Abstract Background and purpose The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. Methods We performed a three-stage epigenome-wide association study to evaluate DNA methylation associated with the difference between the National Institutes of Health Stroke Scale (NIHSS) at baseline and at discharge (ΔNIHSS) in ischaemic stroke patients. DNA...

Supplemental Material for Physiotherapy for patients on extracorporeal membrane oxygenation support: How, When, and Who. An international EuroELSO survey by Massimiliano Polastri, Allaina Eden, Antonio Loforte, Andrea Dell’Amore, Marta Velia Antonini, Jordi Riera, Nicholas A Barrett and Justyna Swol

Background and purposeExtracorporeal membrane oxygenation (ECMO) continues to play an essential role in organ support in cardiogenic shock or acute respiratory distress syndrome and bridging to transplantation. The main purpose of the present survey was to define which clinical and organizational practices are adopted for the administration of physiotherapy in adult patients undergoing ECMO support worldwide.MethodsThis international survey was conceived in November 2021. The survey launch was announced at the 10th EuroELSO (European ELSO chapter)...

Abstract Background The incidence of sepsis can be estimated between 250 and 500 cases/100.000 people per year and is responsible for up to 6% of total hospital admissions. Identified as one of the most relevant global health problems, sepsis is the condition that generates the highest costs in the healthcare system. Important changes in the management of septic patients have been included in recent years; however, there is no information about how changes in the...

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Supplemental material, sj-xlsx-2-cep-10.1177_03331024221146317 for Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization by Marta Vila-Pueyo, Ester Cuenca-León, Ana C. Queirós, Marta Kulis, Cèlia Sintas, Bru Cormand, José Ignacio Martín-Subero, Patricia Pozo-Rosich, Noèlia Fernàndez-Castillo, Alfons Macaya in Cephalalgia

Additional file 2: Table S2. Demographic data from the fingolimod patients included in the study.

BackgroundSeveral novel treatments targeting the calcitonin gene-related peptide pathway have been developed for migraine. We evaluated the efficacy of these medications, including atogepant, rimegepant, erenumab, eptinezumab, fremanezumab, and galcanezumab, for the prevention of migraine via network meta-analysis.MethodsDatabases, including MEDLINE via PubMed, EMBASE, and Cochrane central, were systematically reviewed, and all eligible phase 3 randomised controlled trials were included.ResultsNineteen studies (n = 14,584 participants) were included. Studies included episodic (n = 11) and chronic (n =...

Supplemental material, sj-pdf-1-cep-10.1177_03331024231159366 for Evaluating the efficacy of CGRP mAbs and gepants for the preventive treatment of migraine: A systematic review and network meta-analysis of phase 3 randomised controlled trials by Faraidoon Haghdoost, Francesca Puledda, David Garcia-Azorin, Eva-Maria Huessler, Roberta Messina and Patricia Pozo-Rosich in Cephalalgia

Supplemental material, sj-pdf-2-cep-10.1177_03331024231159366 for Evaluating the efficacy of CGRP mAbs and gepants for the preventive treatment of migraine: A systematic review and network meta-analysis of phase 3 randomised controlled trials by Faraidoon Haghdoost, Francesca Puledda, David Garcia-Azorin, Eva-Maria Huessler, Roberta Messina and Patricia Pozo-Rosich in Cephalalgia

Abstract Background and purpose The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. Methods We performed a three-stage epigenome-wide association study to evaluate DNA methylation associated with the difference between the National Institutes of Health Stroke Scale (NIHSS) at baseline and at discharge (ΔNIHSS) in ischaemic stroke patients. DNA...

Additional file 1. Supplemental Methods.

Additional file 1. Additional methods (definitions, additional methods, statistical analyses and ethics), Additional tables (Tables S1–S8) and Additional figures (Figs. S1–S2).

Additional file 1. Additional methods (definitions, additional methods, statistical analyses and ethics), Additional tables (Tables S1–S8) and Additional figures (Figs. S1–S2).

Additional file 1: Figure S1. PRISMA flowchart of systematic review. Table S1. Pain relief at different timepoints. Table S2. Pain relief and pain-free at 2 hours. Table S3. Headache recurrence within 24 hours. Table S4. Rescue medication. Table S5. Response in triptan non-responders. Table S6. Comparisons of different triptan formulations. Table S7. Comparisons between early and late treatment with triptans. Table S8. Agreement on questions submitted in Round 1. Table S9. Conflicts of interest of...

Abstract Background Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. Main body The Consensus process included a preliminary literature review, a Delphi round and...

Additional file 1: Table S1. Association between hand hygiene and activity index during baseline and intervention; Table S2. Overall (i.e. for all HCWs) hand hygiene compliance per hospital, during baseline and the intervention period; Figure S1. Boxplot (median, quartiles and ranges) of individual HH compliance both during baseline and intervention period; Figure S2. Boxplot (median, quartiles and ranges) of hand hygiene increase (in percentage points) in the group of improving HCWs; Figure S3. Variability within...

Supplemental material, sj-docx-1-msj-10.1177_13524585221141964 for Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis by Alberto Calvi, Margareta A Clarke, Ferran Prados, Declan Chard, Olga Ciccarelli, Manel Alberich, Deborah Pareto, Marta Rodríguez Barranco, Jaume Sastre-Garriga, Carmen Tur, Alex Rovira and Frederik Barkhof in Multiple Sclerosis Journal

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

IntroductionAn analysis on the ECLS use for patients with respiratory or cardiac support in COVID-19 based on an international response to EuroELSO survey, aims to generate a more comprehensive understanding of ECLS role during the recent viral pandemic.MethodsEuroELSO announced the survey at the 10th annual congress in London, May 2022. The survey covered 26 multiple-choice questions.ResultsThe survey returned 69 questionnaires from 62 centers across 22 European countries and seven centers across five non-European countries. Most...

Additional file 1: Table S1. List of antibodies used for flow cytometry and histology.

Additional file 1: Table S1. List of antibodies used for flow cytometry and histology.