhibitor and short-term lipid control in patients with acute myocardial infarction

Bowen Lou, Hui Liu, Yongbai Luo, Gulinigaer Tuerhong Jiang, Haoyu Wu, Chen Wang, Yue Wu, Bo Zhou, Zuyi Yuan, Jianqing She & Junhui Liu
Additional file 1: Fig. S1. Jitter and hist plots (statin plus evolocumab-based PSM).

Two sesquiterpene lactones, arnicolide B and arnicolide C, isolated from Centipeda minima, exert anti-inflammatory effects in LPS stimulated RAW 264.7 macrophages via inactivation of the MAPK pathway

Ge Wang, Hongfang Liu, Qingran Zhang, Xiaofeng Mou, Yan Zhao, Huaying Fan, Hui Xu, Daquan Chen, Feng Qiu & Feng Zhao
Arnicolide B and arnicolide C are two sesquiterpene lactones isolated and identified from Centipeda minima, but the anti-inflammatory effects and mechanisms of these two compounds have not been reported. In this study, LPS was used to establish RAW 264.7 macrophages inflammatory response model. Griess, ELISA, Western blot were used to investigate the anti-inflammatory effects in vitro and the molecular mechanisms of these two active compounds. The results showed that arnicolide B and arnicolide C could...

Additional file 1 of Chemotherapy induces ACE2 expression in breast cancer via the ROS-AKT-HIF-1α signaling pathway: a potential prognostic marker for breast cancer patients receiving chemotherapy

Xiaoyan Zuo, Sixin Ren, He Zhang, Jianfei Tian, Ruinan Tian, Baoai Han, Hui Liu, Qian Dong, Zhiyong Wang, Yanfen Cui, Ruifang Niu & Fei Zhang
Additional file 1: Table S1. The primers used for qRT-PCR in this study. Table S2. The sequence of siRNAs target ACE2 and HIF-1α used in this study. Table S3. The sequence for shACE2 used in this study. Table S4. Clinicopathological characteristics of healthy donors and breast cancer patients enrolled in this study. Table S5. IC50 of breast cancer, colorectal cancer and pancreatic cancer cell lines in GDSC.

Additional file 2 of Chemotherapy induces ACE2 expression in breast cancer via the ROS-AKT-HIF-1α signaling pathway: a potential prognostic marker for breast cancer patients receiving chemotherapy

Xiaoyan Zuo, Sixin Ren, He Zhang, Jianfei Tian, Ruinan Tian, Baoai Han, Hui Liu, Qian Dong, Zhiyong Wang, Yanfen Cui, Ruifang Niu & Fei Zhang
Additional file 2: Figure S1. (A) qRT-PCR analysis showed no significant changes in ACE2 expression in colorectal and pancreatic cancer cells after exposure to EPI, PTX or 5-FU. All data are shown as mean ± SD; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns P > 0.05 versus control, N = 3.

Additional file 4 of Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin & David F. Stroncek
Additional file 4: Figure S4. Percentage of integration events at each genomic features based on gender and transduction efficiency. Related to Figure 6.

Additional file 5 of Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin & David F. Stroncek
Additional file 5: Figure S5. Percentage of integration sites at genomic features in each group with different clinical outcomes. Related to Figure 7.

Additional file 7 of Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin & David F. Stroncek
Additional file 7: Table S2. Differentially expressed genes in non-transduced and transduced CAR T-cell products.

Additional file 8 of Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin & David F. Stroncek
Additional file 8: Table S3. Differential alternative splicing transcripts with viral integration.

Bortezomib induces cellular senescence in A549 lung cancer cells by stimulating telomere shortening

Lei Wang, Hang Yin, Shiren Huang, Sini Huang, Congcong Huang, Zhao Zhang & Hui Liu
Bortezomib (BTZ) is a first-generation proteasome inhibitor with anti-tumor properties for multiple myeloma and mantle cell lymphoma. Increasing evidence has shown that BTZ exhibits toxic effects on diverse tumor cells, including non-small cell lung cancer (NSCLC) cells. However, the mechanism has not been fully evaluated. Here, we examined the regulatory effect of BTZ on cellular senescence, a potent tumor suppressive mechanism, in NSCLC cell lines. SA-β-gal staining assay showed that BTZ caused a significant increase...

Additional file 2 of Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese mice

Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu & Zhide Ding
Additional file 2.

Additional file 5 of Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese mice

Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu & Zhide Ding
Additional file 5.

Additional file 7 of Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese mice

Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu & Zhide Ding
Additional file 7.

Additional file 6 of Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese mice

Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu & Zhide Ding
Additional file 6.

Additional file 6 of Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese mice

Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu & Zhide Ding
Additional file 6.

Additional file 12 of Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese mice

Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu & Zhide Ding
Additional file 12.

Additional file 13 of Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese mice

Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu & Zhide Ding
Additional file 13.

Additional file 15 of Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese mice

Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu & Zhide Ding
Additional file 15.

Additional file 1 of CT radiomics-based long-term survival prediction for locally advanced non-small cell lung cancer patients treated with concurrent chemoradiotherapy using features from tumor and tumor organismal environment

Nai-Bin Chen, Mai Xiong, Rui Zhou, Yin Zhou, Bo Qiu, Yi-Feng Luo, Su Zhou, Chu Chu, Qi-Wen Li, Bin Wang, Hai-Hang Jiang, Jin-Yu Guo, Kang-Qiang Peng, Chuan-Miao Xie & Hui Liu
Additional File 1. 4DCT image acquisition

Additional file 2 of CT radiomics-based long-term survival prediction for locally advanced non-small cell lung cancer patients treated with concurrent chemoradiotherapy using features from tumor and tumor organismal environment

Nai-Bin Chen, Mai Xiong, Rui Zhou, Yin Zhou, Bo Qiu, Yi-Feng Luo, Su Zhou, Chu Chu, Qi-Wen Li, Bin Wang, Hai-Hang Jiang, Jin-Yu Guo, Kang-Qiang Peng, Chuan-Miao Xie & Hui Liu
Additional File 2. Genetic algorithm

Additional file 4 of CT radiomics-based long-term survival prediction for locally advanced non-small cell lung cancer patients treated with concurrent chemoradiotherapy using features from tumor and tumor organismal environment

Nai-Bin Chen, Mai Xiong, Rui Zhou, Yin Zhou, Bo Qiu, Yi-Feng Luo, Su Zhou, Chu Chu, Qi-Wen Li, Bin Wang, Hai-Hang Jiang, Jin-Yu Guo, Kang-Qiang Peng, Chuan-Miao Xie & Hui Liu
Additional File 4. Tumor response after CCRT in the low-risk and high-risk group

Registration Year

  • 2022
    151
  • 2020
    1
  • 2019
    2
  • 2017
    1

Resource Types

  • Text
    84
  • Collection
    32
  • Dataset
    23
  • Image
    16

Affiliations

  • Dali University
    155
  • Zhejiang University
    128
  • Nanjing Agricultural University
    114
  • Tianjin Medical University General Hospital
    100
  • Tianjin Medical University
    98
  • Chinese Academy of Sciences
    92
  • Huazhong University of Science and Technology
    90
  • Shanghai Jiao Tong University
    90
  • Capital Medical University
    86
  • Huazhong Agricultural University
    86