219 Works

Information Literacy and Librarians’ Experiences with Teaching Grey Literature to Medical Students and Healthcare Practitioners

Yongtao Lin & Marcus Vaska
The concept of information literacy, which describes the knowledge and skills required in all contexts (i.e. educational sectors, the workplace), as well as in people’s everyday lives in today’s information rich society, was introduced in the United States in the early 1970s. According to the Association of College and Research Libraries Information Literacy Competency Standards for Higher Education (2000), it has been concluded that an information literate individual is able to determine the extent of...

Blood Workshop # 2 Thrombosis

Dawn Goodyear & Deirdre Jenkins
Generative clinical problem solving within the domain of Hematology.

Hematology Week 1

Deirdre Jenkins
Generative clinical problem solving within the domain of Hematology.

Polycythemia and Splenomegaly

Deirdre Jenkins & Chris Brown
Generative clinical problem solving within the domain of Hematology.

Guiding the Grey: The Implementation and Evaluation of a Journal Club amongst a Librarian and Clinical Practice Guideline Developers – A Cancer Care Case Study

Marcus Vaska & et al
As a research-intensive facility located within a cancer care environment, library services provided at the Holy Cross Site closely adhere to an embedded librarian mandate, one where the librarian “actively engages in activities, possesses extensive knowledge of the researcher’s work, and offers assistance above and beyond common library service expectations” (Strain, 2011). The Guideline Utilization Resource Unit (GURU) is composed of knowledge management specialists (KMS) and nurse facilitators (NF) who support multidisciplinary teams in developing,...

Canoe Reach Geothermal Field

Investigate the structure of the Canoe Reach Geothermal Field near Valemount, British Columbia. This array was also deployed to investigate the dynamics of the Rocky Mountain Trench in the Canadian Cordillera. The network included the temporary deployment of 10 three-component sensors comprised of a combination of broadband and short period instruments. These instruments occupied 12 locations. The network recorded continuous data between the late summer of 2017 until the summer of 2019.

Dehydration - Treatment

Susan Bannister & Michael Paget
Generative clinical problem solving within the domain of canuc-paeds.

Dehydration - Assessment

Susan Bannister & Michael Paget
Generative clinical problem solving within the domain of canuc-paeds.

Data from: Differential impact of severe drought on infant mortality in two sympatric neotropical primates

Fernando Campos, Urs Kalbitzer, Amanda Melin, Jeremy Hogan, Saul Cheves, Evin Murillo-Chacon, Adrián Guadamuz, Monica Myers, Colleen Schaffner, Katharine Jack, Filippo Aureli & Linda Fedigan
Extreme climate events can have important consequences for the dynamics of natural populations, and severe droughts are predicted to become more common and intense due to climate change. We analysed infant mortality in relation to drought in two primate species (white-faced capuchins, Cebus capucinus imitator, and Geoffroy's spider monkeys, Ateles geoffroyi) in a tropical dry forest in north-western Costa Rica. Our survival analyses combine several rare and valuable long-term data sets, including long-term primate life-history,...

Evaluating the use of hair as a non-invasive indicator of trace mineral status in woodland caribou (Rangifer tarandus caribou)

Naima Jutha, Claire Jardine, Helen Schwantje, Jesper Mosbacher, David Kinniburgh & Susan Kutz
Trace mineral imbalances can have significant effects on animal health, reproductive success, and survival. Monitoring their status in wildlife populations is, therefore, important for management and conservation. Typically, livers and kidneys are sampled to measure mineral status, but biopsies and lethal-sampling are not always possible, particularly for Species at Risk. We aimed to: 1) determine baseline mineral levels in Northern Mountain caribou (Rangifer tarandus caribou; Gmelin, 1788) in northwestern British Columbia, Canada, and 2) determine...

Data from: Flowering overlap and floral trait similarity help explain the structure of pollination network

Víctor Parra-Tabla, Alexander Suárez-Mariño, Gerardo Arceo-Gómez & Cristopher Albor
Co-flowering communities are usually characterized by high plant generalization but knowledge of the underlying factors leading to high levels of generalization and pollinator sharing, and how these may contribute to network structure is still limited. Flowering phenology and floral trait similarity are considered among the most important factors determining plant generalization and pollinator sharing. However, these have been evaluated independently even though they can act in concert with each other. Moreover, the importance of flowering...

Human walking in the real world: interactions between terrain type, gait parameters, and energy expenditure

Daniel Kowalsky, John Rebula, Lauro Ojeda, Peter Adamczyk & Art Kuo
Humans often traverse real-world environments with a variety of surface irregularities and inconsistencies, which can disrupt steady gait and require additional effort. Such effects have, however, scarcely been demonstrated quantitatively, because few laboratory biomechanical measures apply outdoors. Walking can nevertheless be quantified by other means. In particular, the foot’s trajectory in space can be reconstructed from foot-mounted inertial measurement units (IMUs), to yield measures of stride and associated variabilities. But it remains unknown whether such...

Comparative gene expression analysis reveals mechanism of Pinus contorta response to the fungal pathogen Dothistroma septosporum

Mengmeng Lu, Nicolas Feau, Dragana Obreht Vidakovic, Nicholas Ukrainetz, Barbara Wong, Sally Aitken, Richard Hamelin & Sam Yeaman
Many conifers have distributions that span wide ranges in both biotic and abiotic conditions, but the basis of response to biotic stress has received much less attention than response to abiotic stress. In this study, we investigated the gene expression response of lodgepole pine (Pinus contorta) to attack by the fungal pathogen Dothistroma septosporum, which causes Dothistroma needle blight (DNB), a disease that has caused severe climate-related outbreaks in northwestern British Columbia. We inoculated tolerant...

Vape flavorants dull sensory perception and cause hyperactivity in developing zebrafish embryos

Patrick Gauthier, Alison Holloway & Mathilakath Vijayan
E-cigarette use (vaping) during pregnancy has been increasing, and the potential exists for the developing brain in utero to be exposed to chemical constituents in the vape. Vapes come in over 7,000 unique flavors with and without nicotine, and while nicotine is a known neurotoxicant, the effects of vape flavoring alone, in the absence of nicotine, on brain function are not well understood. Here we performed a screen of vape aerosol extracts (VAEs) to determine...

Prospective Quantification of CSF Biomarkers in Antibody-Mediated Encephalitis

Gregory Day, Melanie L. Yarbrough, Peter Körtvelyessy, Harald Prüss, Robert C. Bucelli, Marvin J. Fritzler, Warren Mason, David F. Tang-Wai, Claude Steriade, Julien Hébert, Rachel L. Henson, Elizabeth M. Herries, Jack H. Ladenson, A. Sebastian Lopez-Chiriboga, Neill R. Graff-Radford, John C. Morris & Anne Fagan
Objective: To determine whether neuronal and neuroaxonal injury, neuroinflammation, and synaptic dysfunction associate with clinical course and outcomes in antibody-mediated encephalitis (AME), we measured biomarkers of these processes in CSF from patients presenting with AME and cognitively normal individuals. Methods: Biomarkers of neuronal (total tau, VILIP-1) and neuroaxonal damage (neurofilament light chain [NfL]), inflammation (YKL-40), and synaptic function (neurogranin, SNAP-25) were measured in CSF obtained from 45 patients at the time of diagnosis of NMDA...

Repolarization and contractility in hypertrophic cardiomyopathy patients

Andrew Radbill, Lucy Lei, Sachin Paranjape, Robert Abraham, Derek Chew, Satish Raj & Bjorn Knollmann
Aims: Arrhythmia mechanisms in hypertrophic cardiomyopathy remain uncertain. Preclinical models suggest hypertrophic cardiomyopathy-linked mutations perturb sarcomere length-dependent activation, alter cardiac repolarization in rate-dependent fashion and potentiate triggered electrical activity. This study was designed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy. Methods: All participants had a cardiac implantable device capable of atrial pacing. Cases had clinical diagnosis of hypertrophic cardiomyopathy, controls were age-matched. Continuous electrocardiogram and blood pressure...

Earthworm invasion causes declines across soil fauna size classes and biodiversity facets in northern North American forests

Malte Jochum, Olga Ferlian, Madhav Thakur, Marcel Ciobanu, Bernhard Klarner, Jörg-Alfred Salamon, Lee Frelich, Ed Johnson & Nico Eisenhauer
Anthropogenic pressures alter the biodiversity, structure, and organization of biological communities with severe consequences for ecosystem processes. Species invasion is such a human-induced ecosystem change with pronounced impacts on recipient ecosystems. Around the globe, earthworms invade habitats and impact abiotic soil conditions and a wide range of above- and belowground organisms. In northern North America, where earthworms have been largely absent since the last glaciation period and most earthworm species present today have only been...

Data from: Species loss drives ecosystem function in experiments, but in nature the importance of species loss depends on dominance

Mark A. Genung, Jeremy Fox & Rachael Winfree
Aim: Decades of experimental research have conclusively shown a positive relationship between species richness and ecosystem function. However, authoritative reviews find no consensus on how species loss affects function in natural communities. We analyse experimental and observational data in an identical way and test whether they produce similar results. Location: North America and Europe (experimental communities); global (natural communities). Time period: Experimental communities: 1998–2013; natural communities: 1982–2018. Major taxa studied: Experimental communities: temperate grassland plants;...

Niche Differentiation Data

Shasta Webb, Amanda Melin & Rachel Williamson
Understanding variation in social grouping patterns among animal taxa is an enduring goal of ethologists, who seek to evaluate the selective pressures shaping the evolution of sociality. Cohesive association with conspecifics increases intragroup feeding competition and is posited as an important pressure affecting grouping patterns. Furthermore, in sexually dimorphic species, males and females may have different nutritional requirements, which may lead to suboptimal foraging in mixed-sex groups. How do animals living in permanent social groups...

Data from: Experimental evidence that primate trichromacy is well suited for detecting primate social colour signals

Chihiro Hiramatsu, Amanda D. Melin, William L. Allen, Constance Dubuc & James P. Higham
Primate trichromatic colour vision has been hypothesized to be well tuned for detecting variation in facial coloration, which could be due to selection on either signal wavelengths or the sensitivities of the photoreceptors themselves. We provide one of the first empirical tests of this idea by asking whether, when compared with other visual systems, the information obtained through primate trichromatic vision confers an improved ability to detect the changes in facial colour that female macaque...

Data from: Chronic protein restriction in mice impacts placental function and maternal body weight before fetal growth

Paula N. Gonzalez, Malgorzata Gasperowicz, Jimena Barbeito-Andrés, Natasha Klenin, James C. Cross & Benedikt Hallgrímsson
Mechanisms of resource allocation are essential for maternal and fetal survival, particularly when the availability of nutrients is limited. We investigated the responses of feto-placental development to maternal chronic protein malnutrition to test the hypothesis that maternal low protein diet produces differential growth restriction of placental and fetal tissues, and adaptive changes in the placenta that may mitigate impacts on fetal growth. C57BL/6J female mice were fed either a low-protein diet (6% protein) or control...

Data from: Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial

W. Taylor Kimberly, Matthew B. Bevers, Rüdiger Von Kummer, Andrew M. Demchuk, Javier M. Romero, Jordan J. Elm, Holly E. Hinson, Bradley J. Molyneaux, J. Marc Simard & Kevin Navin Sheth
Objective: In this secondary analysis of the GAMES-RP trial, we report the effect of IV glyburide on adjudicated, edema-related endpoints. Methods: Blinded adjudicators assigned designations for hemorrhagic transformation, neurological deterioration, malignant edema and edema-related death to patients from the GAMES-RP Phase II randomized controlled trial of IV glyburide for large hemispheric infarct. Rates of these endpoints were compared between treatment arms in the per-protocol sample. In those participants with malignant edema, the effects of treatment...

Data from: Aging in the natural world: comparative data reveal similar mortality patterns across primates

Anne M. Bronikowski, Jeanne Altmann, Diane K. Brockman, Marina Cords, Linda M. Fedigan, Anne Pusey, Tara Stoinski, William F. Morris, Karen B. Strier & Susan C. Alberts
Human senescence patterns – late onset of mortality increase, slow mortality acceleration, and exceptional longevity – are often described as unique in the animal world. Using an individual-based dataset from longitudinal studies of wild populations of seven primate species, we show that contrary to assumptions of human uniqueness, human senescence falls within the primate continuum of aging, the tendency for males to have shorter lifespans and higher age-specific mortality than females throughout much of adulthood...

Data from: Impacts of genetic correlation on the independent evolution of body mass and skeletal size in mammals

Marta Marchini, Leah Sparrow, Miranda Cosman, Alexandra S. Dowhanik, Carsten B. Krueger, Benedikt Hallgrimsson & Campbell Rolian
Mammals show a predictable scaling relationship between limb bone size and body mass. This relationship has a genetic basis which likely evolved via natural selection but it is unclear how much the genetic correlation between these traits in turn impacts their capacity to evolve independently. We selectively bred laboratory mice for increases in tibia length independent of body mass to test the hypothesis that a genetic correlation with body mass constrains evolutionary change in tibia...

Data from: Association between integration structure and functional evolution in the opercular four-bar apparatus of the threespine stickleback, Gasterosteus aculeatus (Pisces: Gasterosteidae)

Heather A. Jamniczky, Emily E. Harper, Rebecca Garner, William A. Cresko, Peter C. Wainwright, Benedikt Hallgrimsson & Charles B. Kimmel
Phenotypes may evolve to become integrated in response to functional demands. Once evolved, integrated phenotypes, often modular, can also influence the trajectory of subsequent responses to selection. Clearly, connecting modularity and functionally adaptive evolution has been challenging. The teleost skull and jaw structures are useful for understanding this connection because of the key roles that these structures play in feeding in novel environments with different prey resources. In the present study, we examined such a...

Registration Year

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Affiliations

  • University of Calgary
    216
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