Data from: Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Scott J. Dixon, Darpan N. Patel, Matthew Welsch, Rachid Skouta, Eric D. Lee, Ajit G. Thomas, Caroline E. Gleason, Nicholas Tatonetti, Barbara S. Slusher, Brent R. Stockwell, Miki Hayano & Nicholas P Tatonetti
Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc− is implicated in numerous pathologies. Pharmacological agents that inhibit system xc− activity with high potency have long been sought, but have remained elusive. In this study, we report that the small molecule erastin is a potent, selective inhibitor of system xc−. RNA sequencing revealed that inhibition of cystine–glutamate exchange leads to activation of an ER stress response and upregulation of CHAC1, providing a...

Registration Year

  • 2014

Resource Types

  • Dataset


  • Columbia University
  • Johns Hopkins Medicine