18 Works

Data from: Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial

W. Taylor Kimberly, Matthew B. Bevers, Rüdiger Von Kummer, Andrew M. Demchuk, Javier M. Romero, Jordan J. Elm, Holly E. Hinson, Bradley J. Molyneaux, J. Marc Simard & Kevin Navin Sheth
Objective: In this secondary analysis of the GAMES-RP trial, we report the effect of IV glyburide on adjudicated, edema-related endpoints. Methods: Blinded adjudicators assigned designations for hemorrhagic transformation, neurological deterioration, malignant edema and edema-related death to patients from the GAMES-RP Phase II randomized controlled trial of IV glyburide for large hemispheric infarct. Rates of these endpoints were compared between treatment arms in the per-protocol sample. In those participants with malignant edema, the effects of treatment...

Data from: GloPL, a global data base on pollen limitation of plant reproduction

Joanne. M. Bennett, Janette. A. Steets, Jean. H. Burns, Walter Durka, Jana. C. Vamosi, Gerardo Arceo-Gómez, Martin Burd, Laura. A. Burkle, Allan. G Ellis, Leandro Freitas, Junmin Li, James. G. Rodger, Marina Wolowski, Jing Xia, Tia-Lynn Ashman & Tiffany. M. Knight
Plant reproduction relies on transfer of pollen from anthers to stigmas, and the majority of flowering plants depend on biotic or abiotic agents for this transfer. A key metric for characterizing if pollen receipt is insufficient for reproduction is pollen limitation, which is assessed by pollen supplementation experiments. In a pollen supplementation experiment, fruit or seed production by flowers exposed to natural pollination is compared to that following hand pollination either by pollen supplementation (i.e....

Data from: Occasional long-distance dispersal increases spatial synchrony of population cycles

Jessica Hopson & Jeremy W. Fox
1. Spatially-separated populations of the same species often exhibit correlated fluctuations in abundance, a phenomenon known as spatial synchrony. Dispersal can generate spatial synchrony. In nature, most individuals disperse short distances with a minority dispersing long distances. The effect of occasional long-distance dispersal on synchrony is untested, and theoretical predictions are contradictory. Occasional long-distance dispersal might either increase both overall synchrony and the spatial scale of synchrony, or reduce them. 2. We conducted a protist...

Data from: Natural regeneration on seismic lines influences movement behaviour of wolves and grizzly bears

Laura Finnegan, Karine E. Pigeon, Jerome Cranston, Mark Hebblewhite, Marco Musiani, Lalenia Neufeld, Fiona Schmiegelow, Julie Duval & Gordon B. Stenhouse
Across the boreal forest of Canada, habitat disturbance is the ultimate cause of caribou (Rangifer tarandus caribou) declines. Habitat restoration is a focus of caribou recovery efforts, with a goal to finding ways to reduce predator use of disturbances, and caribou-predator encounters. One of the most pervasive disturbances within caribou ranges in Alberta, Canada are seismic lines cleared for energy exploration. Seismic lines facilitate predator movement, and although vegetation on some seismic lines is regenerating,...

Data from: Partitioning drivers of spatial genetic variation for a continuously-distributed population of boreal caribou: implications for management unit delineation

Pauline Priadka, Micheline Manseau, Tim Trottier, Dave Hervieux, Paul Galpern, Philip D. McLoughlin & Paul J. Wilson
Isolation-by-distance (IBD) is a natural pattern not readily incorporated into theoretical models nor traditional metrics for differentiating populations, although clinal genetic differentiation can be characteristic of many wildlife species. Landscape features can also drive population structure additive to baseline IBD resulting in differentiation through isolation-by-resistance (IBR). We assessed the population genetic structure of boreal caribou across western Canada using non-spatial (STRUCTURE) and spatial (MEMGENE) clustering methods and investigated the relative contribution of IBD and IBR...

Data from: Quantifying how constraints limit the diversity of viable routes to adaptation

Samuel Yeaman, Aleeza C. Gerstein, Kathryn A. Hodgins, Michael C. Whitlock & Sam Yeaman
Convergent adaptation can occur at the genome scale when independently evolving lineages use the same genes to respond to similar selection pressures. These patterns provide insights into the factors that facilitate or constrain the diversity of genetic responses that contribute to adaptive evolution. A first step in studying such factors is to quantify the observed amount of repeatability relative to expectations under a null hypothesis. Here, we formulate a novel metric to quantify the constraints...

Data from: Mating consequences of contrasting hermaphroditic plant sexual systems

Caitlin E. Tomaszewski, Mason W. Kulbaba & Lawrence D. Harder
For hermaphroditic angiosperms with multiple flowers the sex roles can be exclusively combined in bisexual flowers (monocliny), strictly separated among different flowers (monoecy), or arrayed in mixtures of bisexual flowers with female flowers (gynomonoecy) or male flowers (andromonoecy). The hypothesized benefits favoring the evolution of these contrasting hermaphroditic sexual systems are typically examined individually, usually by assessing success through only one sex role. We tested predictions of most hypotheses experimentally with an andromonoecious species, Anticlea...

Data from: Contemporary ancestor? Adaptive divergence from standing genetic variation in Pacific marine threespine stickleback

Matthew Richard John Morris, Ella Bowles, Brandon Eugene Allen, Heather A. Jamniczky & Sean M. Rogers
Background: Populations that have repeatedly colonized novel environments are useful for studying the role of ecology in adaptive divergence - particularly if some individuals persist in the ancestral habitat. Such "contemporary ancestors" can be used to demonstrate the effects of selection by comparing phenotypic and genetic divergence between the derived population and their extant ancestors. However, evolution and demography in these "contemporary ancestors" can complicate inferences about the source (standing genetic variation, de novo mutation)...

Data from: Persistently rare species experience stronger negative frequency dependence than common species: a statistical attractor that is hard to avoid

Jacob Rovere & Jeremy W. Fox
Aim: Why are so many species rare, yet persistent? Possibly, rare species experience strong negative frequency dependence (NFD, i.e. strong intraspecific competition relative to interspecific competition), which both makes them rare and buffers them against extinction. A second, not mutually exclusive, possibility is that rare species that experience weak NFD go extinct quickly due to demographic and environmental stochasticity. Both possibilities predict that persistent rare species will experience stronger NFD than common ones. Yenni et...

Data from: A coupled soil water balance model for simulating depression-focused groundwater recharge

Saskia L. Noorduijn, Masaki Hayashi, Getachew A. Mohammed & Aaron A. Mohammed
In arid and semi-arid environments focussed infiltration of rain and snowmelt water under topographic depressions is an important mechanism of groundwater recharge. Quantifying the aggregated recharge from numerous small depressions is a major challenge in water resource management. Building on field-based investigations into the surface water-groundwater interaction of individual depressions and their catchments (i.e. uplands) in the Canadian Prairies, we have developed a simple water balance model to simulate groundwater recharge considering the hydrological coupling...

Data from: Modularity of genes involved in local adaptation to climate despite physical linkage

Katie E. Lotterhos, Sam Yeaman, Jon Degner, Sally Aitken & Kathryn A. Hodgins
Background: Linkage among genes experiencing different selection pressures can make natural selection less efficient. Theory predicts that when local adaptation is driven by complex and non-covarying stresses, increased linkage is favored for alleles with similar pleiotropic effects, with increased recombination favored among alleles with contrasting pleiotropic effects. Here, we introduce a framework to test these predictions with a co-association network analysis, which clusters loci based on differing associations. We use this framework to study the...

Data from: A method for deducing neck mobility in plesiosaurs, using the exceptionally preserved Nichollssaura borealis

Ramon S. Nagesan, Donald M. Henderson & Jason S. Anderson
The elongate-necked aquatic plesiosaurs existed for 135 million years during the Mesozoic. The function of this elongate neck is a point of debate. Using computed tomography (CT) and 3-dimensional (3D) modelling, the range of motion (ROM) of the plesiosaur *Nichollssaura borealis* neck was assessed. To quantify the ROM, the intervertebral mobility was measured along the cervical vertebral column. This was done by manipulating the 3D models in the lateral and dorso-ventral directions during two trials....

Data from: Isotopic turnover rates and diet-tissue discrimination depend on feeding habits of freshwater snails

Chen-Hua Li, James D. Roth & Jillian T. Detwiler
Estimates of animal diets and trophic structure using stable isotope analysis are strongly affected by diet-tissue discrimination and tissue turnover rates, yet these factors are often unknown for consumers because they must be measured using controlled-feeding studies. Furthermore, these parameters may be influenced by diet quality, growth, and other factors. We measured the effect of dietary protein content on diet-tissue discrimination and tissue turnover in three freshwater snail species. We fed lettuce to individually housed...

Data from: Testosterone in ancient hair from an extinct species

Lee Koren, Devorah Matas, Patrícia Pečnerová, Love Dalén, Alexei Tikhonov, M. Thomas P. Gilbert, Katherine E. Wynne-Edwards & Eli Geffen
Testosterone is a key regulator in vertebrate development, physiology, and behaviour. Whereas technology allows extraction of a wealth of genetic information from extant as well as extinct species, complimentary information on steroid hormone levels may add a social, sexual, and environmental context. Hair shafts have been previously used to sequence DNA from >50,000 14C years old Siberian woolly mammoths (Mammuthus primigenius). Hair-testing has also been used to measure endogenous steroids in multiple extant species. Here...

Data from: Artificial selection sheds light on developmental mechanisms of limb elongation

Marta Marchini & Campbell Rolian
Species diversity in limb lengths and proportions is thought to have evolved adaptively in the context of locomotor and habitat specialization, but the heritable cellular processes that drove this evolution within species are poorly understood. In this study, we take a novel “micro-evo-devo” approach, using artificial selection on relative limb length to amplify phenotypic variation in a population of mice, known as Longshanks, to examine the cellular mechanisms of postnatal limb development that contribute to...

Data from: Coordinated species importation policies are needed to reduce serious invasions globally: the case of alien bumblebees in South America

Marcelo A. Aizen, Cecilia Smith-Ramirez, Carolina L. Morales, Lorena Vieli, Agustín Sáez, Rodrigo M. Barahona-Segovia, Marina P. Arbetman, José Montalva, Lucas A. Garibaldi, David W. Inouye & Lawrence D. Harder
The global trade of species promotes diverse human activities but also facilitates the introduction of potentially invasive species into new environments. As species ignore national boundaries, unilateral national decisions concerning species trade set the stage for transnational species invasion with significant conservation, economic and political consequences. The need for a coordinated approach to species importation policies is demonstrated by the introduction of two bumblebee species into Chile for crop pollination, despite Argentina banning commercial importation...

Data from: Effects of intraspecific phenotypic variation on species coexistence

Stephen Hausch, Steven M. Vamosi & Jeremy W. Fox
Intraspecific variation can promote or inhibit species coexistence, both by increasing species' competitive abilities, and by altering the relative strengths of intraspecific and interspecific competition. Effects of intraspecific variation on coexistence can occur via complementarity of different variants, and via a selection effect: initially-variable populations are more likely to contain highly competitive variants that might determine the competitive ability of the population as a whole. We tested the effects of intraspecific variation and composition on...

Data from: Towards the validation of endogenous steroid testing in wildlife hair

Lee Koren, Heather Bryan, Devorah Matas, Simon Tinman, Asa Fahlman, Douglas Whiteside, Judit Smits & Katherine Wynne-Edwards
1. Hair is emerging as a popular tool to examine steroid hormone levels in wild mammals. The reliability of this approach, however, depends on an understanding of steroid hormone incorporation into hair as well as appropriate validations. 2. We reviewed studies that have examined steroid hormones in wildlife hair with the goal of summarizing the analytical, physiological, and biological evidence that this approach is meaningful. Accordingly, we differentiated among validations aimed at evaluating the reliability...

Registration Year

  • 2018

Resource Types

  • Dataset


  • University of Calgary
  • Monash University
  • University of Minnesota
  • University of Pittsburgh
  • University of Manitoba
  • Massachusetts General Hospital
  • University of Montana
  • Parks Canada
  • Oregon Health & Science University
  • Department of Plant Biology