Data categories: Other, Survey data Material collected: Other Experimental data: Other Number of donors: 159 Sex : Female, Male Age: 18-85 Year Diseases studied: Hemiplegia, unspecified Polyarthrosis, Cervical disc disorders, Myositis
The PIAMA-study is a large ongoing population-based cohort study with prenatal inclusion and follow-up until the current age of 18 years. The study was designed to investigate the influence of lifestyle and environment on the development of asthma, allergy and lung function. It therefore contains a detailed characterization of lifestyle and environmental exposures in all stages of childhood.
birth cohort, extensive environmental measures; 1600 trio's
Longitudinal and cross-sectional data of technique development during a 1500m for junior speed skaters. Observational data from healthy people.
MeDAS PET: a non-invasive imaging tool for quantitative assessment of myelin loss in multiple sclerosisErik de Vries
PET and MR imaging dataset of patients (n=10) with primary and secondary progressive multiple sclerosis.
Transplantation is a very successful and life-saving treatment. Yet, after transplantation, many transplant recipients face a multitude of health problems, impairing quality of life, length of life and duration of organ function. TransplantLines is a biobank aiming at finding biomarkers for early and non-invasive detection of health problems and yet unsolved questions that transplantation patients face.
Autoimmune β-cell destruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear. To help address this void, we created an open-access online repository composed of large-scale electron microscopy images (‘nanotomy’) of human pancreas tissue obtained from the Network for Pancreatic Organ donors with Diabetes (nPOD; www.nanotomy.org). Nanotomy allows analyses of complete donor islets with up to macromolecular resolution. Our first results of mining the database support recent findings that suggest that type 1...
Data from: Productive activities, mental health and quality of life in disability: exploring the role enhancement and the role strain hypothesesChristine Fekete, Johannes Siegrist, Marcel W. M. Post & Martin W. G. Brinkhof
Background: Engagement in productive activities is an important determinant of mental health and quality of life (QoL). Persons with physical disabilities are often confronted with constraints to engage in productive activities and it remains largely unknown whether persons who nevertheless manage to be productive experience beneficial effects for mental health and QoL. This is the first study to analyse different productive activities (paid work, volunteering, education, housework) and its gender-specific associations with mental health and...
In 1965 one of the first large epidemiological studies started in the Netherlands: the population study in Vlagtwedde and Vlaardingen. Over 8000 people took part. The cohort study was concluded in 1990, but the data from the databank still provide useful information in the research into the origin of lung diseases. For instance, follow-up research into mortality in this cohort has resulted in the discovery that people with a higher airway sensitivity have a greater...
Predictive value of the microlesion effect on motor and cognitive outcome after Deep Brain Stimulation in Parkinson’s DiseaseJ. Marc C. van Dijk & T. van Laar
Study to investigate the motor and cognitive effects of inserting a Deep Brain Stimulation electrode into the brain of a Parkinson’s disease patient.
The department of Gastroenterology and Hepatology of the University Medical Center Groningen initiated the 1000IBD project to prospectively follow more than a 1000 IBD patients from the Northern provinces of the Netherlands. We have collected a uniquely large number of phenotypes and generated multi-omics profiles for these patients. To date, 1,215 participants have been enrolled in the 1000IBD project, and enrolment is on-going. Patients that participate in the 1000IBD project are followed prospectively and the...
Daily nutrient intake (energy(kcal), energy (kJ), total protein (g), plant protein (g), animal protein (g), total fat (g), total carbohydrates (g), total alcohol (g), total protein (en%), plant protein (en%), animal protein (en%), total fat (en%), total carbohydrates (en%), total alcohol (en%),) Lifelines DEEP participants
The overall aim of the GECKO Drenthe cohort is to study the prevalence and early risk factors for the development of childhood overweight and fat distribution at very young age. Within this birth cohort the growth of the children is closely followed, starting at birth until adulthood. The children are followed using questionnaires that the parents have to answer and the regular visits to the Well Baby Clinics, where length, weight, head circumference and hip...
Sex: Female, Male Diseases studied: Care involving use of other rehabilitation procedures
An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA...
Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infantsSanne Arjaans, Brandie Wagner, Peter Mourani, Erica Mandell, Brenda Poindexter, Rolf Berger & Steven Abman
Introduction: Early pulmonary vascular disease in preterm infants is associated with the subsequent development of bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH), however, mechanisms that contribute to or identify infants with increased susceptibility for BPD and/or PH are incompletely understood. Therefore, we tested if changes in circulating angiogenic peptides during the first week of life are associated with the later development of BPD and/or PH. We further sought to determine alternate peptides and related signalling...
Data from: A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetesXiaojing Chu, Yang Li, Cees Tack, Anna Janssen & Hans Koenen
Background: The large inter-individual variability in immune-cell cell composition and function determines immune responses in general and susceptibility to immune-mediated diseases in particular. While much has been learned about the genetic variants relevant for type 1 diabetes (T1D), the pathophysiological mechanisms through which these variations exert their effects remain unknown. Methods: Blood samples were collected from 243 patients with T1D of Dutch descent. We applied genetic association analysis on > 200 immune cell traits and...
Data categories: Survey data Number of donors: 33 Sex: Male, Female Age: 27-69 Year
Data from: Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemiaNatanja Oosterom, Pieter H. Griffioen, Marissa A. H. Den Hoed, Rob Pieters, Robert De Jonge, Wim J.E. Tissing, Marry M. Van Den Heuvel-Eibrink, Sandra G. Heil & Wim J. E. Tissing
BACKGROUND Children with acute lymphoblastic leukemia (ALL) often suffer from toxicity of chemotherapeutic drugs such as Methotrexate (MTX). Previously, we reported that 20% of patients receiving high-dose MTX developed oral mucositis. MTX inhibits folate metabolism, which is essential for DNA methylation. We hypothesize that MTX inhibits DNA methylation, which results into adverse effects. We studied DNA methylation markers during high-dose methotrexate treatment in pediatric acute lymphoblastic leukemia (ALL) in relation to developing oral mucositis. MATERIALS...
Data from: Statin use and cognitive function: population-based observational study with long-term follow-upHanneke Joosten, Sipke T. Visser, Marlise E. Van Eersel, Ron T. Gansevoort, Henk J. Bilo, Joris P. Slaets, Gerbrand J. Izaks & Henk J. G. Bilo
We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0; best score, 175 points) and the Visual Association Test (VAT; low performance, 0–10; high performance, 11–12 points) in an observational study that included 4,095 community-dwelling participants aged 35–82 years. Data on statin use were obtained from a computerized pharmacy database. Analysis were done for the total cohort and subsamples...
Prospective cohort; focus on renal and cardiovascular disease. 8592 subjects measured at baseline and during 5 follow-up screening rounds.
100 asthmatics followed from childhood over 30 years, 280 asthma patients with follow up >30 years from which 200 families with proband with asthma (n=1259), 200 unrelated asthma, asthma trios (n=405), Rhinitis trios (n=226), untreated asthma and controls (n=150), 200 asthmapatients with airway biopsies, followed over >5 years), 75 families with two children with asthma.
Pragmatic randomized controlled trial to study the efficacy of two experience sampling intervention modules for depression.
Data categories: Survey data Material collected: Not available Experimental data: Not available Number of donors: 373 Sex: Female, Male Age: 19-29 Year
University Medical Center Groningen62
University of Groningen15
VU University Medical Center4
Erasmus University Medical Center2
Maastricht University Medical Centre2
University of Copenhagen2
University of Helsinki2
Swiss Paraplegic Research2
University of Innsbruck2