231 Works

Additional file 4 of CT radiomics-based long-term survival prediction for locally advanced non-small cell lung cancer patients treated with concurrent chemoradiotherapy using features from tumor and tumor organismal environment

Nai-Bin Chen, Mai Xiong, Rui Zhou, Yin Zhou, Bo Qiu, Yi-Feng Luo, Su Zhou, Chu Chu, Qi-Wen Li, Bin Wang, Hai-Hang Jiang, Jin-Yu Guo, Kang-Qiang Peng, Chuan-Miao Xie & Hui Liu
Additional File 4. Tumor response after CCRT in the low-risk and high-risk group

sj-docx-1-imj-10.1177_10815589221149185 – Supplemental material for Clinical characteristics, prognostic factors, and outcomes of ventricular septal rupture in patients with acute myocardial infarction

Feifei Ning, Hui Liu & Yang Yan
Supplemental material, sj-docx-1-imj-10.1177_10815589221149185 for Clinical characteristics, prognostic factors, and outcomes of ventricular septal rupture in patients with acute myocardial infarction by Feifei Ning, Hui Liu and Yang Yan in Journal of Investigative Medicine

Additional file 1 of Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin & David F. Stroncek
Additional file 1: Figure S1. Bioinformatic workflow and positive control for VISA pipeline. Related to Figure 1.

Additional file 1 of Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin & David F. Stroncek
Additional file 1: Figure S1. Bioinformatic workflow and positive control for VISA pipeline. Related to Figure 1.

Additional file 2 of Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin & David F. Stroncek
Additional file 2: Figure S2. Viral integration sites on chromosomes in products with different CAR type and each individual. Related to Figure 2.

Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin & David F. Stroncek
Abstract Background Clinical CAR T-cell therapy using integrating vector systems represents a promising approach for the treatment of hematological malignancies. Lentiviral and γ-retroviral vectors are the most commonly used vectors in the manufacturing process. However, the integration pattern of these viral vectors and subsequent effect on CAR T-cell products is still unclear. Methods We used a modified viral integration sites analysis (VISA) pipeline to evaluate viral integration events around the whole genome in pre-infusion CAR...

Chemotherapy induces ACE2 expression in breast cancer via the ROS-AKT-HIF-1α signaling pathway: a potential prognostic marker for breast cancer patients receiving chemotherapy

Xiaoyan Zuo, Sixin Ren, He Zhang, Jianfei Tian, Ruinan Tian, Baoai Han, Hui Liu, Qian Dong, Zhiyong Wang, Yanfen Cui, Ruifang Niu & Fei Zhang
Abstract Background Angiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin-angiotensin system and a well-known functional receptor for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells. The COVID-19 pandemic has brought ACE2 into the spotlight, and ACE2 expression in tumors and its relationship with SARS-COV-2 infection and prognosis of cancer patients have received extensive attention. However, the association between ACE2 expression and tumor therapy and prognosis, especially in...

Effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines against SARS-CoV-2 Omicron BA. 2 variant infection, severe illness, and death

Zhuoying Huang, Shuangfei Xu, Jiechen Liu, Linlin Wu, Jing Qiu, Nan Wang, Jia Ren, Zhi Li, Xiang Guo, Fangfang Tao, Jian Chen, Donglei Lu, Xiaodong Sun & Weibing Wang
Abstract Background Limited data are available on the effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines in real-world use—especially against Omicron variants in SARS-CoV-2 infection-naïve population. Methods A matched case-control study was conducted among people aged ≥ 3 years between 2 December 2021 and 13 May 2022. Cases were SARS-CoV-2-infected individuals, individuals with severe/critical COVID-19, or COVID-19-related deaths. Controls were selected from consecutively test-negative individuals at the same time as cases were diagnosed and were exact-matched...

Supplemental Material - Bortezomib induces cellular senescence in A549 lung cancer cells by stimulating telomere shortening

Lei Wang, Hang Yin, Shiren Huang, Sini Huang, Congcong Huang, Zhao Zhang & Hui Liu
Supplemental Material for Bortezomib induces cellular senescence in A549 lung cancer cells by stimulating telomere shortening by Lei Wang, Hang Yin, Shiren Huang, Sini Huang, Congcong Huang, Zhao Zhang, amd Hui Liu in Human & Experimental Toxicology

CT radiomics-based long-term survival prediction for locally advanced non-small cell lung cancer patients treated with concurrent chemoradiotherapy using features from tumor and tumor organismal environment

Nai-Bin Chen, Mai Xiong, Rui Zhou, Yin Zhou, Bo Qiu, Yi-Feng Luo, Su Zhou, Chu Chu, Qi-Wen Li, Bin Wang, Hai-Hang Jiang, Jin-Yu Guo, Kang-Qiang Peng, Chuan-Miao Xie & Hui Liu
Abstract Background Definitive concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced non-small cell lung cancer (LANSCLC) patients, but the treatment response and survival outcomes varied among these patients. We aimed to identify pretreatment computed tomography-based radiomics features extracted from tumor and tumor organismal environment (TOE) for long-term survival prediction in these patients treated with CCRT. Methods A total of 298 eligible patients were randomly assigned into the training cohort and validation cohort with...

Regional shape alteration of left thalamus associated with late chronotype in young adults

Cheng Xu, Hui Xu, Zhenliang Yang & Chenguang Guo
Chronotype reflects individual differences in circadian rhythms and influences individual psychology and behavior. Previous studies found altered subcortical structures are closely related to individual chronotypes. However, these studies have been conducted mainly using voxel-based morphometry and traditional volume measurement methods with certain limitations. This study aimed to investigate subcortical aberrant volume and shape patterns in late chronotypes (LC) young adults compared to early chronotypes (EC) young adults. Magnetic resonance imaging (MRI) scanning and chronotype assessment...

Additional file 1 of Comparison of clinical outcomes of frozen-thawed D5 and D6 blastocysts undergoing preimplantation genetic testing

Guanling Yu, Shuiying Ma, Hui Liu, Yujin Liu, Haozhen Zhang, Wenjia Zhang & Keliang Wu
Additional file 1: Figure S1. More representative images of blastocysts from frozen-thawed D5 (A) and frozen-thawed D6 (B). Figure S2. Representative images of blastocysts from frozen-thawed D5 (A) and frozen-thawed D6 (B) during aspiration. Figure S3. Comparisons of the pregnancy ratio (A) and abortion ratio (B) between patients received high quality of blastocyst transplantation from frozen-thawed D5 and general quality from frozen-thawed D6. Fisher’s exact test. Figure S4. Comparisons of the pregnancy ratio (A) and...

Additional file 1 of Comparison of clinical outcomes of frozen-thawed D5 and D6 blastocysts undergoing preimplantation genetic testing

Guanling Yu, Shuiying Ma, Hui Liu, Yujin Liu, Haozhen Zhang, Wenjia Zhang & Keliang Wu
Additional file 1: Figure S1. More representative images of blastocysts from frozen-thawed D5 (A) and frozen-thawed D6 (B). Figure S2. Representative images of blastocysts from frozen-thawed D5 (A) and frozen-thawed D6 (B) during aspiration. Figure S3. Comparisons of the pregnancy ratio (A) and abortion ratio (B) between patients received high quality of blastocyst transplantation from frozen-thawed D5 and general quality from frozen-thawed D6. Fisher’s exact test. Figure S4. Comparisons of the pregnancy ratio (A) and...

Additional file 2 of Evolution and functional analysis of the GRAS family genes in six Rosaceae species

Yibo Bai, Hui Liu, Kaikai Zhu & Zong-Ming Cheng
Additional file 2: Fig. S2. Phylogenetic tree of GRAS genes in the six Rosaceae species and Arabidopsis.

Additional file 4 of Evolution and functional analysis of the GRAS family genes in six Rosaceae species

Yibo Bai, Hui Liu, Kaikai Zhu & Zong-Ming Cheng
Additional file 4: Fig. S4. Mapchart shown the distribution of GRAS genes on 17 chromosomes in apple.

Additional file 5 of Evolution and functional analysis of the GRAS family genes in six Rosaceae species

Yibo Bai, Hui Liu, Kaikai Zhu & Zong-Ming Cheng
Additional file 5: Fig. S5. Mapchart shown the distribution of GRAS genes on 8 chromosomes in peach.

SETD2 detection may reveal response to induction therapy and survival profile in acute myeloid leukemia patients

Hui Liu
SET domain containing protein 2 (SETD2) involves in the progression and development of chemotherapy resistance in acute myeloid leukemia (AML). Hence, this study aimed to investigate the relationship of SETD2 expression with disease risk, features, treatment response, and survival profile in AML. One-hundred and sixty primary AML patients were retrospectively analyzed. Their bone marrow (BM) samples before and after induction therapy were retrieved for SETD2 detection by RT-qPCR. Moreover, SETD2 expression in BM samples of...

miR-199a-3p plays an anti-tumorigenic role in lung adenocarcinoma by suppressing anterior gradient 2

Hui Liu, Yanfeng Wang, Yi Wang, Daoyuan Wu & He Zhang
Previous studies have explored the association between protein-coding genes and microRNAs (miRNAs) in lung adenocarcinoma (LUAD). However, the influence of the miR-199a-3p/anterior gradient 2 (AGR2) axis in LUAD has not yet been fully explored. Therefore, this study aimed to examine the underlying roles of AGR2 and miR-199a-3p in the development of LUAD. The expression levels of miR-199a-3p and AGR2 in LUAD tissues and cells were detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A luciferase...

High hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the Wnt/β-catenin pathway

Zongting Shi, Jun He, Jian He & Yuan Xu
Hydrostatic pressure is known to regulate bovine nucleus pulposus cell metabolism, but its mechanism in human nucleus pulposus cells (HNPCs) remains obscure, which attracts our attention and becomes the focus in this study. Specifically, HNPCs were treated with SKL2001 (an agonist in the Wnt/β-catenin pathway) or XAV-939 (an inhibitor of the Wnt/β-catenin pathway), and pressurized under the hydrostatic pressure of 1, 3 and 30 atm. The viability, apoptosis and proteoglycan synthesis of treated HNPC were...

Sesquiterpenoids isolated from feces-residing Streptomyces sp. inhibit the cellular entry of influenza a viruses

Shengsheng Lu, Jianan Hu, Xi Xie, Ruifeng Huang & Jian He
Five metabolites (1–5), including two new sesquiterpenoids, designated ganodermanol L (1) and 4α,15-epoxyeudesmane-1β,6α,11-triol (2), together with three known structurally related compounds (3-5), have been isolated from the cultures of Streptomyces sp. XM17, a bacteria residing in the fresh feces of the giant panda Ailuropoda melanoleuca. The structures of 1–2 were established on the basis of extensive spectroscopic analyses, including 1D- and 2D-NMR (1H-1H COSY, HMQC, HMBC and NOESY) experiments. Furthermore, the absolute configuration of 1...

Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma

Ke Shi, Xinyue Zhu, Jiali Wu, Yuhong Chen, Jingfa Zhang & Xiaodong Sun
Retinoblastoma is the most common intraocular malignancy during childhood. Currently, there is no effective treatment for metastatic retinoblastoma. We investigated potential biomarkers of retinoblastoma by utilizing three datasets from a public database. Functional enrichment analysis, including gene ontology, Kyoto encyclopedia of genes and genomes, gene set enrichment analysis and variation analysis, suggested that differentially expressed genes in retinoblastoma were enriched in accelerated cell cycle events. Protein-protein interaction analysis constructed a network consisting of six hub...

Whole-Rock Geochemistry, Zircon U-Pb geochronology and Lu-Hf isotopic constraints on metasedimentary rocks (Paragneisses) in Stornes Peninsula, Larsemann Hills,East Antarctica

Shi Zong, Liudong Ren, Meiqian Wu, Hui Xu & Shifei Zhu
Understanding the geological history of the Larsemann Hills and other exposures along the southeastern coast of Prydz Bay is essential for reconstructing the formation and evolution of the East Gondwana continent. This research involves analyses of the major elements, trace elements, REE, U-Pb and Lu-Hf isotopes of zircons from the metasedimentary rocks found in the Larsemann Hills. The results suggest that the provenance of the metasedimentary rocks within the Larsemann Hills is mainly Mesoproterozoic to...

Hypoxia triggers the outbreak of infectious spleen and kidney necrosis virus disease through viral hypoxia response elements

Jian He, Yang Yu, Zhi-Min Li, Zhi-Xuan Liu, Shao-Ping Weng, Chang-Jun Guo & Jian-Guo He
Hypoxia frequently occurs in aquatic environments, especially in aquaculture areas. However, research on the relationship between hypoxic aquatic environments with viral diseases outbreak is limited, and its underlying mechanisms remain elusive. Herein, we demonstrated that hypoxia directly triggers the outbreak of infectious spleen and kidney necrosis virus (ISKNV) disease. Hypoxia or activated hypoxia-inducible factor (HIF) pathway could remarkably increase the levels of viral genomic DNA, titers, and gene expression, indicating that ISKNV can response to...

Hypoxia triggers the outbreak of infectious spleen and kidney necrosis virus disease through viral hypoxia response elements

Jian He, Yang Yu, Zhi-Min Li, Zhi-Xuan Liu, Shao-Ping Weng, Chang-Jun Guo & Jian-Guo He
Hypoxia frequently occurs in aquatic environments, especially in aquaculture areas. However, research on the relationship between hypoxic aquatic environments with viral diseases outbreak is limited, and its underlying mechanisms remain elusive. Herein, we demonstrated that hypoxia directly triggers the outbreak of infectious spleen and kidney necrosis virus (ISKNV) disease. Hypoxia or activated hypoxia-inducible factor (HIF) pathway could remarkably increase the levels of viral genomic DNA, titers, and gene expression, indicating that ISKNV can response to...

Southwest China, the last refuge of continental primates in East Asia

He Zhang, Jiqi Lu, Shiyi Tang, Zhipang Huang, Liangwei Cui, Daoying Lan, Rong Hou, Wen Xiao, Haitao Wang, Songtao Guo Guo, Gang He, Kang Huang, Pei Zhang, Hao Pan, Charles Oxnard, Ruliang Pan & Baoguo Li
Knowledge of primate evolutionary history from the Late Miocene to the present in East Asia is necessary to develop a tangible conservation strategy for their today and future. This background is especially evident from the distributions of fossil-bearing sites in the Pleistocene and historical records over the past 800 years. They illustrate catarrhines’ early dispersal and radiation routes, paths, and later shrinking trajectories, based on which their future distribution areas can be predicted, providing robust...

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