2 Works

Data from: Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers

George H. Perry, Matthieu Foll, Jean-Christophe Grenier, Etienne Patin, Yohann Nédélec, Alain Pacis, Maxime Barakatt, Simon Gravel, Xiang Zhou, Sam L. Nsobya, Laurent Excoffier, Lluis Quintana-Murci, Nathaniel J. Dominy & Luis B. Barreiro
The evolutionary history of the human pygmy phenotype (small body size), a characteristic of African and Southeast Asian rainforest hunter-gatherers, is largely unknown. Here we use a genome-wide admixture mapping analysis to identify 16 genomic regions that are significantly associated with the pygmy phenotype in the Batwa, a rainforest hunter-gatherer population from Uganda (east central Africa). The identified genomic regions have multiple attributes that provide supporting evidence of genuine association with the pygmy phenotype, including...

Data from: Genetic diversity and population structure of Trypanosoma brucei in Uganda: implications for the epidemiology of sleeping sickness and Nagana

Richard Echodu, Mark J. Sistrom, Rosemary Bateta, Grace Murilla, Loyce Okedi, Serap Aksoy, Chineme Enyioha, John Enyaru, Elizabeth Opiyo, Wendy Gibson, Caccone Adalgisa, Mark Sistrom & Adalgisa Caccone
Background: While Human African Trypanosomiasis (HAT) is in decline on the continent of Africa, the disease still remains a major health problem in Uganda. There are recurrent sporadic outbreaks in the traditionally endemic areas in south-east Uganda, and continued spread to new unaffected areas in central Uganda. We evaluated the evolutionary dynamics underpinning the origin of new foci and the impact of host species on parasite genetic diversity in Uganda. We genotyped 269 Trypanosoma brucei...

Registration Year

  • 2014
    2

Resource Types

  • Dataset
    2

Affiliations

  • Makerere University
    2
  • Swiss Institute of Bioinformatics
    1
  • McGill University
    1
  • University of Chicago
    1
  • École Polytechnique Fédérale de Lausanne
    1
  • Kenya Agricultural Research Institute
    1
  • Yale University
    1
  • Gulu University
    1
  • Dartmouth College
    1
  • Pennsylvania State University
    1