6 Works

Supplementary code for: Polygenic local adaptation in metapopulations: a stochastic eco-evolutionary model

Eniko Szep, Himani Sachdeva & Nick Barton
This paper analyzes the conditions for local adaptation in a metapopulation with infinitely many islands under a model of hard selection, where population size depends on local fitness. Each island belongs to one of two distinct ecological niches or habitats. Fitness is influenced by an additive trait which is under habitat-dependent directional selection. Our analysis is based on the diffusion approximation and accounts for both genetic drift and demographic stochasticity. By neglecting linkage disequilibria, it...

Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies

Barbara Casillas-Pérez, Christopher Pull, Filip Naiser, Elisabeth Naderlinger, Jiri Matas & Sylvia Cremer
Infections early in life can have enduring effects on an organism’s development and immunity. In this study, we show that this equally applies to developing “superorganisms” – incipient social insect colonies. When we exposed newly mated Lasius niger ant queens to a low pathogen dose, their colonies grew more slowly than controls before winter, but reached similar sizes afterwards. Independent of exposure, queen hibernation survival improved when the ratio of pupae to workers was small....

Data from: Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis

Eva Koch, Hernán Morales, Jenny Larsson, Anja Westram, Rui Faria, Alan Lemmon, Emily Lemmon, Kerstin Johannesson & Roger Butlin
Chromosomal inversion polymorphisms, segments of chromosomes that are flipped in orientation and occur in reversed order in some individuals, have long been recognized to play an important role in local adaptation. They can reduce recombination in heterozygous individuals and thus help to maintain sets of locally adapted alleles. In a wide range of organisms, populations adapted to different habitats differ in frequency of inversion arrangements. However, getting a full understanding of the importance of inversions...

Was bietet die IFLA der VÖB? – Warum Bibliothekar*innen international aktiv sein sollten - Statement

Patrick Danowski
75 Jahre VÖB. 1946–2021, Hg. v. Alker-Windbichler, Bauer und Köstner-Pemsel, 2021, S. 143–145

BayesW time-to-event analysis posterior outputs and summary statistics

Sven Erik Ojavee & Matthew Robinson
Here, we develop a Bayesian approach (BayesW) that provides probabilistic inference of the genetic architecture of age-at-onset phenotypes in a hybrid-parallel sampling scheme that facilitates Bayesian time-to-event large-scale biobank analyses. We show in extensive simulation work that BayesW achieves a greater number of discoveries, better model performance and improved genomic prediction as compared to other approaches. In the UK Biobank, we find many thousands of common genomic regions underlying the age-at-onset of high blood pressure...

Probabilistic inference of the genetic architecture of functional enrichment of complex traits

Matthew Robinson
We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 seconds per iteration to estimate 8.4 million SNP-effects and 78 SNP-heritability parameters in the UK Biobank. We find that only $\leq$ 10\% of the genetic variation captured for height, body mass index, cardiovascular disease, and type 2 diabetes is attributable to proximal regulatory regions within 10kb upstream of genes, while 12-25% is attributed...

Registration Year

  • 2021
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Affiliations

  • Institute of Science and Technology Austria
    6
  • University of Lausanne
    1
  • University of Gothenburg
    1
  • University of Copenhagen
    1
  • Czech Technical University in Prague
    1
  • University of Vienna
    1
  • Florida State University
    1
  • University of Sheffield
    1