6 Works

Data from: Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor

Maude W. Baldwin, Yasuka Toda, Tomoya Nakagita, Mary J. O'Connell, Kirk C. Klasing, Takumi Misaka, Scott V. Edwards & Stephen D. Liberles
Sensory systems define an animal's capacity for perception and can evolve to promote survival in new environmental niches. We have uncovered a noncanonical mechanism for sweet taste perception that evolved in hummingbirds since their divergence from insectivorous swifts, their closest relatives. We observed the widespread absence in birds of an essential subunit (T1R2) of the only known vertebrate sweet receptor, raising questions about how specialized nectar feeders such as hummingbirds sense sugars. Receptor expression studies...

Data from: Natural selection for the Duffy-null allele in the recently admixed people of Madagascar

Jason A. Hodgson, Joseph K. Pickrell, Laurel N. Pearson, Ellen E. Quillen, Antonio Prista, Jorge Rocha, Himla Soodyall, Mark D. Shriver & George H. Perry
While gene flow between distantly related populations is increasingly recognized as a potentially important source of adaptive genetic variation for humans, fully characterized examples are rare. In addition, the role that natural selection for resistance to vivax malaria may have played in the extreme distribution of the protective Duffy-null allele, which is nearly completely fixed in mainland sub-Saharan Africa and absent elsewhere, is controversial. We address both these issues by investigating the evolution of the...

Data from: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

Isaac M. Chiu, Lee B. Barrett, Erika Williams, David E. Strochlic, Seungkyu Lee, Andy D. Weyer, Shan Lou, Gregory Bryman, David P. Roberson, Nader Ghasemlou, Cara Piccoli, Ezgi Ahat, Victor Wang, Enrique J. Cobos, Cheryl L. Stucky, Qiufu Ma, Stephen D. Liberles, Clifford J. Woolf & Gregory S Bryman
The somatosensory nervous system is critical for the organism’s ability to respond to mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are functionally and anatomically diverse but their molecular profiles are not well-defined. Here, we used transcriptional profiling to analyze the detailed molecular signatures of dorsal root ganglion (DRG) sensory neurons. We used two mouse reporter lines and surface IB4 labeling to purify three major non-overlapping classes of neurons: 1)IB4+SNS-Cre/TdTomato+, 2)IB4-SNS-Cre/TdTomato+, and 3)Parv-Cre/TdTomato+ cells, encompassing the...

Data from: Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast

Eduardo M. Torres, Noah Dephoure, Sunyoung Hwang, Ciara O’Sullivan, Stacie E. Dodgson, Steve P. Gygi, Angelika Amon & Ciara O'Sullivan
Aneuploidy causes severe developmental defects and is a near universal feature of tumor cells. Despite its profound effects, the cellular processes affected by aneuploidy are not well characterized. Here, we examined the consequences of aneuploidy on the proteome of aneuploid budding yeast strains. We show that although protein levels largely scale with gene copy number, subunits of multi-protein complexes are notable exceptions. Posttranslational mechanisms attenuate their expression when their encoding genes are in excess. Our...

Data from: Associations between changes in city and address specific temperature and QT interval - the VA Normative Aging Study

Amar J. Mehta, Itai Kloog, Antonella Zanobetti, Brent A. Coull, David Sparrow, Pantel Vokonas & Joel Schwartz
Background: The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily mean temperature and standard deviation of temperature was associated with heart rate-corrected QT interval (QTc) duration, a marker of ventricular repolarization in a prospective cohort of older men. Methods: This longitudinal analysis included 487 older men participating in the VA Normative Aging Study with up to three...

Data from: Delayed transmission selects for increased survival of vesicular stomatitis virus

Brian R. Wasik, Ambika Bhushan, C. Brandon Ogbunugafor & Paul E. Turner
Life-history theory predicts that traits for survival and reproduction cannot be simultaneous maximized in evolving populations. For this reason, in obligate parasites such as infectious viruses, selection for improved between-host survival during transmission may lead to evolution of decreased within-host reproduction. We tested this idea using experimental evolution of RNA virus populations, passaged under differing transmission times in the laboratory. A single ancestral genotype of Vesicular Stomatitis Virus (VSV), a negative-sense RNA Rhabdovirus, was used...

Registration Year

  • 2014

Resource Types

  • Dataset


  • Harvard Medical School
  • Harvard University
  • Howard Hughes Medical Institute
  • Boston Children's Hospital
  • Medical College of Wisconsin
  • National Health Laboratory Service
  • Dana-Farber Cancer Institute
  • Pedagogical University
  • F. M. Kirby Foundation
  • Boston University School of Medicine