53 Works

Additional file 1 of Trends in mortality in septic patients according to the different organ failure during 15 years

Carolina Lorencio Cárdenas, Juan Carlos Yébenes, Emili Vela, Montserrat Clèries, Josep Mª Sirvent, Cristina Fuster-Bertolín, Clara Reina, Alejandro Rodríguez, Juan Carlos Ruiz-Rodríguez, Josep Trenado & Elisabeth Esteban Torné
Additional file 1. ICD‑9‑MC codes used to identify infectious process, site of infection, acute organ dysfunction and procedures used in intensive care unit.

Hand hygiene improvement of individual healthcare workers: results of the multicentre PROHIBIT study

Tjallie van der Kooi, Hugo Sax, Hajo Grundmann, Didier Pittet, Sabine de Greeff, Jaap van Dissel, Lauren Clack, Albert W. Wu, Judith Davitt, Sofia Kostourou, Alison Maguinness, Anna Michalik, Viorica Nedelcu, Márta Patyi, Janja Perme Hajdinjak, Milena Prosen, David Tellez, Éva Varga, Fani Veini, Mirosław Ziętkiewicz & Walter Zingg
Abstract Background Traditionally, hand hygiene (HH) interventions do not identify the observed healthcare workers (HWCs) and therefore, reflect HH compliance only at population level. Intensive care units (ICUs) in seven European hospitals participating in the “Prevention of Hospital Infections by Intervention and Training” (PROHIBIT) study provided individual HH compliance levels. We analysed these to understand the determinants and dynamics of individual change in relation to the overall intervention effect. Methods We included HCWs who contributed...

Hand hygiene improvement of individual healthcare workers: results of the multicentre PROHIBIT study

Tjallie van der Kooi, Hugo Sax, Hajo Grundmann, Didier Pittet, Sabine de Greeff, Jaap van Dissel, Lauren Clack, Albert W. Wu, Judith Davitt, Sofia Kostourou, Alison Maguinness, Anna Michalik, Viorica Nedelcu, Márta Patyi, Janja Perme Hajdinjak, Milena Prosen, David Tellez, Éva Varga, Fani Veini, Mirosław Ziętkiewicz & Walter Zingg
Abstract Background Traditionally, hand hygiene (HH) interventions do not identify the observed healthcare workers (HWCs) and therefore, reflect HH compliance only at population level. Intensive care units (ICUs) in seven European hospitals participating in the “Prevention of Hospital Infections by Intervention and Training” (PROHIBIT) study provided individual HH compliance levels. We analysed these to understand the determinants and dynamics of individual change in relation to the overall intervention effect. Methods We included HCWs who contributed...

Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study

Niccolò Buetti, Alexis Tabah, Ambre Loiodice, Stéphane Ruckly, Abdullah Tarik Aslan, Giorgia Montrucchio, Andrea Cortegiani, Nese Saltoglu, Bircan Kayaaslan, Firdevs Aksoy, Akova Murat, Özlem Akdoğan, Kemal Tolga Saracoglu, Cem Erdogan, Marc Leone, Ricard Ferrer, José-Artur Paiva, Yoshiro Hayashi, Mahesh Ramanan, Andrew Conway Morris, François Barbier & Jean-François Timsit
Abstract Background The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients’ characteristics, source of infection...

Supplemental Material - Physiotherapy for patients on extracorporeal membrane oxygenation support: How, When, and Who. An international EuroELSO survey

Massimiliano Polastri, Allaina Eden, Antonio Loforte, Andrea Dell’Amore, Marta Velia Antonini, Jordi Riera, Nicholas A Barrett & Justyna Swol
Supplemental Material for Physiotherapy for patients on extracorporeal membrane oxygenation support: How, When, and Who. An international EuroELSO survey by Massimiliano Polastri, Allaina Eden, Antonio Loforte, Andrea Dell’Amore, Marta Velia Antonini, Jordi Riera, Nicholas A Barrett and Justyna Swol

sj-docx-1-msj-10.1177_13524585221141964 – Supplemental material for Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis

Alberto Calvi, Margareta A Clarke, Ferran Prados, Declan Chard, Olga Ciccarelli, Manel Alberich, Deborah Pareto, Marta Rodríguez Barranco, Jaume Sastre-Garriga, Carmen Tur, Alex Rovira & Frederik Barkhof
Supplemental material, sj-docx-1-msj-10.1177_13524585221141964 for Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis by Alberto Calvi, Margareta A Clarke, Ferran Prados, Declan Chard, Olga Ciccarelli, Manel Alberich, Deborah Pareto, Marta Rodríguez Barranco, Jaume Sastre-Garriga, Carmen Tur, Alex Rovira and Frederik Barkhof in Multiple Sclerosis Journal

Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis

Alberto Calvi, Margareta A Clarke, Ferran Prados, Declan Chard, Olga Ciccarelli, Manel Alberich, Deborah Pareto, Marta Rodríguez Barranco, Jaume Sastre-Garriga, Carmen Tur, Alex Rovira & Frederik Barkhof
Background:Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs).Objectives:To identify the relationship between SELs and PRLs in MS, and their association with disability.Methods:61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score...

Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis

Celia Camacho-Toledano, Isabel Machín-Díaz, Leticia Calahorra, María Cabañas-Cotillas, David Otaegui, Tamara Castillo-Triviño, Luisa María Villar, Lucienne Costa-Frossard, Manuel Comabella, Luciana Midaglia, José Manuel García-Domínguez, Jennifer García-Arocha, María Cristina Ortega & Diego Clemente
Abstract Background The increasing number of treatments that are now available to manage patients with multiple sclerosis (MS) highlights the need to develop biomarkers that can be used within the framework of individualized medicine. Fingolimod is a disease-modifying treatment that belongs to the sphingosine-1-phosphate receptor modulators. In addition to inhibiting T cell egress from lymph nodes, fingolimod promotes the immunosuppressive activity of myeloid-derived suppressor cells (MDSCs), whose monocytic subset (M-MDSCs) can be used as a...

Effect of changes in MS diagnostic criteria over 25 years on time to treatment and prognosis in patients with clinically isolated syndrome

Mar Tintore, Alvaro Cobo-Calvo, Pere Carbonell, Georgina Arrambide, Susana Otero-Romero, Jordi Rio, Carmen Tur, Manuel Comabella, Carlos Nos, Maria Jesus Arevalo, Luciana Midaglia, Ingrid Galan, Angela Vidal-Jordana, Joaquín Castilló, Breogan Rodriguez Acevedo, Ana Zabalza De Torres, Annalaura Salerno, Cristina Auger, Jaume Sastre-Garriga, Alex Rovira & Xavier Montalban
Objectives: To explore whether time to diagnosis, time to treatment initiation and age to reach disability milestones has changed in patients with clinically isolated syndrome (CIS) according to different multiple sclerosis (MS)-diagnostic criteria periods. Methods: Retrospective study based on data prospective collected from the Barcelona-CIS cohort between 1994 and 2020. Patients were classified into five periods according to different MS criteria, and the time to MS diagnosis and treatment initiation were evaluated. The age at...

Additional file 1 of Trends in mortality in septic patients according to the different organ failure during 15 years

Carolina Lorencio Cárdenas, Juan Carlos Yébenes, Emili Vela, Montserrat Clèries, Josep Mª Sirvent, Cristina Fuster-Bertolín, Clara Reina, Alejandro Rodríguez, Juan Carlos Ruiz-Rodríguez, Josep Trenado & Elisabeth Esteban Torné
Additional file 1. ICD‑9‑MC codes used to identify infectious process, site of infection, acute organ dysfunction and procedures used in intensive care unit.

Additional file 1 of European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure

Simona Sacco, Christian Lampl, Faisal Mohammad Amin, Mark Braschinsky, Christina Deligianni, Derya Uludüz, Jan Versijpt, Anne Ducros, Raquel Gil-Gouveia, Zaza Katsarava, Paolo Martelletti, Raffaele Ornello, Bianca Raffaelli, Deirdre M. Boucherie, Patricia Pozo-Rosich, Margarita Sanchez-del-Rio, Alexandra Sinclair, Antoinette Maassen van den Brink & Uwe Reuter
Additional file 1: Figure S1. PRISMA flowchart of systematic review. Table S1. Pain relief at different timepoints. Table S2. Pain relief and pain-free at 2 hours. Table S3. Headache recurrence within 24 hours. Table S4. Rescue medication. Table S5. Response in triptan non-responders. Table S6. Comparisons of different triptan formulations. Table S7. Comparisons between early and late treatment with triptans. Table S8. Agreement on questions submitted in Round 1. Table S9. Conflicts of interest of...

European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure

Simona Sacco, Christian Lampl, Faisal Mohammad Amin, Mark Braschinsky, Christina Deligianni, Derya Uludüz, Jan Versijpt, Anne Ducros, Raquel Gil-Gouveia, Zaza Katsarava, Paolo Martelletti, Raffaele Ornello, Bianca Raffaelli, Deirdre M. Boucherie, Patricia Pozo-Rosich, Margarita Sanchez-del-Rio, Alexandra Sinclair, Antoinette Maassen van den Brink & Uwe Reuter
Abstract Background Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. Main body The Consensus process included a preliminary literature review, a Delphi round and...

Additional file 2 of Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis

Celia Camacho-Toledano, Isabel Machín-Díaz, Leticia Calahorra, María Cabañas-Cotillas, David Otaegui, Tamara Castillo-Triviño, Luisa María Villar, Lucienne Costa-Frossard, Manuel Comabella, Luciana Midaglia, José Manuel García-Domínguez, Jennifer García-Arocha, María Cristina Ortega & Diego Clemente
Additional file 2: Table S2. Demographic data from the fingolimod patients included in the study.

Additional file 3 of Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis

Celia Camacho-Toledano, Isabel Machín-Díaz, Leticia Calahorra, María Cabañas-Cotillas, David Otaegui, Tamara Castillo-Triviño, Luisa María Villar, Lucienne Costa-Frossard, Manuel Comabella, Luciana Midaglia, José Manuel García-Domínguez, Jennifer García-Arocha, María Cristina Ortega & Diego Clemente
Additional file 3: Table S3. Correlations between M-MDSCs and clinical parameters after 12 months of fingolimod treatment.

Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis

Celia Camacho-Toledano, Isabel Machín-Díaz, Leticia Calahorra, María Cabañas-Cotillas, David Otaegui, Tamara Castillo-Triviño, Luisa María Villar, Lucienne Costa-Frossard, Manuel Comabella, Luciana Midaglia, José Manuel García-Domínguez, Jennifer García-Arocha, María Cristina Ortega & Diego Clemente
Abstract Background The increasing number of treatments that are now available to manage patients with multiple sclerosis (MS) highlights the need to develop biomarkers that can be used within the framework of individualized medicine. Fingolimod is a disease-modifying treatment that belongs to the sphingosine-1-phosphate receptor modulators. In addition to inhibiting T cell egress from lymph nodes, fingolimod promotes the immunosuppressive activity of myeloid-derived suppressor cells (MDSCs), whose monocytic subset (M-MDSCs) can be used as a...

Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis

Alberto Calvi, Margareta A Clarke, Ferran Prados, Declan Chard, Olga Ciccarelli, Manel Alberich, Deborah Pareto, Marta Rodríguez Barranco, Jaume Sastre-Garriga, Carmen Tur, Alex Rovira & Frederik Barkhof
Background:Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs).Objectives:To identify the relationship between SELs and PRLs in MS, and their association with disability.Methods:61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score...

Association of gray matter atrophy patterns with clinical phenotype and progression in multiple sclerosis

Maria A Rocca, Paola Valsasina, Alessandro Meani, Claudio Gobbi, Chiara Zecca, Alex Rovira, Jaume Sastre-Garriga, Hugh Kearney, Olga Ciccarelli, Lucy Matthews, Jacqueline Palace, Antonio Gallo, Alvino Bisecco, Carsten Lukas, Barbara Bellenberg, Frederik Barkhof, Hugo Vrenken, Paolo Preziosa & Massimo Filippi
Objectives. Grey matter (GM) involvement is clinically relevant in multiple sclerosis (MS). Using source-based morphometry (SBM), we characterized GM atrophy and its 1-year evolution across different MS phenotypes. Methods. Clinical and MRI data were obtained at 8 European sites from 170 healthy controls (HCs) and 398 MS patients (34 clinically isolated syndromes [CIS], 226 relapsing-remitting [RR], 95 secondary progressive [SP] and 43 primary progressive [PP] MS). Fifty-seven HC and 144 MS underwent 1-year follow-up. Baseline...

Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study

Natalia Cullell, Carolina Soriano-Tárraga, Cristina Gallego-Fábrega, Jara Cárcel-Márquez, Elena Muiño, Laia Llucià-Carol, Miquel Lledós, Manel Esteller, Manuel Castro de Moura, Joan Montaner, Anna Rosell, Pilar Delgado, Joan Martí-Fábregas, Jerzy Krupinski, Jaume Roquer, Jordi Jiménez-Conde & Israel Fernández-Cadenas
Abstract Background and purpose The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. Methods We performed a three-stage epigenome-wide association study to evaluate DNA methylation associated with the difference between the National Institutes of Health Stroke Scale (NIHSS) at baseline and at discharge (ΔNIHSS) in ischaemic stroke patients. DNA...

Supplemental Material - Physiotherapy for patients on extracorporeal membrane oxygenation support: How, When, and Who. An international EuroELSO survey

Massimiliano Polastri, Allaina Eden, Antonio Loforte, Andrea Dell’Amore, Marta Velia Antonini, Jordi Riera, Nicholas A Barrett & Justyna Swol
Supplemental Material for Physiotherapy for patients on extracorporeal membrane oxygenation support: How, When, and Who. An international EuroELSO survey by Massimiliano Polastri, Allaina Eden, Antonio Loforte, Andrea Dell’Amore, Marta Velia Antonini, Jordi Riera, Nicholas A Barrett and Justyna Swol

Physiotherapy for patients on extracorporeal membrane oxygenation support: How, When, and Who. An international EuroELSO survey

Massimiliano Polastri, Allaina Eden, Antonio Loforte, Andrea Dell’Amore, Marta Velia Antonini, Jordi Riera, Nicholas A Barrett & Justyna Swol
Background and purposeExtracorporeal membrane oxygenation (ECMO) continues to play an essential role in organ support in cardiogenic shock or acute respiratory distress syndrome and bridging to transplantation. The main purpose of the present survey was to define which clinical and organizational practices are adopted for the administration of physiotherapy in adult patients undergoing ECMO support worldwide.MethodsThis international survey was conceived in November 2021. The survey launch was announced at the 10th EuroELSO (European ELSO chapter)...

Trends in mortality in septic patients according to the different organ failure during 15 years

Carolina Lorencio Cárdenas, Juan Carlos Yébenes, Emili Vela, Montserrat Clèries, Josep Mª Sirvent, Cristina Fuster-Bertolín, Clara Reina, Alejandro Rodríguez, Juan Carlos Ruiz-Rodríguez, Josep Trenado & Elisabeth Esteban Torné
Abstract Background The incidence of sepsis can be estimated between 250 and 500 cases/100.000 people per year and is responsible for up to 6% of total hospital admissions. Identified as one of the most relevant global health problems, sepsis is the condition that generates the highest costs in the healthcare system. Important changes in the management of septic patients have been included in recent years; however, there is no information about how changes in the...

Additional file 2 of Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis

Celia Camacho-Toledano, Isabel Machín-Díaz, Leticia Calahorra, María Cabañas-Cotillas, David Otaegui, Tamara Castillo-Triviño, Luisa María Villar, Lucienne Costa-Frossard, Manuel Comabella, Luciana Midaglia, José Manuel García-Domínguez, Jennifer García-Arocha, María Cristina Ortega & Diego Clemente
Additional file 2: Table S2. Demographic data from the fingolimod patients included in the study.

Supplemental Material - Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey

Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett & Justyna Swol
Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Supplemental Material - Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey

Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett & Justyna Swol
Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Supplemental Material - Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey

Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett & Justyna Swol
Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Registration Year

  • 2023
    10
  • 2022
    40
  • 2021
    2
  • 2020
    1

Resource Types

  • Text
    30
  • Collection
    20
  • Dataset
    3

Affiliations

  • Vall d'Hebron Hospital Universitari
    50
  • Vall d'Hebron Institut de Recerca
    30
  • Instituto de Salud Carlos III
    26
  • University Hospital of Geneva
    12
  • University Hospital Regensburg
    10
  • Friedrich-Loeffler-Institut
    10
  • Maastricht University Medical Centre
    10
  • University of Bern
    10
  • Bambino Gesù Children's Hospital
    10
  • Assistance Publique - Hôpitaux de Paris
    8