2 Works

Data from: Cutting through the complexity of cell collectives

Carey D. Nadell, Vanni Bucci, Knut Drescher, Simon A. Levin, Bonnie L. Bassler & Joao B. Xavier
Via strength in numbers, groups of cells can influence their environments in ways that individual cells cannot. Large-scale structural patterns and collective functions underpinning virulence, tumour growth and bacterial biofilm formation are emergent properties of coupled physical and biological processes within cell groups. Owing to the abundance of factors influencing cell group behaviour, deriving general principles about them is a daunting challenge. We argue that combining mechanistic theory with theoretical ecology and evolution provides a...

Data from: Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions

Victor P. Andrade, Irina Ostrovnaya, Venkatraman E. Seshan, Mary Morrogh, Dilip Giri, Narciso Olvera, Marina De Brot, Monica Morrow, Colin B. Begg & Tari A. King
INTRODUCTION: Lobular carcinoma in situ (LCIS) has been accepted as a marker of risk for the development of invasive breast cancer, yet modern models of breast carcinogenesis include LCIS as a precursor of low-grade carcinomas. We provide evidence favoring a clonal origin for LCIS and synchronous estrogen receptor-positive malignant lesions of the ductal and lobular phenotype. METHODS: Patients with prior LCIS undergoing mastectomy were identified preoperatively from 2003-2008. Specimens were widely sampled, and frozen blocks...

Registration Year

  • 2012
    2

Resource Types

  • Dataset
    2

Affiliations

  • Memorial Sloan Kettering Cancer Center
    2
  • Princeton University
    1