254 Works

Data from: Nectar sugar composition of European Caryophylloideae (Caryophyllaceae) in relation to flower length, pollination biology and phylogeny

Taina Witt, Andreas Jürgens & Gerhard Gottsberger
Floral nectar composition has been explained as an adaptation to factors that are either directly or indirectly related to pollinator attraction. However, it is often unclear whether the sugar composition is a direct adaptation to pollinator preferences. Firstly, the lower osmolality of sucrose solutions means that they evaporate more rapidly than hexose solutions, which might be one reason why sucrose-rich nectar is typically found in flowers with long tubes (adapted to long-tongued pollinators), where it...

Data from: Acoustic identification of Mexican bats based on taxonomic and ecological constraints on call design

Veronica Zamora-Gutierrez, Celia Lopez-Gonzalez, M. Cristina MacSwiney Gonzalez, Brock Fenton, Gareth Jones, Elisabeth K. V. Kalko, Sebastien J. Puechmaille, Vassilios Stathopoulos & Kate E. Jones
Monitoring global biodiversity is critical for understanding responses to anthropogenic change, but biodiversity monitoring is often biased away from tropical, megadiverse areas that are experiencing more rapid environmental change. Acoustic surveys are increasingly used to monitor biodiversity change, especially for bats as they are important indicator species and most use sound to detect, localise and classify objects. However, using bat acoustic surveys for monitoring poses several challenges, particularly in megadiverse regions. Many species lack reference...

Data from: Sexual selection on cuticular hydrocarbons of male sagebrush crickets in the wild

Sandra Steiger, Geoffrey D. Ower, Johannes Stökl, Christopher Mitchell, John Hunt, Scott K. Sakaluk & J. Stokl
Cuticular hydrocarbons (CHCs) play an essential role in mate recognition in insects but the form and intensity of sexual selection on CHCs has only been evaluated in a handful of studies, and never in a natural population. We quantified sexual selection operating on CHCs in a wild population of sagebrush crickets, a species in which nuptial feeding by females imposes an unambiguous phenotypic marker on males. Multivariate selection analysis revealed a saddle-shaped fitness surface, suggesting...

Images obtained by fluorescence microscopy technique for monitoring diffusion of PI molecules into pressure-treated Listeria monocytogenes cells

Bahareh Nikparvar, Alicia Subires, Marta Capellas, Manuela Hernandez-Herrero, Peter Crauwels, Christian U. Riedel & Nadav Bar
The effect of environmental stresses on microorganisms is well studied and cellular response to stresses such as heat, cold, acids, and salts was extensively discussed. Although high pressure processing (HPP) as a preservation method is becoming more popular in the food industry, the characteristics of the cellular damage caused by high pressure are unclear, and the microbial response to this stress is not well explored yet. We exposed the pathogen Listeria monocytogenes to HPP (400...

Altering transcription factor binding reveals comprehensive transcriptional kinetics of a basic gene

Achim P. Popp, Johannes Hettich & J. Christof M. Gebhardt
Transcription is a vital process activated by transcription factor (TF) binding. The active gene releases a burst of transcripts before turning inactive again. While the basic course of transcription is well understood, it is unclear how binding of a TF affects the frequency, duration and size of a transcriptional burst. We systematically varied the residence time and concentration of a synthetic TF and characterized the transcription of a synthetic reporter gene by combining single molecule...

Data from: Female choice for male cuticular hydrocarbon profile in decorated crickets is not based on similarity to their own profile

Sandra Steiger, Alexandra Capodeanu-Nägler, Susan N. Gershman, Carie B. Weddle, James Rapkin, Scott K. Sakaluk & John Hunt
Indirect genetic benefits derived from female mate choice comprise additive (good genes) and non-additive genetic benefits (genetic compatibility). Although good genes can be revealed by condition-dependent display traits, the mechanism by which compatibility alleles are detected is unclear because evaluation of the genetic similarity of a prospective mate requires the female to assess the genotype of the male and compare it to her own. Cuticular hydrocarbons (CHCs), lipids coating the exoskeleton of most insects, influence...

Data from: Home-made cost effective preservation buffer is a better alternative to commercial preservation methods for microbiome research

Sebastian Menke, Mark A. F. Gillingham, Kerstin Wilhelm & Simone Sommer
The investigation of wildlife gastrointestinal microbiomes by next-generation sequencing approaches is a growing field in microbial ecology and conservation. Such studies often face difficulties in sample preservation if neither freezing facilities nor liquid nitrogen (LQN) are readily available. Thus, in order to prevent microbial community changes because of bacterial growth after sampling, preservation buffers need to be applied to samples. However, the amount of microbial community variation attributable to the different preservation treatments and potentially...

Data from: Disentangling synergistic disease dynamics: Implications for the viral biocontrol of rabbits

Konstans Wells, Damien A. Fordham, Barry W. Brook, Phillip Cassey, Tarnya Cox, Robert B. O’Hara, Nina I. Schwensow & Robert B. O'Hara
European rabbits (Oryctolagus cuniculus) have been exposed to rabbit haemorrhagic disease virus (RHDV) and myxoma virus (MYXV) in their native and invasive ranges for decades. Yet, the long‐term effects of these viruses on rabbit population dynamics remain poorly understood. In this context, we analysed 17 years of detailed capture–mark–recapture data (2000–2016) from Turretfield, South Australia, using a probabilistic state‐space hierarchical modelling framework to estimate rabbit survival and epidemiological dynamics. While RHDV infection and disease‐induced death...

Data from: Species divergence in offspring begging and parental provisioning is linked to nutritional dependency

Alexandra Capodeanu-Nägler, Anne-Katrin Eggert, Heiko Vogel, Scott K. Sakaluk & Sandra Steiger
In animal species in which parents provide food to their dependent young, offspring often display conspicuous begging signals. These solicitation behaviors are important components of parent–offspring communication, but it is currently unclear how they and the parental response covary with offspring dependency on parental food provisioning across species. Burying beetles (Nicrophorus) are well known for providing elaborate biparental care, including provisioning of begging larvae. By using a multispecies approach, we show that larval begging intensity,...

Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice

Maria Carolina Florian, Hanna Leins, Michael Gobs, Yang Han, Gina Marka, Karin Soller, Angelika Vollmer, Vadim Sakk, Kalpana J. Nattamai, Ahmad Rayes, Xueheng Zhao, Kenneth Setchell, Medhanie Mulaw, Wolfgang Wagner, Yi Zheng & Hartmut Geiger
Cdc42 is a small RhoGTPase regulating multiple functions in eukaryotic cells. The activity of Cdc42 is significantly elevated in several tissues of aged mice, while the Cdc42 gain-of-activity mouse model presents with a pre-mature aging-like phenotype and with decreased lifespan. These data suggest a causal connection between elevated activity of Cdc42, aging and reduced lifespan. Here, we demonstrate that systemic treatment of aged (75-week old) female C57BL/6 mice with a Cdc42 activity specific inhibitor (CASIN)...

Analyse von Mortalität nach Hüftfraktur auf Individual-, Krankenhaus- und regionaler Ebene in Deutschland

Claudia Schulz, Hans-Helmut König, Kilian Rapp, Clemens Becker, Dietrich Rothenbacher & Gisela Büchele
Einleitung. Die Mehrzahl der Studien, die die Mortalität nach Hüftfraktur analysieren, konzentrieren sich auf die Untersuchungsebene der Patienten und weniger auf die von Krankenhäusern oder Regionen. Ein tiefgreifendes Verständnis der beeinflussenden Faktoren aller Ebenen könnte jedoch dabei helfen, relevante Ungleichheiten aufzudecken, um Präventionsmaßnahmen zu motivieren und Verbesserungen in der Versorgung anzuregen. Daher untersuchte diese Studie die Variation der Mortalität nach Hüftfraktur auf Individual-, Krankenhaus- und regionaler Ebene in Deutschland. Methodik. Diese retrospektive Kohortenstudie basiert auf...

Increase in coercive measures in psychiatric hospitals during the COVID-19 Pandemic

Erich Flammer
Objective: To examine whether the pandemic in 2020 caused changes in psychiatric hospital cases, the percentage of patients exposed to coercive interventions, and aggressive incidents. Results: The number of cases in adult psychiatry decreased by 7.6% from 105,782 to 97,761. The percentage of involuntary cases increased from 12.3 to 14.1%, and the absolute number of coercive measures increased by 4.7% from 26,269 to 27,514. The percentage of cases exposed to any kind of coercive measure...

sj-docx-1-jic-10.1177_08850666221132246 - Supplemental material for Comparison of Different Ultrasound Methods to Assess Changes in Muscle Mass in Critically ill Patients

Kristina E. Fuest, Hugo Lanz, Jana Schulz, Bernhard Ulm, Victoria A. Bennett, Julius J. Grunow, Björn Weiss, Manfred Blobner & Stefan J. Schaller
Supplemental material, sj-docx-1-jic-10.1177_08850666221132246 for Comparison of Different Ultrasound Methods to Assess Changes in Muscle Mass in Critically ill Patients by Kristina E. Fuest, Hugo Lanz, Jana Schulz, Bernhard Ulm, Victoria A. Bennett, Julius J. Grunow, Björn Weiss, Manfred Blobner and Stefan J. Schaller in Journal of Intensive Care Medicine

Data from: Disentangling direct from indirect effects of habitat disturbance on multiple components of biodiversity

Nina Isabell Schwensow, Alexander Christoph Heni, Julian Schmid, B. Karina Montero, Stefan Dominik Brändel, Tanja Katharina Halczok, Gerd Mayer, Gloria Fackelmann, Kerstin Wilhelm, Dominik Werner Schmid & Simone Sommer
Human habitat disturbance affects both species diversity and intraspecific genetic diversity, leading to correlations between these two components of biodiversity (termed species - genetic diversity correlation, SGDC). However, whether SGDC predictions extend to host-associated communities, such as the intestinal parasite and gut microbial diversity, remains largely unexplored. Additionally, the role of dominant generalist species is often neglected despite their importance in shaping the environment experienced by other members of the ecological community, and their role...

Garvicin Q: characterization of biosynthesis and mode of action

Christian K. Desiderato, Katharina M. Hasenauer, Sebastian J. Reich, Oliver Goldbeck, Lalaina Holivololona, Kirill V. Ovchinnikov, Alexander Reiter, Marco Oldiges, Dzung B. Diep, Bernhard J. Eikmanns & Christian U. Riedel
Abstract Bacteriocins are ribosomally synthesized antimicrobial peptides, that either kill target bacteria or inhibit their growth. Bacteriocins are used in food preservation and are of increasing interest as potential alternatives to conventional antibiotics. In the present study, we show that Lactococcus petauri B1726, a strain isolated from fermented balsam pear, produces a heat-stable and protease-sensitive compound. Following genome sequencing, a gene cluster for production of a class IId bacteriocin was identified consisting of garQ (encoding...

Additional file 1 of Garvicin Q: characterization of biosynthesis and mode of action

Christian K. Desiderato, Katharina M. Hasenauer, Sebastian J. Reich, Oliver Goldbeck, Lalaina Holivololona, Kirill V. Ovchinnikov, Alexander Reiter, Marco Oldiges, Dzung B. Diep, Bernhard J. Eikmanns & Christian U. Riedel
Additional file 1. Data file with supplementary Figures and Tables S1-14.

Additional file 2 of Artificial intelligence-informed mobile mental health apps for young people: a mixed-methods approach on users’ and stakeholders’ perspectives

Christian Götzl, Selina Hiller, Christian Rauschenberg, Anita Schick, Janik Fechtelpeter, Unai Fischer Abaigar, Georgia Koppe, Daniel Durstewitz, Ulrich Reininghaus & Silvia Krumm
Additional file 2: Interview topic guide–expert interviews.

Additional file 3 of Artificial intelligence-informed mobile mental health apps for young people: a mixed-methods approach on users’ and stakeholders’ perspectives

Christian Götzl, Selina Hiller, Christian Rauschenberg, Anita Schick, Janik Fechtelpeter, Unai Fischer Abaigar, Georgia Koppe, Daniel Durstewitz, Ulrich Reininghaus & Silvia Krumm
Additional file 3: Online survey.

Additional file 5 of Artificial intelligence-informed mobile mental health apps for young people: a mixed-methods approach on users’ and stakeholders’ perspectives

Christian Götzl, Selina Hiller, Christian Rauschenberg, Anita Schick, Janik Fechtelpeter, Unai Fischer Abaigar, Georgia Koppe, Daniel Durstewitz, Ulrich Reininghaus & Silvia Krumm
Additional file 5: COREQ-Checklist.

Differential in vitro effects of targeted therapeutics in primary human liver cancer: importance for combined liver cancer

Ihtzaz Ahmed Malik, Mansi Rajput, Rieke Werner, Dorothea Fey, Niloofar Salehzadeh, Christine A. F. von Arnim & Jörg Wilting
Abstract The incidence of primary liver tumors, hepatocellular carcinoma (HCC), intrahepatic cholangiocellular carcinoma (ICC), and combined HCC/ICC (cHCC/CC) is increasing. For ICC, targeted therapy exists only for a small subpopulation of patients, while for HCC, Sorafenib and Lenvatinib are in use. Diagnosis of cHCC/CC is a great challenge and its incidence is underestimated, bearing the risk of unintended non-treatment of ICC. Here, we investigated effects of targeted inhibitors on human ICC cell lines (HUH28, RBE,...

Additional file 10 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 10: Fig. S6. Expression correlation between BCL11B & C14ORF64 (LINC01550). Expression correlation between BCL11B & C14ORF64 (LINC01550) in 426 human datasets with 42563 samples from R2: Genomics analysis and visualization platform (https://hgserver1.amc.nl/cgi-bin/r2/main.cgi).

Additional file 4 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 4: Fig. S3A. Gene Ontology analysis of genes hyper- (A) and hypomethylated (B) of T-LGL patients. Significant Biological processes (GO database) enriched in genes associated with significantly differentially methylated CpG loci in T-LGL. Enrichment represented as odds ratio. Point size represents the gene count of each pathway. Enrichment p value obtained by overrepresentation analysis [30], represented by point color. A Gene Ontology analysis of hypermethylated genes in T-LGL.

Additional file 6 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 6: Fig. S4. Differential gene expression of IL6 between T-LGL and healthy donor-derived CD8+ memory T cells. Differential gene expression for IL6 was measured by qPCR. Bulk CD8+ cells from two healthy donors were used for comparison. In line with previous publications, the T-LGLL cohort analyzed exhibits a higher IL6 expression compared to healthy donor-derived C8+ cells. HD Healthy donor.

Additional file 7 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 7: Fig. S5A. (A and B): Location of differentially methylated CpG loci in the genes BCL11B and C14orf64 (LINC01550). A Significant differentially methylated CpGs in BCL11B (T-LGLL compared to CD8+. memory T cells) were located in the gene body and assigned as enhancers by ENCODE, which match as enhancers in CD8-positive memory cells.

Additional file 8 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 8: Fig. S5B. (A and B): Location of differentially methylated CpG loci in the genes BCL11B and C14orf64 (LINC01550). B Significant differentially methylated CpGs in C14orf64 (LINC01550) (T-LGL compared to CD8 pos. memory T cells).

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