138 Works

Data from: Complex longitudinal diversification across South China and Vietnam in Stejneger's pit viper, Viridovipera stejnegeri (Schmidt, 1925) (Reptilia: Serpentes: Viperidae)

Peng Guo, Qin Liu, Fei Zhu, Guang H. Zhong, Xin Chen, Edward A. Myers, Jing Che, Liang Zhang, Thomas Ziegler, Truong Q. Nguyen & Frank T. Burbrink
Viridovipera stejnegeri is one of the most common pit vipers in Asia, with a wide distribution in southern China and Vietnam. We investigated historical demography and explored how the environment and climatic factors have shaped genetic diversity and the evolutionary history of this venomous snake. A total of 171 samples from 47 localities were sequenced and analysed for two mitochondrial gene fragments and three nuclear genes. Gene trees reveal the existence of two well-supported clades...

Whole-genome resequencing reveals aberrant autosomal SNPs affect chicken feathering rate

Mohan Qiu, Chaowu Yang, Huarui Du, Qingyun Li, Zengrong Zhang, Xia Xiong, Chunlin Yu, Xiaoyan Song, Chenming Hu, Bo Xia, Li Yang, Han Peng, Lan Liu & Xiaosong Jiang
Previous studies have shown that the feather growth rate of chicks is determined by two alleles located on the sex chromosome Z; however, in chicken production, feathering is usually not consistently controlled by the sex chromosome. To identify whether the feathering rate is related to autosomal inheritance, whole-genome resequencing was performed in eight chickens with slow- and fast-feathering rate. A total of 54,984 autosomal single nucleotide polymorphisms (SNPs) were identified, including 393 and 376 exonic...

Additional file 2 of Transcriptome analysis of MYB transcription factors family and PgMYB genes involved in salt stress resistance in Panax ginseng

Mingming Liu, Ke Li, Shichao Sheng, Mingyu Wang, Panpan Hua, Yanfang Wang, Ping Chen, Kangyu Wang, Mingzhu Zhao, Yi Wang & Meiping Zhang
Additional file 2: Table S2. The PgMYB protein sequences for phylogenetic analysis.

Association between frequency of dairy product consumption and hypertension: a cross-sectional study in Zhejiang Province, China

Hao Wang, Lingli Chen, Yuan Cao, Kaixu Xie, Chunmei Wang, Pei Pei, Yu Guo, Fiona Bragg, Min Yu, Zhengming Chen & Liming Li
Abstract Background Hypertension, a well-known risk factor, contributes to millions of deaths from cardiovascular and renal diseases worldwide. However, evidence on the association between frequency of dairy product consumption and hypertension is inconsistent. Methods The data for the present study are from the Tongxiang baseline dataset of the China Kadoorie Biobank prospective study. A total of 53,916 participants aged 30–79 years were included in the final analysis. Multivariable logistic regression was utilized to evaluate the...

MMP-9-mediated regulation of hypoxia-reperfusion injury-related neutrophil inflammation in an in vitro proximal tubular cell model

Yan Dong, Hong Zhao, Jiangwei Man, Shengjun Fu & Li Yang
Hypoxia-reperfusion (HR) and inflammation are causes of renal allograft injury. Pathological evidence has indicated that ischemia followed by reperfusion leads to the proteolysis and destruction of the extracellular matrix (ECM) in renal tubular epithelial cells. Matrix metalloproteinases (MMPs), such as MMP-2 and MMP-9, play roles in cleaving and reshaping the ECM. Acute accumulation of MMP-9 secreted from neutrophils promotes the incidence of inflammation and exacerbates graft trauma. Our goal was to investigate the activities of...

Additional file 1 of Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

Xin Zhao, Yubing Hu, Yan Zhao, Lin Wang, Zifang Wu, Myat Thu Soe, Myat Phone Kyaw, Liwang Cui, Xiaotong Zhu & Yaming Cao
Additional file 1: Table S1. Primers used in Pvs230 amplification and sequencing.

Additional file 2 of Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

Xin Zhao, Yubing Hu, Yan Zhao, Lin Wang, Zifang Wu, Myat Thu Soe, Myat Phone Kyaw, Liwang Cui, Xiaotong Zhu & Yaming Cao
Additional file 2: Table S2. The diversity pattern of the N-terminal repeat region in IVP of Pvs230 from global isolates. Related to Fig. 2.

Additional file 2 of Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

Xin Zhao, Yubing Hu, Yan Zhao, Lin Wang, Zifang Wu, Myat Thu Soe, Myat Phone Kyaw, Liwang Cui, Xiaotong Zhu & Yaming Cao
Additional file 2: Table S2. The diversity pattern of the N-terminal repeat region in IVP of Pvs230 from global isolates. Related to Fig. 2.

Furosemide improves the stone clearance rate of extracorporeal shockwave lithotripsy for kidney stones but not ureteral stones: a systematic review and meta-analysis

Feng Yao, Ke Li, ShiQuan Huang, XueSong Cheng & XiaoLiang Jiang
Introduction:We conducted a meta-analysis (MA) to investigate the effects of furosemide on the prognosis of extracorporeal shockwave lithotripsy (SWL) therapy to remove renal (RS) and ureteric stones (US).Methods:We screened scientific databases including PubMed, Clinicalkey, Google Scholar, Medline, Embase, and Cochrane, from the date of establishment until March 2022, to search for randomized controlled trials evaluating SWL, in combination with furosemide (experimental group) or with SWL alone (control group), in treating RS or US. Our search...

Additional file 1 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 1: Fig. S1. DNA methylation level trends. (A) Bean plots showing the methylation level distribution of methylation sites in the context of CpG, CHG and CHH at genome wide scale. (B) The methylation level trends around gene features per sample. a = promoter (2 kb upstream of transcription start site); b = first exon; c = first intron; d = inner exons; e = inner introns; f = last exon; g = downstream...

Additional file 2 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 2: Fig. S2. Methylation status of differentially methylated sites. (A-B) Volcano plots showing DMCs in the context of CHG (A) and CHH (B). (C) Bar plots showing distribution of differences in methylation levels of DMCs.

Additional file 4 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 4: Fig. S4. DNA methylation landscape. (A) The number of DMCs grouped by the differences in methylation levels per chromosome. (B-D) Manhattan plots showing the global distribution of DMCs in the context of CpG (B), CHG (C) and CHH (D). (E) DNA methylation landscape of chromosome 2.

Additional file 16 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 16: Table S11. The results of functional enrichment differentially methylated and expressed genes (MetGDE genes).

Additional file 17 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 17: Table S12. The cluster of functional annotations enriched by differential methylated and expressed genes (MetGDE genes).

Additional file 8 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 8: Table S3. The list of differentially methylated cytosines (DMCs) in the context of CpG, CHG and CHH.

Additional file 8 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 8: Table S3. The list of differentially methylated cytosines (DMCs) in the context of CpG, CHG and CHH.

Oxidative stress and NF-κB signaling are involved in LPS induced pulmonary dysplasia in chick embryos

Yun Long, Guang Wang, Ke Li, Zongyi Zhang, Ping Zhang, Jing Zhang, Xiaotan Zhang, Yongping Bao, Xuesong Yang & Pengcheng Wang
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, the precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness of alveolar gas exchange zone, and accumulation of PAS+ immature pulmonary cells, accompanied with reduced expression of alveolar epithelial cell markers and lamellar body count. Upon LPS exposure, pulmonary cell proliferation was...

Implementing a Canadian shared-care ADHD program in Beijing: Barriers and facilitators to consider prior to start-up

Sayna Bahraini, Alexander R. Maisonneuve, Yirong Liu, André Samson, Qian Ying, Fei Li, Li Yang & Philippe Robaey
Abstract Background The shared care pathway for ADHD is a program developed in Canada with two main strategies: (a) implement a shared care pathway between general practitioners (GPs) and specialists, and (b) step up or down care so that the patient is treated at the most appropriate level of care, depending on the complexity or outcome of their illness. The current study aims to identify the challenges and facilitators of implementing this program in a...

Implementing a Canadian shared-care ADHD program in Beijing: Barriers and facilitators to consider prior to start-up

Sayna Bahraini, Alexander R. Maisoneuve, Yirong Liu, André Samson, Qian Ying, Fei Li, Li Yang & Philippe Robaey
Abstract Background The shared care pathway for ADHD is a program developed in Canada with two main strategies: (a) implement a shared care pathway between general practitioners (GPs) and specialists, and (b) step up or down care so that the patient is treated at the most appropriate level of care, depending on the complexity or outcome of their illness. The current study aims to identify the challenges and facilitators of implementing this program in a...

Pre-concentration of quartz from sea sand through superconducting high gradient magnetic separation technology

Yongkui Li, Suqin Li, Xiaodong Pan, Xin Zhao & Penghui Guo
In this study, a superconducting high gradient magnetic separation (S-HGMS) technology was used to separate and extract quartz from sea sand. Under optimal conditions (i.e., a magnetic flow ratio of 0.085 T·s/m, slurry flow velocity of 400 ml/min, and pulp concentration of 40 g/L), the SiO2 grade increased from 79.45% of the raw material to 91.35% of quartz concentrate, and the removal rate of Al and Fe reached 91.97% and 82.10%, respectively. Weakly magnetic particles...

Association of TP73-AS1 gene polymorphisms with the risk and survival of gastric cancer in a Chinese Han Population

Wangwang Chen, Jian Xiao, Liang Shi, Linling Lin, Mingkun Jiang, Yugang Ge, Zengliang Li, Hao Fan, Li Yang & Zekuan Xu
It was investigated that TP73-AS1(TP73 antisense RNA 1) could function as an oncogene in gastric cancer (GC). The expression and function of long noncoding RNAs (lncRNAs) could be impacted by single nucleotide polymorphisms (SNPs), which are related to cancer susceptibility and prognosis. This study was to reveal the association between lncRNAs TP73-AS1 polymorphisms (rs1181865 A > G, rs9800 G > C, rs3737589 A > G, rs2298222 G > A, rs7515164 C > A) and GC...

Additional file 1 of Association between frequency of dairy product consumption and hypertension: a cross-sectional study in Zhejiang Province, China

Hao Wang, Lingli Chen, Yuan Cao, Kaixu Xie, Chunmei Wang, Pei Pei, Yu Guo, Fiona Bragg, Min Yu, Zhengming Chen & Liming Li
Additional file 1. Table S1. Unadjusted and adjusted β coefficients for SBP and DBP associated with frequency of dairy product consumption among adults without self-reported physician-diagnosed hypertension in Zhejiang. Table S2. Unadjusted and adjusted prevalence ratios for hypertension associated with frequency of dairy product consumption among adults in Zhejiang. Table S3. Adjusted odds ratios for hypertension associated with consuming dairy products weekly vs. never according to participant characteristics.

Additional file 1 of A CT-based nomogram for differentiating invasive fungal disease of the lung from bacterial pneumonia

Meilin Gong, Jingmei Xu, Kang Li, Ke Li, Yuwei Xia, Yang Jing, Jiafei Chen, Jing Li, Jing Yang, Mingshan Du, Wenjing Hou, Yuan Ou, Lian Li & Wei Chen
Additional file 1. On the orininal data of the study.

Whole-genome resequencing reveals aberrant autosomal SNPs affect chicken feathering rate

Mohan Qiu, Chaowu Yang, Huarui Du, Qingyun Li, Zengrong Zhang, Xia Xiong, Chunlin Yu, Xiaoyan Song, Chenming Hu, Bo Xia, Li Yang, Han Peng, Lan Liu & Xiaosong Jiang
Previous studies have shown that the feather growth rate of chicks is determined by two alleles located on the sex chromosome Z; however, in chicken production, feathering is usually not consistently controlled by the sex chromosome. To identify whether the feathering rate is related to autosomal inheritance, whole-genome resequencing was performed in eight chickens with slow- and fast-feathering rate. A total of 54,984 autosomal single nucleotide polymorphisms (SNPs) were identified, including 393 and 376 exonic...

Whole-genome resequencing reveals aberrant autosomal SNPs affect chicken feathering rate

Mohan Qiu, Chaowu Yang, Huarui Du, Qingyun Li, Zengrong Zhang, Xia Xiong, Chunlin Yu, Xiaoyan Song, Chenming Hu, Bo Xia, Li Yang, Han Peng, Lan Liu & Xiaosong Jiang
Previous studies have shown that the feather growth rate of chicks is determined by two alleles located on the sex chromosome Z; however, in chicken production, feathering is usually not consistently controlled by the sex chromosome. To identify whether the feathering rate is related to autosomal inheritance, whole-genome resequencing was performed in eight chickens with slow- and fast-feathering rate. A total of 54,984 autosomal single nucleotide polymorphisms (SNPs) were identified, including 393 and 376 exonic...

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