3 Works

Data from: Evaluating in vitro-in vivo extrapolation of toxicokinetics

John F. Wambaugh, Michael F. Hughes, Caroline L. Ring, Denise K. MacMillan, Jermaine Ford, Timothy R. Fennell, Sherry R. Black, Rodney W. Snyder, Nisha S. Sipes, Barbara Wetmore, Joost Westerhout, R. Woodrow Setzer, Robert Pearce, Jane-Ellen Simmons, Russell S. Thomas, Robert G Pearce, Barbara A Wetmore & Jane Ellen Simmons
Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in vivo extrapolation (IVIVE) methods have been developed to predict TK, but most of the in vivo TK data available to benchmark these methods are from pharmaceuticals. Here we report on new, in vivo rat TK experiments for 26 non-pharmaceutical chemicals...

Artificial stream channels for ecological experiments: Design, use, and example applications

Emma Rosi, Joanna Blaszczak, Christopher Dutton, Stephen Hamilton, Timothy Hoellein, John J. Kelly, Sylvia S. Lee, Heather Malcom, Alexander Reisinger, Erinn Richmond, Arial J. Shogren, Aaron Stoler, Amanda L. Subalusky, Jennifer Tank & Holly A. Wellard Kelly
The Cary artificial stream facility is located in a greenhouse on the Cary Institute of Ecosystem Studies. The facility consists of 20 artificial streams that can be used for experiments that explore diverse ecological and environmental questions.

Data from: In silico site-directed mutagenesis informs species-specific predictions of chemical susceptibility derived from the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool

Jon A. Doering, Sehan Lee, Kurt Kristiansen, Linn Evenseth, Mace G. Barron, Ingebrigt Sylte & Carlie A. LaLone
Chemical hazard assessment requires extrapolation of information from model organisms to all species of concern. The Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool was developed as a rapid, cost effective method to aid cross-species extrapolation of susceptibility to chemicals acting on specific protein targets through evaluation of protein structural similarities and differences. The greatest resolution for extrapolation of chemical susceptibility across species involves comparisons of individual amino acid residues at key positions involved...

Registration Year

  • 2018
    3

Resource Types

  • Dataset
    2
  • Other
    1

Affiliations

  • Environmental Protection Agency
    3
  • Environmental Protection Agency
    2
  • National Institute of Environmental Health Sciences
    1
  • The Arctic University of Norway
    1
  • Netherlands Organisation for Applied Scientific Research
    1
  • Cary Institute of Ecosystem Studies
    1
  • Monash University
    1
  • Environmental Protection Agency
    1
  • RTI International
    1