Coronavirus disease 2019 (COVID-19) increases the risk of coagulopathy. Although the presence of antiphospholipid antibodies (aPLs) has been proposed as a possible mechanism of COVID-19-induced coagulopathy, its clinical significance remains uncertain. Therefore, this study aimed to evaluate the prevalence and clinical significance of aPLs among critically ill patients with COVID-19. This prospective observational study included 60 patients with COVID-19 admitted to intensive care units (ICU). The study outcomes included prevalence of aPLs, and a primary...

One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). blaNDM-1 (45; 30.2%) and blaOXA-48 (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common...

The aim was to critically appraise, synthesise and present the evidence of medication errors amongst hospitalised patients in Middle Eastern countries, specifically prevalence, nature, severity and contributory factors. CINAHL, Embase, Medline, Pubmed and Science Direct were searched for studies published in English from 2000 to March 2018, with no exclusions. Study selection, quality assessment (using adapted STROBE checklists) and data extraction were conducted independently by two reviewers. A narrative approach to data synthesis was adopted;...

Supplemental material, sj-docx-1-smo-10.1177_20503121231155996 for Awareness and knowledge of familial Mediterranean fever among medical scope students in Syrian universities: A cross-sectional study by Jamal Ataya, Jameel Soqia, Massa Alfawal, Nour Kara Tahhan, Nour Albani and Yahya Hani in SAGE Open Medicine

Introduction:Familial Mediterranean fever is an autoinflammatory autosomal recessive disorder common among individuals of Mediterranean descent. It is characterized by recurrent episodes of fever accompanied by peritonitis, pleurisy, pericarditis, and/or arthritis, sometimes accompanied by an erysipelas-like rash. Mimicking manifestation of other inflammatory conditions and the diversity of symptoms leads to insufficient knowledge and understanding. General knowledge about this disease is considered low in most populations, but this bears greater consequences in people with high incidence rates....

Supplemental material, sj-docx-2-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

Supplemental material, sj-docx-2-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

Supplemental material, sj-docx-3-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

Additional file 2: Supplementary Table 2. Distribution of participants according to the AT(N) system classification of Alzheimer’s disease pathology.

Additional file 2: Table S1: List of significantly upregulated miRNAs in OBM compared to OBO. Here RQ refers to Relative Quantification measure using the standard formula [24]. An RQ value showcases the fold-change (FC) of a specific miRNA in two populations. An RQ=1 indicated that a specific miRNA was not differentially expressed in OBM versus OBO samples. Only those miRNAs were considered which were above the limit of quantification (LOQ). Table S2. List of significantly...

Additional file 2: Table S1: List of significantly upregulated miRNAs in OBM compared to OBO. Here RQ refers to Relative Quantification measure using the standard formula [24]. An RQ value showcases the fold-change (FC) of a specific miRNA in two populations. An RQ=1 indicated that a specific miRNA was not differentially expressed in OBM versus OBO samples. Only those miRNAs were considered which were above the limit of quantification (LOQ). Table S2. List of significantly...

Abstract Objectives To examine the hypothesis that obesity complicated by the metabolic syndrome, compared to uncomplicated obesity, has distinct molecular signatures and metabolic pathways. Methods We analyzed a cohort of 39 participants with obesity that included 21 with metabolic syndrome, age-matched to 18 without metabolic complications. We measured in whole blood samples 754 human microRNAs (miRNAs), 704 metabolites using unbiased mass spectrometry metabolomics, and 25,682 transcripts, which include both protein coding genes (PCGs) as well...

Additional file 2: Supplemental tables.Table S1. HIV seroprevalence survey data. Table S2. ANC sentinel surveillance data. Table S3. HIV and covariates surveys excluded from this analysis. Table S4. Sources for pre-existing covariates. Table S5. HIV covariate survey data. Table S6. Fitted model parameters.

Additional file 4: Supplemental results.1. README. 2. Prevalence range across districts. 3. Prevalence range between sexes. 4. Prevalence range between ages. 5. Age-specific district ranges.

Abstract Background The genetic architecture underlying Familial Hypercholesterolemia (FH) in Middle Eastern Arabs is yet to be fully described, and approaches to assess this from population-wide biobanks are important for public health planning and personalized medicine. Methods We evaluate the pilot phase cohort (n = 6,140 adults) of the Qatar Biobank (QBB) for FH using the Dutch Lipid Clinic Network (DLCN) criteria, followed by an in-depth characterization of all genetic alleles in known dominant (LDLR,...

Supplemental material, sj-docx-3-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

BackgroundThe economic benefit of the clinical pharmacist's role in ensuring the optimum use of medicines is potentially considerable, particularly when it comes to cancer management. We sought to evaluate the overall economic impact of clinical pharmacist interventions in the main cancer setting in Qatar.MethodsThe total economic benefit of the clinical pharmacy interventions were analyzed from the public hospital perspective. Patient records in March 2018, July/August 2018, and January 2019 were retrospectively reviewed at the National...

Supplemental material, sj-docx-5-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

Supplemental material, sj-docx-4-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

Introduction Decreased insulin sensitivity occurs early in type 2 diabetes (T2D). T2D is highly prevalent in the Middle East and North Africa regions. This study assessed the variations in insulin sensitivity in normal apparently healthy subjects and the levels of adiponectin, adipsin and inflammatory markers. Research design and methods A total of 60 participants (aged 18–45, body mass index <28) with a normal oral glucose tolerance test (OGTT) completed hyperinsulinemic-euglycemic clamp (40 mU/m2/min) and body...

Supplemental material, sj-pdf-1-qch-10.1177_0272684X211004923 for Knowledge, Attitude, and Practice Regarding HIV, HBV, and HCV Among Medical Students of Syrian Private University, Damascus, Syria by Fatema Mohsen, Mosa Shibani, Nazir Ibrahim, Ghaith Alhourani, Sara Melhem, Mhd Amin Alzabibi, Hlma Ismail, Aliaa Bakr, Khaled Turkmani and Bisher Sawaf in International Quarterly of Community Health Education

Supplemental material, sj-pdf-1-qch-10.1177_0272684X211004923 for Knowledge, Attitude, and Practice Regarding HIV, HBV, and HCV Among Medical Students of Syrian Private University, Damascus, Syria by Fatema Mohsen, Mosa Shibani, Nazir Ibrahim, Ghaith Alhourani, Sara Melhem, Mhd Amin Alzabibi, Hlma Ismail, Aliaa Bakr, Khaled Turkmani and Bisher Sawaf in International Quarterly of Community Health Education

Background: Posttraumatic stress disorder (PTSD) is one of the most prevalent mental disorders in war-affected regions. Syria has endured 9 years of war and yet little is known about the impact of the conflict on the well-being of Syrians who remain. In this study, we investigated trauma and estimated PTSD prevalence among university students in Deir-ez-Zor, a Syrian governorate that was under the siege by ISIS for over 3 years. Methods: A descriptive cross-sectional study...

Background: Posttraumatic stress disorder (PTSD) is one of the most prevalent mental disorders in war-affected regions. Syria has endured 9 years of war and yet little is known about the impact of the conflict on the well-being of Syrians who remain. In this study, we investigated trauma and estimated PTSD prevalence among university students in Deir-ez-Zor, a Syrian governorate that was under the siege by ISIS for over 3 years. Methods: A descriptive cross-sectional study...

Enteroaggregative Escherichia coli (EAEC) is a common diarrhoeagenic human pathogen, isolated from patients in both developing and industrialized countries, that is becoming increasingly resistant to many frontline antibiotics. In this study, we screened 50 E. coli strains from children presenting with diarrhea at the outpatients clinic of Assiut University Children’s Hospital, Egypt. We show that all of these isolates were resistant to multiple classes of antibiotics and identified two as being typical EAEC strains. Using...