13 Works

Data from: Force and torque on spherical particles in micro-channel flows using computational fluid dynamics

Jin Suo, Erin E. Edwards, Ananyaveena Anilkumar, Todd Sulchek, Don P. Giddens & Susan N. Thomas
To delineate the influence of hemodynamic force on cell adhesion processes, model in vitro fluidic assays that mimic physiological conditions are commonly employed. Herein, we offer a framework for solution of the three-dimensional Navier–Stokes equations using computational fluid dynamics (CFD) to estimate the forces resulting from fluid flow near a plane acting on a sphere that is either stationary or in free flow, and we compare these results to a widely used theoretical model that...

Data from: Evolution of behavioral and cellular defenses against parasitoid wasps in the Drosophila melanogaster subgroup

Zachary R. Lynch, Todd A. Schlenke & Jacobus C. De Roode
It may be intuitive to predict that host immune systems will evolve to counter a broad range of potential challenges through simultaneous investment in multiple defenses. However, this would require diversion of resources from other traits, such as growth, survival, and fecundity. Therefore, ecological immunology theory predicts that hosts will specialize in only a subset of possible defenses. We tested this hypothesis through a comparative study of a cellular immune response and a putative behavioral...

Data from: Fitness costs of animal medication: antiparasitic plant chemicals reduce fitness of monarch butterfly hosts

Leiling Tao, Kevin M. Hoang, Mark D. Hunter & Jacobus C. De Roode
The emerging field of ecological immunology demonstrates that allocation by hosts to immune defence against parasites is constrained by the costs of those defences. However, the costs of non-immunological defences, which are important alternatives to canonical immune systems, are less well characterized. Estimating such costs is essential for our understanding of the ecology and evolution of alternative host defence strategies. Many animals have evolved medication behaviours, whereby they use antiparasitic compounds from their environment to...

Data from: Reconstruction of the cortical maps of the Tasmanian tiger and comparison to the Tasmanian devil

Gregory S. Berns & Ken W. S. Ashwell
The last known Tasmanian tiger (Thylacinus cynocephalus)–aka the thylacine–died in 1936. Because its natural behavior was never scientifically documented, we are left to infer aspects of its behavior from museum specimens and historical recollections of bushmen. Recent advances in brain imaging have made it possible to scan postmortem specimens of a wide range of animals, even more than a decade old. Any thylacine brain, however, would be more than 100 years old. Here, we show...

Data from: Nematode-bacteria nutualism: selection within the mutualism supersedes selection outside of the mutualism

Levi T. Morran, McKenna J. Penley, Victoria S. Byrd, Andrew J. Meyer, Timothy S. O'Sullivan, Farrah Bashey-Visser, Heidi Goodrich-Blair, Curtis M. Lively & Farrah Bashey
The coevolution of interacting species can lead to codependent mutualists. Little is known about the effect of selection on partners within verses apart from the association. Here, we determined the effect of selection on bacteria (Xenorhabdus nematophila) both within and apart from its mutualistic partner (a nematode, Steinernema carpocapsae). In nature, the two species cooperatively infect and kill arthropods. We passaged the bacteria either together with (M+), or isolated from (M−), nematodes under two different...

Data from: Sexual selection on male vocal fundamental frequency in humans and other anthropoids

David A. Puts, Alexander K. Hill, Drew H. Bailey, Robert S. Walker, Drew Rendall, John R. Wheatley, Lisa L. M. Welling, Khytam Dawood, Rodrigo A. Cárdenas, Robert P. Burriss, Nina G. Jablonski, Mark D. Shriver, Daniel J. Weiss, Adriano R. Lameira, Coren L. Apicella, Michael J. Owren, Claudia Barelli, Mary E. Glenn & Gabriel Ramos-Fernandez
In many primates, including humans, the vocalizations of males and females differ dramatically, with male vocalizations and vocal anatomy often seeming to exaggerate apparent body size. These traits may be favoured by sexual selection because low-frequency male vocalizations intimidate rivals and/or attract females, but this hypothesis has not been systematically tested across primates, nor is it clear why competitors and potential mates should attend to vocalization frequencies. Here we show across anthropoids that sexual dimorphism...

Data from: A methylation-to-expression feature model for generating accurate prognostic risk scores and identifying disease targets in clear cell kidney cancer

Jeffrey A. Thompson & Carmen J. Marsit
Many researchers now have available multiple high-dimensional molecular and clinical datasets when studying a disease. As we enter this multi-omic era of data analysis, new approaches that combine different levels of data (e.g. at the genomic and epigenomic levels) are required to fully capitalize on this opportunity. In this work, we outline a new approach to multi-omic data integration, which combines molecular and clinical predictors as part of a single analysis to create a prognostic...

Data from: Reliability and construct validity of the Psychopathic Personality Inventory-Revised in a Swedish non-criminal sample: a multimethod approach including psychophysiological correlates of empathy for pain

Karolina Sörman, Gustav Nilsonne, Katarina Howner, Sandra Tamm, Shilan Caman, Hui-Xin Wang, Martin Ingvar, John F. Edens, Petter Gustavsson, Scott O. Lilienfeld, Predrag Petrovic, Håkan Fischer & Marianne Kristiansson
Cross-cultural investigation of psychopathy measures is important for clarifying the nomological network surrounding the psychopathy construct. The Psychopathic Personality Inventory-Revised (PPI-R) is one of the most extensively researched self-report measures of psychopathic traits in adults. To date however, it has been examined primarily in North American criminal or student samples. To address this gap in the literature, we examined PPI-R’s reliability, construct validity and factor structure in non-criminal individuals (N = 227) in Sweden, using...

Data from: Coevolutionary interactions with parasites constrain the spread of self-fertilization into outcrossing host populations

Samuel Preston Slowinski, Levi T. Morran, , Eric R. Cui, Amrita Bhattacharya, Curtis M. Lively, Patrick C. Phillips & Raymond C. Parrish
Given the cost of sex, outcrossing populations should be susceptible to invasion and replacement by self-fertilization or parthenogenesis. However, biparental sex is common in nature, suggesting that cross-fertilization has substantial short-term benefits. The Red Queen hypothesis (RQH) suggests that coevolution with parasites can generate persistent selection favoring both recombination and outcrossing in host populations. We tested the prediction that coevolving parasites can constrain the spread of self-fertilization relative to outcrossing. We introduced wild-type Caenorhabditis elegans...

Data from: Specificity in the symbiotic association between fungus-growing ants and protective Pseudonocardia bacteria

Matías J. Cafaro, Michael Poulsen, Ainslie E. F. Little, Shauna L. Price, Nicole M. Gerardo, Bess Wong, Alison E. Stuart, Bret Larget, Patrick Abbot & Cameron R. Currie
Fungus-growing ants (tribe Attini) engage in a mutualism with a fungus that serves as the ants' primary food source, but successful fungus cultivation is threatened by microfungal parasites (genus Escovopsis). Actinobacteria (genus Pseudonocardia) associate with most of the phylogenetic diversity of fungus-growing ants; are typically maintained on the cuticle of workers; and infection experiments, bioassay challenges and chemical analyses support a role of Pseudonocardia in defence against Escovopsis through antibiotic production. Here we generate a...

Data from: Calling in sick: impacts of fever on intra-urban human mobility

T. Alex Perkins, Valerie A. Paz-Soldan, Steven T. Stoddard, Amy C. Morrison, Brett M. Forshey, Kanya C. Long, Eric S. Halsey, Tadeusz J. Kochel, John P. Elder, Uriel Kitron, Thomas W. Scott & Gonzalo M. Vazquez-Prokopec
Pathogens inflict a wide variety of disease manifestations on their hosts, yet the impacts of disease on the behaviour of infected hosts are rarely studied empirically and are seldom accounted for in mathematical models of transmission dynamics. We explored the potential impacts of one of the most common disease manifestations, fever, on a key determinant of pathogen transmission, host mobility, in residents of the Amazonian city of Iquitos, Peru. We did so by comparing two...

Data from: Within-host competition and drug resistance in the human malaria parasite Plasmodium falciparum

Mary Bushman, Lindsay Morton, Nancy Duah, Neils Quashie, Benjamin Abuaku, Kwadwo Koram, Pedro Dimbu, Mateusz Plucinski, Julie Gutman, Peter Lyaruu, Steven Kachur, Jacobus De Roode, Venkatachalam Udhayakumar, Jacobus C. De Roode, S. Patrick Kachur & Kwadwo A. Koram
Infections with the malaria parasite Plasmodium falciparum typically comprise multiple strains, especially in high-transmission areas where infectious mosquito bites occur frequently. However, little is known about the dynamics of mixed-strain infections, particularly whether strains sharing a host compete or grow independently. Competition between drug-sensitive and drug-resistant strains, if it occurs, could be a crucial determinant of the spread of resistance. We analyzed 1,341 P. falciparum infections in children from Angola, Ghana, and Tanzania and found...

Data from: Na+/K+ pump interacts with the h-current to control bursting activity in central pattern generator neurons of leeches

Daniel Kueh, William H. Barnett, Gennady S. Cymbalyuk & Ronald L. Calabrese
The dynamics of different ionic currents shape the bursting activity of neurons and networks that control motor output. Despite being ubiquitous in all animal cells, the contribution of the Na+/K+ pump current to such bursting activity has not been well studied. We used monensin, a Na+/H+ antiporter, to examine the role of the pump on the bursting activity of oscillator heart interneurons in leeches. When we stimulated the pump with monensin, the period of these...

Registration Year

  • 2016

Resource Types

  • Dataset


  • Emory University
  • University of Wisconsin-Madison
  • Indiana University Bloomington
  • University of Michigan-Ann Arbor
  • University of Notre Dame
  • University of California System
  • Museo delle Scienze
  • National Institutes of Health
  • Texas A&M University
  • University of Ghana