2 Works

Data from: Genetic mapping identifies a major locus spanning P450 clusters associated with pyrethroid resistance in kdr-free Anopheles arabiensis from Chad

Claudia Witzig, Matthew Parry, John C. Morgan, Helen Irving, Andrew Steven, Nelson Cuamba, Clement Kerah-Hinzoumbé, Hilary Ranson & Charles S. Wondji
Prevention of malaria transmission throughout much of Africa is dependent on bednets that are impregnated with pyrethroid insecticides. Anopheles arabiensis is the major malaria vector in Chad and efforts to control this vector are threatened by the emergence of pyrethroid resistance. WHO bioassays revealed that An. arabiensis from Ndjamena is resistant to pyrethroids and dichlorodiphenyltrichloroethane (DDT) but fully susceptible to carbamates and organophosphates. No 1014F or 1014S kdr alleles were detected in this population. To...

Data from: Positional cloning of rp2 QTL associates the P450 genes CYP6Z1, CYP6Z3 and CYP6M7 with pyrethroid resistance in the malaria vector Anopheles funestus

Helen Irving, Jacob M. Riveron, Sulaiman S. Ibrahim, Neil F. Lobo & Charles S. Wondji
Pyrethroid resistance in Anopheles funestus is threatening malaria control in Africa. Elucidation of underlying resistance mechanisms is crucial to improve the success of future control programs. A positional cloning approach was used to identify genes conferring resistance in the uncharacterised rp2 QTL previously detected in this vector using F6 Advanced Intercross Lines (AIL). A 113 kb BAC clone spanning rp2 was identified and sequenced revealing a cluster of fifteen P450 genes and one salivary protein...

Registration Year

  • 2012
    2

Resource Types

  • Dataset
    2

Affiliations

  • Liverpool School of Tropical Medicine
    2
  • University of Notre Dame
    1
  • National Institute of Health
    1