Additional file 1.

Abstract Objective To explore the application effect of the clinical basic integration teaching mode constructed by case studies and the MOOC platform in obstetrics and gynecology internship teaching in the face of public health emergencies. Methods One hundred ten clinical medical students of grade 2020 were selected as the experimental group, and 110 clinical medical students of grade 2021 were selected as the control group. The experimental group adopted the online teaching mode combined with...

Abstract Objective To explore the application effect of the clinical basic integration teaching mode constructed by case studies and the MOOC platform in obstetrics and gynecology internship teaching in the face of public health emergencies. Methods One hundred ten clinical medical students of grade 2020 were selected as the experimental group, and 110 clinical medical students of grade 2021 were selected as the control group. The experimental group adopted the online teaching mode combined with...

Supplemental material, sj-tif-3-onc-10.1177_11795549221134735 for First-Line Osimertinib in Patients With EGFR-Mutated Non-Small Cell Lung Cancer: Effectiveness, Resistance Mechanisms, and Prognosis of Different Subsequent Treatments by Naifu Nie, Jianghua Li, Jian Zhang, Jie Dai, Zhulin Liu, Zhenyu Ding, Yubo Wang, Mengxiao Zhu, Chen Hu, Rui Han, Huan Tang, Li Li and Yong He in Clinical Medicine Insights: Oncology

Background:Although the clinical application of osimertinib, a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), has been a new step forward in the first-line treatment of non-small cell lung cancer (NSCLC), an increasing number of patients with progression on osimertinib represents a great challenge clinically. The patterns of resistance mechanisms and subsequent treatment strategies after first-line osimertinib resistance are not well established.Methods:Between January 1, 2016 and October 31, 2020, a consecutive of 56 EGFR-mutant lung...

Abstract Background Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally controlled Notch activation to promote AVF maturation while avoiding neointima formation. Methods Temporal Notch activation was controlled by regulating the expression of Notch transcription factor, RBP-Jκ, or dnMAML1 (dominant negative MAML2) in vascular smooth muscle cells (VSMCs). AVF mouse model was...

We, the Editors and Publisher of the journal Cell Cycle, have retracted the following article: Hao Gao, Xiaofeng Li, Guangxi Zhan, Yong Zhu, Jing Yu, Jiapo Wang, Li Li, Weimin Wu, Na Liu and Xiaoqing Guo. Long noncoding RNA MAGI1-IT1 promoted invasion and metastasis of epithelial ovarian cancer via the miR-200a/ZEB axis. Cell Cycle. 2019;18(12):1393-1406. doi: 10.1080/15384101.2019.1618121 Since publication, concerns have been raised about the integrity of the data in the article. When approached for...

Aiming at developing a current plant lighting source with both the suitable illumination area and high illumination uniformity, we proposed a lighting system for plant growth based on the combination of LD and LED lighting mode. We added a triangular prism shaped base plate element to the previous array type optical structure to increase the light coupling degree and expand the illumination area in this way. Taguchi method was used in our design and experiment,...

A φ-OFDR strain sensor with a submillimeter-spatial-resolution of 233 μm, was demonstrated by using the femtosecond laser induced permanent scatters (PSs) in standard single mode fiber (SMF). The PSs-inscribed SMF, i.e., strain sensor, with an interval of 233 μm exhibited a Rayleigh backscattering intensity (RBS) enhancement of 26 dB and insertion loss of 0.6 dB, respectively. A novel method, i.e., PSs-assisted φ-OFDR, was proposed to demodulate the strain distribution based on the extracted phase difference...

Abstract Background Chrysanthemum seticuspe has emerged as a model plant species of cultivated chrysanthemums, especially for studies involving diploid and self-compatible pure lines (Gojo-0). Its genome was sequenced and assembled into chromosomes. However, the genome annotation of C. seticuspe still needs to be improved to elucidate the complex regulatory networks in this species. Results In addition to the 74,259 mRNAs annotated in the C. seticuspe genome, we identified 18,265 novel mRNAs, 51,425 novel lncRNAs, 501...

Supplemental Document

Additional file 10.

Additional file 4.

Additional file 1: Figure S1. Pan-cancer analysis of ACE2 expression in tumor and para-tumor tissues in the TCGA database. Significance was calculated with Student’s t-test. ns-P>0.05, *P<0.05, **P<0.01, ***P<0.001, ****P < 0.0001. Figure S2. Pan-cancer analysis of the correlations between ACE2 and immunological features. (A) Correlations between ACE2 and 122 immunomodulators (chemokines, receptors, MHC and immunostimulators). The color reveals the correlation coefficient. The asterisks reveal statistical differences assessed by Pearson analysis. (B) Correlations between ACE2...

Additional file 1: COVID-19 Vaccine Hesitancy Scale Item Description.

Abstract Background COVID-19 vaccines have been administered in many countries; however, a sufficient vaccine coverage rate is not guaranteed due to vaccine hesitancy. To improve the uptake rate of COVID-19 vaccine, it is essential to evaluate the rate of vaccine hesitancy and explore relevant factors in different populations. An urgent need is to measure COVID-19 vaccine hesitancy among different population groups, hence a validated scale for measuring COVID-19 vaccine hesitancy is necessary. The present study...

Additional file 10. Figure S7: Prognostic value of presurgical ctDNA detection. A). The recurrence-free survival analysis of patients stratified by presurgical ctDNA detection. B). The multi-variant Cox regression for presurgical ctDNA detection. Abbreviations: RFS – recurrence-free survival, LNM – lymph node metastasis, LUAD – lung adenocarcinoma, LUSC - lung squamous-cell carcinoma.

Additional file 13. Supplementary results.

Additional file 1. Table S1: Patient demography.

Additional file 6. Figure S3: Prognostic values of postsurgical ctDNA detection at 3 months and 6 months. A-B) The recurrence-free survival analysis (top panel) and multi-variant Cox regression (bottom panel) of postsurgical ctDNA detection at 3 months (A) and 6 months (B). For the analysis at 6 months after surgeries, only patients with plasma samples available at this scheduled point and followed-up for more than 6 months were included. Abbreviations: RFS – recurrence-free survival, LNM...

Femtosecond laser filamentation propagating tens of meters to several kilometers with high intensity in the atmosphere has been demonstrated as a powerful tool for remote sensing. In contrast to the refractive systems, the reflective optical systems possess a variety of advantages including broad bandwidth, large aperture, light weight and low energy loss. However, astigmatic aberration is inevitably introduced by off-axis reflective mirrors. It can greatly affect the filament quality, which is critical for exciting and...

1. Design of off-axis reflective system for filamentation;2. Parameters of optimized free-form surface

Abstract Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to the pathogenesis of choroidal neovascularization (CNV) in exudative AMD (wet AMD). This study describes the effects of cyclooxygenase-2 (COX2)/prostaglandin E2 (PGE2) signalling on the macrophage activation and CNV formation of wet AMD. In a mouse model of laser-induced wet AMD, the mice received an intravitreal...

Additional file 11. qPCR Primer list.

Additional file 6. Common and unique EB regulated genes on GD 3 and GD 4.5.