5 Works

Data from: Pneumococcal colonisation density: a new marker for disease severity in HIV-infected adults with pneumonia

Werner C. Albrich, Shabir A. Madhi, Peter V. Adrian, Nadia Van Niekerk, Jean-Noel Telles, Naseem Ebrahim, Melina Messaoudi, Glaucia Paranhos-Baccalà, Sven Giersdorf, Guy Vernet, Beat Mueller & Keith P. Klugman
Objective: A high genomic load of Pneumococcus from blood or cerebrospinal fluid has been associated with increased mortality. We aimed to analyse whether nasopharyngeal colonisation density in HIV-infected patients with community-acquired pneumonia (CAP) is associated with markers of disease severity or poor outcome. Methods: Quantitative lytA real-time PCR was performed on nasopharyngeal swabs in HIV-infected South African adults hospitalised for acute CAP at Chris Hani Baragwanath Hospital, Soweto, South Africa. Pneumonia aetiology was considered pneumococcal...

Data from: Programmed death in a unicellular organism has species-specific fitness effects

Pierre M. Durand, Rajdeep Choudhury, Armin Rashidi & Richard E. Michod
Programmed cell death (PCD) is an ancient phenomenon and its origin and maintenance in unicellular life is unclear. We report that programmed death provides differential fitness effects that are species specific in the model organism Chlamydomonas reinhardtii. Remarkably, PCD in this organism not only benefits others of the same species, but also has an inhibitory effect on the growth of other species. These data reveal that the fitness effects of PCD can depend upon genetic...

Data from: Revisiting the link between breeding effort and oxidative balance through field evaluation of two sympatric sibling insect species

Benjamin Rey, Pierre-François Pélisson, Marie-Claude Bel-Venner, Yann Voituron & Samuel Venner
The idea that oxidative stress could be a major force governing evolutionary trade-offs has recently been challenged by experimental approaches in laboratory conditions triggering extensive debates centered on theoretical and methodological issues. Here, we revisited the link between oxidative stress and reproduction by measuring multiple antioxidant and oxidative damages in wild-caught females of two sibling weevil species (Curculio elephas, C. glandium). The strength of our study arises from: (1) studied species are sympatric and exploit...

Data from: Functional attributes of savannah soils: contrasting effects of tree canopies and herbivores on bulk density, nutrients and moisture dynamics

Ricardo M. Holdo & Michelle C. Mack
1. Savannahs are highly heterogeneous tree-grass mixtures, and the structural variation imposed by a discontinuous canopy cover results in spatial variation in soil properties such as plant-available nutrients, temperature and soil moisture. Many savannahs are also dominated by large vertebrate herbivores, which impose a different suite of effects on soil properties related to consumption, excretion and physical disturbance. 2. In nutrient-poor, water-limited systems, variation in soil resource availability may play a fundamental role in structuring...

Data from: Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ Lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial

Klaus Reither, Lynn Katsoulis, Trevor Beattie, Nicolene Gardiner, Nicole Lenz, Khadija Said, Elirehema Mfinanga, Christian Pohl, Katherine L. Fielding, Hannah Jeffery, Benjamin M. Kagina, Elisabeth J. Hughes, Thomas J. Scriba, Willem A. Hanekom, Søren T. Hoff, Peter Bang, Ingrid Kromann, Claudia Daubenberger, Peter Andersen & Gavin J. Churchyard
Background: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of the novel H1/IC31 vaccine, a fusion protein of Ag85B-ESAT-6 (H1) formulated with the adjuvant IC31, was evaluated in HIV-infected adults. Methods: HIV-infected adults with CD4+ T cell counts >350/mm3 and without evidence of active tuberculosis were enrolled and followed until day 182. H1/IC31 vaccine or...

Registration Year

  • 2014
    5

Resource Types

  • Dataset
    5

Affiliations

  • University of the Witwatersrand
    5
  • London School of Hygiene & Tropical Medicine
    1
  • Kantonsspital St. Gallen
    1
  • Fondation Mérieux
    1
  • University of Lyon System
    1
  • Aurum Institute
    1
  • University of Florida
    1
  • University of Missouri
    1
  • Swiss Tropical and Public Health Institute
    1
  • University of Arizona
    1