11 Works

Neurofilament light chain (NfL) as a biomarker of hereditary transthyretin-mediated amyloidosis

Paul Nioi, Simina Ticau, Gautham V. Sridharan, Shira Tsour, William L. Cantley, Amy Chan, Jason A. Gilbert, David Erbe, Emre Aldinc, Mary M. Reilly, David Adams, Michael Polydefkis, Kevin Fitzgerald & Akshay Vaishnaw
To identify changes in the proteome associated with onset and progression of ATTRv amyloidosis, we performed an observational, case-controlled study which compared proteomes of patients with ATTRv amyloidosis and healthy controls. Plasma levels of >1,000 proteins were measured in patients with ATTRv amyloidosis with polyneuropathy who received either placebo or patisiran in the APOLLO study and in healthy controls. The impact of patisiran on the time profile of each protein was determined by linear mixed...

Multigene phylogenetics of euglenids based on single-cell transcriptomics of diverse phagotrophs

Gordon Lax, Martin Kolisko, Yana Eglit, Won Je Lee, Naoji Yubuki, Anna Karnkowska, Leander Brian, Gertraud Burger, Patrick Keeling & Alastair Simpson
Euglenids are a well-known group of single-celled eukaryotes, with phototrophic, osmotrophic and phagotrophic members. Phagotrophs represent most of the phylogenetic diversity of euglenids, and gave rise to the phototrophs and osmotrophs, but their evolutionary relationships are poorly understood. Symbiontids, in contrast, are anaerobes that are alternatively inferred to be derived euglenids, or a separate euglenozoan group. Most phylogenetic studies of euglenids have examined the SSU rDNA gene only, which is often highly divergent. Also, many...

Gross primary production responses to warming, elevated CO2 , and irrigation: quantifying the drivers of ecosystem physiology in a semiarid grassland

Elise Pendall, Edmund M. Ryan, Kiona Ogle, Drew Peltier, David G. Williams, Anthony P. Walker, Martin G. De Kauwe, Belinda E. Medlyn, William Parton, Shinichi Asao, Bertrand Guenet, Anna B. Harper, Xingjie Lu, Kristina A. Luus, Sönke Zaehle, Shijie Shu, Christian Werner & Jianyang Xia
Determining whether the terrestrial biosphere will be a source or sink of carbon (C) under a future climate of elevated CO2 (eCO2) and warming requires accurate quantification of gross primary production (GPP), the largest flux of C in the global C cycle. We evaluated 6 years (2007–2012) of flux‐derived GPP data from the Prairie Heating and CO2 Enrichment (PHACE) experiment, situated in a grassland in Wyoming, USA. The GPP data were used to calibrate a...

Competition and climate Great and Blue tit

Anders Pape Møller & Javier Balbontín
We studied the relationship between temperature and the coexistence of great tit Parus major and blue tit Cyanistes caeruleus, breeding in 75 study plots across Europe and North Africa. We expected an advance in laying date and a reduction in clutch size during warmer springs as a general response to climate warming and a delay in laying date and a reduction in clutch size during warmer winters due to density-dependent effects. As expected, as spring...

Data from: A new Devonian euthycarcinoid evidences the use of different respiratory strategies during the marine-to-terrestrial transition in the myriapod lineage

Pierre Gueriau, James C. Lamsdell, Roy A. Wogelius, Phillip L. Manning, Victoria M. Egerton, Uwe Bergmann, Loïc Bertrand & Julien Denayer
Myriapods were, together with arachnids, the earliest animals to occupy terrestrial ecosystems, by at least the Silurian. The origin of myriapods and their land colonization have long remained puzzling until euthycarcinoids, an extinct group of aquatic arthropods considered amphibious, were shown to be stem group myriapods, extending the lineage to the Cambrian and evidencing a marine-to-terrestrial transition. Although possible respiratory structures comparable to the air-breathing tracheal system of myriapods are visible in several euthycarcinoids, little...

Predation risk in relation to brain size in alternative prey of pygmy owls varies depending on the abundance of main prey

Anders Møller, Kari Hongisto & Erkki Korpimäki
Large brains in prey may allow adoption of anti-predator behavior that facilitates escape. Prey species with relatively large brains have been shown to be less likely to fall prey to predators. This leads to the hypothesis that individuals that have been captured by predators on average should have smaller brains than sympatric individuals. We exploited the fact that Eurasian pygmy owls Glaucidium passerinum hoard small mammals and birds in cavities and nest-boxes for over-winter survival,...

Data from: First evidence for allotriploid hybrids between Juniperus thurifera and J. sabina in a sympatric area in the French Alps

Perla Farhat, Najat Takvorian, Maria Avramidou, Luc Garraud, Robert P. Adams, Sonja Siljak-Yakovlev, Magda Bou Dagher Kharrat & Thierry Robert
At Saint Crépin location (French Alps), where sympatry between the tetraploid Juniperus thurifera and the diploid Juniperus sabina occurs, three individuals with an atypical morphology, have been observed. AFLP markers were used to unravel hybridization and potential introgression events in this population. In total, 147 polymorphic loci remained after the process of peak selection. This dataset demonstrates hybrids originated from a cross between J. sabina and J. thurifera and suggests that back-cross at least to...

Honey bee lifespan: the critical role of pre-foraging stage

Alberto Prado, Fabrice Requier, Didier Crauser, Yves Le Conte, Vincent Bretagnolle & Cedric Alaux
Assessing the various anthropogenic pressures imposed on honey bees requires characterizing the patterns and drivers of natural mortality. Using automated life-long individual monitoring devices, we monitored worker bees in different geographical, seasonal and colony contexts creating a broad range of hive conditions. We measured their life-history traits and notably assessed whether lifespan is influenced by pre-foraging flight experience. Our results show that the age at the first flight and onset of foraging are critical factors...

Data from: Pushing Raman spectroscopy over the edge: purported signatures of organic molecules in fossil animals are instrumental artefacts

Julien Alleon, Gilles Montagnac, Bruno Reynard, Thibault Brulé, Mathieu Thoury & Pierre Gueriau
Widespread preservation of fossilized biomolecules in many fossil animals has recently been reported in six studies, based on Raman microspectroscopy. Here, we show that the putative Raman signatures of organic compounds in these fossils are actually instrumental artefacts resulting from intense background luminescence. Raman spectroscopy is based on the detection of photons scattered inelastically by matter upon its interaction with a laser beam. For many natural materials, this interaction also generates a luminescence signal that...

Data from: Disturbance and predation risk influence vigilance synchrony of Black-necked Cranes Grus nigricollis, but not as strongly as expected

Dejun Kong, Anders Pape Møller & Yanyun Zhang
Animals monitor surrounding dangers independently or cooperatively (synchronized and coordinated vigilance), with independent and synchronized scanning being prevalent. Coordinated vigilance, including unique sentinel behaviour, is rare in nature, since it is time-consuming and limited in terms of benefits. No evidence showed animals adopt alternative vigilance strategies during antipredation scanning yet. Considering the non-independent nature of both synchronization and coordination, we assessed whether group members could keep alert synchronously or in a coordinated fashion under different...

What Peer-review Experiences Can Offer To Early Career Scientists And To The Scientific Community

Gwenaëlle Gremion, Mathieu Casado, Kelsey Aho, Jilda Alicia Caccavo, Nicolas Champollion, Emily Choy, Sarah L. Connors, Rahul Dey, Alfonso Fernandez, Gerlis Fugmann, Juan Höfer, Shridhar Jawak, Martine Lizotte, Sarah Maes, Kyle Mayers, Katja Mintenbeck, Jhon Fredy Mojica Moncada, Prashant H. Pandit, Elvira Poloczanska, Paul Rosenbaum, Elisa Seyboth, Sarah Shakil & Maud van Soest

Registration Year

  • 2020
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Resource Types

  • Dataset
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  • Text
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Affiliations

  • University of Paris-Saclay
    11
  • University of Lausanne
    2
  • Baylor University
    1
  • University of Liège
    1
  • New York University Abu Dhabi
    1
  • Horiba (France)
    1
  • Alnylam Pharmaceuticals (United States)
    1
  • West Virginia University
    1
  • University of Wyoming
    1
  • University of Alberta
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