4 Works

Data from: How does epistasis influence the response to selection?

Nicholas H. Barton
Much of quantitative genetics is based on the "infinitesimal model", under which selection has a negligible effect on the genetic variance. This is typically justified by assuming a very large number of loci with additive effects. However, it applies even when genes interact, provided that the number of loci is large enough that selection on each of them is weak relative to random drift. In the long term, directional selection will change allele frequencies, but...

Data from: Error-robust modes of the retinal population code

Adrianna R. Loback, Gašper Tkačik, Jason S. Prentice, Mark L. Ioffe, , Olivier Marre & Michael J. Berry
Across the nervous system, certain population spiking patterns are observed far more frequently than others. A hypothesis about this structure is that these collective activity patterns function as population codewords–collective modes–carrying information distinct from that of any single cell. We investigate this phenomenon in recordings of ∼150 retinal ganglion cells, the retina’s output. We develop a novel statistical model that decomposes the population response into modes; it predicts the distribution of spiking activity in the...

Data from: Ret and Etv4 promote directed movements of progenitor cells during renal branching morphogenesis

Paul Riccio, Cristina Cebrian, Hui Zong, Simon Hippenmeyer & Frank Costantini
Branching morphogenesis of the epithelial ureteric bud forms the renal collecting duct system and is critical for normal nephron number, while low nephron number is implicated in hypertension and renal disease. Ureteric bud growth and branching requires GDNF signaling from the surrounding mesenchyme to cells at the ureteric bud tips, via the Ret receptor tyrosine kinase and coreceptor Gfrα1; Ret signaling up-regulates transcription factors Etv4 and Etv5, which are also critical for branching. Despite extensive...

Data from: Down syndrome cell adhesion molecule 1: testing for a role in insect immunity, behaviour and reproduction

Robert Peuß, Kristina U. Wensing, Luisa Woestmann, Hendrik Eggert, Barbara Milutinović, Marlene G. U. Sroka, Jörn P. Scharsack, Joachim Kurtz & Sophie A. O. Armitage
Down syndrome cell adhesion molecule 1 (Dscam1) has wide-reaching and vital neuronal functions although the role it plays in insect and crustacean immunity is less well understood. In this study, we combine different approaches to understand the roles that Dscam1 plays in fitness-related contexts in two model insect species. Contrary to our expectations, we found no short-term modulation of Dscam1 gene expression after haemocoelic or oral bacterial exposure in Tribolium castaneum, or after haemocoelic bacterial...

Registration Year

  • 2016

Resource Types

  • Dataset


  • Institute of Science and Technology Austria
  • Institut de la Vision
  • Columbia University
  • Princeton University
  • University of Münster
  • University of Virginia
  • University of Helsinki