Additional file 3. (Focus Group Interview- and Field Note Guide): the same guide is used for both focus group interviews and field notes, based on the Normalization Process Theory.

Additional file 1. PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) 2015 checklist.

Additional file 1. PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) 2015 checklist.

Additional file 2. Search strategy for all electronic databases.

Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

Supplementary Material 1

Additional file 1.

Poor school performance is linked to higher risks of self-harm. The association might be explained through genetic liabilities for depression or educational attainment. We investigated the association between school performance and self-harm in a population-based sample while assessing the potential influence of polygenic risk scores (PRSs) for depression (PRSMDD) and for educational attainment (PRSEDU). We conducted a follow-up study of individuals born 1987–98 and followed from age 18 until 2016. The total sample consisted of...

Research Data for Interventional treatment of keratoacanthoderma: a case report by Dan Mei, Lei Song, Jin-Qi Gao and Jie Wu in Journal of International Medical Research

Additional file 1: Figure S1. Venn diagram of gene lists linked to type 2 diabetes by different types of evidence. Figure S2. Heterozygosity inferred by comparing the paternal and maternal scaffolded contigs, shown on the paternal scaffolds. Figure S3. Length distributions of structural variants. Figure S4. Functional classification of duplicated genes. Figure S5. Sequence alignment of Nile rat Gckr proteins to 113 mammalian orthologs. Figure S6. Missing Nile rat Hadh gene present in alternate haplotype...

Additional file 1: Figure S1. Proportions within LDL-C thresholds among the type 1 diabetes population by lipidlowering drug use.

Additional file 3: Table S1. Risk factors and corresponding Nomenclature for Properties and Units codes.

Additional file 4: Table S2. International Classification of Diseases 10th revision (ICD-10) codes and Danish procedure codes used to define micro- and macrovascular complications.

Abstract Background Cerebellar abiotrophy (CA) is an uncommon hereditary neurodegenerative disorder affecting the cerebellar Purkinje cells. Equine CA has been reported in several breeds, but a genetic etiology has only been confirmed in the Arabian breed, where CA is caused by an autosomal recessive mutation. Case presentation. Clinical and histological findings consistent with CA are reported in an 8.5-month-old Icelandic filly. The filly showed a perceived sudden onset of marked head tremor, incoordination, ataxia, lack...

Additional file1. Table S1: Characteristics and prevalence of pre- and postmenopausal breast cancer among women included in the analyses of birthweight and women who could potentially have been included in these analyses. Table S2: Characteristics and prevalence of pre- and postmenopausal breast cancer among women included in the analyses of puberty markers and women who could potentially have been included in these analyses. Table S3: Characteristics of women with and without information on ER status...

Description of the participants (number of respondents in each demographic category) who took part in the survey. ;Overview of number of correct responses, incorrect responses and questions answered as ‘not sure’, for each species and each dimension.;Summary of the model outputs.

Vocalizations constitute an effective way to communicate both emotional arousal (bodily activation) and valence (negative/positive). There is strong evidence suggesting that the convergence of coding of emotional arousal among animal species occurs, hence enabling cross-species perception of arousal, but it is not clear if the same is true for emotional valence. Here, we conducted a large online survey to test the ability of humans to perceive emotions in the contact calls of several wild and...

Abstract Background The cold pressor test (CPT) is a widely used pain provocation test to investigate both pain tolerance and cardiovascular responses. We hypothesize, that performing multi-omic analyses during CPT gives the opportunity to home in on molecular mechanisms involved. Twenty-two females were phenotypically assessed before and after a CPT, and blood samples were taken. RNA-Sequencing, steroid profiling and untargeted metabolomics were performed. Each ‘omic level was analyzed separately at both single-feature and systems-level (principal...

Additional file 2: Additional file 2. Clinical scoring of pig health.

Abstract Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 108 CFU or 1010 CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 pigs), pigs were inoculated with ETEC F4ab or F4ac. Across trials, all inoculated pigs that developed ETEC diarrhea were CHCF1...

Background:Many children and adolescents with incurable cancer and their families prefer to receive end-of-life care and to die at home. This implies a transition of care from hospital to home and presupposes the establishment of a well-functioning collaboration between the family and professionals across health care sectors.Aim:To identify and explore key elements of home-based end-of-life care collaboration for children with cancer, as experienced by their parents and grandparents and the hospital- and community-based professionals involved.Design:Descriptive...

Additional file 1: Table S1. Allocation of the fish at the start of the experiment. Table S2. Analysis of the composition of the β-glucan used in this study. Figure S3. Principal component analysis showing the microbiota of the fish at week 6. Figure S4. Heatmap showing the 10 most abundant bacterial phyla in the intestine of the fish for the two control groups and the groups receiving the three different concentration of β-glucan. Table S5....

Additional file 1. Supplementary material A 1: Self-complete questionnaire for surgical patients

Abstract Background Subjects with Type 1 diabetes mellitus (T1DM) have an increased incidence of heart failure (HF). Several pathophysiological mechanisms have been involved in its development. The aim of this study was to analyze the potential contribution of the advanced lipoprotein profile and plasma glycosylation (GlycA) to the presence of subclinical myocardial dysfunction in subjects with T1DM. Methods We included subjects from a Danish cohort of T1DM subjects (Thousand & 1 study) with either diastolic...