3 Works

An unbiased molecular approach using 3’UTRs resolves the avian family-level tree of life

Heiner Kuhl, Carolina Frankl-Vilches, Antje Bakker, Gerald Mayr, Gerhard Nikolaus, Stefan Boerno, Sven Klages, Bernd Timmermann & Manfred Gahr
Presumably, due to a rapid early diversification, major parts of the higher-level phylogeny of birds are still resolved controversially in different analyses or are considered unresolvable. To address this problem, we produced an avian tree of life, which includes molecular sequences of one or several species of ∼ 90% of the currently recognized family-level taxa (429 species, 379 genera) including all 106 for the non-passerines and 115 for the passerines (Passeriformes). The unconstrained analyses of...

Systematic genetics and single-cell imaging reveal widespread morphological pleiotropy and cell-to-cell variability.

Brenda Andrews
Our ability to understand the genotype-to-phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single-cell level. To systematically assess cell-to-cell phenotypic variability, we combined automated yeast genetics, high-content screening and neural network-based image analysis of single cells, focussing on genes that influence the architecture of four subcellular compartments of the endocytic pathway as a model system. Our unbiased assessment of the morphology of these compartments — endocytic patch, actin patch,...

Systematic genetics and single-cell imaging reveal widespread morphological pleiotropy and cell-to-cell variability.

Brenda Andrews
Our ability to understand the genotype-to-phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single-cell level. To systematically assess cell-to-cell phenotypic variability, we combined automated yeast genetics, high-content screening and neural network-based image analysis of single cells, focussing on genes that influence the architecture of four subcellular compartments of the endocytic pathway as a model system. Our unbiased assessment of the morphology of these compartments — endocytic patch, actin patch,...

Registration Year

  • 2020
    3

Resource Types

  • Image
    2
  • Dataset
    1

Affiliations

  • Institució Catalana de Recerca i Estudis Avançats
    3
  • RIKEN
    2
  • Institute for Research in Biomedicine
    2
  • Memorial Sloan Kettering Cancer Center
    2
  • Institute of Biomedical Research of Barcelona
    2
  • University of Toronto
    2
  • Max Planck Institute for Ornithology
    1
  • Senckenberg Nature Research Society
    1
  • Leibniz Institute of Freshwater Ecology and Inland Fisheries
    1
  • Max Planck Institute for Molecular Genetics
    1