Data from: Alcoholism gender differences in brain responsivity to emotional stimuliKayle S Sawyer, Nasim Maleki, Trinity Urban, Marinkovic Ksenija, Karson Steven, Susan Mosher Ruiz, Gordon J Harris & Marlene Oscar-Berman
Men and women may use alcohol to regulate emotions differently, with corresponding differences in neural responses. We explored how the viewing of different types of emotionally salient stimuli impacted brain activity observed through functional magnetic resonance imaging (fMRI) from 42 long-term abstinent alcoholic (25 women) and 46 nonalcoholic (24 women) participants. Analyses revealed blunted brain responsivity in alcoholic compared to nonalcoholic groups, as well as gender differences in those activation patterns. Brain activation in alcoholic...
Supplement to: Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysisRaul Nogueira, Muhammed Qureshi, Mohamad Abdalkader, Sheila Martins, Hiroshi Yamagami, Zhongming Qiu, Ossama Mansour, Anvitha Sathya, Anna Czlonkowska, Georgios Tsivgoulis, Diana Aguiar De Sousa, Jelle Demeestere, Robert Mikulik, Peter Vanacker, James Siegler, Janika Korv, Jose Biller, Conrad Liang, Navdeep Sangha, Alicia Zha, Alexandra Czap, Christine Holmstedt, Tanya Turan, George Ntaios, Konark Malhotra … & Thanh Nguyen
Objective: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in...
Evaluating the effects of pod-based electronic cigarettes on human endothelial cell functionSana Majid, Robert M. Weisbrod, Jessica L. Fetterman, Rachel J. Keith, Syed H. M. Rizvi, Yuxiang Zhou, Leili Behrooz, Rose Marie Robertson, Aruni Bhatnagar, Daniel J. Conklin & Naomi M. Hamburg
Pod-based electronic (e-) cigarettes more efficiently deliver nicotine using a protonated formulation. The cardiovascular effects associated with these devices are poorly understood. We evaluated whether pod-based e-liquids and their individual components impair endothelial cell function. We isolated endothelial cells from people who are pod users (n=10), tobacco never users (n=7), and combustible cigarette users (n=6). After a structured use, pod users had lower acetylcholine-mediated endothelial nitric oxide synthase (eNOS) activation compared with never users and...
Data from: Decreased brain levels of vitamin B12 in aging, autism and schizophreniaYiting Zhang, Nathaniel W. Hodgson, Malav S. Trivedi, Hamid M. Abdolmaleky, Margot Fournier, Michel Cuenod, Kim Quang Do & Richard C. Deth
Many studies indicate a crucial role for the vitamin B12 and folate-dependent enzyme methionine synthase (MS) in brain development and function, but vitamin B12 status in the brain across the lifespan has not been previously investigated. Vitamin B12 (cobalamin, Cbl) exists in multiple forms, including methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), serving as cofactors for MS and methylmalonylCoA mutase, respectively. We measured levels of five Cbl species in postmortem human frontal cortex of 43 control subjects,...
Slashing Undernutrition Sustainably for Abatement of Tuberculosis in India (SUSTAIN-India)
India has a quarter of the global burden of TB. Undernutrition is the leading risk factor for TB in India. Despite a broad consensus that undernutrition must be addressed, there is lack of clarity as to what strategy would work best in India: cash transfers or in-kind supplementation such as food baskets. Thusfar, policy decisions have been made without rigorously collected data that tie nutritional interventions to tangible health outcomes. I hypothesize that cash transfers...
Linking cellular senescence to dysfunctional extracellular matrix remodeling in aging tendonsBrianne K Connizzo
Age-related tendon degeneration is a major clinical and economic burden for our growing aging population, resulting in functional deficits, significant pain, and loss of independence. Despite its high prevalence, the etiology and pathogenesis of tendon disease is still not well understood. One key feature of tendon disease is the loss of extracellular matrix (ECM) homeostasis, resulting in aberrant remodeling that can lead to tissue degeneration, weakening and ultimately injuries. While many studies have explored matrix...
Data from: Associations between changes in city and address specific temperature and QT interval - the VA Normative Aging StudyAmar J. Mehta, Itai Kloog, Antonella Zanobetti, Brent A. Coull, David Sparrow, Pantel Vokonas & Joel Schwartz
Background: The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily mean temperature and standard deviation of temperature was associated with heart rate-corrected QT interval (QTc) duration, a marker of ventricular repolarization in a prospective cohort of older men. Methods: This longitudinal analysis included 487 older men participating in the VA Normative Aging Study with up to three...
Data from: Cambrian origin of the CYP27C1-mediated vitamin A1-to-A2 switch, a key mechanism of vertebrate sensory plasticityAla Morshedian, Matthew B. Toomey, Gabriel E. Pollock, Rikard Frederiksen, Jennifer M. Enright, Stephen D. McCormick, M. Carter Cornwall, Gordon L. Fain & Joseph C. Corbo
The spectral composition of ambient light varies across both space and time. Many species of jawed vertebrates adapt to this variation by tuning the sensitivity of their photoreceptors via the expression of CYP27C1, an enzyme that converts vitamin A1 into vitamin A2, thereby shifting the ratio of vitamin A1-based rhodopsin to red-shifted vitamin A2-based porphyropsin in the eye. Here, we show that the sea lamprey (Petromyzon marinus), a jawless vertebrate that diverged from jawed vertebrates...
Data from: Evidence for normal novel object recognition abilities in developmental prosopagnosiaRegan Fry, Jeremy Wilmer, Isabella Xie, Mieke Verfaellie & Joseph DeGutis
The issue of the face specificity of recognition deficits in developmental prosopagnosia (DP) is fundamental to the organisation of high-level visual memory and has been increasingly debated in recent years. Previous DP investigations have found some evidence of object recognition impairments, but have almost exclusively used familiar objects (e.g., cars), where performance may depend on acquired object-specific experience and related visual expertise. An object recognition test not influenced by experience could provide a better, less...
Data from: Using routinely collected laboratory data to identify high rifampicin-resistant tuberculosis burden communities in the Western Cape Province, South Africa: a retrospective spatiotemporal analysisAvery I. McIntosh, Helen E. Jenkins, Laura F. White, Marinus Barnard, Dana Thompson, Tania Dolby, John Simpson, Elizabeth M. Streicher, Mary B. Kleinman, Elizabeth J. Ragan, Paul D. Van Helden, Megan B. Murray, Robin M. Warren & Karen R. Jacobson
Background: South Africa has the highest tuberculosis incidence globally (781/100,000), with an estimated 4.3% of cases being rifampicin resistant (RR). Control and elimination strategies will require detailed spatial information to understand where drug-resistant tuberculosis exists and why it persists in those communities. We demonstrate a method to enable drug-resistant tuberculosis monitoring by identifying high-burden communities in the Western Cape Province using routinely collected laboratory data. Methods and findings: We retrospectively identified cases of microbiologically confirmed...
Supplemental material for: NINDS consensus diagnostic criteria for Traumatic Encephalopathy SyndromeDouglas Katz, Charles Bernick, David Dodick, Jesse Mez, Megan Mariani, Charles Adler, Michael Alosco, Laura Balcer, Sarah Banks, William Barr, David Brody, Robert Cantu, Kristen Dams-O'Connor, Yonas Geda, Barry Jordan, Thomas McAllister, Elaine Peskind, Ronald Petersen, Jennifer Wether, Ross Zafonte, Eimear Foley, Debra Babcock, Walter Koroshetz, Ann McKee, Martha Shenton … & Robert Stern
Objective: To develop evidence-informed, expert consensus research diagnostic criteria for Traumatic Encephalopathy Syndrome (TES), the clinical disorder associated with neuropathologically diagnosed Chronic Traumatic Encephalopathy (CTE). Methods: A panel of 20 expert clinician-scientists in neurology, neuropsychology, psychiatry, neurosurgery, and physical medicine and rehabilitation, from 11 academic institutions, participated in a modified Delphi procedure to achieve consensus, initiated at the First NINDS Consensus Workshop to Define the Diagnostic Criteria for TES, April, 2019. Prior to consensus, panelists...
Data from: Circulating cortisol and cognitive and structural brain measures in a middle-aged cohort: the Framingham Heart StudyJustin B. Echouffo-Tcheugui, Sarah C. Conner, Jayandra J. Himali, Pauline Maillard, Charles S. DeCarli, Alexa S. Beiser, Ramachandran S. Vasan & Sudha Seshadri
Objective: To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia. Methods: We evaluated dementia-free Framingham Study (Generation 3) participants (mean age 48.5 years; 46.8% men), who underwent cognitive testing for memory, abstract reasoning, visual perception, attention, and executive function (n= 2231), and brain MRI (n=2018) to assess total white matter, lobar gray matter, and white matter hyperintensity volumes and fractional...
Unraveling Cellular and Molecular Complexity in Novel Mouse Models of AD and ADRD TauopathyJason Hinman
This project will use advanced mouse models and innovative techniques to identify cell type-specific molecular pathways that drive microvasculopathy, neuroinflammation, tauopathy, and neurodegeneration relevant to late-onset Alzheimer’s disease (AD, LOAD), frontotemporal dementia (FTD), chronic traumatic encephalopathy (CTE), and other tau protein AD-related dementias (ADRDs). Converging evidence indicates that microvascular dysfunction modulates the location, severity, and progression of neuroinflammation, tauopathy, and neurodegeneration in AD/ADRD tauopathies. The goal of this multi-PI project is to identify both shared...
Impact of Microglial Cell Fate on NeurodegenerationTuan Leng Tay
Alzheimer’s disease (AD) and other forms of dementia are highly prevalent forms of neurodegenerative diseases affecting millions of patients and their caregivers. These progressive brain pathologies involve multiple complex factors (e.g., genetic risk genes, aberrant accumulation of protein plaques, neuronal death, glial reactivity), and we have not made great strides in creating successful preventive and therapeutic strategies for AD. Because lesion-associated microgliosis, defective phagocytosis, and elevation of dysregulated and proinflammatory microglia are major pathological hallmarks...
Boston University School of Medicine14
Harvard Medical School4
Boston Medical Center2
Emory University School of Medicine1
Massachusetts General Hospital1
New York University Langone Medical Center1
Kwame Nkrumah University of Science and Technology1
Ain Shams University1
University of Washington1