18 Works

The cost effectiveness of surgery for drug resistant temporal lobe epilepsy in the US

Shehryar Sheikh, Michael Kattan, Michael Steinmetz, Mendel Singer, Belinda Udeh & Lara Jehi
Objective: Surgery is an effective but costly treatment for many patients with drug resistant temporal lobe epilepsy (DR-TLE). We aim to evaluate whether, in the United States, 1) surgery is cost-effective compared to medical management for patients deemed surgical candidates, 2) surgical evaluation is cost-effective for DR-TLE patients in general. Methods: We use a semi-Markov model to assess the cost-effectiveness of surgery and surgical evaluation over a lifetime horizon. We use 2nd order Monte Carlo...

Data from: Comparing radiomic classifiers and classifier ensembles for detection of peripheral zone prostate tumors on T2-weighted MRI: a multi-site study

Satish E. Viswanath, Prathyush V. Chirra, Michael C. Yim, Neil M. Rofsky, Andrei S. Purysko, Mark A. Rosen, Nicolas B. Bloch & Anant Madabhushi
Background: For most computer-aided diagnosis (CAD) problems involving prostate cancer detection via medical imaging data, the choice of classifier has been largely ad hoc, or been motivated by classifier comparison studies that have involved larger synthetic datasets. More significantly, it is currently unknown how classifier choices and trends generalize across multiple institutions, due to heterogeneous acquisition and intensity characteristics (especially when considering MR imaging data). In this work, we empirically evaluate and compare a number...

Data from: Whole genome sequencing reveals absence of recent gene-flow and separate demographic histories for Anopheles punctulatus mosquitoes in Papua New Guinea

Kyle Logue, Scott T. Small, Ernest R. Chan, Lisa Reimer, Peter M. Siba, Peter A. Zimmerman & David Serre
Anopheles mosquitoes are the vectors of several human diseases including malaria. In many malaria endemic areas, several species of Anopheles coexist, sometimes in the form of related sibling species that are morphologically indistinguishable. Determining the size and organization of Anopheles populations, and possible ongoing gene flow among them is important for malaria control and, in particular, for monitoring the spread of insecticide resistance alleles. However, these parameters have been difficult to evaluate in most Anopheles...

Data from: Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials

Leonard H Van Den Berg, Eric Sorenson, Gary Gronseth, Eric A. Macklin, Jinsy Andrews, Robert H. Baloh, Michael Benatar, James D. Berry, Adriano Chio, Philippe Corcia, Angela Genge, Amelie K. Gubitz, Catherine Lomen-Hoerth, Christopher J. McDermott, Erik P. Pioro, Jeffrey Rosenfeld, Vincenzo Silani, Martin R. Turner, Markus Weber, Benjamin Rix Brooks, Robert G. Miller & Hiroshi Mitsumoto
Objective: To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS). Methods: A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patient representatives, research funding representatives, industry and regulatory agencies) addressed nine areas of need within ALS research: 1. Pre-clinical studies; 2. Biological and phenotypic heterogeneity; 3. Outcome measures; 4. Disease-modifying and symptomatic interventions;...

Modeling Hospital-Wide Extracorporeal Cardiopulmonary Resuscitation: Pros and Cons

Shiksha Joshi, Sandipan Shringi, Manpreet Sira & Maya Guglin
Background We aimed to analyze the potential benefits of implementing a hospital-wide extracorporeal cardiopulmonary resuscitation (ECPR) protocol. Methods We analyzed in-hospital cardiac arrests in a large, academic hospital for two consecutive years. For this model, we assumed that ECPR would be started in all adults, with no upper age limit, who have a full code status. We excluded codes lasting <15 minutes, arrests with asystole as an initial rhythm, and patients with hemorrhagic shock or...

Reproducibility Paper Data: Data and analysis package for the draft manuscript that assesses reporting and reproducibility across a cohort of literature-based knee modeling studies. The package contains the raw data, which are the reviews performed by the KneeHub team members, and the corresponding statistical analysis.

Jason Halloran, Neda Abdollahi Nohouji, Mhd Ammar Hafez, Thor Besier, Snehal Chokhandre, Shady Elmasry, Donald Hume, Carl Imhauser, Nynke Rooks, Marco Schneider, Ariel Schwartz, Kevin Shelburne, William Zaylor & Ahmet Erdemir
Reproducible research serves as a pillar of the scientific method and is a foundation for scientific advancement. However, estimates for irreproducibility of preclinical science range from 75% to 90%. The importance of reproducible science has not been assessed in the context of mechanics-based modeling of human joints such as the knee, despite this being an area that has seen dramatic growth. Framed in the context of five experienced teams currently documenting knee modeling procedures, the...

Data from: Oxidative stress in the retina and retinal pigment epithelium (RPE): role of aging, and DJ-1

Vera Bonilha, Mala Upadhya, Caroline Milliner & Brent Bell
High levels of oxidative radicals generated by daily light exposure and high metabolic rate suggest that the antioxidant machinery of the retina and retinal pigment epithelium (RPE) is crucial for their survival. DJ-1 is a redox-sensitive protein that has been shown to have neuroprotective function in the brain in Parkinson’s disease and other neurodegenerative diseases. Here, we analyzed the role of DJ-1 in the retina during oxidative stress and aging. We induced low-level oxidative stress...

Open Knee(s): Virtual Biomechanical Representations of the Knee Joint

Ahmet Erdemir & Snehal Chokhandre
This site contains magnetic resonance imaging (MRI) and joint mechanical characterization data for 8 human cadaveric knees that included male and female, young and elderly, and healthy and osteoarthritic donors. Imaging was performed on a 3T magnet and included general purpose imaging (3D T1-weighted without fat suppression, isotropic, 0.5 mm resolution); cartilage imaging (3D T1-weighted with fat suppression, 0.35 mm sagittal plane resolution, 0.7 mm out of plane resolution); and connective tissue imaging (proton density,...

Data from: Variation in non-invasive ventilation use in amyotrophic lateral sclerosis

Nimish J. Thakore, Brittany R. Lapin, Erik P. Pioro & Loutfi S. Aboussouan
Objective: We sought to examine prevalence and predictors of non-invasive ventilation (NIV) in a composite cohort of amyotrophic lateral sclerosis (ALS) patients followed in a clinical trials setting (PRO-ACT database). Methods: NIV initiation and status were ascertained from response to question 12 of the revised ALS functional rating scale (ALSFRS-R). Factors affecting NIV use in patients with forced vital capacity (FVC) ≤ 50% of predicted were examined. Predictors of NIV were evaluated by Cox proportional...

Large mitochondrial DNA deletions in HIV sensory neuropathy

Ricardo Roda, David Bargiela, Weiran Chen, Ken Perry, Ronald J. Ellis, David B. Clifford, Ajay Bharti, Asha Kallianpur, Michelli F Oliveira, Monica M. Diaz, Leah H. Rubin, Christina Gavegnano, Justin C. McArthur, Ahmet Hoke & Michael Polydefkis
Objective: The primary objective of this study was to evaluate the correlation of large mitochondrial DNA deletions in skin samples of people with HIV with measure of neuropathy and prior exposure to therapy. We hypothesized that deletions would be associated with the presence of neuropathy. As secondary objectives we determined the correlation of deletion burden with demographic data and neuropathy measures. Methods: In this retrospective cohort study we measured the accumulation of large mtDNA deletions...

Pain in patients with Type 2 diabetes-related polyneuropathy is associated with vascular events and mortality

Brittany Lapin, Kevin M Pantalone, Alex Milinovich, Shannon Morrison, Andrew Schuster, Fernanda Boulos, Kristen Johnson & Nimish J Thakore
Type 2 diabetes–related polyneuropathy (DPN) is associated with increased vascular events and mortality, but determinants and outcomes of pain in DPN are poorly understood. We sought to examine the effect of neuropathic pain on vascular events and mortality in patients without DPN, DPN with pain (DPN + P), and DPN without pain (DPN-P). A retrospective cohort study was conducted within a large health system of adult patients with type 2 diabetes from January 1, 2009...

Human Knee Cartilage Histopathology Assessment

Venkata P Mantripragada, Ronald Midura, Ahmet Erdemir & George Muschler
90 patients with varus knees scheduled for total knee arthroplasty were recruited after getting their informed consent. Inclusion criteria required patients with a diagnosis of idiopathic OA (primarily medial compartment and/or patellofemoral disease) exhibiting a relatively preserved lateral compartment (JSW: 2–10 mm, median: 6 mm in the lateral compartment) based on preoperative weight-bearing anterior-posterior (AP) radio- graphs taken in full extension and 30° of flexion. During TKA, the Lateral Femoral Condyle (LFC) was collected and...

Data from: Revisiting protein aggregation as pathogenic in sporadic Parkinson’s and Alzheimer’s diseases

Alberto J. Espay, Joaquin A. Vizcarra, Luca Marsili, Anthony E. Lang, David K. Simon, Aristide Merola, Keith A. Josephs, Alfonso Fasano, Francesca Morgante, Rodolfo Savica, J. Timothy Greenamyre, Franca Cambi, Tritia R. Yamasaki, Caroline M. Tanner, Ziv Gan-Or, Irene Litvan, Ignacio F. Mata, Cyrus P. Zabetian, Patrik Brundin, Hubert H. Fernandez, David G. Standaert, Marcelo A. Kauffman, Michael A. Schwarzschild, S. Pablo Sardi, Todd Sherer … & James B. Leverenz
The gold standard for a definitive diagnosis of Parkinson’s disease (PD) is the pathologic finding of aggregated alpha-synuclein into Lewy bodies and for Alzheimer’s disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Implicit in this clinico-pathologic-based nosology is the assumption that pathological protein aggregation at autopsy reflect pathogenesis at disease onset. While these aggregates may in exceptional cases be on a causal pathway in humans (e.g., aggregated alpha-synuclein in SNCA gene multiplication...

Data from: A survey of risk tolerance to multiple sclerosis therapies

Robert J. Fox, Carol Cosenza, Lauren Cripps, Paul Ford, MaryBeth Mercer, Sneha Natarajan, Amber Salter, Tuula Tyry & Stacey S. Cofield
Objective: To determine tolerance to various risk scenarios associated with current MS therapies. Methods: People with MS from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry’s online cohort and the National Multiple Sclerosis Society were invited to complete a questionnaire on tolerance to real-world risks associated with a hypothetical therapy. Multiple risks levels were presented including, skin rash, infection, kidney injury, thyroid injury, liver injury, and PML. Results: Both progressive multifocal leukoencephalopathy (PML)...

Data from: Age and sex differences in burnout, career satisfaction, and well-being in US neurologists

Kathrin LaFaver, Janis M. Miyasaki, Christopher M. Keran, Carol Rheaume, Lisa Gulya, Kerry H. Levin, Elaine C. Jones, Heidi B. Schwarz, Jennifer R. Molano, Amy Hessler, Divya Singhal, Tait D. Shanafelt, Jeff A. Sloan, Paul J. Novotny, Terrence L. Cascino & Neil A. Busis
Objective: To examine age and sex differences in burnout, career satisfaction, and well-being in US neurologists. Methods: Quantitative and qualitative analyses of men’s (n = 1,091) and women’s (n = 580) responses to a 2016 survey of US neurologists. Results: Emotional exhaustion in neurologists initially increased with age, then started to decrease as neurologists got older. Depersonalization decreased as neurologists got older. Fatigue and overall quality of life in neurologists initially worsened with age, then...

Genetic and cellular/biochemical data for mouse Pycard gene differences altering mRNA turnover and IL-1b release

Jonathan D. Smith
Quantitative trait locus mapping for interleukin-1b release after inflammasome priming and activation was performed on bone marrow-derived macrophages (BMDM) from an AKRxDBA/2 strain intercross. The strongest associated locus mapped very close to the Pycard gene on chromosome 7, which codes for the inflammasome adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC). The DBA/2 and AKR Pycard genes only differ at single nucleotide polymorphism (SNP) in their 3’ untranslated region (UTR). DBA/2 vs. AKR BMDM...

Data from: Validation of serum neurofilaments as prognostic & potential pharmacodynamic biomarkers for ALS

Michael Benatar, Lanyu Zhang, Lily Wang, Volkan Granit, Jeffrey Statland, Richard Barohn, Andrea Swenson, John Ravitz, Carlayne Jackson, Ted Burns, Jaya Trivedi, Erik Pioro, James Caress, Jonathan Katz, Jacob McCauley, Rosa Rademakers, Andrea Malaspina, Lyle Ostrow & Joanne Wuu
Objective. Identify preferred neurofilament assays, and clinically validate serum NfL and pNfH as prognostic and potential pharmacodynamic biomarkers relevant to ALS therapy development. Methods. Prospective, multi-center, longitudinal observational study of patients with ALS (n=229), primary lateral sclerosis (PLS, n=20) and progressive muscular atrophy (PMA, n=11). Biological specimens were collected, processed and stored according to strict standard operating procedures (SOPs) 1. Neurofilament assays were performed in a blinded manner by independent contract research organizations (CROs). Results....

Palatal myoclonus, abnormal eye movements and olivary hypertrophy in GAD65-related disorder

Gabrielle Macaron, Mary A Willis, Daniel Ontaneda, Hubert Fernandez, Sanghoon Kim, Stephen E Jones, Erik Pioro & Jeffrey A Cohen
We report a patient with GAD65-Abs with relapsing diplopia, cerebellar syndrome, and palatal myoclonus with hypertrophy of the inferior olivary nuclei (ION) seen on 1.5T MRI and a dentato-rubro-olivary pathway lesion on 7T MRI.

Registration Year

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Resource Types

  • Dataset
    17
  • Data Paper
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Affiliations

  • Cleveland Clinic
    18
  • Mayo Clinic
    4
  • University of California, San Diego
    3
  • University of Kentucky
    3
  • Case Western Reserve University
    3
  • Massachusetts General Hospital
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  • University of Alabama at Birmingham
    2
  • University of Pennsylvania
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  • University of Cincinnati
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  • McGill University
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