Upper-ocean velocities along the cruise track of Meteor cruise M169 were continuously collected by a vessel-mounted Teledyne RD Instruments 75 kHz Ocean Surveyor ADCP. The transducer was located at 5.0 m below the water line. The instrument was operated in broadband mode with 4 m bins and a blanking distance of 4.0 m, while 50 bins were recorded using a pulse of 0.80 s. The ship's velocity was calculated from position fixes obtained by the...
Broad-Spectrum Tunable Photoluminescent Nanomaterials Constructed from a Modular Light-Harvesting Platform Based on Macrocyclic AmphiphilesZhe Xu, Shu Peng, Yu-Ying Wang, Ji-Kai Zhang, Alexandra I. Lazar & Dong-Sheng Guo
Broad-spectrum tunable photoluminescent nanomaterials are developed based on macrocyclic amphiphiles serving as a novel modular light-harvesting platform with discrete addressability of luminophores ...
Triple Emission fromp-Dimethylaminobenzonitrile-Cucurbituril Triggers the Elusive Excimer EmissionMhejabeen Sayed, Frank Biedermann, Vanya D. Uzunova, Khaleel I. Assaf, Achikanath C. Bhasikuttan, Haridas Pal, Werner M. Nau & Jyotirmayee Mohanty
Abstract The intriguing dual-emission behavior of p- dimethylaminobenzonitrile (DMABN) and the identity of the associated excited states is, arguably, the most extensively investigated and also con...
Until he gets you to the other side: Highly efficient counterion activation by amphiphilic calixarenes (gray cones) can mediate the transport of short peptide substrates for kinases across lipid memb...
An Amphiphilic Sulfonatocalixarene as an Activator for Membrane Transport of Lysine‐rich Peptides and ProteinsYu-Chen Pan, Andrea Barba-Bon, Han‐Wen Tian, Fei Ding, Andreas Hennig, Werner Nau & Dong-Sheng Guo
An amphiphilic sulfonatocalixarene (sCx5-6C) was rationally designed as an activator for membrane transport of lysine-rich peptides and proteins. sCx5-6C binds tightly with lysine and is able to e...
Cucurbit[n]urils (CBn, n = 7, 8) serve as artificial receptors for steroids (21 tested), including the hormones testosterone and estradiol as well as steroidal drugs. Fluorescence displacement titrations and isothermal titration calorimetry (ITC) provided up to nanomolar binding affinities in aqueous solution for these hydrophobic target molecules, exceeding the values of known synthetic receptors. Remarkable binding selectivities, even for homologous steroid pairs, were investigated in detail by NMR, X-ray crystal diffraction, ITC, and quantum chemical...
Supramolecular Tandem Enzyme Assays for Multiparameter Sensor Arrays and Enantiomeric Excess Determination of Amino AcidsDavid M. Bailey, Andreas Hennig, Vanya D. Uzunova & Werner M. Nau
Abstract The coupling of an enzymatic transformation with dynamic host-guest exchange allows the unselective binding of macrocycles to be used for highly selective analyte sensing. The resulting su...
Underway temperature and salinity data was collected along the cruise track with two autonomous thermosalinograph (TSG) systems, each consisting of a SBE21 TSG together with a SBE38 Thermometer. Both systems worked independent from each other throughout the cruise. While temperature is taken at the water inlet in about 2.5 m depth, salinity is estimated within the interior TSG from conductivity and interior temperature. No correction against independent data was performed for temperature and salinity. Finally,...
Identification, classification, and signal amplification capabilities of high-turnover gas binding hosts in ultra-sensitive NMRMartin Kunth, Christopher Witte, Andreas Hennig & Leif Schröder
Labile complexation of cucurbituril with xenon becomes detectable through saturation transfer with highly efficient gas turnover for ultra-sensitive NMR applications.
Determining Protease Substrate Selectivity and Inhibition by Label-Free Supramolecular Tandem Enzyme AssaysGarima Ghale, Vijayakumar Ramalingam, Adam R. Urbach & Werner M. Nau
An analytical method has been developed for the continuous monitoring of protease activity on unlabeled peptides in real time by fluorescence spectroscopy. The assay is enabled by a reporter pair comprising the macrocycle cucurbituril (CB7) and the fluorescent dye acridine orange (AO). CB7 functions by selectively recognizing N-terminal phenylalanine residues as they are produced during the enzymatic cleavage of enkephalin-type peptides by the metalloendopeptidase thermolysin. The substrate peptides (e.g., Thr-Gly-Ala-Phe-Met-NH2) bind to CB7 with moderately...
Inclusion of neutral guests by water-soluble macrocyclic hosts – a comparative thermodynamic investigation with cyclodextrins, calixarenes and cucurbiturilsDong-Sheng Guo, Vanya D. Uzunova, Khaleel I. Assaf, Alexandra I. Lazar, Yu Liu & Werner M. Nau
(2016). Inclusion of neutral guests by water-soluble macrocyclic hosts – a comparative thermodynamic investigation with cyclodextrins, calixarenes and cucurbiturils. Supramolecular Chemistry: Vol. 28, Thirteenth International Conference on Calixarenes (Calix 2015), pp. 384-395.
Institute of Nanotechnology2
Jacobs University Bremen gGmbH2
Department of Chemistry and Earth Sciences2
State Key Laboratory of Polymer Physics and Chemistry2
European Remanufacturing Council1
GEOMAR - Helmholtz Centre for Ocean Research Kiel1
Karlsruhe Institute of Technology1