73 Works

Causal effect of familial short stature on three quantitative traits in Taiwan

Jian-Shiun Chiou, Chen-Hsing Chou, Ting-Yuan Liu, Hsing-Fang Lu, Jan-Gowth Chang, Wen-Miin Liang, Jai-Sing Yang, I-Ching Chou, Cheng-Wen Lin, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Chang-Hai Tsai, Kai-Cheng Hsu, Mu-Lin Chiu, Ying-Ju Lin & Fuu-Jen Tsai
Objectives: With the accumulation of genetic basis for familial (genetic) short stature (FSS), the genetic association of FSS with health-related outcomes remains to be elucidated. In this study, we aimed to investigate the FSS genetic architecture and its causal effect on three quantitative traits in Taiwan. Methods: We conducted an FSS genome-wide association study (GWAS) analysis (1,640 FSS cases and 22,372 controls). We performed a GWAS meta-analysis for the Taiwanese meta-height from the Taiwan Biobank...

Additional file 3 of Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang & Shun-Jen Chang
Additional file 3: Supplementary Table 3. The susceptible variants significantly associated with hyperuricemia comparedto normal.

Additional file 4 of Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang & Shun-Jen Chang
Additional file 4: Supplementary Table 4. The susceptible variants significantly associated with gout compared tohyperuricemia.

Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang & Shun-Jen Chang
Abstract Background Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status. We performed a genome-wide association study (GWAS) and polygenic risk score (PRS) analysis to illustrate the new genetic architectures of gout and asymptomatic hyperuricemia (AH). Methods GWAS was performed to identify variants associated with gout/AH compared with normouricemia. The participants were males, enrolled from the Taiwan Biobank and China Medical University,...

Additional file 3 of Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages

Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Hui-Fang Kao, Li-Fan Liu, Zhi-Gang Liu, Wen-Yih Jeng & Jiu-Yao Wang
Additional file 3: Table S1. Experimental protocol of ion-exchange chromatography. Table S2. Experimental protocol of size-exclusion chromatography. Table S3. Data collection and refinement statistics of the LGp40 crystal. Figure S1. IL-12p40 levels of crude extracts used to stimulate mouse BMDC. Figure S2. Ion-exchange chromatography of crude extracts on a DEAE-Sepharose Fast Flow column. Figure S3. IL-12p40 levels of IE1-1 to IE4-2 fractions (fractions from ion-exchange chromatography) used to stimulate mouse BMDC. Figure S4. Size-exclusion chromatography...

Additional file 1 of Global child and adolescent mental health perspectives: bringing change locally, while thinking globally

Sowmyashree Mayur Kaku, Jordan Sibeoni, Salah Basheer, Jane Pei-Chen Chang, Dulangi Maneksha Amerasinghe Dahanayake, Matias Irarrazaval, Jamie M Lachman, Boladale Moyosore Mapayi, Anilena Mejia, Massimiliano Orri, Tze Jui-Goh, Md Saleh Uddin & Inge Vallance
Supplementary Material 1

Additional file 1 of Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis

Changcheng Guo, Yin Sun, Wei Zhai, Xudong Yao, Dongkui Gong, Bosen You, Chi-Ping Huang, Junhua Zheng & Chawnshang Chang
Additional file 1: Figure S1. The expression of protein level related to AR. (A) The AR protein level expression under hypoxia (H) and normoxia (N) in OSRC-2 and SW839 cells. (B) The EZH2 and SRC expression under hypoxia (H) and normoxia (N) in OSRC-2 cells. (C) The efficiency of shRNA-AR at the protein level (left) in SW839 cells and the efficiency of oe-AR in OSRC-2 cells (right) determined at mRNA level. (D) The HIF1α expression...

Additional file 2 of Global child and adolescent mental health perspectives: bringing change locally, while thinking globally

Sowmyashree Mayur Kaku, Jordan Sibeoni, Salah Basheer, Jane Pei-Chen Chang, Dulangi Maneksha Amerasinghe Dahanayake, Matias Irarrazaval, Jamie M Lachman, Boladale Moyosore Mapayi, Anilena Mejia, Massimiliano Orri, Tze Jui-Goh, Md Saleh Uddin & Inge Vallance
Supplementary Material 2

Global child and adolescent mental health perspectives: bringing change locally, while thinking globally

Sowmyashree Mayur Kaku, Jordan Sibeoni, Salah Basheer, Jane Pei-Chen Chang, Dulangi Maneksha Amerasinghe Dahanayake, Matias Irarrazaval, Jamie M Lachman, Boladale Moyosore Mapayi, Anilena Mejia, Massimiliano Orri, Tze Jui-Goh, Md Saleh Uddin & Inge Vallance
Abstract Child and adolescent mental health (CAMH) are a global priority. Different countries across the globe face unique challenges in CAMH services that are specific to them. However, there are multiple issues that are also similar across countries. These issues have been presented in this commentary from the lens of early career CAMH professionals who are alumni of the Donald J Cohen Fellowship program of the IACAPAP. We also present recommendations that can be implemented...

Diabetes management behaviors associated with depression in the U.S.

Tim C. Lai, Cassidi C. McDaniel & Chiahung Chou
Abstract Background There is a lack of nationally representative evidence from the U.S. investigating the relationships between depression and diabetes management behaviors. Our study aimed to assess the associations between diabetes management behaviors and depression status, and to compare U.S. population-level percentages of diabetes management behaviors among patients with and without depression. Methods A cross-sectional study was conducted using population-based survey data to assess patient-reported variables retrospectively. We used the Behavioral Risk Factor Surveillance System...

Additional file 1 of Diabetes management behaviors associated with depression in the U.S.

Tim C. Lai, Cassidi C. McDaniel & Chiahung Chou
Additional file 1. Table S1. BRFSS survey questions for the diabetes management behaviors and the number of missing values. Table S2. BRFSS survey questions for covariates and the number of missing values.

Additional file 1 of Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang & Shun-Jen Chang
Additional file 1: Supplementary Table1. The distribution of age and uric acid of those participated in the studycohort.

Additional file 6 of Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang & Shun-Jen Chang
Additional file 6: SupplementaryFigure 1. The linkage disequilibrium of the four variants significantlyassociated with gout in genes DNAJC16 and AGMAT. The variant rs7546668 showedhigh associations with the other three variants (r2 >=0.68). Thered line indicates the cut-off significant p-value by 1e-8.

Additional file 6 of Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang & Shun-Jen Chang
Additional file 6: SupplementaryFigure 1. The linkage disequilibrium of the four variants significantlyassociated with gout in genes DNAJC16 and AGMAT. The variant rs7546668 showedhigh associations with the other three variants (r2 >=0.68). Thered line indicates the cut-off significant p-value by 1e-8.

Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang & Shun-Jen Chang
Abstract Background Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status. We performed a genome-wide association study (GWAS) and polygenic risk score (PRS) analysis to illustrate the new genetic architectures of gout and asymptomatic hyperuricemia (AH). Methods GWAS was performed to identify variants associated with gout/AH compared with normouricemia. The participants were males, enrolled from the Taiwan Biobank and China Medical University,...

Additional file 1 of CLIN_SKAT: an R package to conduct association analysis using functionally relevant variants

Amrita Chattopadhyay, Ching-Yu Shih, Yu-Chen Hsu, Jyh-Ming Jimmy Juang, Eric Y. Chuang & Tzu-Pin Lu
Additional file 1: Table S1. List of functions and corresponding GitHub links. Table S2. Complete list of gene sets from MsigDb to be used in function: relate2GeneDisease, for obtaining pathway analysis results. Table S3. Details of global populations for calculating weights to be utilized in case–control analysis. Figure S1. CLIN_SKAT gene plots. Bar plots depicting P value of each of the significant genes obtained after CLIN_SKAT analysis. Figure S2. Power plots comparing CLIN_SKAT and SKAT....

Additional file 1 of Identification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus

Wei-Chung Chiou, Hsu-Feng Lu, Jui-Chieh Chen, Yu-Heng Lai, Ming-Fu Chang, Yuan-Li Huang, Ni Tien & Cheng Huang
Additional file 1. Fig. S1. Binding of HDV-I, HDV-II, and HDV-III HDAg-L to CHC.

Additional file 2 of Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages

Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Hui-Fang Kao, Li-Fan Liu, Zhi-Gang Liu, Wen-Yih Jeng & Jiu-Yao Wang
Additional file 2. Details of RNA-seq analysis.

Identification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus

Wei-Chung Chiou, Hsu-Feng Lu, Jui-Chieh Chen, Yu-Heng Lai, Ming-Fu Chang, Yuan-Li Huang, Ni Tien & Cheng Huang
Abstract Background Hepatitis delta virus (HDV), a satellite virus of hepatitis B virus (HBV), is a small, defective RNA virus strongly associated with the most severe form of hepatitis and progressive chronic liver disease and cirrhosis. Chronic hepatitis D, resulting from HBV/HDV coinfection, is considered to be the most severe form of viral hepatitis and affects 12–20 million people worldwide. Involved in the endocytosis and exocytosis of cellular and viral proteins, clathrin contributes to the...

Additional file 4 of Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages

Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Hui-Fang Kao, Li-Fan Liu, Zhi-Gang Liu, Wen-Yih Jeng & Jiu-Yao Wang
Additional file 4. Raw data of sub-fraction IE3-3G1 proteomics analysis using LC–MS/MS.

Additional file 1 of Global child and adolescent mental health perspectives: bringing change locally, while thinking globally

Sowmyashree Mayur Kaku, Jordan Sibeoni, Salah Basheer, Jane Pei-Chen Chang, Dulangi Maneksha Amerasinghe Dahanayake, Matias Irarrazaval, Jamie M Lachman, Boladale Moyosore Mapayi, Anilena Mejia, Massimiliano Orri, Tze Jui-Goh, Md Saleh Uddin & Inge Vallance
Supplementary Material 1

sj-docx-1-ict-10.1177_15347354221132790 – Supplemental material for The Use of Traditional Chinese Medicine in Patients with Oral, Oropharynx, Nasopharynx, and Hypopharynx Cancers: A Retrospective Longitudinal Cohort Study in Taiwan

Eyal Ben-Arie, Chanya Inprasit, Bernice Lottering, Hei-Tung Yip, Wen-Chao Ho, Yu-Chen Lee & Pei-Yu Kao
Supplemental material, sj-docx-1-ict-10.1177_15347354221132790 for The Use of Traditional Chinese Medicine in Patients with Oral, Oropharynx, Nasopharynx, and Hypopharynx Cancers: A Retrospective Longitudinal Cohort Study in Taiwan by Eyal Ben-Arie, Chanya Inprasit, Bernice Lottering, Hei-Tung Yip, Wen-Chao Ho, Yu-Chen Lee and Pei-Yu Kao in Integrative Cancer Therapies

Additional file 1 of Adverse outcomes after non-hepatic surgeries in patients with alcoholic liver diseases: a propensity-score matched study

Hsin-Yun Wu, Chuen-Chau Chang, Chun-Chieh Yeh, Ming-Yao Chen, Yih-Giun Cherng, Ta-Liang Chen & Chien-Chang Liao
Additional file 1. Table S1. Codes of liver-related surgical procedure. Table S2. Liver-related characteristics of surgical patients with and without preoperative alcoholic liver disease. Table S3. Risks of postoperative mortality for surgical patients with the severity of alcoholic liver disease. Table S4. Risks of postoperative adverse events for surgical patients with the severity of alcoholic liver disease

Adverse outcomes after non-hepatic surgeries in patients with alcoholic liver diseases: a propensity-score matched study

Hsin-Yun Wu, Chuen-Chau Chang, Chun-Chieh Yeh, Ming-Yao Chen, Yih-Giun Cherng, Ta-Liang Chen & Chien-Chang Liao
Abstract Background The influence of alcoholic liver disease (ALD) on the postoperative outcomes is not completely understood. Our purpose is to evaluate the complications and mortality after nonhepatic surgeries in patients with ALD. Methods We conducted a retrospective cohort study included adults aged 20 years and older who underwent nonhepatic elective surgeries using data of Taiwan’s National Health Insurance, 2008–2013. Using a propensity-score matching procedure, we selected surgical patients with ALD (n = 26,802); or...

Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis

Changcheng Guo, Yin Sun, Wei Zhai, Xudong Yao, Dongkui Gong, Bosen You, Chi-Ping Huang, Junhua Zheng & Chawnshang Chang
Abstract Background Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasis, but its linkage to RCC progression under hypoxia, remains unclear. Results Here we found AR expression in RCC cells decreased in response to hypoxia, which might then lead to increase the cancer stem cells (CSC) phenotype through the lncTCFL5-2-modulated YBX1/SOX2 signals. The consequences of such hypoxia-modulated AR/lncTCFL5-2/YBX1/SOX2 signals ablity to alter the CSC phenotype might render...

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