Additional file 3: The Macrocodes to convert the MSA in a FASTA format into an Excel format.

Abstract Olfactory marker protein (OMP) is a cytosolic protein expressed in mature olfactory receptor neurons (ORNs). OMP modulates cAMP signalling and regulates olfactory sensation and axonal targeting. OMP is a small soluble protein, and passive diffusion between nucleus and cytoplasm is expected. However, OMP is mostly situated in the cytosol and is only sparsely detected in the nuclei of a subset of ORNs, hypothalamic neurons and heterologously OMP-expressing cultured cells. OMP can enter the nucleus...

Additional file 2: The raw MSA of OMP in FASTA format downloaded from COBALT.

Abstract Background Impaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases, and play a crucial role in brain health in older people; nonetheless, such age-related changes have not been well elucidated. Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) is a neuroimaging phenotype of idiopathic normal-pressure hydrocephalus, originating from impaired CSF dynamics, and closely associated with aging. This study aimed to investigate the pathophysiology of DESH and determine age-related changes in CSF dynamics. Methods...

Abstract Background Neonatal hemochromatosis causes acute liver failure during the neonatal period, mostly due to gestational alloimmune liver disease (GALD). Thalassemia causes hemolytic anemia and ineffective erythropoiesis due to mutations in the globin gene. Although neonatal hemochromatosis and thalassemia have completely different causes, the coexistence of these diseases can synergistically exacerbate iron overload. We report that a newborn with εγδβ-thalassemia developed neonatal hemochromatosis, which did not respond to iron chelators and rapidly worsened, requiring living-donor...

Two new rhenium(I) porphyriniod complexes (H2PY: 3,3-rhenium(I) tricarbonyl chloride-(31E,32Z,71E,72Z)-4,8-bis(perfluorophenyl)-11H,32H,72H-51λ2,71λ4-1,5(2,5),3,7(5,2)-tetrapyrrola-2,6(1,2)-dibenzenacyclooctaphane, and H2PZ: 3,3-rhenium(I) tricarbonyl acetate-(31E,32Z,71E,72Z)-4,8-bis(perfluorophenyl)-11H,32H,72H-51λ2,71λ4-1,5(2,5),3,7(5,2)-tetrapyrrola-2,6(1,2)-dibenzenacyclooctaphane) containing two different Re(I)−N π-bonding networks were prepared from the saddle-shaped porphyrin(2.1.2.1) bearing pentafluorophenyl substituents at the two meso-positions (H2Por: 31E,32Z,71E,72Z)-4,8-bis(perfluorophenyl)-11H,32H,51H,72H-1,5(2,5),3,7(5,2)-tetrapyrrola-2,6(1,2)-dibenzenacyclooctaphane). Despite the tetrapyrrolic nature of the porphyrin(2.1.2.1) scaffold, this is the first case of a pyrrole-based macrocycle which acts as a bipyridyl-like complexing ligand in the formation of an octahedral Re(I) complex. X-ray analysis and 1H NMR studies show that...

Additional file 1: Supplementary Figure. Quadriceps muscle biopsy of the patient. There were no myopathic features or inclusion bodies. (a) (b) Hematoxylin and eosin staining (Scale bar: 100 μm) (c) Modified Gomori trichrome staining (Scale bar: 100 μm) (d) Nicotinamide adenine dinucleotide dehydrogenase-tetrazolium reductase staining (Scale bar: 100 μm)

Additional file 1: Supplementary Figure. Quadriceps muscle biopsy of the patient. There were no myopathic features or inclusion bodies. (a) (b) Hematoxylin and eosin staining (Scale bar: 100 μm) (c) Modified Gomori trichrome staining (Scale bar: 100 μm) (d) Nicotinamide adenine dinucleotide dehydrogenase-tetrazolium reductase staining (Scale bar: 100 μm)

Abstract Olfactory maturation marker protein (OMP) is expressed in olfactory receptor neurons and hypothalamic neurons. OMP is a nested gene located in the intron of calpain 5 (CAPN5), a Ca2+-dependent cysteine protease. Despite being located at the same genomic locus, genetic regulation of the reciprocal expression of OMP and CAPN5 has been suggested. By performing a motif search, we detected possible calpain cleavage sites in OMP. However, the direct proteolytic regulation of OMP by CAPN5...

Abstract Olfactory maturation marker protein (OMP) is expressed in olfactory receptor neurons and hypothalamic neurons. OMP is a nested gene located in the intron of calpain 5 (CAPN5), a Ca2+-dependent cysteine protease. Despite being located at the same genomic locus, genetic regulation of the reciprocal expression of OMP and CAPN5 has been suggested. By performing a motif search, we detected possible calpain cleavage sites in OMP. However, the direct proteolytic regulation of OMP by CAPN5...

Data from: Jun-ichi Ishihara, Tomohiro Mekubo, Chikako Kusaka, Suguru Kondo, Ryotaro Oiko, Kensuke Igarashi, Hirofumi Aiba, Shu Ishikawa, Naotake Ogasawara, Taku Oshima and Hiroki Takahashi. 2022.

Additional file 1: The raw data presented in this study.

One of the characteristic aspects of odour sensing in humans is the activation of olfactory receptors in a slightly different manner to different enantiomers. Here, we focused on whether plants showed enantiomer-specific responses similar to that in humans. We exposed Arabidopsis seedlings to methanol (control) and (+)- or (−)-borneol, and found that only (+)-borneol reduced the root length. Furthermore, the root-tip width was more increased upon (+)-borneol exposure than upon (−)-borneol exposure. In addition, root-hair...

Abstract Background Variants in the valosin-containing protein (VCP) gene were identified as one of the causes for inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (FTD). Previously identified pathogenic variants in VCP are associated with frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) pathologically, but p.Asp395Gly VCP was recently reported to cause familial FTD with tauopathy characterized by neurofibrillary tau tangles (NFT) and not FTLD-TDP. We describe the clinical and genetic...

Abstract Background Variants in the valosin-containing protein (VCP) gene were identified as one of the causes for inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (FTD). Previously identified pathogenic variants in VCP are associated with frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) pathologically, but p.Asp395Gly VCP was recently reported to cause familial FTD with tauopathy characterized by neurofibrillary tau tangles (NFT) and not FTLD-TDP. We describe the clinical and genetic...

Natural selection against maladaptive interspecific reproductive interactions may cause greater divergence in mating traits between sympatric populations than between allopatric populations in a pair of species, known as reproductive character displacement (RCD), evidence for the lock-and-key hypothesis of genital evolution. However, the relative importance of various processes contributing to RCD in genital morphology (e.g., reinforcement, reproductive interference, and population filtering or the Templeton effect) is not clear. Here, we examined hypotheses for RCD in genital...

Additional file 1. A Database Search Strategy.

Two new rhenium(I) porphyriniod complexes (H2PY: 3,3-rhenium(I) tricarbonyl chloride-(31E,32Z,71E,72Z)-4,8-bis(perfluorophenyl)-11H,32H,72H-51λ2,71λ4-1,5(2,5),3,7(5,2)-tetrapyrrola-2,6(1,2)-dibenzenacyclooctaphane, and H2PZ: 3,3-rhenium(I) tricarbonyl acetate-(31E,32Z,71E,72Z)-4,8-bis(perfluorophenyl)-11H,32H,72H-51λ2,71λ4-1,5(2,5),3,7(5,2)-tetrapyrrola-2,6(1,2)-dibenzenacyclooctaphane) containing two different Re(I)−N π-bonding networks were prepared from the saddle-shaped porphyrin(2.1.2.1) bearing pentafluorophenyl substituents at the two meso-positions (H2Por: 31E,32Z,71E,72Z)-4,8-bis(perfluorophenyl)-11H,32H,51H,72H-1,5(2,5),3,7(5,2)-tetrapyrrola-2,6(1,2)-dibenzenacyclooctaphane). Despite the tetrapyrrolic nature of the porphyrin(2.1.2.1) scaffold, this is the first case of a pyrrole-based macrocycle which acts as a bipyridyl-like complexing ligand in the formation of an octahedral Re(I) complex. X-ray analysis and 1H NMR studies show that...

Abstract Japanese Hayabusa2 spacecraft has successfully carried out an impact experiment using a small carry-on impactor (SCI) on an asteroid (162173) Ryugu. We examine the size distribution of particles inside and outside an artificial impact crater (the SCI crater) based on the images taken by the optical navigation camera onboard the Hayabusa2 spacecraft. The circumferential variation in particle size distribution inside the SCI crater is recognized and we interpret that major circumferential variation is caused...

Supplementary information (PDF 4.6 MB)

Additional file 1: Fig. S1. Overview of the slope around the SCI impact site.

Abstract Japanese Hayabusa2 spacecraft has successfully carried out an impact experiment using a small carry-on impactor (SCI) on an asteroid (162173) Ryugu. We examine the size distribution of particles inside and outside an artificial impact crater (the SCI crater) based on the images taken by the optical navigation camera onboard the Hayabusa2 spacecraft. The circumferential variation in particle size distribution inside the SCI crater is recognized and we interpret that major circumferential variation is caused...

Additional file 1. A Database Search Strategy.

Abstract Rationale This systematic review aims to synthesise the outcomes of different strategies of incorporating functional biological markers in the radiation therapy plans of patients with glioblastoma to support clinicians and further research. Methods The systematic review protocol was registered on PROSPERO (CRD42021221021). A structured search for publications was performed following PRISMA guidelines. Quality assessment was performed using the Newcastle–Ottawa Scale. Study characteristics, intervention methodology and outcomes were extracted using Covidence. Data analysis focused on...

Abstract Olfactory marker protein (OMP) is a cytosolic protein expressed in mature olfactory receptor neurons (ORNs). OMP modulates cAMP signalling and regulates olfactory sensation and axonal targeting. OMP is a small soluble protein, and passive diffusion between nucleus and cytoplasm is expected. However, OMP is mostly situated in the cytosol and is only sparsely detected in the nuclei of a subset of ORNs, hypothalamic neurons and heterologously OMP-expressing cultured cells. OMP can enter the nucleus...