1,017 Works

Data from: No evidence of foliar disease impact on crop root functional strategies and soil microbial communities: What does this mean for organic coffee?

Stephanie Gagliardi, Jacques Avelino, Roberta Fulthorpe, Elias De Melo Virginio Filho & Marney Isaac
Global climate change is increasing pest and pathogen pressures on plant communities, deteriorating optimal plant functioning. In plant communities, root functional trait expression and microbial communities are important indicators of plant functioning belowground, and, when confronted with pathogens aboveground, can simultaneously reflect plant defence strategies. Yet, while research is continuing to emerge on the response of root functional traits and microbial processes to pathogens aboveground, little work has investigated these interactions in tree-crops, or the...

A new marrellomorph arthropod from southern Ontario: A rare case of soft tissue preservation on a late Ordovician open marine shelf

Joseph Moysiuk, Alejandro Izquierdo-López, George E. Kampouris & Jean-Bernard Caron
Ordovician open marine lagerstätten are relatively rare and widely dispersed, producing a patchy picture of the diversity and biogeography of non-mineralized marine organisms, and challenging our understanding of the fate of Cambrian groups. Here, for the first time, we report soft-bodied fossils, including a well-preserved marrellomorph arthropod, fragmentary carapaces, and macroalgae, from the late Ordovician (Katian) Upper Member of the Kirkfield Formation near Brechin, Ontario. The unmineralized elements and associated exceptionally preserved shelly biota were...

Quantifying and comparing male harm between two Drosophila serrata lab populations

Howard Rundle, Julie Colpitts, Will M.C. Jarvis & Aneil F. Agrawal
Male harm arises when traits that increase reproductive success in competition with other males also harm females as a side-effect. The extent of harm depends on male and female phenotypes, both of which can diverge between populations. Within a population, harm is inferred when increased exposure to males reduces female fitness, but studies of the divergence of male harm rarely manipulate male exposure. Here, we quantify male harm and compare its magnitude between two lab...

Data from: Above- and belowground drivers of intraspecific trait variability across subcontinental gradients for five ubiquitous forest plants in North America

Isabelle Aubin, Françoise Cardou, Alison Munson, Madhur Anand, André Arsenault, F. Wayne Bell, Yves Bergeron, Isabelle Boulangeat, Sylvain Delagrange, Nicole J. Fenton, Dominique Gravel, François Hébert, Jill Johnstone, S. Ellen Macdonald, Azim Mallik, Anne C.S. McIntosh, Jennie R. McLaren, Christian Messier, Dave Morris, Bill Shipley, Luc Sirois, Nelson Thiffault, Laura Boisvert-Marsh & Bright B. Kumordzi
Intraspecific trait variability (ITV) provides the material for species adaptation to environmental changes. To advance our understanding of how ITV can contribute to species adaptation to a wide range of environmental conditions, we studied five widespread understory forest species exposed to both continental-scale climate gradients, and local soil and disturbance gradients. We investigated the environmental drivers of between-site leaf and root trait variation, and tested whether higher between-site ITV was associated with increased trait sensitivity...

Morphological adaptations linked to flight efficiency and aerial lifestyle determine natal dispersal distance in birds

Brian Weeks, Bruce OBrien, Jonathan Chu, Santiago Claramunt, Catherine Sheard & Joseph Tobias
Natal dispersal—the movement from birthplace to breeding location—is often considered the most significant dispersal event in an animal’s lifetime. Natal dispersal distances may be shaped by a variety of intrinsic and extrinsic factors, and remain poorly quantified in most groups, highlighting the need for indices that capture variation in dispersal among species. In birds, it is hypothesized that dispersal distance can be predicted by flight efficiency, which can be estimated using wing morphology. However, the...

Evolution in response to climate in the native and introduced ranges of a globally distributed plant

Simon Innes, James Santangelo, Nicholas Kooyers, Kenneth Olsen & Marc Johnson
The extent to which species can adapt to spatiotemporal climatic variation in their native and introduced ranges remains unresolved. To address this, we examined how clines in cyanogenesis (HCN production—an antiherbivore defense associated with decreased tolerance to freezing) have shifted in response to climatic variation in space and time over a 60-year period in both the native and introduced ranges of Trifolium repens. HCN production is a polymorphic trait controlled by variation at two Mendelian...

Barcoded Bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

Alex N. Nguyen Ba, Katherine Lawrence, Artur Rego-Costa, Shreyas Gopalakrishnan, Daniel Temko, Franziska Michor & Michael Desai
Mapping the genetic basis of complex traits is critical to uncovering the biological mechanisms that underlie disease and other phenotypes. Genome-wide association studies (GWAS) in humans and quantitative trait locus (QTL) mapping in model organisms can now explain much of the observed heritability in many traits, allowing us to predict phenotype from genotype. However, constraints on power due to statistical confounders in large GWAS and smaller sample sizes in QTL studies still limit our ability...

Data and source code from: Contingency and selection in mitochondrial genome dynamics

Christopher Nunn & Sidhartha Goyal
Eukaryotic cells contain numerous copies of mitochondrial DNA (mtDNA), allowing for the coexistence of mutant and wild-type mtDNA in individual cells. The fate of mutant mtDNA depends on their relative replicative fitness within cells and the resulting cellular fitness within populations of cells. Yet the dynamics of the generation of mutant mtDNA and features that inform their fitness remain unaddressed. Here we utilize long read single-molecule sequencing to track mtDNA mutational trajectories in Saccharomyces cerevisiae....

Introduced populations of ragweed show as much evolutionary potential as native populations

Brechann McGoey & John Stinchcombe
Invasive species are a global economic and ecological problem. They also offer an opportunity to understand evolutionary processes in a colonizing context. The impacts of evolutionary factors, such as genetic variation, on the invasion process are increasingly appreciated, but there remain gaps in the empirical literature. The adaptive potential of populations can be quantified using genetic variance–covariance matrices (G), which encapsulate the heritable genetic variance in a population. Here, we use a multivariate Bayesian approach...

Community science reveals links between migration arrival timing advance, migration distance, and wing shape

Jonathan Chu, Daniel Gillis & Shelby Riskin
Substantial global data show that many taxa are shifting their phenologies in response to climate change. For birds, migration arrival dates in breeding regions have been shifting earlier, and there is evidence that both evolutionary adaptation and behavioural flexibility influence these shifts. As more efficient flyers may be able to demonstrate more flexibility to respond to changing conditions during migratory flight, we hypothesize that differences among passerine species in flight efficiency, as reflected by morphology,...

Data: Applying stochastic and Bayesian integral projection modeling to amphibian population viability analysis

Arianne Messerman, Adam Clause, Levi Gray, Martin Krkošek, Hilary Rollins, Peter Trenham, Bradley Shaffer & Christopher Searcy
Integral projection models (IPMs) can estimate the population dynamics of species for which both discrete life stages and continuous variables influence demographic rates. Stochastic IPMs for imperiled species, in turn, can facilitate population viability analyses (PVAs) to guide conservation decision-making. Biphasic amphibians are globally distributed, often highly imperiled, and ecologically well-suited to the IPM approach. Herein, we present the first stochastic size- and stage-structured IPM for a biphasic amphibian, the U.S. federally threatened California tiger...

Additional file 1 of A scoping review of perceptions from healthcare professionals on antipsychotic prescribing practices in acute care settings

Natalia Jaworska, Stephana J. Moss, Karla D. Krewulak, Zara Stelfox, Daniel J. Niven, Zahinoor Ismail, Lisa D. Burry & Kirsten M. Fiest
Additional file 1.

Additional file 2 of Integrative analysis of m3C associated genes reveals METTL2A as a potential oncogene in breast Cancer

Shuai Wang, Huiting Li, Jiheng Liu, Qianqian Zhang, Wei Xu, Juanjuan Xiang, Li Fang, Ping Xu & Zheng Li
Additional file 2: Fig. S2 Relationship between METTL2A expression and clinicopathological parameters in BRCA form GEO cohorts. Distribution of METTL2A expression stratified by a, b Age, c N stage, d M stage, and e-g PR status.

Additional file 4 of Interventions to address potentially inappropriate prescriptions and over-the-counter medication use among adults 65 years and older in primary care settings: protocol for a systematic review

Andrew Beck, Navindra Persaud, Laure A. Tessier, Roland Grad, Michael R. Kidd, Scott Klarenbach, Christina Korownyk, Ainsley Moore, Brett D. Thombs, Dee Mangin, Rita K. McCracken, Emily G. McDonald, Caroline Sirois, Salmaan Kanji, Frank Molnar, Stuart G. Nicholls, Kednapa Thavorn, Alexandria Bennett, Nicole Shaver, Becky Skidmore, Bradley R. Mitchelmore, Marc Avey, Elizabeth Rolland-Harris, Julian Little & David Moher
Additional file 4. Definitions.

Integrative analysis of m3C associated genes reveals METTL2A as a potential oncogene in breast Cancer

Shuai Wang, Huiting Li, Jiheng Liu, Qianqian Zhang, Wei Xu, Juanjuan Xiang, Li Fang, Ping Xu & Zheng Li
Abstract RNA methylation modifications, especially m6A mRNA modification, are known to be extensively involved in tumor development. However, the relationship between N3-methylcytidine (m3C) related genes and tumorigenesis has rarely been studied. In this research, we found that m3C-related genes were expressed at different levels and affected patients’ prognosis across multiple cancer types from The Cancer Genome Atlas and multi-omics levels. Importantly, methyltransferase-like proteins 2A (METTL2A) had a high amplification frequency (~ 7%) in patients with...

Additional file 1 of Effect of different feeding methods on gastrointestinal function in critical patients (DFM-GFC): study protocol for a randomized controlled trial

Guang Yang, Aijing Deng, Bojun Zheng, Jian Li, Yi Yu, Honglian Ouyang, Xin Huang & Hong Chen
Additional file 1.

Additional file 1 of Association of stress hyperglycemia ratio and in-hospital mortality in patients with coronary artery disease: insights from a large cohort study

Wei Xu, Qirui Song, Xiang Wang, Zinan Zhao, Xuyang Meng, Chenxi Xia, Yibo Xie, Chenguang Yang, Ying Guo, Yatong Zhang & Fang Wang
Supplementary Material 1: Association of stress hyperglycemiaratioandin-hospital mortality in patients withcoronaryartery disease: Insights froma large cohortstudy

Additional file 1 of Identifying existing approaches used to evaluate the sustainability of evidence-based interventions in healthcare: an integrative review

Rachel Flynn, Bonnie Stevens, Arjun Bains, Megan Kennedy & Shannon D. Scott
Additional file 1. Search strategy. The four databases searched on Dec 21, 2018, as well as an additional search in July 2020. The file depicts the date of searchers and strategy used, including all search terms in each database.

Additional file 2 of Identifying existing approaches used to evaluate the sustainability of evidence-based interventions in healthcare: an integrative review

Rachel Flynn, Bonnie Stevens, Arjun Bains, Megan Kennedy & Shannon D. Scott
Additional file 2. PRISMA 2020 Checklist. The complete 2020 PRISMA checklist for new systematic reviews.

Additional file 4 of Identifying existing approaches used to evaluate the sustainability of evidence-based interventions in healthcare: an integrative review

Rachel Flynn, Bonnie Stevens, Arjun Bains, Megan Kennedy & Shannon D. Scott
Additional file 4. Citation list of included studies. A table of the sustainability outcomes reported in all of the included studies (n=64). The table depicts which of the 9 sustainability outcomes were reported in each study.

Additional file 4 of Identifying existing approaches used to evaluate the sustainability of evidence-based interventions in healthcare: an integrative review

Rachel Flynn, Bonnie Stevens, Arjun Bains, Megan Kennedy & Shannon D. Scott
Additional file 4. Citation list of included studies. A table of the sustainability outcomes reported in all of the included studies (n=64). The table depicts which of the 9 sustainability outcomes were reported in each study.

Additional file 2 of Exploratory study to assess feasibility of intracerebral hemorrhage detection by point of care cranial ultrasound

Aarti Sarwal, Yash Patel, Ralph D’Agostino, Patrick Brown, Stacey Q. Wolfe, Cheryl Bushnell, Casey Glass & Pamela Duncan
Additional file 2: Table S1. Narrative summary of published studies investigating the accuracy of cranial ultrasound compared to CT in ICH diagnosis. AIS—acute ischemic stroke. NR-not reported or details not obtainable from data provided.

Additional file 2 of Exploratory study to assess feasibility of intracerebral hemorrhage detection by point of care cranial ultrasound

Aarti Sarwal, Yash Patel, Ralph D’Agostino, Patrick Brown, Stacey Q. Wolfe, Cheryl Bushnell, Casey Glass & Pamela Duncan
Additional file 2: Table S1. Narrative summary of published studies investigating the accuracy of cranial ultrasound compared to CT in ICH diagnosis. AIS—acute ischemic stroke. NR-not reported or details not obtainable from data provided.

Supplemental Material - Prevalence, causes, and consequences of moral distress in healthcare providers caring for people living with dementia in long-term care during a pandemic

Lynn Haslam-Larmer, Alisa Grigorovich, Hannah Quirt, Katia Engel, Steven Stewart, Kevin Rodrigues, Pia Kontos, Arlene Astell, Josephine McMurray, AnneMarie Levy, Kathleen S Bingham, Alastair J Flint, Colleen Maxwell & Andrea Iaboni
Supplemental Material for Prevalence, causes, and consequences of moral distress in healthcare providers caring for people living with dementia in long-term care during a pandemic by Lynn Haslam-Larmer, Alisa Grigorovich, Hannah Quirt, Katia Engel, Steven Stewart, Pia Kontos, Arlene Astell, Josephine McMurray, AnneMarie Levy, Kathleen S. Bingham, Kevin Rodrigues, Alastair J. Flint, Colleen Maxwell, Andrea Iaboni in Dementia

Plain language summary for the manuscript: Infections in patients with rheumatoid arthritis receiving tofacitinib versus tumour necrosis factor inhibitors: results from the open-label, randomised controlled ORAL Surveillance trial

Andra R Balanescu, Gustavo Citera, Virginia Pascual-Ramos, Deepak L Bhatt, Carol A Connell, David Gold, All-Shine Chen, Gosford Sawyerr, Andrea B Shapiro, Janet Pope & Hendrik Schulze-Koops
This is a plain language summary (PLS) of an article published in a peer-reviewed scientific journal. This PLS is not peer-reviewed. The publisher of the original manuscript was not involved in the preparation of this PLS and has neither reviewed nor approved its content.

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