The use of real decision-making incentives remains under debate after decades of economic experiments. In time preferences experiments involving future payments, real incentives are particularly problematic due to between-options differences in transaction costs, among other issues. What if hypothetical payments provide accurate data which, moreover, avoid transaction cost problems? In this paper, we test whether the use of hypothetical or one-out-of-ten-participants probabilistic—versus real—payments affects the elicitation of short-term and long-term discounting in a standard multiple...

Abstract Background Social robots have demonstrated promising outcomes in terms of increasing the social health and well-being of people with dementia and mild cognitive impairment. According to the World Health Organization’s Monitoring and assessing digital health interventions framework, usability and feasibility studies are crucial before implementing prototype social robots and proving their efficacy and effectiveness. This protocol paper aims to detail the plan for conducting the usability and feasibility study of the MINI robot based...

Abstract Background Small extracellular vesicles (sEVs) are emerging natural nanoplatforms in cancer diagnosis and therapy, through the incorporation of signal components or drugs in their structure. However, for their translation into the clinical field, there is still a lack of tools that enable a deeper understanding of their in vivo pharmacokinetics or their interactions with the cells of the tumor microenvironment. In this study, we have designed a dual-sEV probe based on radioactive and fluorescent...

Additional file 3. Observed Emotions Rating Scale.

Additional file 3. Observed Emotions Rating Scale.

This paper uses Canadian matched employer-employee data to show that working hours are gross complements in production rather than perfect substitutes, as is typically assumed. We exploit within-establishment and individual-level variation in hours and wages to document novel evidence consistent with complementarities in hours worked. Next, we estimate an elasticity of substitution in working hours of 0.69 in the aggregate and between 0.52 and 1.04 at the industry level. We validate our estimates by showing...

Additional file 1. Almere model base questionnaire for Acceptability.

Additional file 1. Almere model base questionnaire for Acceptability.

Additional file 2. System Usability Scale.

Additional file 1. Fig. S1. Physicochemical characterization of non-labeled sEVs by transmission electron microscopy. Images showing the morphology and size of unlabeled sEVs. Fig. S2. In vivo and ex vivo studies of dual-sEVs. A In vivo SPECT/CT imaging of a tumor 24 h after i.v injection of the dual-sEVs. B In vivo optical imaging of tumor-bearing mice 3 h after i.v. injection in the lateral (left) and prone (right) positions. C Ex vivo optical imaging...

Additional file 1. Fig. S1. Physicochemical characterization of non-labeled sEVs by transmission electron microscopy. Images showing the morphology and size of unlabeled sEVs. Fig. S2. In vivo and ex vivo studies of dual-sEVs. A In vivo SPECT/CT imaging of a tumor 24 h after i.v injection of the dual-sEVs. B In vivo optical imaging of tumor-bearing mice 3 h after i.v. injection in the lateral (left) and prone (right) positions. C Ex vivo optical imaging...

Abstract Background Small extracellular vesicles (sEVs) are emerging natural nanoplatforms in cancer diagnosis and therapy, through the incorporation of signal components or drugs in their structure. However, for their translation into the clinical field, there is still a lack of tools that enable a deeper understanding of their in vivo pharmacokinetics or their interactions with the cells of the tumor microenvironment. In this study, we have designed a dual-sEV probe based on radioactive and fluorescent...

Additional file 2. System Usability Scale.

Abstract Background Social robots have demonstrated promising outcomes in terms of increasing the social health and well-being of people with dementia and mild cognitive impairment. According to the World Health Organization’s Monitoring and assessing digital health interventions framework, usability and feasibility studies are crucial before implementing prototype social robots and proving their efficacy and effectiveness. This protocol paper aims to detail the plan for conducting the usability and feasibility study of the MINI robot based...

RISC Report Series, 22-10