3 Works

Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100

Simona Capponi, Nadja Stöffler, Manuel Irimia, Frederik M.A. Van Schaik, Mercedes M. Ondik, Martin L. Biniossek, Lisa Lehmann, Julia Mitschke, Marit W. Vermunt, Menno P. Creyghton, Ann M. Graybiel, Thomas Reinheckel, Oliver Schilling, Benjamin J. Blencowe, Jill R. Crittenden & H. Th. Marc Timmers
Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34ʹ is included in the neuronal form of TAF1 mRNA, which encodes the largest subunit of the basal transcription factor TFIID. In this study, we investigate the tissue distribution of TAF1-34ʹ mRNA and protein and the mechanism responsible for its neuronal-specific splicing. Using isoform-specific RNA probes and antibodies,...

Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100

Simona Capponi, Nadja Stöffler, Manuel Irimia, Frederik M.A. Van Schaik, Mercedes M. Ondik, Martin L. Biniossek, Lisa Lehmann, Julia Mitschke, Marit W. Vermunt, Menno P. Creyghton, Ann M. Graybiel, Thomas Reinheckel, Oliver Schilling, Benjamin J. Blencowe, Jill R. Crittenden & H. Th. Marc Timmers
Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34ʹ is included in the neuronal form of TAF1 mRNA, which encodes the largest subunit of the basal transcription factor TFIID. In this study, we investigate the tissue distribution of TAF1-34ʹ mRNA and protein and the mechanism responsible for its neuronal-specific splicing. Using isoform-specific RNA probes and antibodies,...

Supporting data for \"On the origin and evolution of RNA editing in metazoans\"

Qiye Li, Pei Zhang, Ji Li, Hao Yu, Xiaoyu Zhan, Yuanzhen Zhu, Qunfei Guo, Huishuang Tan, Nina Lundholm, Lydia Garcia, Michael D.Martin, Meritxell Antó Subirats, Yi-Hsien Su, Iñaki Ruiz-Trillo, Mark Q. Martindale, Jr-Kai Yu, M.Thomas P.Gilbert & Guojie Zhang
Extensive adenosine-to-inosine (A-to-I) editing of nuclear-transcribed RNAs is the hallmark of metazoan transcriptional regulation, and is fundamental to numerous biochemical processes. Here we explore the origin and evolution of this regulatory innovation, by quantifying its prevalence in 22 species that represent all major transitions in metazoan evolution.
Files provided in this dataset: 1. Genebody_Anno.tar.gz : Refined gene annotations of the 22 species used in this study in gene transfer format (GTF). 2. Repeat_Anno.tar.gz :...

Registration Year

  • 2019
    3

Resource Types

  • Text
    2
  • Dataset
    1

Affiliations

  • Institució Catalana de Recerca i Estudis Avançats
    3
  • University of Freiburg
    2
  • Heidelberg University
    2
  • Barcelona Institute for Science and Technology
    2
  • University Medical Center Freiburg
    2
  • Centre for Genomic Regulation
    2
  • German Cancer Research Center
    2
  • Pompeu Fabra University
    2
  • Ludwig-Maximilians-Universität München
    2
  • Central South University
    1