293 Works

sj-pdf-1-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-1-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

sj-pdf-2-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-2-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

sj-pdf-5-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-5-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

sj-pdf-17-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-17-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

sj-pdf-10-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-10-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Additional file 3 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 3: Fig. S2. Differential methylation of CpG loci in the SOCS3 promoter in T-LGL samples. Comparison of CpG methylation (beta-value) for CpGs in the SOCS3 promoter between CD8+ memory cells (CD8mem) and T-LGLL samples (LGL). On top, adjusted p val of differential methylation analysis (dmpFDR, top left) and adjusted p value of differential variability analysis (dmVar, top right).

Additional file 5 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 5: Fig. S3B. Gene Ontology analysis of genes hyper- (A) and hypomethylated (B) of T-LGL patients. Significant Biological processes (GO database) enriched in genes associated with significantly differentially methylated CpG loci in T-LGL. Enrichment represented as odds ratio. Point size represents the gene count of each pathway. Enrichment p value obtained by overrepresentation analysis [30], represented by point color. B Gene Ontology analysis of hypomethylated genes in T-LGL.

Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Abstract Background The molecular pathogenesis of T-cell large granular lymphocytic leukemia (T-LGLL), a mature T-cell leukemia arising commonly from T-cell receptor αβ-positive CD8+ memory cytotoxic T cells, is only partly understood. The role of deregulated methylation in T-LGLL is not well known. We analyzed the epigenetic profile of T-LGLL cells of 11 patients compared to their normal counterparts by array-based DNA methylation profiling. For identification of molecular events driving the pathogenesis of T-LGLL, we compared...

Additional file 1 of Emergency medical care of patients with psychiatric disorders - challenges and opportunities: Results of a multicenter survey

Benedikt Schick, Benjamin Mayer, Markus Jäger, Bettina Jungwirth, Eberhard Barth, Martin Eble, Christoph Sponholz, Claus-Martin Muth & Carlos Schönfeldt-Lecuona
Supplementary Material 1

Additional file 1 of Emergency medical care of patients with psychiatric disorders - challenges and opportunities: Results of a multicenter survey

Benedikt Schick, Benjamin Mayer, Markus Jäger, Bettina Jungwirth, Eberhard Barth, Martin Eble, Christoph Sponholz, Claus-Martin Muth & Carlos Schönfeldt-Lecuona
Supplementary Material 1

Additional file 3 of Artificial intelligence-informed mobile mental health apps for young people: a mixed-methods approach on users’ and stakeholders’ perspectives

Christian Götzl, Selina Hiller, Christian Rauschenberg, Anita Schick, Janik Fechtelpeter, Unai Fischer Abaigar, Georgia Koppe, Daniel Durstewitz, Ulrich Reininghaus & Silvia Krumm
Additional file 3: Online survey.

Additional file 4 of Artificial intelligence-informed mobile mental health apps for young people: a mixed-methods approach on users’ and stakeholders’ perspectives

Christian Götzl, Selina Hiller, Christian Rauschenberg, Anita Schick, Janik Fechtelpeter, Unai Fischer Abaigar, Georgia Koppe, Daniel Durstewitz, Ulrich Reininghaus & Silvia Krumm
Additional file 4: Overview of participants in the qualitative study.

Additional file 1 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading & Francesco Roselli
Additional file 1: Figure S1. Glial CREB phosphorylation post injury is limited to IBA1+ cells. A)-B) AAVs are able to infect 89.98 ± 14.47% of cortical neurons. Data are shown as mean ± SD (Red dots represent individual animals). N=8. Scale bar: 50µm. C)-D) Non-neuronal pCREB signal is mainly found in IBA1+ cells (IBA1+ cells: 97.76 ± 0.83% vs. GFAP+ cells: 1.24 ± 0.83%). Data are shown as mean ± SD. N=4. Scale Bar: 50µm.E-F)...

Additional file 3 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading & Francesco Roselli
Additional file 3: Figure S3. Blunting neuronal nuclear calcium signaling did not alter amplitude and velocity of whisker movement post-TBI. A)-C) The amplitudes of the affected (CS = 0.88 ± 0.22; CT = 1.1 ± 0.19; PS = 0.93 ± 0.42; PT = 1.269 ± 0.56) or unaffected (CS = 1.07 ± 0.39; CT = 1.05 ± 0.35; PS = 1.14 ± 0.45; PT = 1.22 ± 0.45) whisker were not significantly changed 24h after...

Additional file 4 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading & Francesco Roselli
Additional file 4: Figure S4. Neuronal expression of osteoprotegerin is upregulated by nuclear calcium signaling and neuronal activity in TBI. A) Negative Control, baseline OPG (TNFRSF11B) signal and a positive Control of the in situ hybridization 24h post injury. B) OPG (TNFRSF11B) in situ signal is mainly found in neuronal sources (neuronal vs non-neuronal 75.38 ± 1.83% vs 24.62% ± 1.83%). N=5. C)-D) Significant increase of OPG (TNFRSF11b) mRNA density 24h post-TBI compared to sham...

Additional file 8 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading & Francesco Roselli
Additional file 8: Table S3. Antibodies and Probes. Full information on antibodies and probes is provided.

Additional file 1 of Differential in vitro effects of targeted therapeutics in primary human liver cancer: importance for combined liver cancer

Ihtzaz Ahmed Malik, Mansi Rajput, Rieke Werner, Dorothea Fey, Niloofar Salehzadeh, Christine A. F. von Arnim & Jörg Wilting
Additional file 1: Suppl. Figure 1. Uncropped Western-blot images of 25µM MK-2206-treated HUH28 and RBE and SSP25 with specific antibodies against total AKT and p-AKT, mTOR and p-mTOR, ERK1/2 and p-ERK1/2. α-Tubulin was used as loading control. Note: Images correspond to figure 1B. Suppl. Figure 2. Uncropped Western-blot images of 25µM MK-2206-treated EGI1 and CCC5 with specific antibodies against total AKT and p-AKT, mTOR and p-mTOR, ERK1/2 and p-ERK1/2. α-Tubulin was used as loading control....

Genomic view of archaeal and bacterial diversity in skeleton of coral Porites lutea and Isopora palifera

Kshitij Tandon, FRANCESCO RICCI, JOANA FERREIRA COSTA, LINDA BLACKALL, Mónica Medina, Michael Kühl & HEROEN VERBRUGGEN
This includes all the figures, scripts and command-line parameters used for the analysis presented in the manuscript Genomic view of archaeal and bacterial diversity in skeleton of coral Porites lutea and Isopora palifera
1. Figure 1. Phylogenetic trees of Metagenome-assembled genomes (MAGs) recovered from P. lutea and I. palifera skeleton. a) 376 bacterial MAGs, with genome completeness, GC content, and genes-of-interest and b) 17 archaeal MAGs with the presence of ammonia oxidising gene AmoA....

Additional file 1 of Mobilisation of critically ill patients receiving norepinephrine: a retrospective cohort study

Maximilian Lindholz, Clara M. Schellenberg, Julius J. Grunow, Simone Kagerbauer, Annette Milnik, Daniel Zickler, Stefan Angermair, Anett Reißhauer, Martin Witzenrath, Mario Menk, Sebastian Boie, Felix Balzer & Stefan J. Schaller
Additional file 1. Table S1. Individual elements of the Elixhauser index. Table S2. All Admission diagnoses with n > 50.

Additional file 1 of Serum phosphorylated tau protein 181 and neurofilament light chain in cognitively impaired heart failure patients

Jan Traub, Markus Otto, Roxane Sell, Dennis Göpfert, György Homola, Petra Steinacker, Patrick Oeckl, Caroline Morbach, Stefan Frantz, Mirko Pham, Stefan Störk, Guido Stoll & Anna Frey
Additional file 1: Supplemental Methods. Table S1. Inclusion and exclusion criteria. Table S2. Outcome of the cognitive test battery. Table S3. Imaging protocol and sequence parameters. Table S4. Correlation of biomarkers to cognitive domains and brain morphology. Table S5. Extended clinical characteristics of NfL quartiles. Table S6. Extended clinical characteristics of pTau quartiles. Table S7. Mediation analysis of parameters affecting serum levels of Ln(NfL). Table S8. Mediation analysis of parameters affecting serum levels of Ln(pTau)....

sj-docx-1-jic-10.1177_08850666221132246 - Supplemental material for Comparison of Different Ultrasound Methods to Assess Changes in Muscle Mass in Critically ill Patients

Kristina E. Fuest, Hugo Lanz, Jana Schulz, Bernhard Ulm, Victoria A. Bennett, Julius J. Grunow, Björn Weiss, Manfred Blobner & Stefan J. Schaller
Supplemental material, sj-docx-1-jic-10.1177_08850666221132246 for Comparison of Different Ultrasound Methods to Assess Changes in Muscle Mass in Critically ill Patients by Kristina E. Fuest, Hugo Lanz, Jana Schulz, Bernhard Ulm, Victoria A. Bennett, Julius J. Grunow, Björn Weiss, Manfred Blobner and Stefan J. Schaller in Journal of Intensive Care Medicine

Comparison of Different Ultrasound Methods to Assess Changes in Muscle Mass in Critically ill Patients

Kristina E. Fuest, Hugo Lanz, Jana Schulz, Bernhard Ulm, Victoria A. Bennett, Julius J. Grunow, Björn Weiss, Manfred Blobner & Stefan J. Schaller
BackgroundMuscle ultrasound represents a promising approach to aid diagnoses of neuromuscular diseases in critically ill patients. Unfortunately, standardization of ultrasound measurements in clinical research is lacking, making direct comparisons between studies difficult. Protocols are required to assess qualitative muscle changes during an ICU stay in patients at high risk for the development of neuromuscular acquired weakness (ICUAW).MethodsWe conducted a retrospective, observational analysis comprised of three prospective observational studies with the aim of diagnosing muscle changes...

The impact of hydrothermal alteration on the physiochemical characteristics of reservoir rocks: the case of the Los Humeros geothermal field (Mexico)

Leandra M. Weydt, Federico Lucci, Alicja Lacinska, Dirk Scheuvens, Gerardo Carrasco-Núñez, Guido Giordano, Christopher A. Rochelle, Stefanie Schmidt, Kristian Bär & Ingo Sass
Abstract Hydrothermal alteration is a common process in active geothermal systems and can significantly change the physiochemical properties of rocks. To improve reservoir assessment and modeling of high-temperature geothermal resources linked to active volcanic settings, a detailed understanding of the reservoir is needed. The Los Humeros Volcanic Complex, hosting the third largest exploited geothermal field in Mexico, represents a natural laboratory to investigate the impact of hydrothermal processes on the rock properties through andesitic reservoir...

Additional file 1 of Willingness to pay for a group and an individual version of the Lifestyle-integrated Functional Exercise program from a participant perspective

Sophie Gottschalk, Hans-Helmut König, Michael Schwenk, Corinna Nerz, Clemens Becker, Jochen Klenk, Carl-Philipp Jansen & Judith Dams
Supplementary Material 1

Additional file 1 of Willingness to pay for a group and an individual version of the Lifestyle-integrated Functional Exercise program from a participant perspective

Sophie Gottschalk, Hans-Helmut König, Michael Schwenk, Corinna Nerz, Clemens Becker, Jochen Klenk, Carl-Philipp Jansen & Judith Dams
Supplementary Material 1

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