51 Works

Alkaloids constituents from the roots of Phragmites australis (Cav.) Trin. ex Steud. with their cytotoxic activities

Ying Chen, Li Li, Li-Rui Jiang, Jia-Yin Tan, Li-Na Guo, Xiao-Li Wang, Wei Dong, Wen-Bao Wang, Ji-Kai Sun & Bo Song
Two new alkaloids, phranisines A–B (1–2), along with two known compounds, N-p-Coumaroyl serotonin (3) and N-p-coumaroyl-tryptamine (4), were isolated from the roots of Phragmites australis. The structures of 1–4 were established on the basis of extensive spectroscopic. The absolute configuration of compounds 1–2 were identified through quantum-chemical electronic circular dichroism (ECD) calculation compared with their experimental CD. All the isolated compounds were tested for their cytotoxic activities against HeLa and MCF-7 human cancer cell lines,...

High plasticity in marmoset monkey vocal development from infancy to adulthood

Steffen Hage, Yasemin Gultekin, Kurt Hammerschmidt & David Hildebrand
The vocal behavior of human infants undergoes dramatic changes across their first year, while becoming increasingly speech-like. Surprisingly, vocal development in nonhuman primates has been assumed to be largely predetermined and completed within the first postnatal months. Contradicting this assumption, we found a dichotomy between the development of call features and vocal sequences in marmoset monkeys suggestive of a role for experience. While changes in call features were related to physical maturation, sequences of and...

Data from: Evolution of flexible biting in hyperdiverse parasitoid wasps

Thomas Van De Kamp, István Mikó, Arnold H. Staniczek, Benjamin Eggs, Daria Bajerlein, Tomáš Faragó, Lea Hagelstein, Elias Hamann, Rebecca Spiecker, Tilo Baumbach, Petr Janšta & Lars Krogmann
One key event in insect evolution was the development of mandibles with two joints, which allowed powerful biting, but restricted their movement to a single degree of freedom. These mandibles define the Dicondylia, which constitute over 99 percent of all extant insect species. It was common doctrine that the dicondylic articulation of chewing mandibles remained unaltered for more than 400 million years. We report highly modified mandibles overcoming the restrictions of a single degree of...

Cell membrane-anchored anti-HIV single-chain antibodies and bifunctional inhibitors targeting the gp41 fusion protein: new strategies for HIV gene therapy

Yue Chen, Hongliang Jin, Xiaoran Tang, Li Li, Xiuzhu Geng, Yuanmei Zhu, Huihui Chong & Yuxian He
Emerging studies indicate that infusion of HIV-resistant cells could be an effective strategy to achieve a sterilizing or functional cure. We recently reported that glycosylphosphatidylinositol (GPI)-anchored nanobody or a fusion inhibitory peptide can render modified cells resistant to HIV-1 infection. In this study, we comprehensively characterized a panel of newly isolated HIV-1-neutralizing antibodies as GPI-anchored inhibitors. Fusion genes encoding the single-chain variable fragment (scFv) of 3BNC117, N6, PGT126, PGT128, 10E8, or 35O22 were constructed with...

Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy

Mingming Song, Wentao Xia, Zixuan Tao, Bin Zhu, Wenxiang Zhang, Chang Liu & Siyu Chen
Malignant melanoma is a life-threatening form of skin cancer with a low response rate to single-agent chemotherapy. Although combined therapies of metformin (MET) and doxorubicin (DOX) are effective in treating a variety of cancers, including breast cancer, their different physicochemical properties and administration routines reduce the effective co-accumulation of both drugs in tumors. Nanoparticles (NPs) have been demonstrated to potentially improve drug delivery efficiency in cancer therapy of, for example, liver and lung cancers. Hence,...

Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population

Qian Xin, Gang Xin, Li Li, Wenjuan Sun, Wen Jiang, Jue Wang, Yun Luan, Ying Zhang, Ling Cheng, Shuhong Duan, Fanzhen Hong, Qinghong Ji & Weihong Ma
Preeclampsia (PE) is a disorder that occurs during the pregnancy and could affect the maternal and perinatal mortality as well as morbidity. The aim of our study is to investigate the associations between the hypertension susceptibility genes ITGA9, MOV10 and CACNB2 with PE in Chinese Han population. A case–control study including 178 PE patients and 202 healthy controls was conducted to assess the associations between three loci (ITGA9 rs155524, MOV10 rs2932538 and CACNB2 rs4373814) and...

Evaluating grazing response strategies in winter annuals: a multi-trait approach

Susanne Kurze, Mark C. Bilton, Leonor Álvarez-Cansino, Sara Bangerter, Rüdiger Prasse, Katja Tielbörger & Bettina M. J. Engelbrecht
Plants minimize fitness losses through grazing by three fundamental strategies: tolerance, avoidance and escape. Annual species have been traditionally assumed to escape grazing through their short life cycle and seed dormancy, however, their grazing response strategies remain almost unexplored. How traits and their coordination affect species’ grazing responses, and whether the generalized grazing model, which posits convergent filtering by grazing and drought, is applicable to this ecologically and economically important species group thus remain unclear....

Distinct synaptic transfer functions in same-type photoreceptors

Cornelius Schröder, Takeshi Yoshimatsu, Jonathan Oesterle, Philipp Berens & Tom Baden
Many sensory systems use ribbon-type synapses to transmit their signals to downstream circuits. The properties of this synaptic transfer fundamentally dictate which aspects in the original stimulus will be accentuated or suppressed, thereby partially defining the detection limits of the circuit. Accordingly, sensory neurons have evolved a wide variety of ribbon geometries and vesicle pool properties to best support their diverse functional requirements. However, the need for diverse synaptic functions does not only arise across...

Effect of traditional Chinese medicine formula Guilu Xian on in vitro fertilization and embryo transfer outcome in older women with low prognosis: study protocol for a prospective, multicenter, randomized double-blind study

Yingjie Ma, Xianling Cao, Jingyan Song, Dandan Gao, Xinlei Wang, Li Li & Zhengao Sun
Abstract Introduction In recent years, the prevalence of infertility has significantly increased and has become a global reproductive health problem. The female ovarian reserves have been shown to decrease progressively with an increase in age. Besides, the rate of embryo implantation and clinical pregnancy also decreases. Traditional Chinese medicine has been widely applied in assisted reproductive technology. It is reported to have a significant influence on improving the quality of oocytes, improving endometrial receptivity, increasing...

Additional file 2 of Effect of traditional Chinese medicine formula Guilu Xian on in vitro fertilization and embryo transfer outcome in older women with low prognosis: study protocol for a prospective, multicenter, randomized double-blind study

Yingjie Ma, Xianling Cao, Jingyan Song, Dandan Gao, Xinlei Wang, Li Li & Zhengao Sun
Additional file 2. Schedule of the study process

Unbiased metagenomic next-generation sequencing of blood from hospitalized febrile children in Gabon

José Francisco Fernandes, Florian Laubscher, Jana Held, Isabella Eckerle, Mylène Docquier, Martin Peter Grobusch, Benjamin Mordmüller, Laurent Kaiser & Samuel Cordey
Unbiased metagenomic next-generation sequencing of blood from hospitalized febrile children in Gabon

Three new tyrosol derivatives from Huangjing wine

Yan-Bin Ren, Xing-Wen Wang, Jia-Xuan Bai, Chang Liu, Si-Lin Yu, Yue Zhou, Cong-Cong Lin, Da-Hong Yao, Jian Huang & Jin-Hui Wang
Phytochemical investigation on the concentrate of Huangjing wine, resulted in the isolation of three new tyrosol derivatives 4′′′-hydroxyphenethyl 2-(R)-hydroxy-3-phenylpropionate (1), 4′′′-hydroxyphenethyl(4′-hydroxy-3′-methoxyphenyl)propionate (2) and 4′′-hydroxyphenethyl ethyl succinate (3), together with 5 known compounds, ferulic acid (4), L-phenyllactic acid (5), hydroxytyrosol (6), dihydroferulic acid (7), cyclo(L-Pro-D-Tyr) (8). Their structures were elucidated using spectroscopic analysis and by comparison with the literature data. All compounds displayed antioxidant effect in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical. Among them, the new compound 2...

The emergence of ecotypes in a parasitoid wasp: a case of incipient sympatric speciation in Hymenoptera?

Pawel Malec, Justus Weber, Marc Fiebig, Denise Meinert, Carolin Rein, Ronja Reinisch, Maik Henrich, Viktoria Polyvas, Marie Pollmann, Lea Von Berg, Christian König, Johannes L.M. Steidle & Robin Böhmer
Background To understand which reproductive barriers initiate speciation is a major question in evolutionary research. Despite their high species numbers and specific biology, there are only few studies on speciation in Hymenoptera. This study aims to identify very early reproductive barriers in a local, sympatric population of Nasonia vitripennis (Walker 1836), a hymenopterous parasitoid of fly pupae. We studied ecological barriers, sexual barriers, and the reduction in F1-female offspring as a postmating barrier, as well...

Weak coordination between leaf drought tolerance and proxy traits in herbaceous plants

Maria Májeková, Tomáš Hájek, Agnes J. Albert, Francesco De Bello, Jiří Doležal, Lars Götzenberger, Stepan Janeček, Jan Lepš, Pierre Liancourt & Ondrej Mudrák
Increased drought is predicted to have a major impact on plant performance under environmental change. Yet leaf hydraulic traits directly related to drought tolerance, such as leaf turgor loss point (πtlp), are underrepresented in trait-based studies and have been largely overlooked within the main frameworks evaluating trait–trait coordination and trade-offs: the leaf economics spectrum and the global spectrum of plant form and function. Using 122 herbaceous species from the Central European temperate grasslands, we investigated...

Exhumation pulses in the Southern Patagonian Andes (Torres del Paine, 51°S)

Nevena Andrić-Tomasevic, Sarah Falkowski, Alireza Aghakhani & Todd A. Ehlers
University of Tuebingen, Germany

The Cenozoic exhumational evolution of the Southern Patagonian Andes and its potential tectonic and climatic controls remain poorly constrained. Here, we integrate 21 new and 73 published bedrock thermochronological ages with 3D thermo-kinematic modelling (Pecube) to quantify exhumation pulses in the Torres del Paine area. This approach is used to identify temporal and spatial variations in exhumation rates before and after the start of Late Miocene glaciation. Our new...

KI-Systeme und die individuelle Wahlentscheidung

Jessica Heesen, Christoph Bieber, Armin Grunwald, Tobias Matzner & Alexander Roßnagel
Fake news, disinformation campaigns, upload filters or even election recommendation apps are not new phenomena - even in the run-up to elections. The importance of artificial intelligence (AI) for opinion-forming and individual voting decisions is playing an increasingly important role in this context and evokes two opposing reflexes in the debate: on the one hand, its potential raises great expectations; on the other hand, its use triggers numerous fears such as loss of control, abuse...

Transcriptional response of mushrooms to artificial sun exposure

Franz-Sebastian Krah, Jaqueline Hess, Florian Hennicke, Ritwika Kar & Claus Bässler
Climate change causes increased tree mortality leading to canopy loss and thus sun-exposed forest floors. Sun exposure creates extreme temperatures and radiation, with potentially more drastic effects on forest organisms than the current increase in mean temperature. Such conditions might potentially negatively affect the maturation of mushrooms of forest fungi. A failure of reaching maturation would mean no sexual spore release and, thus, entail a loss of genetic diversity. However, we currently have a limited...

Synchronous activity patterns in the dentate gyrus during immobility

Martin Pofahl, Negar Nikbakht, André Haubrich, Theresa Nguyen, Nicola Masala, Fabian Distler, Oliver Braganza, Jakob Macke, Kurtulus Golcuk, Laura Ewell & Heinz Beck
The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also shows structured activity during immobility and sleep. The properties of these activity patterns at cellular resolution, and their role in hippocampal-dependent memory processes have remained unclear. Using dual-color in-vivo two-photon Ca2+ imaging, we show that in immobile...

Selbstaufklärungsprozesse und Horizontverschiebungen. Zur Aktualität von Max Weber in China

Helwig Schmidt-Glintzer
Auch wenn im Jahrzehnt vor dem Beginn des Ersten Weltkriegs in Europa ferne Welten und darunter auch der Orient immer näher rückten, hat sich Max Weber doch erst während des Krieges mit dem Orient und dem Fernen Osten intensiver beschäftigt. Die ursprünglich „Konfuzianismus“, dann „Konfuzianismus und Taoismus“ betitelte Studie Max Webers, später oft als seine „China-Studie“ bezeichnet, hat zunächst wenig Aufmerksamkeit gefunden.

Introducing digital technologies in the factory: determinants of blue-collar workers’ attitudes towards new robotic tools

Nora Hampel, Kai Sassenberg, Annika Scholl & Matthias Reichenbach
In the context of blue-collar work, digital technologies and robotic systems are introduced at a rapid speed. However, employees are not always motivated to adopt such new technologies. Thus, it is essential to understand the drivers of employees’ attitudes towards new technology at work (e.g. their enthusiasm about new technology or their insecurity or resistance to change). The present study examines (actual and desired) work characteristics as a predictor of attitudes towards new technology in...

Introducing digital technologies in the factory: determinants of blue-collar workers’ attitudes towards new robotic tools

Nora Hampel, Kai Sassenberg, Annika Scholl & Matthias Reichenbach
In the context of blue-collar work, digital technologies and robotic systems are introduced at a rapid speed. However, employees are not always motivated to adopt such new technologies. Thus, it is essential to understand the drivers of employees’ attitudes towards new technology at work (e.g. their enthusiasm about new technology or their insecurity or resistance to change). The present study examines (actual and desired) work characteristics as a predictor of attitudes towards new technology in...

Candidate gene (PHA-E) and phytohemagglutinin content in snap bean (Phaseolus vulgaris L.): an association study

Xiaoxu Yang, Dajun Liu, Yanqiu Hu, Zhishan Yan, Chang Liu & Guojun Feng
Snap bean (Phaseolus vulgaris L.) is low in fat and high in nutrients; however, it also contains toxigenic factors such as phytohemagglutinin (PHA), which is poisonous to humans. Here, we aimed to determine the distribution of PHA in natural populations of snap bean by analyzing a candidate gene (PHA-E) related to PHA content. Functional genome-wide single nucleotide polymorphisms (SNPs) were then scanned to identify SNPs related to PHA content. A total of 150 snap bean...

Sozial eingestellt und / oder religiös?!

Valesca Baert-Knoll & Maike, Maria Domsel
Ziel des Compassion-Projektes ist eine Sensibilisierung von Schüler*innen für fremdes Leid, gemäß der christlichen Perspektive, nach der Gott sich besonders dort offenbart, wo ein Anrühren-Lassen vom Leid anderer geschieht und Compassion im Sinne von „Mitleidenschaft” gelebt wird. Die wissenschaftliche Resonanz betreffend fällt auf, dass zahlreiche Studien existieren, die die soziale Komponente untersuchen, die religiöse Dimension hingegen außen vorlassen. Daher wird durch Auswertung von leitfadengestützten Interviews der Einfluss des Projektes auf die Religiosität von Schüler*innen untersucht.

Supplementary data for article: Central insulin modulates dopamine signaling in the human striatum

Stephanie Kullmann
Objective: Activity in the dopaminergic pathways of the brain is highly sensitive to body weight and metabolic states. Animal studies show that dopamine neurons are important targets for the metabolic hormone insulin with abolished effects in the insulin resistant state, leading to increases in body weight and food intake. In humans, the influence of central acting insulin on dopamine and effects of their interplay are still elusive. Research Design and Methods: We investigated whether central...

‚Neutral‘ unterrichten? Eine Lektüre des Beutelsbacher Konsenses hinsichtlich der Positionalität von Politik- und Religionslehrpersonen

Simone Hiller & Julia Münch-Wirtz
Muss ein/e LehrerIn ‚neutral‘ unterrichten? Was für den Politikunterricht diskutiert wird, scheint im konfessionellen Religionsunterricht nicht möglich. Der Beitrag stellt den in der Politikdidaktik zentralen Beutelsbacher Konsens dar und schließt daraus auf eine transparente Positionalität von Politiklehrpersonen. Dem wird eine kirchliche und religionsdidaktische Standortbestimmung von Religionslehrpersonen gegenübergestellt, um zu zeigen, inwiefern Positionalität und Haltung von Religionslehrpersonen mithilfe des Beutelsbacher Konsenses profiliert werden können.

Registration Year

  • 2021
    51

Resource Types

  • Dataset
    24
  • Text
    22
  • Collection
    2
  • Other
    2
  • Report
    1

Affiliations

  • University of Tübingen
    49
  • Nanjing University
    19
  • Second Military Medical University
    16
  • First Affiliated Hospital of Jinan University
    16
  • Jilin Agricultural University
    16
  • Central South University
    15
  • Capital Medical University
    15
  • Yunnan University
    13
  • Third Affiliated Hospital of Southern Medical University
    13
  • Agricultural University of Hebei
    13