55 Works

Blood Workshop # 2 Thrombosis

Dawn Goodyear & Deirdre Jenkins
Generative clinical problem solving within the domain of Hematology.

Hematology Week 1

Deirdre Jenkins
Generative clinical problem solving within the domain of Hematology.

Polycythemia and Splenomegaly

Deirdre Jenkins & Chris Brown
Generative clinical problem solving within the domain of Hematology.

Dehydration - Treatment

Susan Bannister & Michael Paget
Generative clinical problem solving within the domain of canuc-paeds.

Dehydration - Assessment

Susan Bannister & Michael Paget
Generative clinical problem solving within the domain of canuc-paeds.

Prospective Quantification of CSF Biomarkers in Antibody-Mediated Encephalitis

Gregory Day, Melanie L. Yarbrough, Peter Körtvelyessy, Harald Prüss, Robert C. Bucelli, Marvin J. Fritzler, Warren Mason, David F. Tang-Wai, Claude Steriade, Julien Hébert, Rachel L. Henson, Elizabeth M. Herries, Jack H. Ladenson, A. Sebastian Lopez-Chiriboga, Neill R. Graff-Radford, John C. Morris & Anne Fagan
Objective: To determine whether neuronal and neuroaxonal injury, neuroinflammation, and synaptic dysfunction associate with clinical course and outcomes in antibody-mediated encephalitis (AME), we measured biomarkers of these processes in CSF from patients presenting with AME and cognitively normal individuals. Methods: Biomarkers of neuronal (total tau, VILIP-1) and neuroaxonal damage (neurofilament light chain [NfL]), inflammation (YKL-40), and synaptic function (neurogranin, SNAP-25) were measured in CSF obtained from 45 patients at the time of diagnosis of NMDA...

Repolarization and contractility in hypertrophic cardiomyopathy patients

Andrew Radbill, Lucy Lei, Sachin Paranjape, Robert Abraham, Derek Chew, Satish Raj & Bjorn Knollmann
Aims: Arrhythmia mechanisms in hypertrophic cardiomyopathy remain uncertain. Preclinical models suggest hypertrophic cardiomyopathy-linked mutations perturb sarcomere length-dependent activation, alter cardiac repolarization in rate-dependent fashion and potentiate triggered electrical activity. This study was designed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy. Methods: All participants had a cardiac implantable device capable of atrial pacing. Cases had clinical diagnosis of hypertrophic cardiomyopathy, controls were age-matched. Continuous electrocardiogram and blood pressure...

Earthworm invasion causes declines across soil fauna size classes and biodiversity facets in northern North American forests

Malte Jochum, Olga Ferlian, Madhav Thakur, Marcel Ciobanu, Bernhard Klarner, Jörg-Alfred Salamon, Lee Frelich, Ed Johnson & Nico Eisenhauer
Anthropogenic pressures alter the biodiversity, structure, and organization of biological communities with severe consequences for ecosystem processes. Species invasion is such a human-induced ecosystem change with pronounced impacts on recipient ecosystems. Around the globe, earthworms invade habitats and impact abiotic soil conditions and a wide range of above- and belowground organisms. In northern North America, where earthworms have been largely absent since the last glaciation period and most earthworm species present today have only been...

Niche Differentiation Data

Shasta Webb, Amanda Melin & Rachel Williamson
Understanding variation in social grouping patterns among animal taxa is an enduring goal of ethologists, who seek to evaluate the selective pressures shaping the evolution of sociality. Cohesive association with conspecifics increases intragroup feeding competition and is posited as an important pressure affecting grouping patterns. Furthermore, in sexually dimorphic species, males and females may have different nutritional requirements, which may lead to suboptimal foraging in mixed-sex groups. How do animals living in permanent social groups...

Behavioral responses by a bumble bee to competition with a niche-constructing congener

Nick Rosenberger, Marcelo Aizen, Rachel Dickson & Lawrence Harder
While feeding, foragers can alter their environment. Such alteration constitutes ecological niche construction (ENC) if it enables future benefits for the constructor and conspecific individuals. The environmental modification may also affect non-constructing, bystander species, especially if they share resources with constructor species. If so, ENC could confer the constructor species a competitive advantage by both enhancing its foraging returns and reducing those of bystander species. Expectations – (E1) ENC frequency should vary positively with the...

Primordial GATA6 macrophages function as extravascular platelets in sterile injury

Joel Zindel, Moritz Peiseler, Mokarram Hossain, Carsten Deppermann, Woo Yong Lee, Beat Haenni, Bas Surewaard, Daniel Candinas & Paul Kubes
Most multicellular organisms have a major body cavity that harbors immune cells. In primordial species like purple sea urchins, these cells perform phagocytic functions but are also crucial in repairing injuries. In mammals, the peritoneal cavity contains large numbers of resident GATA6+ macrophages, which may play a similar role. It is unclear how cavity macrophages suspended in the fluid phase (peritoneal fluid) identify and migrate towards injuries, however. Here, we show that cavity macrophages in...

Diet variation driven by color vision phenotype in wild capuchin monkeys

Allegra DePasquale & Amanda Melin
The polymorphic color vision of platyrrhine monkeys is a fascinating example of balancing selection acting on multiple genetic and phenotypic morphs. Yet, the mechanism of natural selection maintaining this variation remains elusive. Past research has demonstrated task-specific foraging advantages to dichromatic (two-opsin vision, red-green colorblind) and trichromatic (three-opsin vision, human “normal”) monkeys, raising the potential for dietary niche differentiation. We ask whether color vision type influences diet variation in a population of wild, white-faced capuchins...

Haploid, diploid, and pooled exome capture recapitulate features of biology and paralogy in two non-model tree species

Brandon Lind, Mengmeng Lu, Dragana Obreht Vidakovic, Pooja Singh, Tom Booker, Sally Aikten & Sam Yeaman
Despite their suitability for studying evolution, many conifer species have large and repetitive giga-genomes (16-31Gbp) that create hurdles to producing high coverage SNP datasets that capture diversity from across the entirety of the genome. Due in part to multiple ancient whole genome duplication events, gene family expansion and subsequent evolution within Pinaceae, false diversity from the misalignment of paralog copies creates further challenges in accurately and reproducibly inferring evolutionary history from sequence data. Here, we...

The energetic basis for smooth human arm movements

Jeremy Wong
The central nervous system plans human reaching movements with stereotypically smooth kinematic trajectories and fairly consistent durations. Smoothness seems to be explained by accuracy as a primary movement objective, whereas duration seems to avoid excess energy expenditure. But energy does not explain smoothness, so that two aspects of the same movement are governed by seemingly incompatible objectives. Here we show that smoothness is actually economical, because humans expend more metabolic energy for jerkier motions. The...

CaMI Field Research Station Geophone Network (CaMI.FRS)

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Surface and borehole geophones installed within a 1 x 1 km area centered on the injection well of the CaMI Field Research Station. The geophone network records continuously to monitor microseismicity and velocity changes due to shallow CO2 injection. More information on the Field Research Station can be found at https://cmcghg.com/cami/field-research-station/

Leukemia and Lymphoma

Deirdre Jenkins & Chris Brown
Generative clinical problem solving within the domain of Hematology.

Abdominal Pain / Mass

Susan Bannister, Michael Paget & Theresa Wu
Generative clinical problem solving within the domain of canuc-paeds.

Pallor / Anemia - Diagnosis

Susan Bannister, Hosanna Au, Angela Punnett & Michael Paget
Generative clinical problem solving within the domain of canuc-paeds.

Episode 1.1: Radclyff Hall / Jana Funke

Karen Bourrier & Kathryn Holland

Are Bank Bailouts Welfare Improving?

Malik Shukayev & Alexander Ueberfeldt
"The financial sector bailouts seen during the Great Recession generated substantial opposition and controversy. We assess the welfare benefits of government-funded emergency support to the financial sector, taking into account its effects on risk-taking incentives. In our quantitative general equilibrium model, the probability of a financial crisis depends on the balance sheet choices of financial intermediaries. Those choices are influenced by capital adequacy constraints and ex ante known emergency support provisions. These policy tools interact...

Ethical Use of Technology in Digital Learning Environments: Graduate Student Perspectives

Barbara Brown, Verena Roberts, Michele Jacobsen, Christie Hurrell, Dean Parthenis, Emma Lockyer, Heather van Streun, Jeff Lowry, Jennifer Ansorger, Kourtney Kerr, Nicole Neutzling, Simo Zarkovic & Terri Marles
This book is the result of a co-design project in a class in the Masters of Education program at the University of Calgary. The course, and the resulting book, focus primarily on the safe and ethical use of technology in digital learning environments. The course was organized according to four topics based on Farrow’s (2016) Framework for the Ethics of Open Education.

Advanced Hemostasis

Deirdre Jenkins, Dawn Goodyear & Kelly Burak
Generative clinical problem solving within the domain of Hematology.

Hematology Week 3

Deirdre Jenkins & Chris Brown
Generative clinical problem solving within the domain of Hematology.

Respiratory distress / Cough

Susan Bannister & Michael Paget
Generative clinical problem solving within the domain of canuc-paeds.

Repurposing Domperidone in Secondary Progressive MS - A Simon 2-Stage Phase 2 Futility Trial - Table e1: Results of the binary logistic regression model

Marcus Koch
Objective: To assess whether treatment with the generic drug domperidone can reduce the progression of disability in secondary progressive multiple sclerosis (SPMS), we conducted a phase 2 futility trial following the Simon two-stage design. Methods: We enrolled patients in an open-label, Simon two-stage, single-center, phase 2, single-arm futility trial at the Calgary MS Clinic if they met the following criteria: age 18 to 60 years, SPMS, screening EDSS score of 4.0 to 6.5 and screening...

Registration Year

  • 2021
    55

Resource Types

  • Dataset
    32
  • Interactive Resource
    14
  • Text
    4
  • Sound
    2
  • Book Chapter
    1
  • Journal Article
    1
  • Report
    1

Affiliations

  • University of Calgary
    54
  • Alberta Health Services
    5
  • University of Toronto
    4
  • University of British Columbia
    3
  • MacEwan University
    2
  • University of Montana
    2
  • University of Alberta
    2
  • University of Bern
    2
  • National University of Comahue
    2
  • Bank of Canada
    2