Additional file 2: Supplementary Fig. S1. TNFAIP2 expression in normal tissues and cancer cell lines. (a) TNFAIP2 expression in normal tissues, analyzed by GTEx portal; (b) TNFAIP2 expression in cancer cell lines analyzed by CCLE.

Additional file 3: Supplementary Fig. S2. Epigenetic alterations of TNFAIP2 in AML. (a) The exact location of CpG sites in gene body of TNFAIP2 from UCSC database. (b) Kaplan-Meier analysis of the prognostic value of TNFAIP2 methylation at gene body region on OS in AML patients, analyzed by MethSurv.

Additional file 12. Supplementary discussion.

The mechanism underlying the antiepileptic actions of norepinephrine (NE) is unclear with conflicting results. Our objectives are to conclusively delineate the specific adrenergic receptor (AR) involved in attenuating hippocampal CA3 epileptiform activity and assess compounds for lead drug development. We utilized the picrotoxin model of seizure generation in rat brain slices using electrophysiological recordings. Epinephrine (EPI) reduced epileptiform burst frequency in a concentration-dependent manner. To identify the specific receptor involved in this response, the equilibrium...

At the request of the authors and American Marketing Association (AMA), the following article has been retracted:

Additional file 6.

Additional file 7.

Abstract Background DNA methyltransferase 1 (DNMT1) exerts imperative functions in neuropathic pain (NP). This study explored the action of RNA interference-mediated DNMT1 silencing in NP by regulating microglial M2 polarization. Methods NP rat models were established using chronic constriction injury (CCI) and highly aggressive proliferating immortalized (HAPI) microglia were treated with lipopolysaccharide (LPS) to induce microglia M1 polarization, followed by treatment of DNMT1 siRNA or si-DNMT1/oe-DNMT1, respectively. The pain threshold of CCI rats was assessed...

Additional file 12.

Additional file 12.

Additional file 2.

Additional file 3.

Additional file 8: Table S6. All genomic SNPs in gene body and 2 kb promoter of ELOVL gene family used for PCA analysis.

Additional file 1. Supplementary Figures and tables for this study.

Additional file 2. Characteristics of 5003 DENV-1 isolates worldwide from 1944 to 2018 inclusive in this study.

Additional file 3. Features of the selected 910 E complete sequences for temporal phylogenic reconstruction covering all spatio-temporal distributions and representing all designated subgenotypes and clades in genotypes I, IV, and V from 5003 DENV-1 strains worldwide.

Additional file 2. Table S2: Adjuvant treatment information.

Additional file 4. Figure S1: Availability of plasma samples. The availability of plasma samples for analysis at each schedule collection time point. Blue and red blocks denote samples collected before and after disease recurrence, respectively. Abbreviations: LUAD – lung adenocarcinoma, LUSC - lung squamous-cell carcinoma, RFS – recurrence-free survival, AT – adjuvant therapy, RT – radiotherapy, LNM – lymph node metastasis.

Abstract Acute promyelocytic leukemia (APL) has become curable over 95% patients under a complete chemo-free treatment with all-trans retinoic acid (ATRA) and arsenic trioxide in low-risk patients. Minimizing chemotherapy has proven feasible in high-risk patients. We evaluated oral arsenic and ATRA without chemotherapy as an outpatient consolidation therapy and no maintenance for high-risk APL. We conducted a multicenter, single-arm, phase 2 study with consolidation phases. The consolidation therapy included Realgar–Indigo naturalis formula (60 mg/kg daily...

Abstract Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to the pathogenesis of choroidal neovascularization (CNV) in exudative AMD (wet AMD). This study describes the effects of cyclooxygenase-2 (COX2)/prostaglandin E2 (PGE2) signalling on the macrophage activation and CNV formation of wet AMD. In a mouse model of laser-induced wet AMD, the mice received an intravitreal...

Additional file 1: Fig. S1: The cytotoxicity of intravitreal injection of celecoxib. Table S1. Key resources table

BETA PRIME: Phase I study of AdAPT-001 as monotherapy and combined with a checkpoint inhibitor in superficially accessible, treatment-refractory solid tumors Infographic

Additional file 2: Table S1. List of antibodies used in this study.

Additional file 1. Additional figures and legends.

Abstract Background Angiotensin-converting enzyme 2 (ACE2) is known as a tumor suppressor and lowly expressed in most cancers. The expression pattern and role of ACE2 in breast cancer (BC) have not been deeply elucidated. Methods A systematic pan-cancer analysis was conducted to assess the expression pattern and immunological role of ACE2 based on RNA-sequencing (RNA-seq) data downloaded from The Cancer Genome Atlas (TCGA). The correlation of ACE2 expression and immunological characteristics in the BC tumor...