1,061 Works

Additional file 6 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 6. Figure S3: Prognostic values of postsurgical ctDNA detection at 3 months and 6 months. A-B) The recurrence-free survival analysis (top panel) and multi-variant Cox regression (bottom panel) of postsurgical ctDNA detection at 3 months (A) and 6 months (B). For the analysis at 6 months after surgeries, only patients with plasma samples available at this scheduled point and followed-up for more than 6 months were included. Abbreviations: RFS – recurrence-free survival, LNM...

Additional file 10 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 10. Figure S7: Prognostic value of presurgical ctDNA detection. A). The recurrence-free survival analysis of patients stratified by presurgical ctDNA detection. B). The multi-variant Cox regression for presurgical ctDNA detection. Abbreviations: RFS – recurrence-free survival, LNM – lymph node metastasis, LUAD – lung adenocarcinoma, LUSC - lung squamous-cell carcinoma.

Additional file 13 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 13. Supplementary results.

Additional file 1 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 1. Table S1: Patient demography.

Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults

Binbin Su, Xiaoxuan Zhu, Kai Yang, Yunfan Xiao, Chunmei Li, Keai Shi, Jia Qu, Fan Lu, Ming Li & Lele Cui
Abstract Background To assess age- and sex-related changes in the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP) in healthy Chinese adults. Methods In this cross-sectional study, all data were derived from the community-based Jidong Eye Cohort Study. Participants underwent optical coherence tomography angiography (OCTA) and other ocular and systemic examinations. The vessel densities of the whole measured area, parafovea, and four quadrants in the SCP and DCP were measured. Results We...

Additional file 1 of Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults

Binbin Su, Xiaoxuan Zhu, Kai Yang, Yunfan Xiao, Chunmei Li, Keai Shi, Jia Qu, Fan Lu, Ming Li & Lele Cui
Additional file 1: Figure S1. Vessel densities of the whole measured area, parafovea, and four quadrants (temporal, superior, nasal, and inferior) in the (a, c) SCP and (b, d) DCP measured with optical coherence tomography angiography stratified by age in males and females. Table S1. Baseline characteristics of male participants in the study. Table S2. Baseline characteristics of female participants in the study. Table S3. Vessel densities of the whole measured area, parafovea, and four...

Mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation

Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han & Sizhou Feng
Abstract Background Mucosal-associated invariant T (MAIT) cells are innate-like T cells, some studies have reported that the number of circulating MAIT cells reduced in patients with acute graft-versus-host-disease (aGVHD) development. However, the role of donor MAIT cells on aGVHD development and subsequent functional change still remain unclear. Methods The study recruited 86 patients with hematological malignancies who underwent allogeneic hematopoietic cell transplantation (HCT) from May 1, 2018 to June 30, 2019. MAIT cells, their subset,...

Additional file 2 of MetaRNN: differentiating rare pathogenic and rare benign missense SNVs and InDels using deep learning

Chang Li, Degui Zhi, Kai Wang & Xiaoming Liu
Additional file 2: Includes 9 figures of additional results. The names of the figures are: Figure S1. Performance (AUC) of different methods benchmarked using the rare nsSNV test set (RNTS, test set 1); Figure S2. Performance (AUC) of different methods benchmarked using the de-novo rare ClinVar test set (DN-RCTS, test set 3); Figure S3. Performance (precision-recall curve) of different methods benchmarked using the de-novo rare ClinVar test set (DN-RCTS, test set 3); Figure S4. Performance...

MetaRNN: differentiating rare pathogenic and rare benign missense SNVs and InDels using deep learning

Chang Li, Degui Zhi, Kai Wang & Xiaoming Liu
Abstract Multiple computational approaches have been developed to improve our understanding of genetic variants. However, their ability to identify rare pathogenic variants from rare benign ones is still lacking. Using context annotations and deep learning methods, we present pathogenicity prediction models, MetaRNN and MetaRNN-indel, to help identify and prioritize rare nonsynonymous single nucleotide variants (nsSNVs) and non-frameshift insertion/deletions (nfINDELs). We use independent test sets to demonstrate that these new models outperform state-of-the-art competitors and achieve...

Additional file 1 of Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization

Anna C. F. Lewis, Emma F. Perez, Anya E. R. Prince, Hana R. Flaxman, Lizbeth Gomez, Deanna G. Brockman, Paulette D. Chandler, Benjamin J. Kerman, Matthew S. Lebo, Jordan W. Smoller, Scott T. Weiss, Carrie L. Blout Zawatksy, James B. Meigs, Robert C. Green, Jason L. Vassy & Elizabeth W. Karlson
Additional file 1: Tables S1 and S2. Further information on patient survey items; Patient interview guide, with mock report designs; Primary Care Physician interview guide, with mock report designs.

Cannabidiol attenuates methamphetamine-induced conditioned place preference in male rats and viability in PC12 cells through the Sigma1R/AKT/GSK3β/CREB signaling pathway

Liu Liu, Juan Li, Chan Wang, Yue Xu, Chi-Kwan Leung, Genmeng Yang, Shucheng Lin, Shuwei Zhang, Yi Tan, Huijie Zhang, Haowei Wang, Jianxing Liu, Ming Li & Xiaofeng Zeng
Background: Methamphetamine use is associated with several negative consequences, including neurotoxicity and greater probability of exhibiting a substance use disorder. Sigma1 receptor is involved in the neurobiological basis of several drug use disorders. Cannabidiol has received attention in the treatment of drug use disorders and neurotoxicity. Objectives: To investigate the effects of cannabidiol on methamphetamine-induced conditioned place preference (CPP) and the viability of PC12 cells. Methods: Adult male rats (n = 70) underwent methamphetamine (2...

Disparities in Loss to Follow-Up Among Adults With Congenital Heart Disease in North Carolina

J.D. Serfas, Toi Spates, Alfred D’Ottavio, Tracy Spears, Elizabeth Ciociola, Karen Chiswell, Linda Davidson-Ray, Grace Ryan, Nina Forestieri, Richard A. Krasuski, Alex R. Kemper, Timothy M. Hoffman, Michael J. Walsh, Charlie J. Sang, Karl F. Welke & Jennifer S. Li
BackgroundThe AHA/ACC Adult Congenital Heart Disease guidelines recommend that most adults with congenital heart disease (CHD) follow-up with CHD cardiologists every 1 to 2 years because longer gaps in care are associated with adverse outcomes. This study aimed to determine the proportion of patients in North Carolina who did not have recommended follow-up and to explore predictors of loss to follow-up.MethodsPatients ages ≥18 years with a healthcare encounter from 2008 to 2013 in a statewide...

New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

Hamada H. H. Mohammed, Amer Ali Abd El-Hafeez, Kareem Ebeid, Aml I. Mekkawy, Mohammed A. S. Abourehab, Emad I. Wafa, Suhaila O. Alhaj-Suliman, Aliasger K. Salem, Pradipta Ghosh, Gamal El-Din A. Abuo-Rahma, Alaa M. Hayallah & Samar H. Abbas
A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC50s ranged from 2.53-8.67 µM, 8.67–62.47 µM, and 4.19–24.37 µM for HCT116, HT29, and Caco-2 cells; respectively, whereas the doxorubicin, showed IC50 values of 1.22, 0.88, and 4.15 µM. Compounds 4a, 4b, 4e, 4i, and 4j were the most potent against HCT116 with IC50 values of 3.57, 4.81, 4.32,...

A survey of resident physicians’ perceptions of competency-based education in standardized resident training in China: a preliminary study

Qi Chen, Ming Li, Na Wu, Xue Peng, GuangMin Tang, Heng Cheng, LiuLing Hu, Bin Yang & ZhongLi Liao
Abstract Background Understanding resident physicians’ perceptions of competency-based medical education(CBME) may help improve approaches for implementing such education in standardized resident training (SRT). We conducted surveys of residents in China to identify their perceptions of CBME and determine the degree to which such education impacts their career plans. Methods Questionnaire contained a total of 24 questions, which were answered using multiple choice or yes/no, was distributed to residents who were undergoing SRT, regardless of specialty,...

Additional file 1 of A survey of resident physicians’ perceptions of competency-based education in standardized resident training in China: a preliminary study

Qi Chen, Ming Li, Na Wu, Xue Peng, GuangMin Tang, Heng Cheng, LiuLing Hu, Bin Yang & ZhongLi Liao
Additional file 1.

Additional file 4 of Vikrahraun—the 1961 basaltic lava flow eruption at Askja, Iceland: morphology, geochemistry, and planetary analogs

Aline Y. Blasizzo, Ingrid A. Ukstins, Stephen P. Scheidt, Alison H. Graettinger, David W. Peate, Tamara L. Carley, Adam J. Moritz & Jennifer E. Thines
Additional file 4: A detailed methodology section outlining each analytical dataset individually.

Additional file 5 of Vikrahraun—the 1961 basaltic lava flow eruption at Askja, Iceland: morphology, geochemistry, and planetary analogs

Aline Y. Blasizzo, Ingrid A. Ukstins, Stephen P. Scheidt, Alison H. Graettinger, David W. Peate, Tamara L. Carley, Adam J. Moritz & Jennifer E. Thines
Additional file 5: Contains supplementary Fig. S1–S5 and associated captions

Additional file 2 of Vikrahraun—the 1961 basaltic lava flow eruption at Askja, Iceland: morphology, geochemistry, and planetary analogs

Aline Y. Blasizzo, Ingrid A. Ukstins, Stephen P. Scheidt, Alison H. Graettinger, David W. Peate, Tamara L. Carley, Adam J. Moritz & Jennifer E. Thines
Additional file 2: Textural data presented in this paper, including crystallinity, vesicularity, density, and viscosity calculations

Research Data for Superselective arterial microcoil embolization for delayed bleeding after peroral endoscopic myotomy

Xuechen Liu, Yonghong Zhou, Xiaoyu Jiang, Li Liu, Dongqiang Zhao, Huihui Ma, Hui Tian & Huiqing Jiang
Research Data for Superselective arterial microcoil embolization for delayed bleeding after peroral endoscopic myotomy by Xuechen Liu, Yonghong Zhou, Xiaoyu Jiang, Li Liu, Dongqiang Zhao, Huihui Ma, Hui Tian and Huiqing Jiang in Journal of International Medical Research

The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery

Mingke Li, Yawei Dai, Shuai Hu, Yansong Li, Dasheng Lu, Rui Zheng & Kai Wang
IntroductionBleeding after heart valve surgery is a serious clinical challenge. Hypocalcemia has been associated with the extent of bleeding in patients with spontaneous intracerebral hemorrhage. However, the association between blood calcium levels and bleeding extent in heart valve replacement patients has not been clearly established. This study aimed at determining the association between blood calcium levels and perioperative hemorrhage after heart valve replacement therapy.MethodsBased on preoperative blood calcium levels, patients were grouped into the hypocalcemia...

Cyber Bird Concerto (1994) - II. Bird in Grief

Jichen Zhang & Takashi Yoshimatsu
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

Additional file 2 of Transcriptional dynamics of transposable elements when converting fibroblast cells of Macaca mulatta to neuroepithelial stem cells

Dahai Liu, Li Liu, Kui Duan, Junqiang Guo, Shipeng Li, Zhigang Zhao, Xiaotuo Zhang, Nan Zhou & Yun Zheng
Additional file 2 Supplementary Figure S1. The expression levels of LTRs in the Cluster L4 of Figure 3A. Supplementary Figure S2. The primers used to validate the expressions of 13 MacERV3 LTRs. (A) The alignment of the forward primer MacERV3_LTR2_34_F and the 13 MacERV3 LTRs. (B) The alignment of the reverse primer MacERV3_LTR2_34_R and the 13 MacERV3 LTRs. (C) The precise loci of the two primers in one of the selected MacERV3 LTRs, MacERV3_LTR2_34. Supplementary...

Direct-reading instruments for aerosols: A review for occupational health and safety professionals part 2: Applications

Maura J. Sheehan, Donna J. H. Vosburgh, Patrick T. O’Shaughnessy, Jae Hong Park & Cathy Sotelo
Direct reading instruments (DRIs) for aerosols have been used in industrial hygiene practice for many years, but their potential has not been fully realized by many occupational health and safety professionals. Although some DRIs quantify other metrics, this article will primarily focus on DRIs that measure aerosol number, size, or mass. This review addresses three applications of aerosol DRIs that occupational health and safety professionals can use to discern, characterize, and document exposure conditions and...

sj-docx-1-tam-10.1177_17588359221132628 – Supplemental material for Data collection framework for electronic medical record-based real-world data to evaluate the effectiveness and safety of cancer drugs: a nationwide real-world study of the Korean Cancer Study Group

Hye Sook Han, Kyoung Eun Lee, Young Ju Suh, Hee-Jung Jee, Bum Jun Kim, Hyeong Su Kim, Keun-Wook Lee, Min-Hee Ryu, Sun Kyung Baek, In Hae Park, Hee Kyung Ahn, Jae Ho Jeong, Min Hwan Kim, Dae Hyung Lee, Siheon Kim, Hyemi Moon, Serim Son, Ji-Hye Byun, Dong Sook Kim, Hyonggin An, Yeon Hee Park & Dae Young Zang
Supplemental material, sj-docx-1-tam-10.1177_17588359221132628 for Data collection framework for electronic medical record-based real-world data to evaluate the effectiveness and safety of cancer drugs: a nationwide real-world study of the Korean Cancer Study Group by Hye Sook Han, Kyoung Eun Lee, Young Ju Suh, Hee-Jung Jee, Bum Jun Kim, Hyeong Su Kim, Keun-Wook Lee, Min-Hee Ryu, Sun Kyung Baek, In Hae Park, Hee Kyung Ahn, Jae Ho Jeong, Min Hwan Kim, Dae Hyung Lee, Siheon Kim, Hyemi...

Data collection framework for electronic medical record-based real-world data to evaluate the effectiveness and safety of cancer drugs: a nationwide real-world study of the Korean Cancer Study Group

Hye Sook Han, Kyoung Eun Lee, Young Ju Suh, Hee-Jung Jee, Bum Jun Kim, Hyeong Su Kim, Keun-Wook Lee, Min-Hee Ryu, Sun Kyung Baek, In Hae Park, Hee Kyung Ahn, Jae Ho Jeong, Min Hwan Kim, Dae Hyung Lee, Siheon Kim, Hyemi Moon, Serim Son, Ji-Hye Byun, Dong Sook Kim, Hyonggin An, Yeon Hee Park & Dae Young Zang
Background:Electronic medical records (EMRs) have the highest value among real-world data (RWD). The aim of the present study was to propose a data collection framework of EMR-based RWD to evaluate the effectiveness and safety of cancer drugs by conducting a nationwide real-world study based on the Korean Cancer Study Group.Methods:We considered all patients who received ramucirumab plus paclitaxel (RAM/PTX) for gastric cancer and trastuzumab emtansine (T-DM1) for breast cancer at relevant institutions in South Korea....

Registration Year

  • 2022
    382
  • 2021
    212
  • 2020
    191
  • 2019
    86
  • 2018
    155
  • 2017
    8
  • 2016
    5
  • 2015
    7
  • 2014
    4
  • 2013
    4

Resource Types

  • Sound
    646
  • Dataset
    156
  • Text
    132
  • Collection
    67
  • Image
    44
  • Audiovisual
    12
  • Journal Article
    2
  • Other
    1
  • Report
    1

Affiliations

  • University of Iowa
    1,061
  • Fudan University
    213
  • Huazhong University of Science and Technology
    183
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    183
  • Kunming Medical University
    183
  • Sun Yat-sen University
    166
  • Capital Medical University
    161
  • Central South University
    159
  • Shandong University
    153
  • Second Affiliated Hospital of Harbin Medical University
    153