3 Works

Data from: Epigenome-wide association study of lung function level and its change

Medea Imboden, Matthias Wielscher, Faisal I Rezwan, Andre F S Amaral, Emmanuel Schaffner, Ayoung Jeong, Anna Beckmeyer-Borowko, Sarah E Harris, John M Starr, Ian J Deary, Claudia Flexeder, Melanie Waldenberger, Annette Peters, Holger Schulz, Su Chen, Shadia KHan Sunny, Wilfried J J Karmaus, Yu Jiang, Gertraud Erhart, Florian Kronenberg, Ryan Arathimos, Gemma C Sharp, Alexander John Henderson, Yu Fu, Paivi Piirila … & Nicole M Probst-Hensch
Previous reports link differential DNA methylation (DNAme) to environmental exposures which are associated with lung function. Direct evidence on lung function DNAme is however limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults. In a discovery-replication EWAS design, DNAme in blood and spirometry were measured twice, six-to-15 years apart, in the same participants of three adult population-based discovery cohorts (n=2,043). Associated DNAme markers (P<5x10-7) were tested...

Data from: Large scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

Gerrit L.J. Onderwater, Lannie Ligthart, Mariska Bot, Ayse Demirkan, Jingyuan Fu, Carla J.H. Van Der Kallen, Lisanne S. Vijfhuizen, René Pool, Jun Liu, Floris H.M. Vanmolkot, Marian Beekman, Hoyan Wen, Najaf Amin, Carisha S. Thesing, Judith A. Pijpers, Dennis A. Kies, Ronald Zielman, Irene De Boer, Marleen M.J. Van Greevenbroek, Ilja C.W. Arts, Yuri Milaneschi, Miranda T. Schram, Pieter C. Dagnelie, Lude Franke, M. Arfan Ikram … & Arn M.J.M. Van Den Maagdenberg
Objective: To identify a plasma metabolomic biomarker signature for migraine. Methods: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test...

Data from: Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia

Laurent M. A. Favié, Floris Groenendaal, Marcel P. H. Van Den Broek, Carin M. A. Rademaker, Timo R. De Haan, Henrica L. M. Van Straaten, Peter H. Dijk, Arno Van Heijst, Jeroen Dudink, Koen P. Dijkman, Monique Rijken, Inge A. Zonnenberg, Filip Cools, Alexandra Zecic, Johanna H. Van Der Lee, Debbie H. G. M. Nuytemans, Frank Van Bel, Toine C. G. Egberts & Alwin J. R. Huitema
Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of morphine in this population are largely unknown. The objective of this study was to describe pharmacokinetics of morphine and its metabolites morphine-3-glucuronide and morphine-6-glucuronide in encephalopathic neonates treated with therapeutic hypothermia and to develop pharmacokinetics based dosing guidelines for this population. Study design: Term and near-term encephalopathic neonates treated with therapeutic hypothermia and...

Registration Year

  • 2019
    3

Resource Types

  • Dataset
    3

Affiliations

  • University Medical Center Groningen
    3
  • VU University Medical Center
    2
  • Vrije Universiteit Brussel
    1
  • VU University Amsterdam
    1
  • Emma Kinderziekenhuis
    1
  • Helmholtz Zentrum München
    1
  • Public Health England
    1
  • Erasmus University Medical Center
    1
  • University of Memphis
    1
  • University of Nottingham
    1