4 Works

Anti-vegf therapy in diabetic macular oedema patients over four years

Dun Jack Fu, Christoph Kern & Pearse Keane
OBJECTIVES: To evaluate visual acuity (VA) outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) in diabetic macular oedema (DMO). METHODS: In this retrospective cohort study, electronic medical records for all patients undergoing intravitreal injections (IVI) in a tertiary referral centre between March 2013 and October 2018 were analysed. Treatment response in terms of visual acuity outcomes were reported for all eyes over a 4-year observation period. RESULTS: Our cohort includes 2614 DMO eyes of 1964...

‘The last channel’: Vision at the temporal margin of the field

Peter Veto, Peter B. M. Thomas, Philip Alexander, Thomas Wemyss & John D. Mollon
The human visual field, on the temporal side, extends to at least 90 degrees from the line of sight. Using a two-alternative forced-choice procedure in which observers are asked to report the direction of motion of a Gabor patch, and taking precautions to exclude unconscious eye movements in the direction of the stimulus, we show that the limiting eccentricity of image-forming vision can be established with precision. There are large, but reliable, individual differences in...

Quantitative analysis of optical coherence tomography for neovascular age-related macular degeneration using deep learning

Gabriella Moraes, Dun Jack Fu, Marc Wilson, Hagar Khalid, Siegfried K. Wagner, Edward Korot, Daniel Ferraz, Livia Faes, Christopher J. Kelly, Terry Spitz, Praveen J. Patel, Konstantinos Balaskas, Tiarnan D. L. Keenan, Pearse A. Keane & Reena Chopra
Purpose: To apply a deep learning algorithm for automated, objective, and comprehensive quantification of optical coherence tomography (OCT) scans to a large real-world dataset of eyes with neovascular age-related macular degeneration (AMD), and make the raw segmentation output data openly available for further research. Design: Retrospective analysis of OCT images from the Moorfields Eye Hospital AMD Database. Participants: 2473 first-treated eyes and another 493 second-treated eyes that commenced therapy for neovascular AMD between June 2012...

Insights from survival analyses during 12 years of anti-VEGF therapy for neovascular age-related macular degeneration

Dun Jack Fu & Pearse Keane
Importance: While multiple imputation models for missing data and use of mixed effects models generally provide better outcome estimates than using only observed data or last observation carried forward in clinical trials, such approaches usually cannot be applied to visual outcomes from retrospective analyses of clinical practice settings, so-called real-world outcomes. Objective: To explore potential utility of survival analysis techniques for retrospective clinical practice visual outcomes. Design: Retrospective cohort study with 12-year observation period. Setting:...

Registration Year

  • 2020

Resource Types

  • Dataset


  • Moorfields Eye Hospital
  • University of Cambridge
  • National Eye Institute
  • Moorfields Eye Hospital NHS Foundation Trust
  • Addenbrooke's Hospital