184 Works

Data from: Disentangling direct from indirect effects of habitat disturbance on multiple components of biodiversity

Nina Isabell Schwensow, Alexander Christoph Heni, Julian Schmid, B. Karina Montero, Stefan Dominik Brändel, Tanja Katharina Halczok, Gerd Mayer, Gloria Fackelmann, Kerstin Wilhelm, Dominik Werner Schmid & Simone Sommer
Human habitat disturbance affects both species diversity and intraspecific genetic diversity, leading to correlations between these two components of biodiversity (termed species - genetic diversity correlation, SGDC). However, whether SGDC predictions extend to host-associated communities, such as the intestinal parasite and gut microbial diversity, remains largely unexplored. Additionally, the role of dominant generalist species is often neglected despite their importance in shaping the environment experienced by other members of the ecological community, and their role...

The child and Adolescent Trauma Screen 2 (CATS-2) – validation of an instrument to measure DSM-5 and ICD-11 PTSD and complex PTSD in children and adolescents

Cedric Sachser, Lucy Berliner, Elizabeth Risch, Rita Rosner, Marianne S. Birkeland, Rebekka Eilers, Gertrud S. Hafstad, Elisa Pfeiffer, Paul L. Plener & Tine K. Jensen
The study examined the psychometric properties of the Child and Adolescent Trauma Screen 2 (CATS-2) as a measure of posttraumatic stress disorder (PTSD) according to DSM-5 and (Complex) PTSD following the ICD-11 criteria in children and adolescents (7–17 years). Psychometric properties were investigated in an international sample of traumatized children and adolescents (N = 283) and their caregivers (N = 255). We examined the internal consistency (α), convergent and discriminant validity, the factor structure of...

Increase in coercive measures in psychiatric hospitals during the COVID-19 Pandemic

Erich Flammer
Objective: To examine whether the pandemic in 2020 caused changes in psychiatric hospital cases, the percentage of patients exposed to coercive interventions, and aggressive incidents. Results: The number of cases in adult psychiatry decreased by 7.6% from 105,782 to 97,761. The percentage of involuntary cases increased from 12.3 to 14.1%, and the absolute number of coercive measures increased by 4.7% from 26,269 to 27,514. The percentage of cases exposed to any kind of coercive measure...

Additional file 2 of Artificial intelligence-informed mobile mental health apps for young people: a mixed-methods approach on users’ and stakeholders’ perspectives

Christian Götzl, Selina Hiller, Christian Rauschenberg, Anita Schick, Janik Fechtelpeter, Unai Fischer Abaigar, Georgia Koppe, Daniel Durstewitz, Ulrich Reininghaus & Silvia Krumm
Additional file 2: Interview topic guide–expert interviews.

Additional file 3 of Artificial intelligence-informed mobile mental health apps for young people: a mixed-methods approach on users’ and stakeholders’ perspectives

Christian Götzl, Selina Hiller, Christian Rauschenberg, Anita Schick, Janik Fechtelpeter, Unai Fischer Abaigar, Georgia Koppe, Daniel Durstewitz, Ulrich Reininghaus & Silvia Krumm
Additional file 3: Online survey.

Additional file 5 of Artificial intelligence-informed mobile mental health apps for young people: a mixed-methods approach on users’ and stakeholders’ perspectives

Christian Götzl, Selina Hiller, Christian Rauschenberg, Anita Schick, Janik Fechtelpeter, Unai Fischer Abaigar, Georgia Koppe, Daniel Durstewitz, Ulrich Reininghaus & Silvia Krumm
Additional file 5: COREQ-Checklist.

Additional file 1 of Garvicin Q: characterization of biosynthesis and mode of action

Christian K. Desiderato, Katharina M. Hasenauer, Sebastian J. Reich, Oliver Goldbeck, Lalaina Holivololona, Kirill V. Ovchinnikov, Alexander Reiter, Marco Oldiges, Dzung B. Diep, Bernhard J. Eikmanns & Christian U. Riedel
Additional file 1. Data file with supplementary Figures and Tables S1-14.

Garvicin Q: characterization of biosynthesis and mode of action

Christian K. Desiderato, Katharina M. Hasenauer, Sebastian J. Reich, Oliver Goldbeck, Lalaina Holivololona, Kirill V. Ovchinnikov, Alexander Reiter, Marco Oldiges, Dzung B. Diep, Bernhard J. Eikmanns & Christian U. Riedel
Abstract Bacteriocins are ribosomally synthesized antimicrobial peptides, that either kill target bacteria or inhibit their growth. Bacteriocins are used in food preservation and are of increasing interest as potential alternatives to conventional antibiotics. In the present study, we show that Lactococcus petauri B1726, a strain isolated from fermented balsam pear, produces a heat-stable and protease-sensitive compound. Following genome sequencing, a gene cluster for production of a class IId bacteriocin was identified consisting of garQ (encoding...

sj-pdf-6-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-6-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Data for: An invasive ant increases deformed wing virus loads in honey bees

Jana Dobelmann, Antoine Felden & Phil Lester
The majority of invasive species are best known for their effects as predators. However, many introduced predators may also be substantial reservoirs for pathogens. Honey bee-associated viruses are found in various arthropod species including invasive ants. We examined how the globally invasive Argentine ant (Linepithema humile), which can reach high densities and infest beehives, is associated with pathogen dynamics in honey bees. Viral loads of Deformed wing virus (DWV), which has been linked to millions...

sj-pdf-6-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-6-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

Genomic view of archaeal and bacterial diversity in skeleton of coral Porites lutea and Isopora palifera

Kshitij Tandon, FRANCESCO RICCI, JOANA FERREIRA COSTA, LINDA BLACKALL, Mónica Medina, Michael Kühl & HEROEN VERBRUGGEN
This includes all the figures, scripts and command-line parameters used for the analysis presented in the manuscript Genomic view of archaeal and bacterial diversity in skeleton of coral Porites lutea and Isopora palifera
1. Figure 1. Phylogenetic trees of Metagenome-assembled genomes (MAGs) recovered from P. lutea and I. palifera skeleton. a) 376 bacterial MAGs, with genome completeness, GC content, and genes-of-interest and b) 17 archaeal MAGs with the presence of ammonia oxidising gene AmoA....

Additional file 1 of Subcutaneous fat necrosis in newborns: a systematic literature review of case reports and model of pathophysiology

Leonie Frank, Stephanie Brandt & Martin Wabitsch
Additional file 1: Table S1. Included publication in analysis of the research question. Table S2. Excluded references and reason for exclusion.

Additional file 4 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 4: Fig. S3A. Gene Ontology analysis of genes hyper- (A) and hypomethylated (B) of T-LGL patients. Significant Biological processes (GO database) enriched in genes associated with significantly differentially methylated CpG loci in T-LGL. Enrichment represented as odds ratio. Point size represents the gene count of each pathway. Enrichment p value obtained by overrepresentation analysis [30], represented by point color. A Gene Ontology analysis of hypermethylated genes in T-LGL.

Additional file 6 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 6: Fig. S4. Differential gene expression of IL6 between T-LGL and healthy donor-derived CD8+ memory T cells. Differential gene expression for IL6 was measured by qPCR. Bulk CD8+ cells from two healthy donors were used for comparison. In line with previous publications, the T-LGLL cohort analyzed exhibits a higher IL6 expression compared to healthy donor-derived C8+ cells. HD Healthy donor.

Additional file 7 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 7: Fig. S5A. (A and B): Location of differentially methylated CpG loci in the genes BCL11B and C14orf64 (LINC01550). A Significant differentially methylated CpGs in BCL11B (T-LGLL compared to CD8+. memory T cells) were located in the gene body and assigned as enhancers by ENCODE, which match as enhancers in CD8-positive memory cells.

Additional file 8 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 8: Fig. S5B. (A and B): Location of differentially methylated CpG loci in the genes BCL11B and C14orf64 (LINC01550). B Significant differentially methylated CpGs in C14orf64 (LINC01550) (T-LGL compared to CD8 pos. memory T cells).

Additional file 1 of Mobilisation of critically ill patients receiving norepinephrine: a retrospective cohort study

Maximilian Lindholz, Clara M. Schellenberg, Julius J. Grunow, Simone Kagerbauer, Annette Milnik, Daniel Zickler, Stefan Angermair, Anett Reißhauer, Martin Witzenrath, Mario Menk, Sebastian Boie, Felix Balzer & Stefan J. Schaller
Additional file 1. Table S1. Individual elements of the Elixhauser index. Table S2. All Admission diagnoses with n > 50.

Additional file 10 of Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann
Additional file 10: Fig. S6. Expression correlation between BCL11B & C14ORF64 (LINC01550). Expression correlation between BCL11B & C14ORF64 (LINC01550) in 426 human datasets with 42563 samples from R2: Genomics analysis and visualization platform (https://hgserver1.amc.nl/cgi-bin/r2/main.cgi).

Visinin-like protein 1 levels in blood and CSF as emerging markers for Alzheimer’s and other neurodegenerative diseases

Steffen Halbgebauer, Petra Steinacker, Daniel Riedel, Patrick Oeckl, Sarah Anderl-Straub, Jolina Lombardi, Christine A. F. von Arnim, Magdalena Nagl, Armin Giese, Albert C. Ludolph & Markus Otto
Abstract Background Visinin-like protein 1 (VILIP-1) belongs to the group of emerging biomarkers with the potential to support the early diagnosis of Alzheimer’s disease (AD). However, studies investigating the differential diagnostic potential in cerebrospinal fluid (CSF) are rare and are not available for blood. Methods We set up a novel, sensitive single molecule array (Simoa) assay for the detection of VILIP-1 in CSF and serum. In total, paired CSF and serum samples from 234 patients...

Additional file 1 of Visinin-like protein 1 levels in blood and CSF as emerging markers for Alzheimer’s and other neurodegenerative diseases

Steffen Halbgebauer, Petra Steinacker, Daniel Riedel, Patrick Oeckl, Sarah Anderl-Straub, Jolina Lombardi, Christine A. F. von Arnim, Magdalena Nagl, Armin Giese, Albert C. Ludolph & Markus Otto
Additional file 1: Supplementary material. Description of assay parallelism and pre-analytical stability.

Additional file 2 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading & Francesco Roselli
Additional file 2: Figure S2. Blunting neuronal nuclear calcium signaling did not alter IBA1+/TMEM119+ cell density and percentage in the perilesional area post-TBI. A) Depiction of the regions of interest: the core area of the injury and the perilesional areas 200µm away from the injury axis. Scale bar 200µm. B) No significant difference in IBA1+ and IBA1+/CD169+ cell density in the perilesional area 24h post injury (IBA1+: CS= 4.10 ± 0.47, CT = 6.73 ±...

Additional file 2 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading & Francesco Roselli
Additional file 2: Figure S2. Blunting neuronal nuclear calcium signaling did not alter IBA1+/TMEM119+ cell density and percentage in the perilesional area post-TBI. A) Depiction of the regions of interest: the core area of the injury and the perilesional areas 200µm away from the injury axis. Scale bar 200µm. B) No significant difference in IBA1+ and IBA1+/CD169+ cell density in the perilesional area 24h post injury (IBA1+: CS= 4.10 ± 0.47, CT = 6.73 ±...

Additional file 4 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading & Francesco Roselli
Additional file 4: Figure S4. Neuronal expression of osteoprotegerin is upregulated by nuclear calcium signaling and neuronal activity in TBI. A) Negative Control, baseline OPG (TNFRSF11B) signal and a positive Control of the in situ hybridization 24h post injury. B) OPG (TNFRSF11B) in situ signal is mainly found in neuronal sources (neuronal vs non-neuronal 75.38 ± 1.83% vs 24.62% ± 1.83%). N=5. C)-D) Significant increase of OPG (TNFRSF11b) mRNA density 24h post-TBI compared to sham...

Additional file 6 of Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading & Francesco Roselli
Additional file 6: Table S1. Neurological Severity Score. All results of the Neurological Severity Score (NSS) are listed for each experimental cohort as total scores per mice in each treatment. Mice killed at either 3h or 24h had their NSS scored at 3h. Mice killed at 7d had their NSS scored at 3h, 2d, 5d and 7d.

Registration Year

  • 2022
    184

Resource Types

  • Text
    80
  • Image
    38
  • Collection
    32
  • Dataset
    31
  • Audiovisual
    2
  • Other
    1

Affiliations

  • University of Ulm
    184
  • University Hospital Ulm
    46
  • Hong Kong University of Science and Technology
    40
  • University of Gothenburg
    40
  • University College London
    40
  • Medical University of Graz
    40
  • Innsbruck Medical University
    40
  • National Hospital for Neurology and Neurosurgery
    40
  • Sahlgrenska University Hospital
    40
  • Heidelberg University
    38