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sj-pdf-10-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-10-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Supplementary material from \"Conservation measures or hotspots of disease transmission? Agri-environment schemes can reduce disease prevalence in pollinator communities\"

Robyn Manley, Vincent Doublet, Owen N. Wright, Toby Doyle, Isobel Refoy, Sophie Hedges, David Pascall, Claire Carvell, Mark J. F. Brown & Lena Wilfert
Insects are under pressure from agricultural intensification. To protect pollinators, conservation measures such as the EU agri-environment schemes (AES) promote planting wildflowers along fields. However, this can potentially alter disease ecology by serving as transmission hubs or by diluting infections. We tested this by measuring plant-pollinator interactions and virus infections (DWV-A, DWV-B and ABPV) across pollinator communities in agricultural landscapes over a year. AES had a direct effect on DWV-B, reducing prevalence and load in...

Self-templated synthesis of an orthoformate in,in-cryptand and its bridgehead inversion by dynamic covalent exchange

Max von Delius, Henrik Löw & Elena Mena-Osteritz
We report the template-free dynamic covalent self-assembly of a small orthoformate cryptand, which appears to be driven by the formation of two sets of intramolecular, four-centre hydrogen bonds.

Self‐Assembly, Adaptive Response, and in , out‐ Stereoisomerism of Large Orthoformate Cryptands

Max von Delius, Henrik Löw, Elena Mena‐Osteritz, Kathleen M. Mullen & Christof Jäger
Abstract We report on triethylene glycol-based orthoformate cryptands, which adapt their bridgehead configurations in response to metal templates and intramolecular hydrogen bonding in a complex ma...

Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling, Chen Hong, Sandra D Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M Braun, Isidro Cortés-Ciriano, Ruibin Xi, Rolf Kabbe, Peter J Park, Roland Eils, Matthias Schlesner, Kadir C Akdemir, Eva G Alvarez, Adrian Baez-Ortega, Rameen Beroukhim, Paul C Boutros, David DL Bowtell, Benedikt Brors, Kathleen H Burns, Peter J Campbell, Kin Chan, Ken Chen, Ana Dueso-Barroso … & Christian von Mering
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the...

Data from: The Golgi-localized γ-ear-containing ARF-binding (GGA) proteins alter amyloid-β precursor protein (APP) processing through interaction of their GAE domain with the beta-site APP cleaving enzyme 1 (BACE1)

Bjoern Von Einem, Anke Wahler, Tobias Schips, Alberto Serrano-Pozo, Christian Proepper, Tobias M. Boeckers, Angelika Rueck, Thomas Wirth, Bradley T. Hyman, Karin M. Danzer, Dietmar R. Thal & Christine A. F. Von Arnim
Proteolytic processing of amyloid-β precursor protein (APP) by beta-site APP cleaving enzyme 1 (BACE1) is the initial step in the production of amyloid beta (Aβ), which accumulates in senile plaques in Alzheimer’s disease (AD). Essential for this cleavage is the transport and sorting of both proteins through endosomal/Golgi compartments. Golgi-localized γ-ear-containing ARF-binding (GGA) proteins have striking cargo-sorting functions in these pathways. Recently, GGA1 and GGA3 were shown to interact with BACE1, to be expressed in...

Data from: Beyond species recognition: somatic state affects long distance sex pheromone communication

Johanna Chemnitz, Petra C. Jentschke, Manfred Ayasse & Sandra Steiger
Long-range sex pheromones have been subjected to substantial research with a particular focus on their biosynthesis, peripheral perception, central processing and the resulting orientation behaviour of perceivers. Fundamental to the research on sex attractants was the assumption that they primarily coordinate species recognition. However, especially when they are produced by the less limiting sex (usually males), the evolution of heightened condition dependence might be expected and long-range sex pheromones might, therefore, also inform about a...

Data from: Modulation frequency as a cue for auditory speed perception

Irene Senna, Cesare V. Parise & Marc O. Ernst
Unlike vision, the mechanisms underlying auditory motion perception are poorly understood. Here we describe an auditory motion illusion revealing a novel cue to auditory speed perception: the temporal frequency of amplitude modulation (AM-frequency), typical for rattling sounds. Naturally, corrugated objects sliding across each other generate rattling sounds whose AM-frequency tends to directly correlate with speed. We found that AM-frequency modulates auditory speed perception in a highly systematic fashion: moving sounds with higher AM-frequency are perceived...

Forest habitat parameters influence abundance and diversity of cadaver-visiting dung beetles in Central Europe

Christian Von Hoermann, Sandra Weithmann, Markus Deißler, Manfred Ayasse & Sandra Steiger
Dung beetles (Scarabaeoidea) provide crucial ecosystem services and serve as model organisms for various behavioural, ecological and evolutionary studies. However, dung beetles have received little attention as consumers of large cadavers. In this study, we trapped copronecrophagous dung beetles on aboveground exposed piglet cadavers in 61 forest plots distributed over three geographically distinct regions in Germany, Central Europe. We examined the effects of land use intensity, forest stand, soil characteristics, vascular plant diversity and climatic...

Data from: Metabolic characterization of intact cells reveals intracellular amyloid beta but not its precursor protein to reduce mitochondrial respiration

Patrick M. Schaefer, Bjoern Von Einem, Paul Walther, Enrico Calzia & Christine A.F. Von Arnim
One hallmark of Alzheimer´s disease are senile plaques consisting of amyloid beta (Aβ), which derives from the processing of the amyloid precursor protein (APP). Mitochondrial dysfunction has been linked to the pathogenesis of Alzheimer´s disease and both Aβ and APP have been reported to affect mitochondrial function in isolated systems. However, in intact cells, considering a physiological localization of APP and Aβ, it is pending what triggers the mitochondrial defect. Thus, the aim of this...

Data from: How to find home backwards? Locomotion and inter-leg coordination during rearward walking of Cataglyphis fortis desert ants

Sarah Elisabeth Pfeffer, Verena Luisa Wahl & Matthias Wittlinger
For insects, flexibility in the performance of terrestrial locomotion is a vital part of facing the challenges of their often unpredictable environment. Arthropods such as scorpions and crustaceans can switch readily from forward to backward locomotion, but in insects this behaviour seems to be less common and, therefore, is only poorly understood. Here we present an example of spontaneous and persistent backward walking in Cataglyphis desert ants that allows us to investigate rearward locomotion within...

Data from: A prospective harmonized multicentre DTI study of cerebral white matter degeneration in ALS

Sanjay Kalra, Hans-Peter Müller, Abdullah Ishaque, Lorne Zinman, Lawrence Korngut, Angela Genge, Christian Beaulieu, Richard Frayne, Simon J. Graham & Jan Kassubek
Objective: To evaluate progressive white matter (WM) degeneration in ALS. Methods: Sixty-six patients with ALS and 43 healthy controls were enrolled in a prospective, longitudinal, multicentre study in the Canadian ALS Neuroimaging Consortium (CALSNIC). Participants underwent a harmonized neuroimaging protocol across 4 centres including diffusion tensor imaging (DTI) for assessment of WM integrity. Three visits were accompanied by clinical assessments of disability (ALSFRS-R) and upper motor neuron (UMN) function. Voxel-wise whole brain and quantitative tractwise...

Does the therapist matter? Therapist characteristics and their relation to outcome in trauma-focused cognitive behavioral therapy for children and adolescents

Elisa Pfeiffer, Silje Mørup Ormhaug, Dunja Tutus, Tonje Holt, Rita Rosner, Tore Wentzel Larsen & Tine K. Jensen
There is a broad evidence-base for the effectiveness of Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) in treating children and adolescents with posttraumatic stress disorder (PTSD). The effect of therapist characteristics on patient symptoms has been neglected in psychotraumatology research and necessitates further investigation. This study aims to investigate the impact of therapist characteristics (gender, clinical experience and theoretical background) on posttraumatic stress symptoms (PTSS) in a heterogeneous and international sample of traumatized children and adolescents. Data from...

Jumping the green wall: the use of PNA-DNA clamps to enhance microbiome sampling depth in wildlife microbiome research

Luis Viquez-R, Ramona Fleischer, Kerstin Wilhelm, Marco Tschapka & Simone Sommer
As microbiome research moves away from model organisms to wildlife, new challenges for microbiome high throughput sequencing arise caused by the variety of wildlife diets. High levels of contamination are commonly observed emanating from the host (mitochondria) or diet (chloroplast). Such high contamination levels affect the overall sequencing depth of wildlife samples thus decreasing statistical power and leading to poor performance in downstream analysis. We developed an amplification protocol utilizing PNA-DNA clamps to maximize the...

Data from: Manipulation of parental nutritional condition reveals competition among family members

Eva M. Keppner, Manfred Ayasse & Sandra Steiger
Parental care is thought to be costly, as it consumes time and energy. Such costs might be reduced in animal parents that raise their young on valuable food sources such as dung or carcasses, as parents are able to invest in self-maintenance by feeding from the same resource. However, this might lower the nutritional value for other family members and, as a consequence, food competition might arise. To promote our understanding of the outcome of...

Leaf water relations in epiphytic ferns

Courtney Campany, Jarmila Pittermann, Alex Baer, Helen Holmlund, Eric Schuettpelz, Klaus Mehltreter &
Opportunistic diversification has allowed ferns to radiate into epiphytic niches in angiosperm dominated landscapes. However, our understanding of how ecophysiological function allowed establishment in the canopy and the potential transitionary role of the hemi-epiphytic life form remain unclear. Here, we surveyed 39 fern species in Costa Rican tropical forests to explore epiphytic trait divergence in a phylogenetic context. We examined leaf responses to water deficits in terrestrial, hemi-epiphytic, and epiphytic ferns and related these findings...

Date From: The myriad of complex demographic responses of terrestrial mammals to climate change and gaps of knowledge: A global analysis

Maria Paniw, Tamora James, C. Ruth Archer, Gesa Römer, Sam Levin, Aldo Compagnoni, Judy Che-Castaldo, Joanne Bennett, Andrew Mooney, Dylan Childs, Arpat Ozgul, Owen Jones, Jean Burns, Andrew Beckerman, Abir Patwari, Nora Sanchez-Gassen, Tiffany Knight & Roberto Salguero-Gómez
Approximately 25% of mammals are currently threatened with extinction, a risk that is amplified under climate change. Species persistence under climate change is determined by the combined effects of climatic factors on multiple demographic rates (survival, development, reproduction), and hence, population dynamics. Thus, to quantify which species and regions on Earth are most vulnerable to climate-driven extinction, a global understanding of how different demographic rates respond to climate is urgently needed. Here, we perform a...

Supplementary Figure S2.pdf

Kshitij Tandon, FRANCESCO RICCI, JOANA FERREIRA COSTA, LINDA BLACKALL, Mónica Medina, Michael Kühl & HEROEN VERBRUGGEN
Supplementary Figure S2.Boxplot for P. lutea and I. palifera MAGs completeness and contamination stats..

Figure 2.pdf

Kshitij Tandon, FRANCESCO RICCI, JOANA FERREIRA COSTA, LINDA BLACKALL, Mónica Medina, Michael Kühl & HEROEN VERBRUGGEN
Figure 2. Phylogenetic tree of bacterial MAGs with representation of different categories of Eukaryotic-like proteins (ELPs) from a) P. lutea and b) I. palifera. From inner to outer, Innermost circle represents MAGs color coded at bacterial class level, heatmap represents different ELP categories (Inner to outer: HEAT repeats; WD domain repeats, WD40; Ankyrin Repeats, ARPs; and Tetratricopeptide repeats, TPRs) and Bar plot represent total ELP counts in MAGs. Bars colored in “sky blue” represent MAGs...

Supplermentary Figure S3.pdf

Kshitij Tandon, FRANCESCO RICCI, JOANA FERREIRA COSTA, LINDA BLACKALL, Mónica Medina, Michael Kühl & HEROEN VERBRUGGEN
Supplementary Figure S3.Stacked barplots for Relative abundance (>1%) of MAGs taxonomic classes for P. lutea and I. palifera. p_Aenigmatarchaeota, p_Nanoarchaeota, p_Thermoproteota represents the Archaea domain.

Figure 3.pdf

Kshitij Tandon, FRANCESCO RICCI, JOANA FERREIRA COSTA, LINDA BLACKALL, Mónica Medina, Michael Kühl & HEROEN VERBRUGGEN
Figure 3. Phylogenetic tree of bacterial MAGs representing functional pathways based on nitrogen, sulphur and anoxygenic photosynthesis KEGG modules in a) P. lutea and b) I. palifera. From inner to outer ring, Innermost circle represents MAGs color coded at bacterial class level. Heatmap represents different KEGG modules (from inner to outer) for Nitrogen metabolism (M000175, M00524, M00529, M00530 and M00531), Sulfur metabolism (M00596, M00176 and M00595) and Anoxygenic photosynthesis (M00597). MAGs with at least one...

Data for: Inhibition of Ca2+-triggered secretion by hydrocarbon-stapled peptides

Axel Brunger, Ying Lai, Giorgio Fois, Jose Flores, Michael Tuvim, Qiangjun Zhou, Kailu Yang, Jeremy Leitz, John Peters, Yunxiang Zhang, Richard Pfuetzner, Luis Esquivies, Philip Jones, Manfred Frick & Burton Dickey
Ca2+-triggered membrane fusion is orchestrated by a conserved set of proteins to mediate synaptic neurotransmitter release, mucin secretion, and other regulated exocytic processes. For neurotransmitter release, the Ca2+ sensitivity is introduced by interactions between the Ca2+ sensor synaptotagmin and the SNARE complex, and sequence conservation and functional studies suggest this mechanism is also conserved for mucin secretion. Disruption of Ca2+-triggered membrane fusion by a pharmacologic agent would have therapeutic value for mucus hypersecretion since it...

sj-pdf-18-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-18-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

sj-pdf-17-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-17-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

sj-pdf-16-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-16-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

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