Additional file 3: Table S3. Correlations between M-MDSCs and clinical parameters after 12 months of fingolimod treatment.

Additional file 1. Supplemental Methods.

Background and purposeExtracorporeal membrane oxygenation (ECMO) continues to play an essential role in organ support in cardiogenic shock or acute respiratory distress syndrome and bridging to transplantation. The main purpose of the present survey was to define which clinical and organizational practices are adopted for the administration of physiotherapy in adult patients undergoing ECMO support worldwide.MethodsThis international survey was conceived in November 2021. The survey launch was announced at the 10th EuroELSO (European ELSO chapter)...

Additional file 1: Supplementary Methods, Results, Tables and Figures.

Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) was a phase 2, randomised, parallel-group, double-blind, placebo-controlled study in Europe, Turkey, Israel, and the USA. Subjects ≥ 18 years old, mechanically ventilated, tracheally colonised with PA, and without new-onset pneumonia, were randomised (1:1:1)...

Objectives To compare the flow of COVID-19 patients in emergency rooms and hospital wards between the pandemic; first and second waves; at the University Hospital of Vall d’Hebron (Barcelona, Spain), and to compare the profiles, severity and mortality of COVID-19 patients between the two waves. Methods Retrospective observational analysis of COVID-19 patients attending the hospital from February 24 to April 26, 2020 (first wave) and from July 24, 2020, to May 18, 2021 (second wave)....

Abstract Background The incidence of sepsis can be estimated between 250 and 500 cases/100.000 people per year and is responsible for up to 6% of total hospital admissions. Identified as one of the most relevant global health problems, sepsis is the condition that generates the highest costs in the healthcare system. Important changes in the management of septic patients have been included in recent years; however, there is no information about how changes in the...

As a result of globalization and constant migratory flows, Chagas disease is now present in almost all continents. The management and treatment of the disease is often influenced by the economic and social context of the societies that host patients. In this manuscript, we aim to provide a comparative review of approaches to patients with Chagas disease in the Americas and Europe.

Supplemental material, sj-xlsx-1-cep-10.1177_03331024221146317 for Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization by Marta Vila-Pueyo, Ester Cuenca-León, Ana C. Queirós, Marta Kulis, Cèlia Sintas, Bru Cormand, José Ignacio Martín-Subero, Patricia Pozo-Rosich, Noèlia Fernàndez-Castillo, Alfons Macaya in Cephalalgia

BackgroundCortical spreading depolarization, the cause of migraine aura, is a short-lasting depolarization wave that moves across the brain cortex, transiently suppressing neuronal activity. Prophylactic treatments for migraine, such as topiramate or valproate, reduce the number of cortical spreading depression events in rodents.ObjectiveTo investigate whether cortical spreading depolarization with and without chronic treatment with topiramate or valproate affect the DNA methylation of the cortex.MethodsSprague-Dawley rats were intraperitoneally injected with saline, topiramate or valproate for four weeks...

Supplemental material, sj-xlsx-4-cep-10.1177_03331024221146317 for Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization by Marta Vila-Pueyo, Ester Cuenca-León, Ana C. Queirós, Marta Kulis, Cèlia Sintas, Bru Cormand, José Ignacio Martín-Subero, Patricia Pozo-Rosich, Noèlia Fernàndez-Castillo, Alfons Macaya in Cephalalgia

Supplemental material, sj-xlsx-5-cep-10.1177_03331024221146317 for Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization by Marta Vila-Pueyo, Ester Cuenca-León, Ana C. Queirós, Marta Kulis, Cèlia Sintas, Bru Cormand, José Ignacio Martín-Subero, Patricia Pozo-Rosich, Noèlia Fernàndez-Castillo, Alfons Macaya in Cephalalgia

Supplemental material, sj-xlsx-2-cep-10.1177_03331024221146317 for Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization by Marta Vila-Pueyo, Ester Cuenca-León, Ana C. Queirós, Marta Kulis, Cèlia Sintas, Bru Cormand, José Ignacio Martín-Subero, Patricia Pozo-Rosich, Noèlia Fernàndez-Castillo, Alfons Macaya in Cephalalgia

Abstract Background The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients’ characteristics, source of infection...

Additional file 1: Table S1. Association between hand hygiene and activity index during baseline and intervention; Table S2. Overall (i.e. for all HCWs) hand hygiene compliance per hospital, during baseline and the intervention period; Figure S1. Boxplot (median, quartiles and ranges) of individual HH compliance both during baseline and intervention period; Figure S2. Boxplot (median, quartiles and ranges) of hand hygiene increase (in percentage points) in the group of improving HCWs; Figure S3. Variability within...

Additional file 1: Supplementary Methods, Results, Tables and Figures.

Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) was a phase 2, randomised, parallel-group, double-blind, placebo-controlled study in Europe, Turkey, Israel, and the USA. Subjects ≥ 18 years old, mechanically ventilated, tracheally colonised with PA, and without new-onset pneumonia, were randomised (1:1:1)...

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

Supplemental Material for Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey by Marcel Fleig, Thomas Müller, Velia M Antonini, Jordi Riera, Mirko Belliato, Lars Mikael Broman, Jo-Anne Fowles, Jan Belohlavek, Roberto Lorusso, Leen Vercaemst, Tim Jones, Peter P Roeleveld, Matteo Di Nardo, Nicholas Barrett and Justyna Swol in Perfusion

IntroductionAn analysis on the ECLS use for patients with respiratory or cardiac support in COVID-19 based on an international response to EuroELSO survey, aims to generate a more comprehensive understanding of ECLS role during the recent viral pandemic.MethodsEuroELSO announced the survey at the 10th annual congress in London, May 2022. The survey covered 26 multiple-choice questions.ResultsThe survey returned 69 questionnaires from 62 centers across 22 European countries and seven centers across five non-European countries. Most...

Supplemental material, sj-pdf-1-cep-10.1177_03331024231159366 for Evaluating the efficacy of CGRP mAbs and gepants for the preventive treatment of migraine: A systematic review and network meta-analysis of phase 3 randomised controlled trials by Faraidoon Haghdoost, Francesca Puledda, David Garcia-Azorin, Eva-Maria Huessler, Roberta Messina and Patricia Pozo-Rosich in Cephalalgia

BackgroundSeveral novel treatments targeting the calcitonin gene-related peptide pathway have been developed for migraine. We evaluated the efficacy of these medications, including atogepant, rimegepant, erenumab, eptinezumab, fremanezumab, and galcanezumab, for the prevention of migraine via network meta-analysis.MethodsDatabases, including MEDLINE via PubMed, EMBASE, and Cochrane central, were systematically reviewed, and all eligible phase 3 randomised controlled trials were included.ResultsNineteen studies (n = 14,584 participants) were included. Studies included episodic (n = 11) and chronic (n =...